Fibrosarcoma is a malignant neoplasm arising from the connective tissues. This usually affects women more than men, especially in the age group from 30 to 40 years of age.
The tumour can be located in any body part, but its preferred spot is the connective tissue of the upper (shoulder area) and lower (thigh area) limbs.
At the moment, the exact reasons for this disease remains unclear. There are several factors that can increase the risk of the malignant process outlined below:
The impact of some viruses that build into the genome of connective tissue cells is being also researched. Viruses change the genome which leads to the malignant process.
Clinical signs of fibrosarcoma depend on its size and location.
Symptoms related to the tumour location are:
Symptoms related to the tumour size are:
If the intoxication syndrome develops, it is manifested by a lack of appetite, weakness, fever, emotional instability (rapid mood swings), and depression.
The appearance of metastases in the bones is manifested by persistent pain sensations, the severity of which practically does not decrease with the use of non-steroidal anti-inflammatory drugs. Metastases in the lungs lead to coughing, shortness of breath and hemoptysis.
Diagnostic measures are prescribed by a doctor on the basis of a clinical exam including a survey, examination of the patient, as well as palpation of tissues in the area of the tumour development and regional lymph nodes.
Objective diagnostics pursues several main goals, which include determining the histological structure of the tumour, its size and the precise location in the body. Diagnostics will also show possible metastases, their number and location.
Such diagnostic goals are reached in modern European hospitals with the use of the latest devices providing accurate results. The tests include:
Additional tests including a complete blood count, urine test, blood biochemistry, and electrocardiogram are conducted. This way, specialists are able to analyse possible functional disorders of various organs and systems.
Comprehensive diagnostics enables a doctor to confirm the stage of fibrosarcoma development and to choose the most effective therapeutic measures.
Radical or palliative treatment is prescribed based on the diagnostics results. The type and extent of the surgery is defined by the location and prevalence of the oncologic process.
Radical treatment in modern European hospital presupposes tumour removal, prevention of recurrence and formation of metastases. Chemotherapy and radiation therapy are used to reach this goal.
Palliative therapy is recommended in the late stages and it can include tumour or metastases removal to restore the tissues function around the fibrosarcoma area and ease the symptoms.
Different kinds of radiation therapy are implemented in German hospitals. This therapy is an additive to the surgery which helps to prolong the patient’s life expectancy.
The following methods are used for the treatment of fibrosarcoma:
Depending on the tissue structure there are highly-differentiated tumours distinguished with a predominance of collagen fibres over cancer cells and low-differentiated fibrosarcomas, where cancer cells predominate. Low-differentiated fibrosarcomas are characterised by more aggressive growth, early metastasis and a worse prognosis.
Five-year survival, depending on the prevalence of fibrosarcoma:
A favourable outcome of the disease is possible only with early radical treatment of a highly differentiated tumour.
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