Hematology: Chronic lymphocytic leukemia (cll) — Stem cell transplant. Treatment
Chronic lymphoblastic leukemia is characterized by slow development, so many patients do not need treatment for years. The therapy is commenced only if the pathology begins to progress. Selection of a particular method depends on the patient's condition. Young patients respond poorly to chemotherapy, so the stem cell transplantation can be indicated.
Preparation for the procedure begins with a detailed diagnosis. Transplant physician reviews the case history and conducts a clinical examination. Additionally, the patient is prescribed:
- complete blood count,
- blood chemistry,
- cytogenetic analysis,
- comprehensive CT/MRI.
Based on the findings, a decision about the need in stem cell transplantation is made.
There are two types of transplantation:
In the first case, the patient is transplanted donor material, and in the second, his/her own, taken during remission. Regardless of the source, the bone marrow is transplanted after a high-dose chemotherapy, during which the patient’s hematopoietic cells are destroyed completely.
The procedure is performed at the clinic setting. The patient is hospitalized for up to 57 days. All this time, s/he stays in a sterile ward where s/he receives meticulous care and supervision.
Stem cells are injected into the body intravenously. From the bloodstream, they enter the bone marrow, where they begin to take roots. Normal hematopoiesis is restored within the next 4 to 6 weeks.
After transplantation, the patient feels a general malaise. S/he may report nausea, vomiting, and increased gum bleeding. Various drugs are prescribed to alleviate the condition. The cost of medication is determined by the treatment intensity.
Before discharge, the patient visits the oncologist, who provides him/her instructions for further treatment.Hide
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