Hematology: Chronic myelogenous leukemia (cml) — Stem cell transplant. Treatment
Drug therapy administered for chronic myeloid leukemia allows achieving a long-term remission, but does not cure completely. Therefore, in the absence of contraindications, the young patients are advised the stem cell transplantation. If successful, this procedure leads to a full recovery.
On the eve of transplantation, the patient consults an oncologist. The physician reviews the case history, clarifies the complaints and conducts clinical examination. The following tests are prescribed:
- complete blood count,
- blood chemistry,
- cytogenetic analysis,
- comprehensive CT or MRI.
According to the research, the general condition of the patient and the risks of the procedure are assessed.
If no related donor is found, the patient is transplanted his/her own stem cells. This transplantation method is called autologous. Cells are taken from the blood of the patient in the chronic phase of the disease, and are stored frozen until procedure.
Transplantation is performed in the clinic setting. The patient is hospitalized for up to 57 days. All this time s/he stays in a sterile ward, where s/he receives meticulous care from the medical staff.
The stem cells are administered intravenously over 1.5 hours (similarly to the blood transfusion). From the bloodstream, the cells enter the bone marrow, where they begin to take roots. This process lasts several weeks.
After transplantation, the patient is vulnerable to infectious diseases, so it is recommended to follow a regime of strict isolation. The patient is monitored by the experiencing medical staff of the clinic. The restrictions are mitigated as soon as the number of white blood cells begins to increase in blood.
As regards the treatment side effects, the patients may report:
- increased gum bleeding.
Various drugs are prescribed to alleviate the condition. The cost of drugs depends on the treatment intensity.
Before discharge, the patient talks to the oncologist who provides recommendations for further action.Hide
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