Hematology: Non-Hodgkin lymphoma (B- and T-cell) — Stem cell transplant. Treatment
Stem cell transplantation may be indicated to patients with lymphomas after chemotherapy failure or disease relapse. If the neoplastic process has not affected the brain, the transplantation material is usually taken from the patient. Otherwise, the selection of a compatible donor is required.
Before the procedure, the patient must take a series of tests, including:
- complete blood count,
- blood chemistry with a complete hemogram,
- cytogenetic analysis,
- abdominal ultrasound,
- comprehensive CT or MRI.
Based on the test findings and case history, the physician designs the best treatment plan, and identifies the eventual risks and complications.
The stem cells are extracted from the patient's own bone marrow or peripheral blood shortly before the procedure. This method is called autologous transplantation. The taken material is processed in a special way and stored frozen until transplantation.
Upon allogeneic transplant, the healthy cells are obtained from another person. The best donors are immediate family members (siblings, parents). If this option is impossible, a suitable donor is sought in the international registry.
Transplantation is performed in a clinic setting. To do this, the patient is hospitalized for 57 days. The stem cells are injected into the bloodstream through the catheter. Circulating in the circulatory system, they gradually colonize the bone marrow and begin to divide. The healing process lasts for several weeks.
During rehabilitation period, the patient stays in an isolated ward, where the sterile conditions are maintained. This is required to protect a weakened body from infections. To eliminate the side effects of transplantation, the physician prescribes a symptomatic treatment. The cost of medication is determined by intensity of activities.
Careful patient care is organized by the nursing staff of the clinic. Before discharge, the patient is provided recommendations for further treatment.Hide
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