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Neurosurgery: Chordoma of the Skull Base

Chordomas are rare malignant tumors growing from embryonic remnants of the chord. In 30% cases, they are located at the base of the skull (cranial chordomas). Most cases are registered at the age of 30 to 60. To confirm the diagnosis, the patients undergo the biopsy followed by histological examination. The compulsory step in chordoma treatment is surgical removal of the tumor. Also, the radiosurgery, proton therapy and chemotherapy can be used.

Surgery

For a long time, the cranial chordoma used to be removed by craniotomy. The radicality of this method was low, and the rate of complications was high.

In modern surgery, this intervention is performed via transnasal (through the nose), or transoral (through the mouth) access, which allows reducing the injury significantly. The affected tissues are excised with microsurgical instruments without compromising the healthly brain structures. The manipulation precision is monitored using the endoscopic techniques.

When possible, the tumor is removed completely, with the capsule. However, most patients are diagnosed when the formation invaded the surrounding tissues, so surgeons must be limited to a partial resection.

Radiosurgery

The essence of radiosurgery is a single tumor irradiation with thin beams of radiation from a variety of angles. The main mass of energy is released precisely into the pathological focus, not spreading to the adjacent healthy tissues. High-dose exposure leads to destruction of the genetic apparatus of malignant cells and their gradual destruction. The procedure effects are manifested over the next 6 to 24 months.

The main indication for radiosurgery is residual postoperative tumors. This technique can be recommended as the only treatment method for small (less than 3 cm) or inoperable tumors.

Good results in patients with chordomas are produced by radiosurgical interventions using the Gamma Knife and Novalis. Both types of therapy are performed on an outpatient basis in one day.

Proton Therapy

Proton therapy is a type of radiotherapy upon which the pathological focus is affected by the beams of heavy particles, i.e. protons. Unlike x-rays, proton beams provide a maximum energy concentration in the final point of impact and substantially do not lose its when passing through healthy surface tissues. In comparison with traditional radiation, such treatment is safer and more effective.

The proton therapy is indicated to patients with chordomas in the postoperative period for destruction of residual tumor. Procedures are conducted daily for several weeks.

Chemotherapy

Anticancer drugs are used upon postoperative radiotherapy failure, or in the case of disease recurrence. The patients are prescribed such innovative drugs as tyrosine kinase inhibitors and platinum drugs.

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Charite University Hospital Berlin

9/10 from 95 Votes

Department of Neurosurgery and Pediatric Neurosurgery

Surgical resection of Chordoma of the skull base #210305

The Department of Neurosurgery and Pediatric Neurosurgery at the University Hospital Charite deals with the treatment of the peripheral and central nervous systems.


Duration: 12 days
Type of Treatment: Inpatient
location_onCountry: Germany
location_searchingCity: Berlin
certificate

Sana Hospital Duisburg

9.8/10 from 5 Votes

Department of Neurosurgery

Surgical resection of Chordoma of the skull base #220465

The Department of Neurosurgery offers surgical treatment of neurological, neuropediatric and orbital diseases. With 68 beds, the department ranks among the largest German Neurosurgy Centers and has a long experience in all fields of microsurgery and neuroendoscopy.


Duration: 12 days
Type of Treatment: Inpatient
location_onCountry: Germany
location_searchingCity: Duisburg

University Hospital Münster

9.4/10 from 78 Votes

Department of Neurosurgery

Surgical resection of Chordoma of the skull base #205101

The Department of Neurosurgery at the University Hospital Münster deals with the surgical treatment of diseases of the central and peripheral nervous systems.


Duration: 12 days
Type of Treatment: Inpatient
location_onCountry: Germany
location_searchingCity: Muenster

University Hospital Rechts der Isar of the Munich Technical University

8.3/10 from 70 Votes

Department of Neurosurgery

Surgical resection of Chordoma of the skull base #201835

The Department of Neurosurgery at the university hospital Klinikum rechts der Isar is a part of the newly established “Neuro-Kopf-Zentrum” since March 2007.


Duration: 12 days
Type of Treatment: Inpatient
location_onCountry: Germany
location_searchingCity: Munich

University Hospital Frankfurt

9.5/10 from 97 Votes

Department of Neurosurgery

Surgical resection of Chordoma of the skull base #210791

The Department of Neurosurgery specializes in the diagnosis and treatment of neurosurgical diseases. The department has state-of-the-art neurosurgical equipment and a team of highly qualified doctors.


Duration: 12 days
Type of Treatment: Inpatient
location_onCountry: Germany
location_searchingCity: Frankfurt am Main

Alfried Krupp Hospital in Essen-Ruettenscheid

7.4/10 from 42 Votes

Department of Neurosurgery

Surgical resection of Chordoma of the skull base #217125

The Department of Neurosurgery at the Alfried Krupp Hospital in Essen focuses on the following tasks and areas: microsurgery, vascular brain surgery, brain tumors, skull base surgery, spinal column surgery, traumatic brain injury, peripheral nerves, pain therapy, radiosurgery.


Duration: 12 days
Type of Treatment: Inpatient
location_onCountry: Germany
location_searchingCity: Essen

Tel Aviv Sourasky Medical Center

9.9/10 from 23 Votes

Department of Neurosurgery

Surgical resection of Chordoma of the skull base #330632

The Department of Neurosurgery at the Tel Aviv Sourasky Medical Center specializes in the treatment of diseases of the brain, spinal cord and peripheral nervous system in children and adults. The Department is considered the leading neurosurgery facility in Israel and worldwide.


Duration: 12 days
Type of Treatment: Inpatient
location_onCountry: Israel
location_searchingCity: Tel Aviv

University Hospital Cologne

9.8/10 from 82 Votes

Department of Neurosurgery

Surgical resection of Chordoma of the skull base #208689

The Department of Neurosurgery is the center of excellence in research and patient care. The department consists of two sections: the Section of General Neurosurgery specializing in the treatment of diseases of the nervous system and the Section of Stereotactic and Functional Neurosurgery.


Duration: 12 days
Type of Treatment: Inpatient
location_onCountry: Germany
location_searchingCity: Cologne

Rambam Health Care Campus

9.8/10 from 23 Votes

Department of Neurosurgery

Surgical resection of Chordoma of the skull base #327604

The Department of Neurosurgery at Rambam Health Care Campus deals with the diagnosis and treatment of the entire spectrum of diseases of the central nervous system. The Department has 32 beds, including 11 neurointensive care beds.


Duration: 12 days
Type of Treatment: Inpatient
location_onCountry: Israel
location_searchingCity: Haifa

University Hospital for Neurosurgery Salzburg

9.6/10 from 39 Votes

Department of Neurosurgery

Surgical resection of Chordoma of the skull base #198523

University Clinic of Neurology specializes in the surgical treatment of acute and chronic diseases of the central and peripheral nervous system, its blood supply, and nerve sheaths, as well as in preoperative and postoperative care for patients.


Duration: 12 days
Type of Treatment: Inpatient
location_onCountry: Austria
location_searchingCity: Salzburg

University Hospital of the Ludwig-Maximilians-University Munich

9.2/10 from 40 Votes

Department of Neurosurgery

Surgical resection of Chordoma of the skull base #203651

The Department of Neurosurgery at the University Hospital of Munich focuses on personalized treatment plans tailored to the patient’s needs, which meet the highest medical and technical standards. Here, the therapy of neurosurgical diseases is performed with the help of leading technologies.


Duration: 12 days
Type of Treatment: Inpatient
location_onCountry: Germany
location_searchingCity: Munich

University Hospital Tubingen

9.2/10 from 55 Votes

Department of Neurosurgery

Surgical resection of Chordoma of the skull base #205319

The Department of Neurosurgery covers the full range of neurosurgical interventions. These include surgery of brain cancer and spinal cord tumor in children and adults, skull base and pituitary surgery, treatment of neurofibromatosis, vascular malformations / aneurysms, hydrocephalus, traumatic brai...


Duration: 12 days
Type of Treatment: Inpatient
location_onCountry: Germany
location_searchingCity: Tuebingen

Academic Hospital Bogenhausen

9.2/10 from 43 Votes

Department of Neurosurgery

Surgical resection of Chordoma of the skull base #203989

The department of neurosurgery d specializes in the diagnosis and treatment of brain and spine diseases. Performing about 2500 surgeries annually, the department is considered one of the leading centers of neurosurgery in Germany.


Duration: 12 days
Type of Treatment: Inpatient
location_onCountry: Germany
location_searchingCity: Munich

University Hospital Erlangen

9.1/10 from 51 Votes

Department of Neurosurgery

Surgical resection of Chordoma of the skull base #252955

As one of the largest clinics of neurosurgery in Germany with over 2,500 operations per year, the Department of Neurosurgery at the University Hospital Erlangen covers the whole range of neurosurgical diseases, injuries, inflammations, tumors and malformations of the brain and spinal cord and their ...


Duration: 12 days
Type of Treatment: Inpatient
location_onCountry: Germany
location_searchingCity: Erlangen
certificate

Hirslanden Clinic St. Anna

9/10 from 3 Votes

Department of Neurosurgery

Surgical resection of Chordoma of the skull base #207249

The goal of the Neurosurgery clinic is to offer the best possible medical treatment for each patient through its high expertise in the areas of the spinal and cranial surgery.


Duration: 12 days
Type of Treatment: Inpatient
location_onCountry: Switzerland
location_searchingCity: Lucerne

Hirslanden Multispecialty Clinic Aarau

8.9/10 from 15 Votes

Department of Neurosurgery

Surgical resection of Chordoma of the skull base #206317

The specialist field of neurosurgery deals with the diagnosis and surgical treatment of diseases, injuries and malformations concerning the central, vegetative and peripheral nervous system. The neurosurgery department is part of the Hirslanden Cranio-Facial Centre.


Duration: 12 days
Type of Treatment: Inpatient
location_onCountry: Switzerland
location_searchingCity: Aarau




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