RWTH University Hospital Aachen

Aachen, Germany

Chemotherapy in chronic myelogenous (myeloid) leukemia chemotherapy and immunotherapy (1 curse) (program ID: 104763)

Tim H. Brümmendorf

Prof. Dr. med.

Tim H. Brümmendorf

Cancer centre – Euregional Comprehensive Cancer Center Aachen (ECCA)

Specialized in: oncology

Curriculum vitae keyboard_arrow_down


  • Akute und chronische Leukämien
  • Maligne Lymphome
  • Molekular zielgerichtete Therapie

Wissenschaftliche Schwerpunkte

  • Telomerbiologie der Hämatopoese
  • Stammzellbiologie der Hämatopoese
  • Kinaseinhibitoren in der Therapie hämatologischer Neoplasien
  • Hypusinierung und der eukaryontische Initiationsfaktor 5a (eIF5a)


Publications keyboard_arrow_down

Marsh JC, Bacigalupo A, Schrezenmeier H, Tichelli A, Risitano AM, Passweg JR, Killik SB, Warren AJ, Foukaneli T, Aljurf M, Al-Zahrani HA, Schafhausen P, Roth A, Franzke A, Brummendorf TH, Dufour C, Oneto R, Sedgwick P, Barrois A, Kordasti S, Elebute MO, Mufti GJ, Socie G (2012) Prospective study of rabbit antithymocyte globulin and ciclosporin for aplastic anemia from the EBMT Severe Aplastic Anemia Working Party. Blood, (DOI)10.1182/blood-2012-02-407684

houry HJ, Cortes JE, Kantarjian HM, Gambacorti-Passerini C, Baccarani M, Kim DW, Zaritskey A, Countouriotis A, Besson N, Leip E, Kelly V, Brummendorf TH (2012) Bosutinib is active in chronic phase chronic myeloid leukemia after imatinib and dasatinib and/or nilotinib therapiy failure. Blood 119(15):3403-12

Brassat U, Balabanov S, Bali D, Dierlamm J, Braig M, Hartmann U, Sirma H, Günes C, Wege H, Fehse B, Gontarewicz A, Dikomey E, Borgmann K, Brummendorf TH (2011) Functional p53 is required for effective execution of telo-merase inhibition in BCR-ABL-positive CML cells. Exp Hematol 39(1):66-76.e1-2.ccc

Wege H, Heim D, Lütgehetmann M, Dierlamm J, Lohse AW, Brummendorf TH (2011) Forced activation of (beta)-catenin signaling is sufficient to drive transforma-tion of hTERT-immortalized human fetal hepatocytes. Mol Cancer Res 9(9):1222-31

Bartolovic K, Balabanov S, Berner B, Bühring H-J, Komor M, Becker S, Hoelzer D, Kanz L, Hofmann W-K, Brummendorf TH (2005) Clonal heterogeneity in growth kinetics of CD34+38- human cord blood cells in vitro is correlated with gene expression pattern and telomere length. Stem Cells 23(7): 946-957


About the department keyboard_arrow_down

The ECCA at the University Hospital Aachen under the direction of Univ.-Prof. Dr. med. Tim H. Brümmendorf offers the patients with malignant diseases a comprehensive interdisciplinary treatment. Furthermore, the involvement of the specialists from various fields in the discussions on diagnosis, therapy, prevention and rehabilitation for the patient after the operation as well as participation in the clinical researchers devoted to oncology play a key role here. 

The ECCA at the University Hospital Aachen was founded on 15th March 2010 as the multidisciplinary medical institution aimed at optimizing the care for cancer patients in the euro region. The Cancer Center consists of 9 centers and modules specializing in the treatment of cancers of certain forms and organs. 

With the aim of a better oncological care of cancer patients, all departments and institutes of the university hospital get together in the ECCA at the University Hospital Aachen and take part in the diagnosis, treatment, and research of cancer.  Due to the interdisciplinary cooperation of the members of the ECCA under the direction of Univ.-Prof. Dr. med. Tim H. Brümmendorf, the patients with oncology get the highest competence and treatment experience. 

The main aim of the ECCA at the University Hospital Aachen under the direction of Univ.-Prof. Dr. med. Tim H. Brümmendorf is to optimize and develop the contacts of various oncology specialized medical institutions in Euroregion.

Program includes:

  • Initial presentation in the clinic
  • clinical history taking
  • review of medical records
  • physical examination
  • laboratory tests:
    • complete blood count
    • general urine analysis
    • biochemical analysis of blood
    • blood smear
    • TSH-basal
    • inflammation indicators
    • indicators blood coagulation
  • CT scan of full body
  • ultrasound of spleen
  • immunophenotyping of lymphocytes
    by flow cytometry
  • cytogenetic analysis with standard
  • cytogenetic analysis for philadelphia
    chromosome detection
  • aspiration biopsy of bone marrow
  • chemotherapy and immunotherapy (1 curse)
  • symptomatic treatment
  • control examinations
  • cost of essential medicines and materials
  • nursing services
  • full hospital accommodation in 2 bed shared room
  • explanation of future recommendations


Type of program :
Duration of program:

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About hospital

The University Hospital Aachen is a so-called hospital of the university maximum care. With its 34 clinics, 25 institutes and five multidisciplinary units covers the University Hospital Aachen not only the entire spectrum of medicine, but also it offers a patient- oriented medical care and nursing, medical education and research of international level. In the current ranking of the magazine FOCUS took the University Hospital Aachen among 2000 hospitals in Germany with number 15 a peak position. That patient care, medical education and research are located in a central building provides the advantage for an intensive interdisciplinary exchange and a close networking between clinics and scientific research. In this way it promotes a better understanding of disease, enables the progress in diagnosis and treatment for decades, thereby its innovations are of national importance.

Accommodation in hospital

Patients rooms

The kid rooms have everything needed for a comfortable stay. The kid bathroom includes both a toilet and a shower. All rooms offer functional beds with orthopaedic mattresses ensuring unsurpassed support for overall body during sleep. There are bedside stands with pull-out tables, lockers and safe boxes in each room. It is also possible to access the Internet from a PC, smartphone or tablet so that kids always keep in touch with their parents and other family members. There is also a TV in each room.
You can opt for a single or a double room. An accompanying person may stay with the kid in the room. A double room is shared with another patient.
The enhanced comfort rooms are equipped with a safety box, a fridge and upholstered furniture.

Meals and Menus

The patient and the accompanying person are offered a daily choice of three menus. If you are on a specific diet for any reason, you will be offered an individual menu. Please inform the medical staff about your dietary preferences prior to the treatment.

Further details

Standard rooms include:






Christian priests are available for the patients at any time. Representatives of other religions may be requested at any time.

Accompanying person

Your companion may stay with you in your room or at a hotel of your choice during the fixed program.


You may stay at the hotel during the outpatient program. Our employees will support you for selecting the best option.