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Allogeneic bone marrow transplantation in multiple myeloma (169899) | Charite University Hospital Berlin - BookingHealth
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Allogeneic bone marrow transplantation in multiple myeloma

Charite University Hospital Berlin

Berlin, Germany
Program id # 169899
Doctor photo
Prof. Dr. med. Angelika Eggert
Department of Pediatric Oncology and Hematology
Specialized in: pediatric oncology and hematology

The program includes:

  • Initial presentation in the clinic
  • case history collection
  • general clinical examination
  • laboratory tests:
    • complete blood count
    • general urine analysis
    • biochemical analysis of blood
    • TSH-basal, fT3, fT4
    • tumor markers
    • indicators of inflammation
    • indicators of blood coagulation
  • CT/MRI scans of the whole body
  • needle biopsy of the bone marrow
  • biopsy and histological examination of CSF
  • examination by experts of:
    • Cardiology
    • Otolaryngology
    • Immunology
    • Ophthalmology
  • registration in the European bone marrow donor base
  • conducting high-dose chemotherapy
  • allogeneic bone marrow transplantation from
    unrelated donor
  • isolation by neutropenic precautions
  • symptomatic treatment
  • the cost of essential medicines and blood products
  • nursing services
  • stay in the hospital with full board
  • accommodation in 2-bed room
  • elaboration of further recommendations

How program is carried out

During the first visit, the doctor will conduct a clinical examination and go through the results of the available diagnostic tests. After that, you will undergo the necessary additional examination, such as the assessment of liver and kidney function, ultrasound scan, CT scan and MRI.

Also, the doctor will conduct a bone marrow biopsy followed by cytological examination of the harvested material. This will help him to determine the histological features of your bone marrow (in particular, identify HLA system antigens) and select a suitable donor. The donor can be a family member or a person from the bone marrow registry. In the second case, the donor material is stored in a bone marrow bank.

Before the procedure, you will receive chemotherapy, if necessary in combination with radiation therapy. The course of chemo- or chemoradiation therapy lasts from 2 to 8 days.

The bone marrow transplant procedure is an intravenous infusion, i.e. the healthy bone marrow will be injected through a catheter, intravenously. You will stay in your room during the procedure. A bone marrow transplant is completely painless and does not require anesthesia.

During the period of healthy bone marrow engraftment, you will stay in a sterile ward. This is a necessary precaution because during this time your immune system is very weak and cannot withstand environmental pathogens. The risk of bleeding is also quite high, so you will be advised to avoid mechanical damage.

A relative or other close person may stay in the ward with you. You will not be allowed to go outside the department and leave your ward often. The rehabilitation period can last from 1 to 2 months.

When your complete blood count returns to normal, your doctor will schedule your discharge from the department. You will receive information about the rules that you will need to follow at home, the frequency and type of control examinations, and subsequent treatment measures. You will also receive a detailed medical report, which will reflect the entire course of treatment.

Required documents

  • Medical records
  • MRI/CT scan (not older than 3 months)
  • Bone marrow biopsy results (if available)

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About the department

The Department of Pediatric Oncology and Hematology at the Charite University Hospital Berlin offers the full range of diagnostics and treatment in its fields of competence. The department is headed by Prof. Dr. med. Angelika Eggert.

The department's doctors specialize in the treatment of malignant diseases of the hematopoietic system, benign and malignant tumors, congenital or acquired benign blood diseases and blood-clotting disorders (sickle cell anemia, thalassemia, hemophilia). The priority focus of the department's work is stem cell transplantation (about 50 transplantations annually). Since 2017, the department has been certified as a specialized Cancer Center, which indicates the outstanding quality of medical service.

All therapeutic activities in the department meet the requirements of the Society of Pediatric Oncology and Hematology, as well as other international societies in the field of pediatric oncology. The department's specialists are proud of their outstanding research activities. Of particular interest in this field are the translational and clinical examinations of leukemia, neuroblastoma and other embryonal tumors.

Special attention in the treatment of children with oncopathologies is paid to the psychological support of young patients and their parents, since the diagnosis of cancer is associated with huge emotional experiences.

The service range of the department includes:

  • Diagnostics and treatment of malignant tumors
    • Special focus on leukemias, neuroblastomas and brain tumors
      • Chemotherapy
      • Radiation therapy
      • Hematopoietic stem cell transplantation
  • Diagnostics and treatment of blood diseases
    • Special focus on sickle cell anemias, thalassemias and Fanconi anaemias
  • Diagnostics and treatment of blood-clotting disorders
    • Special focus on hemophilias, thromboses and stroke
  • Autologous and allogeneic stem cell transplantation (more than 50 transplantations annually) in the case of
    • Relapsed acute lymphoblastic leukemia
    • Acute myeloid leukemia relapse
    • High-risk neuroblastomas
    • Fanconi anaemia
    • Neurometabolic disorders (for example, adrenoleukodystrophy)
    • Immunodeficiencies
  • Other diseases and treatment methods

Curriculum vitae

  • 1993 Study of Medicine at the University of Essen, Germany.
  • 1991 - 1993 Doctorate, Institute of Molecular Biology, University of Essen, Germany. Subject: "Preparation and characterization of adenovirus 12-specific polyclonal antibodies directed against specific E1A tumor antigens".
  • 1993 - 1997 Resident Physician, Department of Pediatric Hematology and Oncology, University Hospital Essen, Germany.
  • 1997 - 2000 Postdoctoral Research Fellow of the Group of Prof. G.M. Brodeur (Deutsche Krebshilfe/Wolfson Career Development Grant), Children’s Hospital of Philadelphia, USA.
  • 2000 - 2002 Clinical Fellow, Department of Pediatric Hematology and Oncology, University Hospital Essen, Germany.
  • 2003 - 2004 Senior Physician, Department of Pediatric Hematology and Oncology, University Hospital Essen, Germany.
  • 2004 Habilitation, University of Duisburg-Essen, Germany. Subject:  "Expression and biological function of neurotrophin receptors and receptors of the TNF-family in embryonal tumors".
  • 2005 - 2008 C3 Professor of Pediatric Oncology and Deputy Director, Department of Pediatric Hematology and Oncology, University Hospital Essen, Germany.
  • 2006 - 2008 Interim Director, Department of Neonatology, Neuropediatrics and Pediatric Intensive Care Medicine.
  • Since 2007 Director, University Hospital Essen, Comprehensive Cancer Center (WTZ).
  • Since 2008 Head of the Department of Pediatric Hematology, Oncology, Pulmonology and Cardiology, University Hospital Essen, Germany.
  • 2009 - 2011 Executive MBA in the International Hospital & Health Care Management, Frankfurt School of Finance and Management, Germany.
  • Since 2013 W3 Professor in Pediatrics and Head of the Department of Hematology and Oncology, Charite University Hospital Berlin.
  • Acting Head of the Department of Pediatric Gastroenterology and Metabolic Medicine, Charite University Hospital Berlin.

Memberships

  • Since 1994 Member of the German Society of Pediatrics.
  • Since 1998 Member of the  American Association for Cancer Research (AACR).
  • Since 2000 Member of the German Society for Pediatric Hematology and Oncology (GPOH).
  • Since 2000 Member of the International Society for Pediatric Oncology (SIOP).

Awards

  • 1997 Young Investigator Award, International Symposium on Advances in Neuroblastoma Research, City of Bath, United Kingdom.
  • 1998 Evans Prize, International Symposium on Advances in Neuroblastoma Research, Philadelphia, USA.
  • 2000 Poster Prize of the German Society of Pediatrics.
  • 2000 Dr. Odile Schweisguth Prize, SIOP Meeting, Amsterdam, the Netherlands.
  • 2000 Research Prize of the WTZ, Essen, Germany.
  • 2001 AACR Young Investigator Award, New Orleans, USA.
  • 2001 Kind Philipp Prize in Pediatric Oncology, GPOH-Meeting, Frankfurt, Germany.

Photo of the doctor: (c) Charité – Universitätsmedizin Berlin 


About hospital

According to the authoritative Focus magazine, the Charite University Hospital Berlin occupies the first place in the rating of the top German medical facilities! 

The hospital in Germany provides modern diagnostics and treatment of patients, as well as the training of practicing physicians and scientists. More than half of all German Nobel Prize winners in the field of medicine and physiology, such as Emil von Behring, Robert Koch and Paul Ehrlich, trained and worked in the hospital. The structure of the medical complex includes over 100 specialized departments and institutes, which allows the doctors to guarantee their patients' services in all the existing medical fields. The hospital in Germany has outstanding experience in treating particularly complex clinical cases.

The hospital annually diagnoses and treats more than 152,693 inpatients and about 692,920 outpatients. It also has a huge medical team consisting of 4,225 scientists and doctors and and more than 4,500 nursing staff members who provide top-class medical treatment in Germany. The key task for all specialists of the medical facility is restoring the patient's health or preserving in critical cases. At the same time, the hospital offers a friendly atmosphere, and each patient feels care, respect and sympathy.

The excellent technical medical equipment, highly skilled personnel, availability of innovative diagnostic and treatment techniques, and high ethical standards form a solid foundation for successful clinical and scientific activities. Thus, the hospital is a leading provider of high-quality treatment in Germany.

Photo: (с) depositphotos

Accommodation in hospital

Patients rooms

The patients of the Charite University Hospital Berlin live in comfortable rooms made of modern design. Each room is equipped with an ensuite bathroom with a toilet and a shower. The standard room furnishing includes an automatically adjustable bed, a bedside table, a wardrobe for storing clothes, a table and chairs for receiving visitors, and a TV. If desired, Wi-Fi access can be provided. The hospital also offers enhanced-comfort rooms.

Meals and Menus

The patient and his accompanying person have a daily choice of three menus. If for any reason, you do not like the food, you will be offered an individual menu. Please inform the medical staff about your dietary preferences before the treatment.

Further details

Standard rooms include:

Toilet
Shower
Wi-Fi
TV

Religion

Religious services are available upon request.

Accompanying person

During the inpatient program, an accompanying person may stay with you in a patient room or at the hotel of your choice.

Hotel

During the outpatient program, you can live at a hotel of your choice. Managers will help you to choose the most suitable options.

The hospital offers a full range of laboratory tests (general, hormonal, tests for infections, antibodies, tumor markers, etc.), genetic tests, various modifications of ultrasound scans, CT scans, MRI and PET / CT, angiography, myelography, biopsy and other examinations. Treatment with medications, endoscopic and robotic operations, stereotaxic interventions is carried out here, modern types of radiation therapy are also used. The hospital offers patients all the necessary therapeutic techniques.

  • Proton therapy
  • CyberKnife treatment
  • Hyperthermic intraperitoneal chemotherapy (HIPEC)
  • PSMA therapy with Lutetium-177
  • Joint replacement in adults and children

These are oncological diseases, benign neoplasms of the brain and spinal cord, heart valve defects, diabetes mellitus and its complications, joint diseases and other pathologies.

  • Neurosurgery
  • Oncology
  • Plastic and reconstructive surgery
  • Interventional radiology
  • Proton therapy (Proton Therapy Center BerlinProtonen)

The medical team includes more than 4,225 highly qualified scientists and doctors.