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Allogeneic bone marrow transplantation in pancytopenia (84003) | University Hospital Duesseldorf - BookingHealth
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After that, you will undergo the necessary additional examination, such as the assessment of liver and kidney function, ultrasound scan, CT scan and MRI.<\/p>\n\n<p style=\"text-align: justify;\">Also, the doctor will conduct a bone marrow biopsy followed by cytological examination of the harvested material. This will help him to determine the histological features of your bone marrow (in particular, identify HLA system antigens) and select a suitable donor. The donor can be a family member or a person from the bone marrow registry. In the second case, the donor material is stored in a bone marrow bank.<\/p>\n\n<p style=\"text-align: justify;\"><strong>Before the procedure<\/strong>, you will receive chemotherapy, if necessary in combination with radiation therapy. The course of chemo- or chemoradiation therapy lasts from 2 to 8 days.<\/p>\n\n<p style=\"text-align: justify;\">The <strong>bone marrow transplant procedure<\/strong> is an intravenous infusion, i.e. the healthy bone marrow will be injected through a catheter, intravenously. You will stay in your room during the procedure. A bone marrow transplant is completely painless and does not require anesthesia.<\/p>\n\n<p style=\"text-align: justify;\">During the <strong>period of healthy bone marrow engraftment<\/strong>, you will stay in a sterile ward. This is a necessary precaution because during this time your immune system is very weak and cannot withstand environmental pathogens. The risk of bleeding is also quite high, so you will be advised to avoid mechanical damage.<\/p>\n\n<p style=\"text-align: justify;\">A relative or other close person may stay in the ward with you. You will not be allowed to go outside the department and leave your ward often. The rehabilitation period can last from 1 to 2 months.<\/p>\n\n<p style=\"text-align: justify;\">When your complete blood count returns to normal, your doctor will schedule your <strong>discharge from the department<\/strong>. You will receive information about the rules that you will need to follow at home, the frequency and type of control examinations, and subsequent treatment measures. You will also receive a detailed medical report, which will reflect the entire course of treatment.<\/p>\n<\/div><div class=\"program_required_documents mt-4\"><h4>Required documents<\/h4><ul>\n\t<li style=\"text-align: justify;\">Medical records<\/li>\n\t<li style=\"text-align: justify;\">Bone marrow biopsy results (if available)<\/li>\n<\/ul>\n<\/div>","program_full_story_crm":"<ul>\n\t<li>Initial presentation in the clinic<\/li>\n\t<li>case history collection<\/li>\n\t<li>general clinical examination<\/li>\n\t<li>laboratory tests:\n\t<ul>\n\t\t<li>complete blood count<\/li>\n\t\t<li>biochemical analysis of blood<\/li>\n\t\t<li>TSH-basal, fT3, fT4<\/li>\n\t\t<li>differential blood count<\/li>\n\t\t<li>inflammation indicators (CRP, ESR)<\/li>\n\t\t<li>indicators of blood coagulation<\/li>\n\t<\/ul>\n\t<\/li>\n\t<li>CT\/MRI scans&nbsp;of the whole body<\/li>\n\t<li>needle biopsy of the bone marrow<\/li>\n\t<li>biopsy and histological examination of&nbsp;CSF<\/li>\n\t<li>examination by&nbsp;experts of:\n\t<ul>\n\t\t<li>cardiology<\/li>\n\t\t<li>otolaryngology<\/li>\n\t\t<li>immunology<\/li>\n\t\t<li>ophthalmology<\/li>\n\t<\/ul>\n\t<\/li>\n\t<li>registration in the European bone marrow donor base<\/li>\n\t<li>conducting high-dose chemotherapy<\/li>\n\t<li>allogeneic bone marrow transplantation from<br \/>\n\tunrelated donor<\/li>\n\t<li>the cost of blood products<\/li>\n\t<li>isolation by neutropenic precautions<\/li>\n\t<li>symptomatic treatment<\/li>\n\t<li>control examinations<\/li>\n\t<li>the cost of essential medicines and materials<\/li>\n\t<li>nursing services<\/li>\n\t<li>full hospital accommodation<\/li>\n\t<li>explanation of future recommendations<\/li>\n<\/ul>\n<div class=\"program_how_program_going mt-4\"><h4>How program is carried out<\/h4><p style=\"text-align: justify;\"><strong>During the first visit<\/strong>, the doctor will conduct a clinical examination and go through the results of the available diagnostic tests. After that, you will undergo the necessary additional examination, such as the assessment of liver and kidney function, ultrasound scan, CT scan and MRI.<\/p>\n\n<p style=\"text-align: justify;\">Also, the doctor will conduct a bone marrow biopsy followed by cytological examination of the harvested material. This will help him to determine the histological features of your bone marrow (in particular, identify HLA system antigens) and select a suitable donor. The donor can be a family member or a person from the bone marrow registry. In the second case, the donor material is stored in a bone marrow bank.<\/p>\n\n<p style=\"text-align: justify;\"><strong>Before the procedure<\/strong>, you will receive chemotherapy, if necessary in combination with radiation therapy. 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Allogeneic bone marrow transplantation in pancytopenia

University Hospital Duesseldorf

Duesseldorf, Germany
Program id # 84003
Doctor photo
Prof. Dr. med. Arndt Borkhardt
Department of Pediatric Oncology, Hematology and Clinical Immunology
Specialized in: pediatric oncology, hematology, clinical immunology

The program includes:

  • Initial presentation in the clinic
  • case history collection
  • general clinical examination
  • laboratory tests:
    • complete blood count
    • biochemical analysis of blood
    • TSH-basal, fT3, fT4
    • differential blood count
    • inflammation indicators (CRP, ESR)
    • indicators of blood coagulation
  • CT/MRI scans of the whole body
  • needle biopsy of the bone marrow
  • biopsy and histological examination of CSF
  • examination by experts of:
    • cardiology
    • otolaryngology
    • immunology
    • ophthalmology
  • registration in the European bone marrow donor base
  • conducting high-dose chemotherapy
  • allogeneic bone marrow transplantation from
    unrelated donor
  • the cost of blood products
  • isolation by neutropenic precautions
  • symptomatic treatment
  • control examinations
  • the cost of essential medicines and materials
  • nursing services
  • full hospital accommodation
  • explanation of future recommendations

How program is carried out

During the first visit, the doctor will conduct a clinical examination and go through the results of the available diagnostic tests. After that, you will undergo the necessary additional examination, such as the assessment of liver and kidney function, ultrasound scan, CT scan and MRI.

Also, the doctor will conduct a bone marrow biopsy followed by cytological examination of the harvested material. This will help him to determine the histological features of your bone marrow (in particular, identify HLA system antigens) and select a suitable donor. The donor can be a family member or a person from the bone marrow registry. In the second case, the donor material is stored in a bone marrow bank.

Before the procedure, you will receive chemotherapy, if necessary in combination with radiation therapy. The course of chemo- or chemoradiation therapy lasts from 2 to 8 days.

The bone marrow transplant procedure is an intravenous infusion, i.e. the healthy bone marrow will be injected through a catheter, intravenously. You will stay in your room during the procedure. A bone marrow transplant is completely painless and does not require anesthesia.

During the period of healthy bone marrow engraftment, you will stay in a sterile ward. This is a necessary precaution because during this time your immune system is very weak and cannot withstand environmental pathogens. The risk of bleeding is also quite high, so you will be advised to avoid mechanical damage.

A relative or other close person may stay in the ward with you. You will not be allowed to go outside the department and leave your ward often. The rehabilitation period can last from 1 to 2 months.

When your complete blood count returns to normal, your doctor will schedule your discharge from the department. You will receive information about the rules that you will need to follow at home, the frequency and type of control examinations, and subsequent treatment measures. You will also receive a detailed medical report, which will reflect the entire course of treatment.

Required documents

  • Medical records
  • Bone marrow biopsy results (if available)

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About the department

The Department of Pediatric Oncology, Hematology and Clinical Immunology at the University Hospital Duesseldorf offers the full range of diagnostics and treatment of diseases of the hematopoietic system, oncopathology, bleeding disorders and diseases of the immuno-rheumatic profile in children of all age groups. The department has all the possibilities of hardware and laboratory diagnostics, adapted to the characteristics of the child's body. The treatment is provided using both traditional and innovative experimental methods approved by the professional societies. The Chief Physician of the department is Prof. Dr. med. Arndt Borkhardt.

The department’s priority is allogeneic stem cell transplantation, including haploidentical transplantation, in which parents become stem cell donors for a sick child (a closely related transplantation). In addition, the department is engaged in active research activities aimed at the development of innovative approaches to post-transplant treatment, such as dendritic cell vaccination (dendritic vaccine).

Another important focus of the department is the diagnostics and treatment of bone marrow diseases, for example, impaired formation and function of platelets, acute or chronic anemias. The children with congenital or acquired hemocoagulation disorders receive medical care within the specialized outpatient clinic. In addition, the doctors of the department specialize in the treatment of children and adolescents with congenital immunodeficiencies, rheumatic and autoimmune inflammatory diseases. In addition, the doctors have a special experience in the treatment and care of children with HIV infection and AIDS.

A separate specialization of the department is the diagnostics and therapy of solid tumors, including recurrent pathologies. The treatment plan is developed individually, taking into account the specific clinical indications. For children with terminal diseases, the competent experts of the department offer high-quality palliative care. If possible, such help is provided at home.

The main clinical focuses of the department include:

  • Allogeneic and autologous stem cell transplantation for leukemia and solid tumors
  • Immunotherapy with dendritic cell vaccination
  • Treatment of solid tumors using regional deep hyperthermia
  • Diagnostics and treatment of congenital and acquired bone marrow diseases
  • Diagnostics and treatment of bleeding disorders
  • Diagnostics and treatment of HIV infection and AIDS, as well as diseases of the immune system in children and adolescents
  • Diagnostics and treatment of rheumatic and autoimmune inflammatory pathologies
  • Palliative care
  • Psychosocial care for young patients and their parents
  • Other medical services

Curriculum vitae

Academic and Professional Career

  • Since 2006, Professor of the Department of Pediatric Hematology, Oncology and Clinical Immunology, Heinrich Heine University Duesseldorf, as well as the Head of the department with the same name at the University Hospital Duesseldorf.
  • 2005 - 2006 C4 Professor and W3 Professor in Pediatric Hematology, Oncology and General Pediatrics at the Universities of Halle, Essen, Duesseldorf and Jena.
  • 2003 C3 Professor, Head of the Department of Pediatric Hematology and Oncology at the Dr. von Hauner Children's Hospital at Ludwig Maximilian University of Munich.
  • 1999 Habilitation in Pediatrics. Subject: "Molecular genetics of chromosomes;
  • aberrations in hemoblastosis in children". He was appointed an Assistant Professor at the Center for Pediatrics at the Justus Liebig University Giessen.
  • 1998 Senior Physician of the Center for Pediatrics at the Justus Liebig University Giessen.
  • 1991 - 1998 Training for a Medical Specialist in Pediatrics, Center for Pediatrics at the Justus Liebig University Giessen.
  • 1990 - 1991 Assistant Physician, Medical Academy of Magdeburg.
  • 1990 Doctorate, Magdeburg Medical Academy.
  • 1984 - 1990 Study of Medicine at the Magdeburg Medical Academy.

Positions in the Scientific Societies and Committees (selected)

  • Since 2009, Board Member of the European Society of Hematology (European Hematological Association - EHA).

Awards and Honorary Memberships (selected)

  • Since 2012, Member of the National Academy of Sciences Leopoldina.
  • 2005 Karus Medal (Leopoldina) and Karus Prize of Schweinfurt city.
  • 2001 Award of the German Society of Hematology and Oncology.
  • 1998 Adalbert Czerny Prize of the German Society of Pediatrics and Adolescent Medicine.

Key Research Focuses

  • Leukemogenesis, bone marrow failure in children, bone marrow transplantation.
  • The role of gene rearrangement in the development of leukemia.
  • Diagnostics of chromosomal aberrations in leukemia.
  • Primary immunodeficiencies.
  • The function of microRNA in the immune system and their role in malignancy.

Photo of the doctor: (c) Universitätsklinikum Düsseldorf  


About hospital

According to the authoritative Focus magazine, the University Hospital Duesseldorf ranks among the top Germany hospitals!

The hospital is an excellent example of a combination of high-quality health care, research and teaching activities. With more than 50,000 inpatients and about 300,000 outpatients every year, the hospital is one of the largest and most prestigious medical institutions in Germany and Europe.

Modern, safe and sparing diagnostic and therapeutic methods guarantee effective treatment of various diseases and their consequences. All therapeutic processes are based on an interdisciplinary approach, which provides comprehensive medical care and optimal treatment result. Obviously, one of the key roles in the successful clinical practice of the medical institution is played by a highly qualified medical personnel, which consists of the best world-class doctors. The hospital also has a special advantage due to the structured equipment with the innovative medical technologies.

The hospital presents almost all fields of modern medicine. Special attention should be given to such focuses as oncology and hematology, stem cell transplantation, neurosurgery and neurology, urology, obstetrics and gynecology, hepatology, kidney transplantation, vascular surgery, cardiac surgery, pediatric surgery, pediatric oncology, etc.

In addition to the outstanding quality of medical services, the hospital guarantees each patient an attentive care, friendly atmosphere, as well as sensitive and respectful attitude.

Photo: (с) depositphotos

Accommodation in hospital

Patients rooms

The patients of the University Hospital Duesseldorf live in comfortable single, double and triple rooms. The patient rooms are made in bright colors and modern design. The room furnishing includes an automatically adjustable bed, a bedside table, a wardrobe, a telephone, a multimedia device (TV, radio, Internet access), a table and chairs for receiving visitors. To use the phone and multimedia device, the patient should have a special chip card, which can be purchased at the reception. In the pediatric departments multimedia device can be used for free.

Meals and Menus

The patients of the hospital are offered a varied, tasty and healthy diet. Every day there are three menus to choose from for adults and four menus to choose from for children, while it is possible to develop an individual menu. When pre-ordering, the international patients may have dishes of various cuisines of the world, for example, Asian and African cuisine. If a patient needs a diet in accordance with the clinical indications, he will be provided with a special diet menu, including drinks.

Every day, the nurses inform the kitchen workers about the patient wishes using an electronic data processing system. Immediately before serving food, there are printed special cards, which indicate for which patient this or that dish is intended.

Also, the hospital houses a cafeteria with a rich selection of delicious, healthy dishes, snacks and drinks.

Further details

Standard rooms include:

Toilet
Shower
Wi-Fi
TV

Religion

Christian priests are available for the patients at any time. Representatives of other religions may be requested at any time.

Accompanying person

Your companion may stay with you in your room or at a hotel of your choice during the fixed program.

Hotel

You may stay at the hotel during the outpatient program. Our employees will support you for selecting the best option.

The hospital offers a full range of laboratory tests (general, hormonal, tests for infections, antibodies, tumor markers, etc.), genetic tests, various modifications of ultrasound scans, CT scans, MRI and PET / CT, angiography, myelography, biopsy and other examinations. Treatment with medications, endoscopic and robotic operations, stereotaxic interventions is carried out here, modern types of radiation therapy are also used. The hospital offers patients all the necessary therapeutic techniques.

  • Dermatosurgery
  • Skull base surgery
  • Gastric bypass and bandage
  • Removal of lung metastases
  • Interventions on the spine

These are skin cancer (including melanoma), head and neck tumors, pathological changes in the chest (including funnel chest), obesity, liver diseases, HIV and other infectious diseases, varicose veins, aortic aneurysm, carotid artery stenosis, joint diseases and other pathologies.

  • Dermatology
  • Oncology
  • Otorhinolaryngology
  • Endocrinology and diabetology
  • Orthopedics and traumatology

Over 800 highly qualified physicians work at the hospital.