University Hospital Frankfurt am Main

Frankfurt am Main, Germany

Spinal muscular atrophy diagnosis (program ID: 302576)

Thomas Klingebiel

Head Physician
Prof. Dr. med.

Thomas Klingebiel

Department of Pediatric and Adolescent Medicine

Specialized in: pediatric and adolescent medicine
Curriculum vitae keyboard_arrow_down

Professor Klingebiel ist Direktor der Klinik für Kinder- und Jugendmedizin der Johann Wolfgang Goethe Universität Frankfurt sowie der Prodekan des Fachbereichs Medizin. Er studierte Humanmedizin an den Universitäten Marburg und Lübeck, promovierte 1981 ebenfalls an der Universität Lübeck. Es folgten wissenschaftliche Assistenzzeiten am pathologischen Institut sowie der Kinderklinik der Universität Tübingen und im Jahre 2000 der Ruf auf eine Professur für Kinderheilkunde am Zentrum für Kinder- und Jugendmedizin der Universität Frankfurt am Main. Professor Klingebiel war Vorsitzender der Gesellschaft für Pädiatrische Onkologie und Hämatologie und ist Mitglied in verschiedenen Studienkommissionen sowie nationalen und internationalen Gesellschaften. Er wurde zudem mit dem Professor-Otto-Roth-Promotions-Preis, dem Van-Bekkum Award sowie dem Preis für Exzellente Lehre des Fachbereichs Medizin der Universität Frankfurt ausgezeichnet.

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About the department keyboard_arrow_down

The Department of Pediatric and Adolescent Medicine at the University Hospital Frankfurt specializes in 5 focuses and deals with the diagnosis and treatment of diseases in children and adolescents. The department has the best specialists and state-of-the-art medical equipment, which ensures the provision of high quality medical services. The department is headed by Prof. Dr. med. T. Klingebiel.

Neonatology: Treatment of premature and newborn babies

Neurology, Neurometabolics and Prevention: Pediatric neurological clinical pictures include:

  • Epileptology (cerebral seizures and their differential diagnoses)
  • Metabolic diseases that affect the nervous system
  • Neuromuscular diseases (myopathies, diseases of the peripheral nerves)
  • Congenital pathological diseases of the nervous system (spina bifida, hydrocephalus, neurofibromatosis)
  • Developmental neurology (arrested development, cerebral palsy, speech development disorder, examination of premature babies)
  • Neuro-oncology (brain tumors)
  • Injuries of the nervous system (injuries of the skull base, spinal cord, peripheral nerves) 
  • Inflammatory diseases of the nervous system (meningitis, encephalitis, multiple sclerosis)
  • Neuropsychological deviations 

Allergology, Pneumology and Cystic Fibrosis: Treatment of infectious, allergic diseases and respiratory tract diseases

  • Outpatient Cystic Fibrosis Clinic
  • Outpatient Gastroenterology Clinic

Oncology, Hematology and Hemostaseology: Treatment of diseases of the hematopoietic system and malignant diseases in children and adolescents

  • Outpatient Hematology and Oncology Clinic
  • Outpatient Clinic for Blood-clotting Disorders
  • Outpatient Clinic for Angioedema
  • Outpatient Clinic for Thalassemia

Stem Cell Transplantation and Immunology: Treatment of benign and malignant diseases by stem cell transplantation and immunological diseases

  • Outpatient Clinic for Immune Deficiency

Pediatric Cardiology
The Outpatient Clinic for Pediatric Cardiology provides treatment to about 4,000 patients every year. The range starts with congenital heart defects, cardiological examination and the further monitoring of medication, for example, in oncological diseases or antipsychotic therapy, and ends up with the acquired heart defect. In cooperation with the University Hospital of Giessen (Prof. Scranz), the Pediatric Cardiology Center of Giessen offers an advanced experience in this field. The department also includes an interdisciplinary intensive care unit, which is supervised together with the Department of Surgery, in particular, with the Department of Pediatric Surgery (Prof. Rolle). Since 2014 the department has its own MRI machine, which is used to examine head and other organs. There can be carried out the procedures of sedation and anesthesia for young children. 

The Department of Pediatric and Adolescent Medicine offers the entire spectrum of non-invasive and invasive pediatric cardiologic diagnosis:

  • ECG
  • Echocardiography
  • Transesophageal echocardiography
  • Continuous ECG
  • 24-hour arterial pressure monitoring 
  • Pacemaker monitoring
  • Load ECG (ergometry of bicycle and treadmill)
  • Orthostatic test

In close collaboration with Prof. D. Schranz, since the moment of the foundation of the Pediatric Cardiology Center of Giessen, which consists of the Department of Pediatric and Adolescent Medicine at the University Hospital Frankfurt and the Pediatric Cardiology Center of Giessen/Marburg, there have been used all interventional catheter diagnostic and treatment methods for the acquired heart defects. Therefore, in November 2009, one of the most advanced Cardiac Catheterization Stations in Germany was put into operation here. 

Program includes:

  • Initial presentation in the clinic
  • clinical history taking
  • review of medical records
  • neurological examination:
    • reflexes
    • muscle strength
    • muscle tone
    • senses of touch and sight
    • coordination
    • balance
  • physical examination
  • laboratory tests:
    • complete blood count
    • general urine analysis
    • biochemical blood test (creatine kinase)
    • inflammation markers (CRP, ESR)
    • blood coagulation analysis (aPTT, PT, INR)
    • hormone test (TSH, parathormone)
    • vitamin test (B12, D)
    • genetic testing (SMN1, SMN2)
  • electroencephalography (EEG)
  • cerebrovascular doppler ultrasound
  • electromyography (EMG)
  • CT/ MRI of head and neck (if indicated clinically,
    additional cost is 650/1200€)
  • muscle biopsy with histological study
    (if indicated clinically, additional cost is 2500€)
  • nursing services
  • treatment by head doctor and all leading experts
  • explanation of individual treatment plan
Type of program :
Expected duration of the program:

The program includes:

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