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Allogeneic bone marrow transplantation in acute lymphoblastic leukemia (575658) | University Hospital Greifswald - BookingHealth
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The rehabilitation period can last from 1 to 2 months.<\/p>\n\n<p style=\"text-align: justify;\">When your complete blood count returns to normal, your doctor will schedule your <strong>discharge from the department<\/strong>. You will receive information about the rules that you will need to follow at home, the frequency and type of control examinations, and subsequent treatment measures. 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Allogeneic bone marrow transplantation in acute lymphoblastic leukemia

University Hospital Greifswald

Greifswald, Germany
Program id # 575658
Doctor photo
Prof. Dr. med. William Krüger
Department of Hematology, Oncology and Stem Cell Transplantation
Specialized in: hematology, oncology, stem cell transplantation

The program includes:

  • Initial presentation in the clinic
  • case history collection
  • general clinical examination
  • laboratory tests:
    • complete blood count
    • biochemical analysis of blood
    • TSH-basal, fT3, fT4
    • differential blood count
    • inflammation indicators (CRP, ESR)
    • indicators of blood coagulation
  • CT/MRI scans of the whole body
  • needle biopsy of the bone marrow with histological:
    • cytochemistry
    • immunocytology
    • cytogenetics (Philadelphia
      chromosome detection)
    • molecular biology
  • biopsy and histological examination of CSF
  • examination by experts of:
    • cardiology
    • otolaryngology
    • immunology
    • ophthalmology
  • registration in the European bone marrow donor base
  • conducting high-dose chemotherapy
  • allogeneic bone marrow transplantation from
    unrelated donor
  • the cost of blood products
  • isolation by neutropenic precautions
  • symptomatic treatment
  • control examinations
  • the cost of essential medicines and materials
  • nursing services
  • full hospital accommodation
  • explanation of future recommendations

How program is carried out

During the first visit, the doctor will conduct a clinical examination and go through the results of the available diagnostic tests. After that, you will undergo the necessary additional examination, such as the assessment of liver and kidney function, ultrasound scan, CT scan and MRI.

Also, the doctor will conduct a bone marrow biopsy followed by cytological examination of the harvested material. This will help him to determine the histological features of your bone marrow (in particular, identify HLA system antigens) and select a suitable donor. The donor can be a family member or a person from the bone marrow registry. In the second case, the donor material is stored in a bone marrow bank.

Before the procedure, you will receive chemotherapy, if necessary in combination with radiation therapy. The course of chemo- or chemoradiation therapy lasts from 2 to 8 days.

The bone marrow transplant procedure is an intravenous infusion, i.e. the healthy bone marrow will be injected through a catheter, intravenously. You will stay in your room during the procedure. A bone marrow transplant is completely painless and does not require anesthesia.

During the period of healthy bone marrow engraftment, you will stay in a sterile ward. This is a necessary precaution because during this time your immune system is very weak and cannot withstand environmental pathogens. The risk of bleeding is also quite high, so you will be advised to avoid mechanical damage.

A relative or other close person may stay in the ward with you. You will not be allowed to go outside the department and leave your ward often. The rehabilitation period can last from 1 to 2 months.

When your complete blood count returns to normal, your doctor will schedule your discharge from the department. You will receive information about the rules that you will need to follow at home, the frequency and type of control examinations, and subsequent treatment measures. You will also receive a detailed medical report, which will reflect the entire course of treatment.

Required documents

  • Medical records
  • MRI/CT scan (not older than 3 months)
  • Bone marrow biopsy results (if available)

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About the department

The Department of Hematology, Oncology and Bone Marrow Transplant at the University Hospital Greifswald offers all the possibilities of advanced medicine in the areas of its specialization. The team of the department's doctors is engaged in the diagnostics and treatment of hematopoietic diseases as well as solid tumors of various localizations. One of the key focuses of the work of the medical facility is a bone marrow transplant – the department has passed the prestigious JACIE certification of the European Group for Blood and Marrow Transplantation. Patients with advanced cancer receive palliative care to relieve pain and maintain a high quality of life. Medical care is available both on an inpatient and outpatient basis. A treatment regimen is developed for each patient on an individual basis at the tumor board, which is attended by oncologists, hematologists, and specialists from related medical fields. The department's doctors have unique experience in bone marrow transplant procedures and innovative immunotherapy with CAR T-cells. Chemotherapy, antibody therapy, and treatment with immune checkpoint inhibitors are also successfully performed here. The department has all the resources available to provide effective medical care, while the focus is always on the patient and his individual needs and wishes. The Head Physician of the department is Prof. Dr. med. William Krüger.

One of the primary focuses of the department's work is the diagnostics and treatment of leukemias and lymphomas. These diseases progress rapidly and require urgent therapeutic measures. The advanced technical base of the department and the long clinical experience of doctors ensure high-precision diagnostics, the results of which largely determine the treatment's success. During the diagnostics, the patient's medical history is accurately studied, and advanced laboratory tests and imaging tests are carried out. Thanks to this, doctors can determine the type of leukemia or lymphoma, the stage of the oncological process, and other factors important for effective therapy. Chemotherapy is the main treatment for leukemia and lymphomas, but a bone marrow transplant is often required to achieve recovery in the advanced stages of the oncological process. In addition, doctors have innovative forms of immunotherapy in their arsenal that allow them to achieve excellent treatment outcomes. These include CAR T-cell therapy and treatment with immune checkpoint inhibitors. The essence of both therapeutic methods is to activate the patient's immune system to destroy cancer cells. Such treatment is available only in the world's most advanced medical facilities, and the results of therapy are impressive.

The department's doctors are deservedly proud of their success with bone marrow transplants. These often save the lives of patients with malignant diseases and some benign blood pathologies. Allogeneic (donor stem cell transplant) and autologous (patient's own stem cell transplant) procedures are performed at the medical facility. The main indications for the transplant are malignant lymphomas, acute leukemias, chronic myeloid leukemias, autoimmune diseases, severe aplastic anemia, some solid tumors, hemoglobinopathies, and congenital immunodeficiencies. The first stage of the transplant is stem cell harvesting. This is carried out using a special separator device that separates the bone marrow cells from the blood, collecting them in a reservoir. This is followed by the stage of processing the stem cells in the laboratory, after which they are transplanted using an intravenous injection. The transplant procedure lasts about 2 hours. It is worth noting that before the transplant, patients usually undergo high-dose chemotherapy (conditioning regimen) to destroy the maximum number of cancer cells. After the completion of the bone marrow transplant, the patient remains at the hospital for several weeks under medical supervision. Doctors monitor his general condition and the engraftment of transplanted cells. About 3 months after the transplant, the specialists can fully assess the treatment results.

The department also regularly admits patients with solid tumors of the internal organs. The most common types of oncopathologies include gastrointestinal cancer, breast cancer, prostate cancer, lung cancer, brain cancer, and urinary system cancer. Each clinical case is considered at an interdisciplinary tumor board, which is attended by oncologists, surgeons, radiation therapists, specialists in radiology and nuclear medicine, as well as doctors specializing in certain medical fields, such as gastroenterologists, gynecologists, and urologists. As for the treatment, the main method of eliminating a malignant solid tumor is its surgical resection. Surgery is often combined with chemotherapy, radiation therapy, targeted therapy, immunotherapy, hormone therapy, and other treatments. The department's doctors always accurately plan a treatment regimen for each patient, choosing the most effective methods. Patients with advanced cancers are provided with palliative care to enable them to have an acceptable quality of life and be free from pain.

The department's key clinical focuses include:

  • Diagnostics and treatment of hematopoietic diseases
    • Malignant diseases
      • Acute and chronic leukemia in adults
      • Lymphomas
      • Multiple myeloma
      • Plasmacytoma
    • Benign pathologies
      • Anemia
      • Thrombocytopenia
      • Leukopenia
      • Blood-clotting disorders
      • Immunodeficiency disorders
  • Diagnostics and treatment of solid tumors
    • Gastrointestinal tumors: neoplasms in the stomach, intestines, esophagus, etc.
    • Urinary system tumors: neoplasms in the kidneys, bladder, ureters, etc.
    • Breast tumors
    • Female reproductive system tumors: neoplasms in the ovaries, uterus, vulva, etc.
    • Male reproductive system tumors: neoplasms in the prostate gland and testicles
    • Skin tumors
    • Soft tissue and bone tumors
    • Central nervous system tumors: neoplasms in the brain and spinal cord
  • Other oncological and hematological diseases

The department's range of therapeutic services includes:

  • Chemotherapy
  • Targeted therapy
  • Hormone therapy
  • Infusion therapy
  • Cellular immunotherapy
    • CAR T-cell therapy
    • Treatment with immune checkpoint inhibitors
  • Bone marrow transplant
    • Autologous stem cell transplant (transplant of the patient's own cells)
    • Allogeneic stem cell transplant (transplant of stem cells from related or unrelated donors)
  • Palliative care for patients with advanced cancers
  • Other treatment methods

Photo of the doctor: (c) Universitätsmedizin Greifswald 


About hospital

According to the reputable Focus magazine, the University Hospital Greifswald is included in the ranking of the best medical complexes throughout Germany!

The hospital is one of the oldest healthcare facilities in Germany, with long traditions and an excellent reputation. The history of the hospital begins in 1456, when the Faculty of Medicine at the University of Greifswald was founded. During this time, the hospital has managed to earn recognition in the national medical arena and gain prestige abroad. The hospital has 19 institutes and 21 specialized departments. The key to successful clinical practice is the combination of state-of-the-art equipment and highly qualified medical personnel who are actively engaged in the development of effective medical techniques and implement them in everyday practice.

The medical team of the university hospital has more than 4,400 employees, including world-famous professors who regularly undergo advanced training in the leading European and American hospitals, where they share their experience with foreign specialists. The doctors at the medical facility annually treat about 180,000 patients. At the same time, the specialists often provide medical care to patients with complex clinical cases, even in those cases that doctors at other medical centers consider hopeless. The hospital has more than 1,000 beds for inpatients, and many highly-specialized outpatient clinics are available in the medical facility for counseling and outpatient medical care.

The hospital presents all the fields of modern medicine. According to Focus magazine, the medical complex is recognized as one of the best in Germany for treating bowel cancer, bladder cancer, malignant brain tumors, skin cancer, multiple sclerosis, Parkinson's disease, dementia, cardiovascular pathologies, knee and hip pathologies, as well as ophthalmic and proctologic diseases. Diagnostic and therapeutic procedures are carried out in strict accordance with national and international standards, which ensures top-class medical care.

The medical team at the hospital makes sure that each patient feels as comfortable as possible during the therapeutic process. Doctors and nursing staff show humanity and understanding, striving to support each patient in every possible way on the path to recovery.

Photo: (с) depositphotos

Accommodation in hospital

Patients rooms

The patients of the University Hospital Greifswald live in comfortable single and double rooms. The patient rooms are made in bright colors and are quite cozy. The furnishings of a standard patient room include an automatically adjustable bed, a bedside table, a TV, and a telephone. The patient room has a table and chairs for receiving visitors. There is also free Wi-Fi in the patient rooms.

If desired, patients can live in enhanced-comfort rooms. In such rooms, patients are additionally offered toiletries, a bathrobe, and a change of towels.

Meals and Menus

The patients of the hospital are offered three healthy and tasty meals a day: a buffet breakfast, a hearty lunch, and dinner. The hospital also houses a cafeteria where one can have a tasty snack, a cup of aromatic coffee, tea, or soft drinks.

Patients staying in enhanced-comfort rooms are offered a special menu with a wide range of main courses, appetizers, desserts, and drinks.

Further details

Standard rooms include:

Shower
Toilet
Wi-Fi
TV

Religion

The services of representatives of religions are available upon request.

Accompanying person

Your accompanying person may stay with you in your patient room or at the hotel of your choice during the inpatient program.

Hotel

You may stay at the hotel of your choice during the outpatient program. Our managers will support you for selecting the best option.