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Prostate Cancer Treatment with Actinium-225 PSMA (program ID: 447911)

University Hospital Halle (Saale)

location_on Halle, Germany
9.6/10 from 78 Votes
Specialized hospital
Andreas Odparlik

Head Physician
Dr. med.

Andreas Odparlik

Specialized in: nuclear medicine

Department of Nuclear Medicine

Program includes:

  • Initial presentation in the clinic
  • clinical history taking
  • general physical examination
  • laboratory tests:
    • complete blood count
    • biochemical analysis of blood
    • urinalysis
    • TSH-basal, fT3, fT4
    • PSA blood level
    • tests for urogenital infections
    • indicators of inflammation
    • indicators of blood coagulation
  • ultrasound scan of the urogenital system
  • renal scintigraphy
  • PSMA PET-CT
  • PSMA treatment with Actinium-225
  • full body scintigraphy after 24 hours
  • full body scintigraphy after 48 hours
  • symptomatic treatment
  • cost of essential medicines
  • nursing services
  • elaboration of further recommendations
  • stay in the hospital with full board 
  • accommodation in 2-bedded room 

How program is carried out

During the first visit, the doctor will carry out a general physical examination and go through the results of previous laboratory and instrumental tests. After that, you will undergo the necessary additional tests such as the assessment of liver and kidney function, scintigraphy of the skeleton and salivary glands, PSMA PET / CT. This will allow the doctor to assess how effective PSMA therapy with Actinium-225 will be and how well you will tolerate it. Also, the doctor will calculate your individual dosage of the radionuclide.

PSMA therapy with Actinium-225 is carried out via intravenous administration of a solution with the radioactive isotope Actinium-225. The solution is injected through a catheter. This is a short procedure, as the infusion usually takes no more than 20 minutes.

During the procedure, you will need to apply cooling bags to the salivary glands, as Actinium-225 partially accumulates in the salivary glands, affecting their function and causing dry mouth. You will also receive intravenous saline solutions to protect your kidneys.

After the infusion of Actinium-225, you will stay in a specially equipped (radiation-shielded) ward for 48 hours. The drug is quickly excreted by the kidneys, and after 48 hours you will no longer be dangerous to others. During these 48 hours, you can read, use a mobile phone, tablet or computer – all these devices will not be a source of radiation in the future.

Follow-up examinations include whole-body scintigraphy or computed tomography in 24 hours and 48 hours after the procedure. Based on the results of the examination, the doctor will determine whether one procedure is enough for you, or whether you will need to visit the hospital again. As a rule, 1-2 procedures are required for achieving a stable positive result. Procedures are carried out with an interval of 8 weeks.

Required documents

  • Medical records
  • PSA blood test
  • MRI/CT scan (not older than 3 months)
  • Bone scintigraphy (if available)
  • Biopsy results (if available)
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About the department

The Department of Nuclear Medicine at the University Hospital Halle (Saale) offers the full range of services in this ​​medical field. It carries out all common and proven types of scintigraphic diagnostics and treatment. A unique offer of the department is SPECT-CT and PET-CT using various tracers and modern targeted radiopharmaceuticals. The department is headed by Dr. med. Andreas Odparlik.

The department has an in-house Section of Radiochemistry, in which all the necessary radiopharmaceuticals for the diagnostics and therapy are synthesized. Thus, the department has all the resources to provide excellent medical service.

The diagnostic options of the department include:

  • Combined positron emission tomography with computed tomography (PET-CT)
  • Gastrointestinal scintigraphy to find the source of bleeding, detect Meckel's diverticulum
  • Myocardial perfusion scintigraphy
  • Brain scintigraphy (neuro-SPECT, DaTSCAN ™ and IBZM-SPECT)
  • Bone scintigraphy
  • Functional liver scintigraphy
  • Scintigraphy using anti-granulocyte antibodies and labeled white blood cells
  • Cerebrospinal fluid scintigraphy
  • Ventilation and perfusion lung scintigraphy
  • Gastric emptying scintigraphy
  • Parathyroid scintigraphy
  • Renal function scintigraphy and static kidney scintigraphy
  • Thyroid diagnostics
    • Thyroid scintigraphy
    • MIBI thyroid scintigraphy
    • Imaging-guided fine needle aspiration biopsy
  • Sentinel lymph node marking
  • Esophageal scintigraphy
  • 123I-mIBG or 111In-octreotide tumor scintigraphy (Octreoscan)
  • Radioimmunological analysis within the framework of the in-house laboratory
  • Other diagnostic services

The therapeutic options of the department include:

  • Radioiodine therapy
    • Benign thyroid diseases
      • Hyperthyroidism due to hormonally active autonomous thyroid nodules (unifocal, multifocal autonomy)
      • Hyperthyroidism due to Graves' disease
      • Enlarged thyroid gland (goiter)
    • Malignant thyroid diseases
      • Differentiated thyroid cancer (follicular and papillary cancer)
      • Other types of recurrent thyroid cancer
  • Radiosynoviorthesis
    • Rheumatoid arthritis
    • Arthrosis of the large joints
    • Conditions after synovectomy
    • Seronegative spondyloarthropathy
    • Crystal arthropathy
    • Villonodular synovitis
    • Arthropathy in hemophilia
  • Selective internal radiotherapy for liver tumors
  • Peptide receptor radionuclide therapy for patients with metastatic neuroendocrine tumors
  • PSMA therapy for patients with metastatic prostate cancer
  • Other therapeutic methods

Curriculum vitae

Since July 2016, Dr. med. Andreas Odparlik has been the Head of the Department of Nuclear Medicine at the University Hospital Halle (Saale). The doctor has been working in this department since 2012 as a Leading Senior Physician and Deputy Head. He also holds the position of the Deputy Head of the newly established Department of Radiation Medicine, which also includes the Department of Radiology and the Department of Radiotherapy. From the very beginning of his professional career, he was engaged in the introduction and further improvement of modern techniques of nuclear medicine, as well as in the creation of hybrid imaging techniques. The latter allow for the combination of information about the morphology of organs and the intensity of metabolic processes in them, which greatly improves the quality of diagnostic data. Dr. Odparlik studied Human Medicine at the Universities of Halle, Greifswald and Pretoria (South Africa). He underwent specialized clinical training in various hospitals in Halle, Erfurt and Jena (Leading Senior Physician at the University Hospital Jena). In addition, the doctor is authorized to conduct preparatory courses for medical students in the field of nuclear medicine.

Photo of the doctor: (c) Universitätsklinikum Halle (Saale)


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