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Allogeneic bone marrow transplantation in multiple myeloma (363573) | University Hospital Tuebingen - BookingHealth
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Allogeneic bone marrow transplantation in multiple myeloma

University Hospital Tuebingen

Tuebingen, Germany
Program id # 363573
Doctor photo
Prof. Dr. med. Rupert Handgretinger
Department of General Pediatrics, Pediatric Hematology and Oncology
Specialized in: general pediatrics, pediatric hematology, oncology

The program includes:

  • Initial presentation in the clinic
  • case history collection
  • general clinical examination
  • laboratory tests:
    • complete blood count
    • general urine analysis
    • biochemical analysis of blood
    • TSH-basal, fT3, fT4
    • tumor markers
    • indicators of inflammation
    • indicators of blood coagulation
  • CT/MRI scans of the whole body
  • needle biopsy of the bone marrow
  • biopsy and histological examination of CSF
  • examination by experts of:
    • Cardiology
    • Otolaryngology
    • Immunology
    • Ophthalmology
  • registration in the European bone marrow donor base
  • conducting high-dose chemotherapy
  • allogeneic bone marrow transplantation from
    unrelated donor
  • isolation by neutropenic precautions
  • symptomatic treatment
  • the cost of essential medicines and blood products
  • nursing services
  • stay in the hospital with full board
  • accommodation in 2-bed room
  • elaboration of further recommendations

How program is carried out

During the first visit, the doctor will conduct a clinical examination and go through the results of the available diagnostic tests. After that, you will undergo the necessary additional examination, such as the assessment of liver and kidney function, ultrasound scan, CT scan and MRI.

Also, the doctor will conduct a bone marrow biopsy followed by cytological examination of the harvested material. This will help him to determine the histological features of your bone marrow (in particular, identify HLA system antigens) and select a suitable donor. The donor can be a family member or a person from the bone marrow registry. In the second case, the donor material is stored in a bone marrow bank.

Before the procedure, you will receive chemotherapy, if necessary in combination with radiation therapy. The course of chemo- or chemoradiation therapy lasts from 2 to 8 days.

The bone marrow transplant procedure is an intravenous infusion, i.e. the healthy bone marrow will be injected through a catheter, intravenously. You will stay in your room during the procedure. A bone marrow transplant is completely painless and does not require anesthesia.

During the period of healthy bone marrow engraftment, you will stay in a sterile ward. This is a necessary precaution because during this time your immune system is very weak and cannot withstand environmental pathogens. The risk of bleeding is also quite high, so you will be advised to avoid mechanical damage.

A relative or other close person may stay in the ward with you. You will not be allowed to go outside the department and leave your ward often. The rehabilitation period can last from 1 to 2 months.

When your complete blood count returns to normal, your doctor will schedule your discharge from the department. You will receive information about the rules that you will need to follow at home, the frequency and type of control examinations, and subsequent treatment measures. You will also receive a detailed medical report, which will reflect the entire course of treatment.

Required documents

  • Medical records
  • MRI/CT scan (not older than 3 months)
  • Bone marrow biopsy results (if available)

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About the department

According to the Focus magazine, the Department of General Pediatrics, Pediatric Hematology and Oncology at the University Hospital Tuebingen ranks among the top German departments specializing in the treatment of diabetes mellitus!

The department offers an accurate diagnostics and effective treatment of general pediatric disorders, malignant pathologies and blood disorders. The department is headed by Prof. Dr. med. Rupert Handgretinger. He is known as one of the world's leading specialists in stem cell transplantation in children suffering from leukemia.

The department is an international leader in stem cell transplantation in the case of leukemia, particularly in haploidentical transplantation, in which the parents can act as donors. In addition, the department specializes in the treatment of diabetes mellitus in childhood and adolescence, allergies and asthma, cystic fibrosis and rheumatism, as well as organ transplantations in children. 

The service range of the department includes:

  • Diagnostics and treatment of cancers
    • Chemotherapy (intravenous injection and intake of pills)
    • Radiation therapy
    • Surgical treatment
    • Stem cell transplantation
  • Diagnostics and treatment of hematological diseases
    • Anemias (thalassemia, sickle cell anemia, globular anemia, etc.)
    • Immunodeficiency
    • Blood coagulation disorders (for example, idiopathic thrombocytopenic purpura)
    • Histiocytosis
    • HIV infection
  • Bowel transplantation in short bowel syndrome
  • Liver transplantation
  • Kidney transplantation in kidney failure
  • Diagnostics and treatment of kidney diseases
    • Dialysis in children
      • Chronic hemodialysis (between the ages of 0 and 18 years)
      • Apheresis procedure, including leukapheresis
      • Chronic peritoneal dialysis (between the ages of 0 and 18 years)
      • Extracorporeal photopheresis in children
    • Functional diagnostics of the kidneys, including 24-hour blood pressure monitoring and kidney biopsy
    • Acute kidney failure
    • Plasmapheresis and immunoadsorption
    • Chronic kidney failure
    • Congenital or acquired glomerulopathies and tubulopathies
    • Polycystic kidney disease
    • Congenital anomalies of the urinary tract
    • Nephrotic syndrome
    • Autoimmune kidney diseases (systemic lupus erythematosus, Wegener's granulomatosis, vasculitides)
    • Genetic and syndromal kidney diseases
  • Diagnostics and treatment of allergies and bronchial asthma
    • Food allergies
    • Insect venom allergy (hyposensibilization)
    • Atopic dermatitis
    • Chronic bronchitis
    • Breathing and lung disorders
    • Functional diagnosis of the lungs
  • Diagnostics and treatment of diabetes mellitus
    • Comprehensive counseling
    • Age-appropriate diabetes mellitus training
    • Nutrition counseling
    • Psychosocial care
    • Insulin pump therapy
    • Continuous blood glucose measurement
  • Diagnostics and treatment of hormonal disorders
    • Growth disorders (short stature, gigantism)
    • Puberty disorders (early or delayed puberty)
    • Adrenal cortex diseases
    • Disorders of sexual differentiation
    • Thyroid diseases
    • Hormonal disorders in newborns
    • Secondary diseases after tumor therapy
  • Diagnostics and treatment of diseases of the gastrointestinal tract, liver
    • Hepatic failure: diseases of the liver and biliary tract, care before and after liver transplantation
    • Intestinal failure: severe and complex eating disorders, (tube feeding, care before and after intestinal transplantation)
    • Chronic inflammatory bowel disease
    • Celiac disease
    • Congenital disorders and malformations of the gastrointestinal tract
    • Pancreatic diseases
  • Diagnostics and treatment of cystic fibrosis
  • Diagnostics and treatment of rheumatic diseases
    • Juvenile idiopathic arthritis
    • Uveitis (eye inflammation)
    • Juvenile systemic lupus erythematosus
    • Juvenile dermatomyositis
    • Juvenile scleroderma
    • Autoinflammatory diseases/periodic fever syndromes
    • Chronic recurrent multifocal osteomyelitis
    • Behcet's disease
    • Autologous stem cell therapy in autoimmune diseases
    • Arthralgia (joint pain)
  • Diagnostics and treatment of other diseases in children and adolescents, other therapeutic techniques

Curriculum vitae

Professional Career

  • 2011 - present Full Professor and Chair, Center for Pediatric and Adolescent Medicine, University Hospital Tuebingen.
  • 2005 - present Medical Director, Department of General Pediatrics, Pediatric Hematology and Oncology, University Hospital Tuebingen.
  • 2000 - 2005 Full Professor, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA.
  • 2000 - 2005 Full Faculty Member and Director, Division of Stem Cell Transplantation, Department of Hematology and Oncology, St. Jude Children’s Research Hospital, Memphis, TN, USA.
  • 1994 - 2000 Head Physician, Department of General Pediatrics, Division of Hematology and Oncology, University Hospital Tuebingen.
  • 1989 - 2000 Director, Stem Cell Processing Laboratory, University Hospital Tuebingen.
  • 1996 Habilitation in Pediatrics, University of Tuebingen.
  • 1989 - 1994 Pediatric Residency, Center for Pediatric and Adolescent Medicine, University Hospital Tuebingen.
  • 1989 Doctoral thesis defense, University of Tuebingen.

Scholarships, Awards and Administrative Functions

  • 2015 - present Member, German National Academy of Sciences Leopoldina.
  • 2014 Research Award of the Robert Pfleger Foundation.
  • 2011 State Research Award of the State of Baden-Württemberg.
  • 1994 German Board of Pediatrics. 

Research Interests

  • Stem cell therapy.
  • Immunotherapy.
  • Growth hormones.
  • Leukemia in infants.
  • Diabetes and kidney diseases in children and adolescents.
  • Allergies.
  • Cystic fibrosis.
  • Organ transplantation in children.

Photo of the doctor: (c) Universitätsklinikum Tübingen 


About hospital

According to the prestigious medical publication Focus, the University Hospital Tuebingen ranks among the top five German hospitals! 

The hospital was founded in 1805, therefore it is proud of its long history, unique experience, and outstanding achievements in the field of medical care, as well as research and teaching activities. Nowadays, it is one of the most advanced medical institutions, which provides a wide range of general and highly specialized medical services. The hospital combines the state-of-art medical technologies in the field of diagnostics and the very latest treatment methods of a wide range of diseases.

The hospital has 17 specialized departments, which cover almost all fields of modern medicine and contribute to the top-class medical service in Germany. It treats about 367,000 outpatients and 74,000 inpatients annually. This testifies to the high authority of the hospital at the national and international medical arena. This is the first German hospital, which confirmed the high quality of healthcare and the effectiveness of service with a KTQ certification (in 2009).

Photo: (с) depositphotos

Accommodation in hospital

Patients rooms

The patients of the University Hospital Tuebingen live in comfortable single and double rooms with an ensuite bathroom equipped with a shower and toilet. The beds in the patient rooms are equipped with orthopedic mattresses that promote good and full sleep. There is a TV in the room, and it is also possible to connect a smartphone or laptop to the Internet. In addition, there is enough space in the patient room to receive 2-3 guests without inconvenience for the second patient.

The enhanced-comfort rooms include a hairdryer, heated towel rail, a large mirror, a direct dial telephone, a flat-screen satellite TV, a writing desk, free Internet access, a mini-bar and a refrigerator.

Meals and Menus

The patients of the hospital are offered tasty and healthy three meals a day: breakfast, lunch and dinner. Breakfast is served as a buffet, while for lunch and dinner there is a choice of several menus. Also, if desired, the patient will be provided with an individual menu. There are several cafes and cafeterias on the territory of the hospital, where one can have a tasty meal or enjoy a cup of coffee, tea and dessert.

Further details

Standard rooms include:

Toilet
Shower
Wi-Fi
TV

Religion

Religious services are available upon request.

Accompanying person

During the inpatient program, an accompanying person can stay with you in a patient room or in a hotel of your choice.

Hotel

During the outpatient program, you can stay in a hotel of your choice. Our managers will help you choose the most suitable option for you.