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Prostate Cancer Treatment with Actinium-225 PSMA (program ID: 578973)

Bundeswehr Academic Hospital Berlin

location_on Berlin, Germany
10/10 from 34 Votes
Specialized hospital
Angela Mai

Head Physician
Dr. med.

Angela Mai

Specialized in: nuclear medicine

Department of Nuclear Medicine

Program includes:

  • Initial presentation in the clinic
  • clinical history taking
  • general physical examination
  • laboratory tests:
    • complete blood count
    • biochemical analysis of blood
    • urinalysis
    • TSH-basal, fT3, fT4
    • PSA blood level
    • tests for urogenital infections
    • indicators of inflammation
    • indicators of blood coagulation
  • ultrasound scan of the urogenital system
  • renal scintigraphy
  • PSMA PET-CT
  • PSMA treatment with Actinium-225
  • full body scintigraphy after 24 hours
  • full body scintigraphy after 48 hours
  • symptomatic treatment
  • cost of essential medicines
  • nursing services
  • elaboration of further recommendations
  • stay in the hospital with full board 
  • accommodation in 2-bedded room 

How program is carried out

During the first visit, the doctor will carry out a general physical examination and go through the results of previous laboratory and instrumental tests. After that, you will undergo the necessary additional tests such as the assessment of liver and kidney function, scintigraphy of the skeleton and salivary glands, PSMA PET / CT. This will allow the doctor to assess how effective PSMA therapy with Actinium-225 will be and how well you will tolerate it. Also, the doctor will calculate your individual dosage of the radionuclide.

PSMA therapy with Actinium-225 is carried out via intravenous administration of a solution with the radioactive isotope Actinium-225. The solution is injected through a catheter. This is a short procedure, as the infusion usually takes no more than 20 minutes.

During the procedure, you will need to apply cooling bags to the salivary glands, as Actinium-225 partially accumulates in the salivary glands, affecting their function and causing dry mouth. You will also receive intravenous saline solutions to protect your kidneys.

After the infusion of Actinium-225, you will stay in a specially equipped (radiation-shielded) ward for 48 hours. The drug is quickly excreted by the kidneys, and after 48 hours you will no longer be dangerous to others. During these 48 hours, you can read, use a mobile phone, tablet or computer – all these devices will not be a source of radiation in the future.

Follow-up examinations include whole-body scintigraphy or computed tomography in 24 hours and 48 hours after the procedure. Based on the results of the examination, the doctor will determine whether one procedure is enough for you, or whether you will need to visit the hospital again. As a rule, 1-2 procedures are required for achieving a stable positive result. Procedures are carried out with an interval of 8 weeks.

Required documents

  • Medical records
  • PSA blood test
  • MRI/CT scan (not older than 3 months)
  • Bone scintigraphy (if available)
  • Biopsy results (if available)
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About the department

The Department of Nuclear Medicine at the Bundeswehr Academic Hospital Berlin offers the diagnostics and treatment of various diseases using modern radioactive drugs and advanced medical equipment. The diagnostic capabilities include various examinations of the thyroid gland, skeleton bones, heart, kidneys, lungs, brain, liver and biliary tract, as well as the search for foci of the inflammatory processes. In the field of therapy, the primary task of the department's doctors is the treatment of thyroid diseases (radioiodine therapy). All medical services comply with the standards of the German Society of Nuclear Medicine. The department is headed by Dr. med. Angela Mai.

In order to assess the structure and function of various organs, the department's specialists inject special radioactive chemical compounds (radiopharmaceuticals or radionuclides) into the human body, which are purposefully accumulated by the organs for the further examination. Scintigraphy involves the use of modern gamma cameras, which record the structure and metabolic processes in various organs. PET-CT is carried out in collaboration with the Charite Hospital.

A feature of the department is a specialized Radioimmunoassay Laboratory, where the doctors work on the radioactive substances. With the help of reliable research methods, the laboratory experts can detect certain concentrations of substances in the blood. The examined biological material is mixed with the radioactive substances, then it is processed in accordance with the standards and re-examined (in vitro diagnostics). Special attention in the laboratory is paid to the examination of the functional activities of the thyroid gland.

The service range of the department includes:

  • Diagnostic options
    • Scintigraphy and ultrasound examination of the thyroid and parathyroid glands
    • Skeletal scintigraphy (separate areas and the   whole body)
    • Myocardial scintigraphy
    • Function renal scintigraphy with the detection of certain parameters
    • Functional pulmonary scintigraphy for the detection of circulatory disorders and ventilation
    • Scintigraphy in cerebral circulation disorders
    • Functional biliary tract scintigraphy
    • Functional salivary gland scintigraphy
    • Bone marrow scintigraphy
    • Special scintigraphic examinations for the identification of inflammatory processes in bones and soft tissues (particularly in the diagnostics of fever of unknown origin)
    • Lymph node scintigraphy (including sentinel lymph nodes) in skin cancer
    • Ultrasound examinations
    • Fine-needle aspiration biopsy
    • Diagnostics within the Radioimmunoassay Laboratory
    • PET-CT (in collaboration with the Charite Hospital)
  • Therapy
    • Pain therapy in bone metastases
    • Pain therapy in chronic inflammatory changes in the knee joint (radiosynoviorthesis)
    • Drug therapy of the thyroid diseases (radioactive iodine therapy)
  • Other diagnostic and treatment methods

Photo of the doctor: (c) Bundeswehrkrankenhaus Berlin 


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