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Prostate Cancer Treatment with Lutetium-177 PSMA (program ID: 599578)

Helios Hospital Berlin-Buch

location_on Berlin, Germany
9.7/10 from 23 Votes
Specialized hospital
Stefan Dresel

Head Physician
Prof. Dr. med.

Stefan Dresel

Specialized in: nuclear medicine

Department of Nuclear Medicine

The program includes:

  • Initial presentation in the clinic
  • history taking
  • general clinical examination
  • laboratory tests:
    • complete blood count
    • biochemical analysis of blood
    • urinalysis
    • TSH-basal, fT3, fT4
    • PSA blood test
    • tests for urogenital infections
    • indicators of inflammation
    • indicators of blood coagulation
  • ultrasound scan of the urogenital system
  • renal scintigraphy
  • PSMA PET-CT (if indicated)
  • PSMA treatment
  • full body scintigraphy after 24 hours
  • full body scintigraphy after 48 hours
  • symptomatic treatment
  • cost of essential medicines
  • nursing services
  • elaboration of further recommendations
  • stay in the hospital with full board 
  • accommodation in a room with 2 beds

How program is carried out

During the first visit, the doctor will carry out a general physical examination and go through the results of your previous laboratory and instrumental tests. After that, you will undergo any necessary additional tests, such as an assessment of your liver and kidney function, a scintigraphy of your skeleton and salivary glands, a PSMA PET/CT. This will allow the doctor to assess how effective PSMA therapy with Lutetium-177 will be for you, and how well you will tolerate it. The doctor will also calculate your individual dosage of the radionuclide.

PSMA therapy with Lutetium-177 is carried out via intravenous administration of a solution containing the radioactive isotope, Lutetium-177. The solution is injected through a catheter. This is a short procedure, as the infusion usually takes no more than 20 minutes.

During the procedure, you will need to apply cooling bags to your salivary glands, as Lutetium-177 partially accumulates in the salivary glands, affecting their function and causing a dry mouth. You will also receive intravenous saline solutions to protect your kidneys.

After the infusion of Lutetium-177, you will stay in a specially equipped (radiation-shielded) ward for 48 hours. The drug is quickly excreted by the kidneys, and after 48 hours you will no longer be dangerous to others. During these 48 hours, you can read, use a mobile phone, tablet or computer – none of these devices will be a source of radiation in the future.

Follow-up examinations include either a whole-body scintigraphy or a computed tomography in 24 hours, and then again 48 hours after the procedure. Based on the results of this examination, the doctor will determine whether one procedure is enough for you, or whether you will need to visit the hospital again. As a rule, 1-2 procedures are required for achieving a stable, positive result. Procedures are carried out with an interval of 8 weeks.

Required documents:

  • Medical records
  • MRI/CT scan (not older than 3 months)
  • Biopsy results (if available)
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About the department

The Department of Nuclear Medicine at the Helios Hospital Berlin-Buch offers the full range of diagnostic and therapeutic procedures using modern radioactive substances. The diagnostic options include scintigraphic studies of the lungs, heart, brain, kidneys, lymph nodes, bones, including in small patients. In the field of therapy, one of the priority focuses is the use of radioiodine therapy for thyroid pathologies. Medical care and patient care are provided by highly qualified doctors and nursing staff who believe that the health and wellbeing of their patients is a top priority. The department is headed by Prof. Dr. med. Stefan Dresel.

A special offer in the field of diagnostics is positron emission tomography (PET). In the course of the study, the doctors use radioactive glucose, which makes it possible to assess the condition and functioning of almost all organs of the human body. Oncology is the main area of ​​application for positron emission tomography (PET), because many types of cancer, such as lung cancer, colon tumors or lymphomas, consume glucose intensively. Thus, with the help of this study, the doctors can exclude or identify tumors and their metastasis in the early stages. In addition, this study is widely used to diagnose neurological disorders (for example, Alzheimer's disease, epilepsy, Parkinson's disease). PET is an effective method for the diagnostics of heart pathologies. The department also offers a combined PET-CT method, which allows to image not only the structure of internal organs and anatomical structures of the body, but also metabolic processes.

The specialists of the department provide the diagnostics and treatment of thyroid diseases. To identify thyroid pathologies, the doctors perform scintigraphy. During the study, the patient is administered an iodine-containing contrast agent, which selectively accumulates in the thyroid gland tissue. The thyroid pathologies can be treated using radioiodine therapy. During therapy, the patient takes radioactive iodine in the form of a small capsule. In more than 90% of all cases of therapy, the doctors manage to achieve a positive treatment result. The advantage of this therapy is that it does not cause any side effects for the patient.

The department’s range of medical services includes:

  • Diagnostics
    • Lung scintigraphy
    • Myocardial scintigraphy
    • Brain scintigraphy
    • Kidney scintigraphy
    • Skeletal scintigraphy, including in children
    • Gamma-camera studies
    • Sentinel lymph node examinations to detect metastasis
    • Positron emission tomography, including the combined PET-CT method
    • Single-photon emission computed tomography (SPECT) for the diagnostics and treatment planning
  • Therapy
    • Radioiodine therapy for the treatment of benign and malignant thyroid diseases
    • DOTATATE therapy for the treatment of neuroendocrine tumors
    • Lu-177 PSMA therapy for advanced prostate cancer
    • Radiosynoviorthesis for the treatment of rheumatic and degenerative joint diseases
  • Other diagnostic and therapeutic options

Curriculum vitae

Education

  • 1984 - 1991 Study of Human Medicine at Ludwig Maximilian University of Munich.
  • 1993 Doctorate.

Professional Career

  • 1992 - 1994 Research Fellow, Department of Radiology, University Hospital of Ludwig Maximilian University of Munich.
  • 1994 - 1995 Research Fellow, Department of Nuclear Medicine, University Hospital of Ludwig Maximilian University of Munich, Campus Grosshadern.
  • 1995 Research Fellow, Institute for Diagnostic Radiology and Magnetic Resonance Imaging, University Hospital of Ludwig Maximilian University of Munich.
  • 1996 Senior Physician, Department of Nuclear Medicine, University Hospital of Ludwig Maximilian University of Munich, Campus Innenstadt.
  • 1996 Board certification in Nuclear Medicine.
  • 1996 - 1998 Research Fellow, Department of Radiology, University of Pennsylvania, Philadelphia, USA.
  • 1998 - 2004 Senior Physician, Department of Nuclear Medicine, University Hospital of Ludwig Maximilian University of Munich, Campus Innenstadt.
  • 201 Habilitation and Venia legendi in Nuclear Medicine.
  • Since 2004 Chief Physician of the Department of Nuclear Medicine at the Helios Hospital Berlin-Buch, as well as Section Head at the Department of Nuclear Medicine at the Helios Hospital Robert-Roessle, Berlin.
  • Since 2007 Extraordinary Professor of Ludwig Maximilian University of Munich.
  • Since 2008 Head of the Specialized Group on Radiology, Radiation Therapy and Nuclear Medicine.

Clinical Focuses

  • Diagnostics and therapy of benign and malignant thyroid diseases.
  • PET-CT diagnostics using F-18 FDG, Ga-68 PSMA and Ga-68 Dotatoc.
  • Radioreceptor therapy for neuroendocrine tumors using Lu-177 Dotatoc.
  • Treatment of metastatic prostate cancer using Lu-177 PSMA.
  • Treatment of liver tumors and liver metastasis using selective internal radiation therapy.

Photo of the doctor: (c) Helios Klinikum Berlin-Buch


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