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Allogeneic bone marrow transplantation in acute myeloid leukemia (program ID: 318750)

Medicana International Ankara Hospital

location_on Ankara, Turkey
9/10 from 23 Votes
Specialized hospital
Ender Soydan

Head Physician
Prof. Dr. med.

Ender Soydan

Specialized in: hematology, bone marrow transplantation

Department of Hematology and Bone Marrow Transplantation

Program includes:

  • Initial presentation in the clinic
  • case history collection
  • general clinical examination
  • laboratory tests:
    • complete blood count
    • biochemical analysis of blood
    • TSH-basal, fT3, fT4
    • differential blood count
    • inflammation indicators (CRP, ESR)
    • indicators of blood coagulation
  • abdominal ultrasound scan
  • CT/MRI scans of the whole body
  • needle biopsy of the bone marrow with histological:
    • cytochemistry
    • immunocytology
    • cytogenetics (Philadelphia
      chromosome detection)
    • molecular biology
  • biopsy and histological examination of CSF
  • examination by experts of:
    • cardiology
    • otolaryngology
    • immunology
    • ophthalmology
  • registration in the European bone marrow donor base
  • conducting high-dose chemotherapy
  • allogeneic bone marrow transplantation from
    unrelated donor
  • isolation by neutropenic precautions
  • symptomatic treatment
  • control examinations
  • the cost of essential medicines and materials
  • nursing services
  • full hospital accommodation
  • explanation of future recommendations

How program is carried out

During the first visit, the doctor will conduct a clinical examination and go through the results of the available diagnostic tests. After that, you will undergo the necessary additional examination, such as the assessment of liver and kidney function, ultrasound scan, CT scan and MRI.

Also, the doctor will conduct a bone marrow biopsy followed by cytological examination of the harvested material. This will help him to determine the histological features of your bone marrow (in particular, identify HLA system antigens) and select a suitable donor. The donor can be a family member or a person from the bone marrow registry. In the second case, the donor material is stored in a bone marrow bank.

Before the procedure, you will receive chemotherapy, if necessary in combination with radiation therapy. The course of chemo- or chemoradiation therapy lasts from 2 to 8 days.

The bone marrow transplant procedure is an intravenous infusion, i.e. the healthy bone marrow will be injected through a catheter, intravenously. You will stay in your room during the procedure. A bone marrow transplant is completely painless and does not require anesthesia.

During the period of healthy bone marrow engraftment, you will stay in a sterile ward. This is a necessary precaution because during this time your immune system is very weak and cannot withstand environmental pathogens. The risk of bleeding is also quite high, so you will be advised to avoid mechanical damage.

A relative or other close person may stay in the ward with you. You will not be allowed to go outside the department and leave your ward often. The rehabilitation period can last from 1 to 2 months.

When your complete blood count returns to normal, your doctor will schedule your discharge from the department. You will receive information about the rules that you will need to follow at home, the frequency and type of control examinations, and subsequent treatment measures. You will also receive a detailed medical report, which will reflect the entire course of treatment.

Required documents

  • Medical records
  • MRI/CT scan (not older than 3 months)
  • Bone marrow biopsy results (if available)
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About the department

The Department of Hematology and Bone Marrow Transplantation at the Medicana International Ankara Hospital, headed by Dr. Ender Soydan, is a leading private medical center in Ankara offering services of bone marrow transplantation. In the nine-bed Department, various kinds of bone marrow transplantation are performed to treat a wide range of both oncohematological and other diseases. Since December 2012, the Department is licensed by the Ministry of Health in Turkey.

Bone marrow transplantation is recommended in case of the following diseases:

  • Oncohematological diseases: acute and chronic myelogenous leukemia, acute lymphoblastic leukemia, lymphoma, plasmacytoma, myelodysplasia, myelofibrosis, etc.
  • Malignant tumors of different organs: breast cancer, ovarian cancer
  • Immune system disorders: beta-thalassemia, immunodeficient diseases, lupus erythematosus, multiple sclerosis
  • Blood diseases: aplastic anaemia, sickle-cell disease
  • Brain dysplasia
  • Inherited blood-formation disturbances

In general, an indication for conducting of bone marrow transplantation are such conditions, in which the patient's own hematopoietic system does not fulfil its function. For instance, in case of non-oncological diseases it will manifest itself in the form of an insufficient production of stem cells, while in case of leucosis – in production of immature stem cells.

Depending on the source of the hematopoietic cells, there are distinguished two types of the transplantation: autologous and allogenic transplantation. In the autologous transplantation technique, the patient’s own healthy stem cells are transplanted to the patient. The affected organ is removed, the patient is prescribed an intensive chemotherapy in order to kill cancerous cells. Once the preparation is completed, the transplantation can be carried out. The autologous transplantation is performed in case of malignant tumors when the tumor has not spread to the bone-marrow tissue. In the allogenic transplantation technique, the hematopoietic material of a related or unrelated donor is used. The transplanted cells of an unrelated donor must be genetically compatible with the recipient’s tissues.

Prior to the transplantation, both patient and donor have to undergo several diagnostic procedures in the Medicana Ankara Hospital in order to prevent postoperative complications. These include, inter alia, biochemical blood test, bone marrow aspiration, pneumonography, lung function test and electrocardiogram. Apart from that, additional diagnostic procedures are required to investigate the genetic compatibility.

In the Department of Hematology and Bone Marrow Transplantation at the Medicana International Ankara Hospital, the bone marrow transplantation is carried out in several stages. Once the preparation is completed, the collection of hematopoietic cells is performed. Bone marrow is harvested from the femur (of the patient or donor). The harvested material is preserved by freezing. The amount of the collected material is up to 2000 ml and depends on the weight of the patient and bone marrow concentration in the material (the lost amount will be restored in the body within a month). The bone marrow transplantation is carried out by using the infusion approach, which resembles the blood transfusion procedure. During the process of bone marrow circulation in the bloodstream, the patient is exposed to the risk of infection and bleeding. Thus, the patient is prescribed an anti-bacterial treatment, blood infusions and immunomodulatory medications (in case of an allogenic transplantation).

The specialists of the Department under the direction of Dr. Ender Soydan put a special emphasis on the rehabilitation process following bone marrow transplantation. The aim of the rehabilitation is to restore the immune system of the patient. For this purpose, it is strictly recommended to restrict communication, visiting public places as well as to wear breathing protection. In addition, patients are also recommended to get a specific vaccination against some diseases over a period of time.

The Medicana International Ankara Hospital enjoys an exceptional reputation in the field of bone marrow transplantation and regularly treats patients from Turkey and many other countries. The offered bone marrow services derive from the latest medical technologies and meet the stringent international requirements. 

Photo of the doctor: (c) Medicana Health Group


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