In vitro fertilization (IVF) long protocol (program ID: 280354)

University Hospital Bonn

location_on Bonn, Germany
9.2/10 from 150 Votes
Specialized hospital
Nicole Sänger

Head Physician
Prof. Dr. med.

Nicole Sänger

Specialized in: gynecological endocrinology, reproductive medicine

Department of Gynecological Endocrinology and Reproductive Medicine

The program includes:

  • Initial presentation in the clinic
  • Case history taking
  • Review of medical records
  • General physical examination
  • Laboratory tests: 
    • Complete blood count 
    • General urine test
    • Biochemical blood test
    • Inflammation markers
    • Blood coagulation test 
    • Immune status
    • Analysis for infections
    • Hormone levels:
      • FSH
      • LH
      • Androgens
      • Progesterone
      • Prolactin
      • TSH-basal, fT3, fT4 
  • Ultrasound examination of abdomen and small pelvic organs 
  • Transvaginal ultrasound examination
  • Gynecological examination
  • Examination of the men:
    • Spermogram
    • Urethral smear analysis
    • Tests for infections
  • Hormonal stimulation 
  • In vitro fertilization (IVF)
  • Nursing services
  • Consultation of related specialists
  • Treatment by head doctor and all leading experts
  • Explanation of the individual treatment plan

All aspects of the program can be discussed with a medical advisor.

How program is carried out

You arrive in the hospital on the 19th day of the menstrual cycle. Our service starts at the airport. Our employee meets you at the airport and holds a sign with your name. In the individual folder you will find detailed information about the program.

The reproductologist will start from the general examination, you will undergo a number of laboratory and instrumental tests. After that, the doctor will elaborate an individual treatment plan, determine the drug dosages. You will receive a detailed explanation of all the procedures and will be able to contact your doctor for advice at any time.

For your convenience, we offer hotels or apartments within walking distance of the hospital. After the first appointment, you will have free time to rest. You can take the prescribed medications on your own or in the hospital. Also, several times, on the appointed days, it will be necessary to have an ultrasound examination (up to 3 times).

Stages of treatment

Blockage. On days 20-21 of the menstrual cycle, the pituitary gland is blocked with GnRH agonists. The purpose of the drug administration is to suppress ovarian function and stimulate maturation of more oocytes.

Ovarian stimulation. On the 2-4th day of the menstrual cycle, active stimulation of the ovaries with gonadotropins under constant ultrasound monitoring begins. It takes 10-14 days on average. An ultrasound examination is required to assess follicular growth. When the follicle is mature enough, a trigger injection is given.

The doctor will appoint the day of visiting the clinic. The time of oocyte collection (puncture) is determined. 36 hours before the puncture, a woman makes a stimulating (trigger) injection of hCG (human chorionic gonadotropin).

Egg collection. In the hospital, the follicles are punctured with the collection of mature eggs (on the 12-15 day of the menstrual cycle). The husband of the patient, on his turn, collects the ejaculate. The ejaculate can be collected naturally, or by a puncture of the testicle (in azoospermia, obstruction of the vas deferens in men – the ICSI procedure).

Fertilization. 2-6 hours after egg collection, eggs are fertilized with the husband’s sperm. This is a laboratory procedure and no patient involvement is required.

Embryo culture. Fertilized eggs will be cultured for 1-5 days. According to patients’ needs and embryo status, best 1-3 embryos can be transferred to the womb.

Preimplantation genetic diagnosis. PGD is usually performed on day 3. It takes 1 day to receive the results. One or two cells from the embryo can be taken without harming it, and some genetic tests can be done in one or two days.

Embryo transfer. This procedure is painless and no anesthesia is required, although some patients need sedation. One hour after the procedure, patients can leave the clinic and can return home on the same day.

Pregnancy test. This test can be done 14 days after the embryo transfer.

Service support

We fully support your trip, regardless of the chosen program. We provide an individual medical coordinator and interpreter, help with choosing and booking a hotel, booking tickets, preparing medical reports.

Required documents:

  • Medical records
  • Results of hormone blood tests (if available)
  • Pelvic ultrasoud (if available)
Type of program :
Expected duration of the program:

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About the department

The Department of Gynecological Endocrinology and Reproductive Medicine at the University Hospital Bonn offers the full range of diagnostic and treatment services in its areas of specialization. In addition to all standard treatment methods of infertility, the department uses additional diagnostic and treatment methods, for example, polar body biopsy (within the preimplantation diagnostics of genetic diseases), auxiliary hatching, the use of calcium ionophores for egg activation, intracytoplasmic morphologically selected sperm injection (IMSI), etc. The department is one of the leading Centers for Reproductive Medicine in Germany. The Chief Physician of the department is Prof. Dr. med. Nicole Sänger.

The department's specialists have independently developed some of the assisted reproductive technologies (ART) and continue to work intensively on their further improvement. The laboratory in the department is among the best in Germany in the field ART. It also offers various methods of cryopreservation of sperm, eggs, cryopreservation of testicular and ovarian tissues, etc. Thus, the department provides the highest quality standards of reproductive medicine services and has an impeccable international reputation.

In the field of gynecological endocrinology, the main focus is on hormonal disorders and related diseases. These include, for example, hair loss, acne, hirsutism, irregular menstruation, etc. Each patient undergoes a comprehensive diagnostics, on the basis of which an individual hormone therapy program is prescribed, if it is indicated.

The department’s diagnostic and therapeutic range of services:

  • Diagnostics and treatment of inflammatory diseases of the pelvic organs in women
  • Diagnostics and treatment of non-inflammatory diseases of the female reproductive organs (for example, endometriosis)
  • Endoscopic surgery
  • Gynecological endocrinology
  • Reproductive medicine
    • IVF
    • Intracytoplasmic sperm injection (ICSI)
    • Open testicular biopsy (TESE)
    • Intrauterine insemination (IUI)
    • Determination of the optimal time for conception
    • Polar body biopsy (within the preimplantation genetic diagnostics)
    • Supportive hatching
    • Use of calcium ionophores for egg activation
    • Intracytoplasmic morphologically selected sperm injection (IMSI)
    • Sequential drugs (antiandrogen therapy in women)
    • EmbryoScope produces
  • Procedures for preserving the reproductive function in oncological diseases
    • Ovarian tissue biopsy with cryopreservation
    • Protection of the ovaries from chemical and radiation injury
    • Ovarian tissue replantation
  • And other diagnostic and therapeutic methods

Curriculum vitae

Membership in Professional Societies

  • German Society of Gynecology and Obstetrics.
  • German Society of Gynecological Endocrinology and Reproductive Medicine.
  • German Menopause Society.
  • Middle Rhine Society for Gynecology and Obstetrics.
  • German Society for Reproductive Medicine.
  • Federal Association of German Reproductive Medical Centres.
  • European Society of Human Reproduction and Embryology (ESHRE).
  • International Society of Fertility Preservation (ISFP).
  • Professional Society FertiPROTEKT.

Board Memberships

  • German Society of Gynecology and Obstetrics.
  • German Society of Gynecological Endocrinology and Reproductive Medicine.
  • Professional Society FertiPROTEKT.

Photo of the doctor: (c) Universitätsklinikum Bonn  

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