Prostate Cancer Treatment with Lutetium-177 PSMA (program ID: 280689)
University Hospital Bonn
Markus EsslerSpecialized in: nuclear medicine
Department of Nuclear Medicine
- Initial presentation in the clinic
- history taking
- general clinical examination
- laboratory tests:
- complete blood count
- biochemical analysis of blood
- TSH-basal, fT3, fT4
- PSA blood test
- tests for urogenital infections
- indicators of inflammation
- indicators of blood coagulation
- ultrasound scan of the urogenital system
- renal scintigraphy
- PSMA PET-CT (if indicated)
- PSMA treatment
- full body scintigraphy after 24 hours
- full body scintigraphy after 48 hours
- symptomatic treatment
- cost of essential medicines
- nursing services
- elaboration of further recommendations
- stay in the hospital with full board
- accommodation in 2-bedded room
How program is carried out
During the first visit, the doctor will carry out a general physical examination and go through the results of previous laboratory and instrumental tests. After that, you will undergo the necessary additional tests such as the assessment of liver and kidney function, scintigraphy of the skeleton and salivary glands, PSMA PET / CT. This will allow the doctor to assess how effective PSMA therapy with Lutetium-177 will be and how well you will tolerate it. Also, the doctor will calculate your individual dosage of the radionuclide.
PSMA therapy with Lutetium-177 is carried out via intravenous administration of a solution with the radioactive isotope Lutetium-177. The solution is injected through a catheter. This is a short procedure, as the infusion usually takes no more than 20 minutes.
During the procedure, you will need to apply cooling bags to the salivary glands, as Lutetium-177 partially accumulates in the salivary glands, affecting their function and causing dry mouth. You will also receive intravenous saline solutions to protect your kidneys.
After the infusion of Lutetium-177, you will stay in a specially equipped (radiation-shielded) ward for 48 hours. The drug is quickly excreted by the kidneys, and after 48 hours you will no longer be dangerous to others. During these 48 hours, you can read, use a mobile phone, tablet or computer – all these devices will not be a source of radiation in the future.
Follow-up examinations include whole-body scintigraphy or computed tomography in 24 hours and 48 hours after the procedure. Based on the results of the examination, the doctor will determine whether one procedure is enough for you, or whether you will need to visit the hospital again. As a rule, 1-2 procedures are required for achieving a stable positive result. Procedures are carried out with an interval of 8 weeks.
- Medical records
- MRI/CT scan (not older than 3 months)
- Biopsy results (if available)
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About the department
The Department of Nuclear Medicine at the University Hospital Bonn offers the full range of radioisotope diagnostics and treatment of various diseases. The department began its work in 1951 and today it is one of the leading and most reputable medical facilities of this kind in Germany. The clinical activities mainly focus on the detection and treatment of pathologies of the thyroid gland, heart, lung cancer, breast cancer, prostate gland, liver cancer and metastases, neuroendocrine tumors, malignant melanoma, and brain tumors. The doctors use only reliable, the most effective innovative methods of examination and therapy, which guarantee an optimal result. The department is headed by Prof. Dr. med. Markus Essler.
Since October 2014, the department has introduced and actively uses the very latest newest treatment method for prostate cancer. The Lutetium-177 PSMA therapy represents a unique option for the provision of targeted specialized medical care to patients with prostate cancer who do not have a positive dynamic during hormonal therapy or chemotherapy. Unlike the treatment with Radium-223, the advantage of Lutetium-177 PSMA therapy is its effectiveness in metastases to the lymph nodes or other organs.
The department’s priority is the diagnostics and treatment of thyroid diseases. The diagnostic capabilities include the ultrasound examinations, scintigraphy, puncture biopsy of the thyroid gland, while radiation therapy is the main therapy method in this field. The department’s physicians specialize in the treatment of "hot" thyroid nodules, Graves' disease, Hashimoto's thyroiditis, De Quervain's thyroiditis, amiodarone-induced thyrotoxicosis, goiter, thyroid cancer and thyroid dysfunction during pregnancy (in collaboration with the Department of Reproductive Medicine).
The service range of the department includes:
- Ultrasound examinations of the thyroid gland
- Thyroid scintigraphy
- Positron emission tomography and PET-CT
- Ga-68-PSMA PET-CT
- Myocardial scintigraphy
- Sentinel lymph node scintigraphy
- Lung scintigraphy
- Kidney scintigraphy
- Skeletal scintigraphy
- Bone mineral density measurement (osteodensitometry)
- Radioactive iodine therapy with I-131 for the treatment of benign thyroid diseases (functional autonomy of the thyroid gland, Graves' disease, goiter)
- Radioactive iodine therapy I-131 for the treatment of thyroid cancer
- Peptide-receptor radionuclide therapy (PRRT) with 177Lu-DOTATATE for the treatment of neuroendocrine tumors
- Selective internal radiation therapy/transarterial radioembolization with yttrium-90 microspheres
- Lutetium-177 PSMA therapy for the treatment of hormone-resistant metastatic prostate cancer
- Ra-223 therapy in prostate cancer with bone metastases
- Radioimmunotherapy using 90Y-ibritumomab tiuxetan (Zevalin)
- Radionuclide MIBG therapy with I-131
- Yttrium-90 radioembolization (Y-90)
- Other diagnostic and therapeutic services
Education and Professional Career
- 1989 - 1995 Study of Medicine at Ludwig Maximilian University of Munich.
- 09.11.1995 Medical examination.
- 1993 - 1996 Doctoral thesis defense at the Institute for the Prevention and Epidemiology of Hematopoietic Diseases, Muenster (under the direction of Prof. Dr. med. Peter K. Weber). Subject: "The role of Ras-like GTPases in the regulation of cytokinesis of myelomonocytic cells".
- 25.04.1996 Doctoral thesis defense with honors.
- 1996 - 2000 Research Fellow, Innenstadt Hospital, Ludwig Maximilian University of Munich.
- 2000 - 2002 Research Grant from the German Research Foundation, Burnham Institute, Cancer Research Center.
- 11.2001 Award from the US Department of Defense (breast cancer).
- Since 07.2002 Research Fellow, Department of Nuclear Medicine, Rechts der Isar Hospital Munich (Head: Prof. Dr. med. Markus Schweiger).
- 15.11.2004 PhD thesis defense and appointment to the position of PD in Clinical Pathophysiology at Ludwig Maximilian University of Munich.
- 26.06.07 Medical Specialist in Nuclear Medicine and Professional Certification of the Bavarian Medical Association.
- 10.2007 Appointment to the position of W3 Professor of Nuclear Medicine, University Hospital Ulm (refusal).
- 06.2009 Position in the Department of Nuclear Medicine at the Hannover Medical School (Successor of Prof. Dr. med. W. Knapp), 2nd place in the list.
- 07.2010 PhD thesis defense and appointment as PD at the Technical University of Munich.
- 11.2010 Appointment as the Clinical Senior Physician.
- 11.2010 Appointment as the Extraordinary Professor, Technical University of Munich.
- 06.2011 Invitation to the Department of Nuclear Medicine, University of Cologne (3rd place in the list).
- 12.2012 Invitation to the Department of Nuclear Medicine at the University of Vienna (2nd place in the list).
- 04.2013 Invitation to the Department of Nuclear Medicine (Successor of the Prof. Dr. med. V. A. Weber), 2nd place in the list.
- 05.2013 Invitation to the Department of Nuclear Medicine, University of Bonn.
- Since 11.2013 Head of the Department of Nuclear Medicine at the University Hospital Bonn.
- 2010 University Certification in Medical Didactics, Carl von Linde Institut, Munich.
- 2011 Healthcare Management Certification, Medical Association of North Rhine, MIBEG Institute, Cologne.
- 60 publications in international journals, including the review activities.
- 33 publications as the first and last "Corresponding Author".
- Specific vascular peptide affiliated to breast tumors ("homing-peptide") for the administration of drugs into the breast tissue in precancerous conditions.
- 2003 Modifications of non-fibrillar collagen in tumor blood vessels and substances tropic to it.
- 2008 Peptides, which are specifically connected to a modified matrix metalloproteinase that breaks down collagen (registered model 20 2008 012716.59)
- 2013 Bi-213 labeled antibodies to the CD38 antigen in the treatment of multiple myeloma.
Memberships in Professional Societies
- German Society of Nuclear Medicine (DGN).
- European Association of Nuclear Medicine (EANM).
- Society of Nuclear Medicine (SNM).
- German Society of Radiation Oncology (DEGRO).
- Bavarian Society of Nuclear Medicine (BGN).
Photo of the doctor: (c) Universitätsklinikum Bonn