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Allogeneic bone marrow transplantation in acute lymphoblastic leukemia (program ID: 294899)

University Hospital Carl Gustav Carus Dresden

location_on Dresden, Germany
9.1/10 from 23 Votes
Specialized hospital
Frank Kroschinsky

Head Physician
Prof. Dr. med.

Frank Kroschinsky

Specialized in: hematology, blood stem cell transplantation

Department of Hematology and Blood Stem Cell Transplantation

Program includes:

  • Initial presentation in the clinic
  • case history collection
  • general clinical examination
  • laboratory tests:
    • complete blood count
    • biochemical analysis of blood
    • TSH-basal, fT3, fT4
    • differential blood count
    • inflammation indicators (CRP, ESR)
    • indicators of blood coagulation
  • CT/MRI scans of the whole body
  • needle biopsy of the bone marrow with histological:
    • cytochemistry
    • immunocytology
    • cytogenetics (Philadelphia
      chromosome detection)
    • molecular biology
  • biopsy and histological examination of CSF
  • examination by experts of:
    • cardiology
    • otolaryngology
    • immunology
    • ophthalmology
  • registration in the European bone marrow donor base
  • conducting high-dose chemotherapy
  • allogeneic bone marrow transplantation from
    unrelated donor
  • the cost of blood products
  • isolation by neutropenic precautions
  • symptomatic treatment
  • control examinations
  • the cost of essential medicines and materials
  • nursing services
  • full hospital accommodation
  • explanation of future recommendations

How program is carried out

During the first visit, the doctor will conduct a clinical examination and go through the results of the available diagnostic tests. After that, you will undergo the necessary additional examination, such as the assessment of liver and kidney function, ultrasound scan, CT scan and MRI.

Also, the doctor will conduct a bone marrow biopsy followed by cytological examination of the harvested material. This will help him to determine the histological features of your bone marrow (in particular, identify HLA system antigens) and select a suitable donor. The donor can be a family member or a person from the bone marrow registry. In the second case, the donor material is stored in a bone marrow bank.

Before the procedure, you will receive chemotherapy, if necessary in combination with radiation therapy. The course of chemo- or chemoradiation therapy lasts from 2 to 8 days.

The bone marrow transplant procedure is an intravenous infusion, i.e. the healthy bone marrow will be injected through a catheter, intravenously. You will stay in your room during the procedure. A bone marrow transplant is completely painless and does not require anesthesia.

During the period of healthy bone marrow engraftment, you will stay in a sterile ward. This is a necessary precaution because during this time your immune system is very weak and cannot withstand environmental pathogens. The risk of bleeding is also quite high, so you will be advised to avoid mechanical damage.

A relative or other close person may stay in the ward with you. You will not be allowed to go outside the department and leave your ward often. The rehabilitation period can last from 1 to 2 months.

When your complete blood count returns to normal, your doctor will schedule your discharge from the department. You will receive information about the rules that you will need to follow at home, the frequency and type of control examinations, and subsequent treatment measures. You will also receive a detailed medical report, which will reflect the entire course of treatment.

Required documents

  • Medical records
  • MRI/CT scan (not older than 3 months)
  • Bone marrow biopsy results (if available)
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About the department

The Department of Hematology and Blood Stem Cell Transplantation at the University Hospital Carl Gustav Carus Dresden offers the full range of services in these medical fields. The department specializes in the treatment of malignant diseases of the hematopoietic and lymphatic systems. In addition, the ​​tasks of the department's doctors include the treatment of rare benign pathologies, congenital and acquired hematopoiesis disorders. The department's therapeutic options include modern types of chemotherapy, immunotherapy and targeted therapy. The department is the largest and one of the most reputable medical facilities in Germany, specializing in allogeneic and autologous blood stem cell transplantation (European JACIE certification). Stem cell transplantation is carried out within a special laboratory, where hygiene and safety standards are strictly met. All doctors and nursing staff working in the department make sure that each patient receives the best possible medical care and regains his health. The department is headed by Prof. Dr. med. Frank Kroschinsky.

The primary focus of the department's clinical practice is on the treatment of acute and chronic leukemias: acute myeloid leukemia, acute lymphoblastic leukemia, chronic myeloid leukemia and chronic lymphocytic leukemia. At the early stages of leukemia, there are no symptoms – the pathology does not manifest itself in any way and is often diagnosed accidentally during examination for other diseases. If leukemia is suspected, such tests as a complete blood count, coagulogram, immunogram, cytogenetic and cytochemical tests, ultrasound scans, computed tomography and magnetic resonance imaging are indicated to the patient. A bone marrow puncture is also performed. The department's doctors have in their arsenal many effective treatment methods for leukemia. The choice of treatment regimen is influenced by the particular type of leukemia and its course, the stage of the oncological process, the degree of damage to the internal organs and the general health condition of the patient. The treatment regimen for each patient is developed individually. The department's doctors successfully use such treatment methods as chemotherapy, targeted therapy and immunotherapy. The last-line treatment is stem cell transplantation.

The department's specialists also provide all modern diagnostic and therapeutic services for patients with Hodgkin's and non-Hodgkin's lymphomas, multiple myeloma and myelodysplastic syndrome. All these diseases are hematopoietic cancers and require comprehensive treatment. As a rule, doctors use modern chemotherapy drugs, targeted therapy and stem cell transplantation. The intensity and duration of the course of treatment depends on the patient's diagnostic results and the stage of cancer.

The patients undergoing inpatient treatment are offered specialized physiotherapy, psycho-oncological care and art therapy. With appropriate indications and if desired, the patient can take part in clinical trials of progressive drugs and treatment methods. It should be noted that the department carries out continuous fruitful research activities in the field of immunotherapy and the use of stem cells (donor or patient's own stem cells that have undergone special processing).

It should be noted that the department has specialized laboratories for a number of diagnostic tests of the hematopoietic and lymphatic systems. The experts have special competence in the field of cytological and cytochemical bone marrow examinations, cytogenetic and molecular genetic tests. The department carries out accurate diagnostics, based on the results of which an optimal treatment regimen is developed, corresponding to the patient's individual needs and wishes.

The department's key clinical focuses include:

  • Diagnostics and treatment of acute and chronic leukemia
    • Acute myeloid leukemia
    • Chronic myeloid leukemia
    • Acute lymphoblastic leukemia
    • Chronic lymphocytic leukemia
  • Diagnostics and treatment of Hodgkin's and non-Hodgkin's lymphomas
  • Diagnostics and treatment of multiple myeloma (plasmacytoma)
  • Diagnostics and treatment of myelodysplastic syndromes
  • Diagnostics and treatment of rare benign pathologies, congenital or acquired hematopoietic disorders
  • Diagnostics and treatment of coagulation disorders
    • Hemophilia A and B
    • Von Willebrand disease
    • Platelet dysfunction (thrombocytopathy)
    • Hemorrhage of unknown origin during operations and other procedures
    • Coagulation disorders during pregnancy
    • Complex disorders of hemostasis in hematological and other diseases
  • Other diseases

The department's range of therapeutic services includes the following options:

  • Chemotherapy
  • Immunotherapy
  • Targeted therapy
  • Stem cell transplantation
    • Allogeneic blood stem cell transplantation
    • Autologous blood stem cell transplantation
    • Mesenchymal stem cell therapy
    • Regulatory T cell therapy
    • CAR T cell therapy
  • Participation in clinical trials
  • Special physiotherapeutic treatment course
  • Psycho-oncological care
  • Other medical services

Photo: (с) depositphotos


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