Charite University Hospital Berlin

location_on Berlin, Germany
9/10 from 95 Votes

Department of Gastroenterology, Infectology and Rheumatology ( 26115)

Britta Siegmund

Prof. Dr. med.

Britta Siegmund

Specialized in: gastroenterology, infectology and rheumatology

Curriculum vitae keyboard_arrow_down
  • 1992 - 1998 Education at the Medical Faculty of the Ludwig Maximilian University of Munichand at the Harvard Medical School, Boston.
  • 2007 and 2009 Medical Specialist in Internal Medicine and Gastroenterology.
  • 2002 - 2007 Research Assistant and Head of Emmy Noether’s Group for Young Specialists at the Department of Gastroenterology, Infectology and Rheumatology, Charite University Hospital Berlin.
  • 2006 Habilitation.
  • Medical Specialist in Internal Medicine, the main specialization – gastroenterology.
  • 2012 Professor of the Heisenberg Program of the German Research Foundation and Deputy Head of the department.
  • Acting Head of the Department of Gastroenterology, Infectology and Rheumatology and W3 Professor W3 at the Charite University Hospital Berlin.
  • Since 2013, Head of the Department of Gastroenterology, Infectology and Rheumatology at the University Hospital Charite, Campus Benjamin Franklin.

Main Clinical Focuses

  • Diseases of the gastrointestinal tract, liver, biliary tract and pancreas.
  • Gastroenterological oncology.
  • Hepatology.
  • Endoscopic treatments.
  • Endosonography (endoscopic ultrasound).
  • ERCP (endoscopic retrograde cholangiopancreatography).
  • Intestinoscopy (examination of the small intestine).
  • Intestinoscopy (examination of the small intestine).
  • Capsule endoscopy (method of medical imaging of the mucous membrane of the digestive tract with the help of a special capsule with a camera).
  • Implantation of stents (tubes made of thin metal of cellular structure for expanding vessel lumen).
  • Necrectomy (removal of dead tissues).
  • Treatment of Zenker's diverticulum.
Publications keyboard_arrow_down

10 most important Publications

  1. B. Siegmund, H. A. Lehr, G. Fantuzzi, C. A. Dinarello. Interleukin-1-converting enzyme (caspase-1) in intestinal inflammation. PNAS 98:13249-54, 2001
  2. B. Siegmund, H. A. Lehr, G. Fantuzzi. Leptin: a pivotal role in intestinal inflammation. Gastroenterology 122:2011-2025, 2002
  3. B. Siegmund, J. A. Senello, J. Jones-Carson, F. Gamboni-Robertson, H. A. Lehr, A. Batra, I. Fedke, M. Zeitz, G. Fantuzzi. Leptin receptor on T lymphocytes modulates chronic intestinal inflammation in mice. Gut 53:965-72, 2004
  4. R. Glauben, A. Batra, I. Fedke, M. Zeitz, H. A. Lehr, F. Leoni, P. Mascagni, G. Fantuzzi, C. A. Dinarello, B. Siegmund. Histone hyperacetylation is associated with amelioration of experimental colitis in mice. J Immunol 176:5015-22, 2006
  5. Batra A, Pietsch J, Fedke I, Glauben R, Okur B, Stroh T, Zeitz M, Siegmund B. Leptindependent TLR expression and resposiveness in preadipocytes and adipocytes. Am J Pathol (2007) 170:890-5.
  6. Glauben R, Batra A, Stroh T, Erben U, Fedke I, Lehr HA, Leoni F, Mascagni P, Dinarello CA, Zeitz M, Siegmund B. Histone deacetylases: novel targets for prevention of colitis-associated cancer in mice. Gut (2008) 57:613-22.
  7. Stroh T, Batra A, Glauben R, Fedke I, Erben U, Kroesen A, Heimesaat MM, Bereswill S, Giradin S, Zeitz M, Siegmund B. Nucleotide oligomerization domains 1 and 2: regulation of expression and function in preadipocytes. J Immunol (2008) 181:3620-7.
  8. Batra A, Okur B, Glauben R, Erben U, Ihbe J, Stroh T, Fedke I, Chang HD, Zeitz M, Siegmund B. Leptin: A critical regulator of CD4+ T-cell polarization in vitro and in vivo. Endocrinology (2010) 151:56-62.
  9. Stroh T, Erben U, Kühl AA, Zeitz M, Siegmund B. Combined pulse electroporation – a novel strategy for highly efficient transfection of human and mouse cells. PLoS One (2010) 5(3):e9488.
  10. Kredel LI, Batra A, Stroh T., Kühl AA, Zeitz M, Erben U, Siegmund B. Adipokines from local cells shape the macrophage compartment of the creeping fat in Crohn’s disease. Gut (2012) in press

The Department of Gastroenterology, Infectology and Rheumatology at the University Hospital Charite offers an effective treatment in the corresponding areas. Located at the Campus Benjamin Franklin, the department is headed by Prof. Dr. Britta Siegmund.

The department is mainly focused on chronic inflammatory diseases of the gastrointestinal tract and joints, chronic diseases of the bowel and gastrointestinal tract. The treatment is offered for the patients with infectious diseases (HIV, tuberculosis, hepatitis, meningitis, endocarditis, gastroenteritis and sexually transmitted diseases), tropical diseases (malaria, schistosomiasis and leishmaniasis), as well as for immunocompromised patients (due to autoimmune diseases, oncological diseases and HIV).

The department offers both treatment and diagnosis of a wide range of rheumatic disorders. In addition, the department provides medical care to the patients suffering from typical syndromes, such as joint swelling, backache and complex rheumatic diseases.

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