Education and Scientific Career
- 2012 W2 Heisenbergprofessorship „Translational Gastroenterology – inflammatory bowel disease“
- 2010 Venia legendi for Innere Medizin, Charité
- 2010 Certificate of the German Society Gastroenterology for Inflammatory Bowel Disease
- 2009 Board Certificate Gastroenterology
- 2009 Chairperson of the German Inflammatory Bowel Disease Working Group
- Since 2008 Scientific Secretary of SFB 633
- Since 2007 Attending Medical Department I, Charité, CBF (Prof. Dr. M. Zeitz)
- 2007 Board Certificate Internal Medicine
- 2006 „Habilitation“/ venia legendi for Experimental Medicine, Charité
- 2002 – 2007 Residency, Medical Department I, Charité, CBF (Prof. Dr. M. Zeitz)
- 2000 – 2002 Postdoctoral Fellow Department of Infectious Diseases, University of Colorado (Prof. C. A. Dinarello)
- 1998 – 2000 Residency, Department of Medicine, Ludwig-Maximilians-University, Munich (Prof. Dr. Dr. h.c. P. Scriba)
- 1995 – 1998 Medical thesis on anti-inflammatory strategies mediated by IL-10, Department of Medicine/ Clinical Pharmacology, Ludwig-Maximilians-University, Munich (Prof. Dr. S. Endres)
- 1992 – 1998 Study of Medicine at the Ludwig-Maximilians-University, Munich and Harvard Medical School, Boston
Awards and Scholarships
- 2006 Rising Star in Gastroenterology, ASNMGE
- 2002 – 2007 Emmy-Noether Young investigator group
- 2001 Young Investigator Award, International Cytokine Society
- 2000 - 2002 Postdoctoral Fellowship by the Deutsche Forschungsgemeinschaft
- 1997 Award from the „Harvard-Munich-Alliance“ for Medical Education
Major interest of our group is to translate clinical findings of patients with inflammatory bowel diseases to the bench and vice versa with the ultimate goal to contribute to the understanding of the disease pathways as well as to identify possible novel therapeutic targets. Two main directions build the current focus of our group.
First, the biological and clinical significance of „creeping fat“, a pathognomic finding in patients with Crohn’s disease is not understood. The mesenteric fat tissue, initially considered as energy storage, not only harbors numerous immune cells but more important strongly regulates the immune response.
Thus the fat tissue builds the source of adipokines, chemokines and cytokines and more important adipocytes and preadipocytes themseives can be considered as cells of the innate immune system. The current work dissects the immune response in the mesenteric fat tissue adjacent to the inflamed intestine.
Second, chronic inflammation drives tumorigenesis in man and in mice. Modification of the state of histone and non-histone acetylation can regulate tumorigenesis as well as inflammation. Knockout mice as well as in vitro knockdown strategies serve to define the role of single histone deacetylases in models models of intestinal inflammation.
10 most important Publications
1. B. Siegmund, H. A. Lehr, G. Fantuzzi, C. A. Dinarello. Interleukin-1-converting enzyme (caspase-1) in intestinal inflammation. PNAS 98:13249-54, 2001
2. B. Siegmund, H. A. Lehr, G. Fantuzzi. Leptin: a pivotal role in intestinal inflammation. Gastroenterology 122:2011-2025, 2002
3. B. Siegmund, J. A. Senello, J. Jones-Carson, F. Gamboni-Robertson, H. A. Lehr, A. Batra, I. Fedke, M. Zeitz, G. Fantuzzi. Leptin receptor on T lymphocytes modulates chronic intestinal inflammation in mice. Gut 53:965-72, 2004
4. R. Glauben, A. Batra, I. Fedke, M. Zeitz, H. A. Lehr, F. Leoni, P. Mascagni, G. Fantuzzi, C. A. Dinarello, B. Siegmund. Histone hyperacetylation is associated with amelioration of experimental colitis in mice. J Immunol 176:5015-22, 2006
5. Batra A, Pietsch J, Fedke I, Glauben R, Okur B, Stroh T, Zeitz M, Siegmund B. Leptindependent TLR expression and resposiveness in preadipocytes and adipocytes. Am J Pathol (2007) 170:890-5.
6. Glauben R, Batra A, Stroh T, Erben U, Fedke I, Lehr HA, Leoni F, Mascagni P, Dinarello CA, Zeitz M, Siegmund B. Histone deacetylases: novel targets for prevention of colitis-associated cancer in mice. Gut (2008) 57:613-22.
7. Stroh T, Batra A, Glauben R, Fedke I, Erben U, Kroesen A, Heimesaat MM, Bereswill S, Giradin S, Zeitz M, Siegmund B. Nucleotide oligomerization domains 1 and 2: regulation of expression and function in preadipocytes. J Immunol (2008) 181:3620-7.
8. Batra A, Okur B, Glauben R, Erben U, Ihbe J, Stroh T, Fedke I, Chang HD, Zeitz M, Siegmund B. Leptin: A critical regulator of CD4+ T-cell polarization in vitro and in vivo. Endocrinology (2010) 151:56-62.
9. Stroh T, Erben U, Kühl AA, Zeitz M, Siegmund B. Combined pulse electroporation – a novel strategy for highly efficient transfection of human and mouse cells. PLoS One (2010) 5(3):e9488.
10. Kredel LI, Batra A, Stroh T., Kühl AA, Zeitz M, Erben U, Siegmund B. Adipokines from local cells shape the macrophage compartment of the creeping fat in Crohn’s disease. Gut (2012) in press