Charite University Hospital Berlin

Berlin, Germany

Department of Gastroenterology, Infectology and Rheumatology

Britta Siegmund

Prof. Dr. med.

Britta Siegmund

Specialized in: gastroenterology, infectology and rheumatology

Curriculum vitae keyboard_arrow_down
Main directions of specialization:
  • Diseases of gastrointestinal and biliary tracts, diseases of liver and pancreas
  • Gastroenterological oncology
  • Hepatology
  • Endoscopic methods
  • Endosonography (endoscopic ultrasound)
  • ERCP (Endoscopic retrograde cholangiopancreatography)
  • Intestinoscopy (endoscopy of the small intestine) *
  • Capsular endoscopy (method which enables medical visualization of the mucous membrane of the digestive tract when the patient swallows capsule with a small camera in it)
  • Implantation of stents (thin metal tubes of cellular structure used for expansion of the vessels` lumen)
  • Necrectomy (removal of dead tissues)
  • Treatment of the Zenker's diverticulum
Educational and professional background
  • Studied at the Medical Faculty of the Ludwig Maximilian University of Munich and at Harvard Medical School, Boston (1992-1998).
  • Therapist and gastroenterologist (2007 and 2009)
  • Scientific researcher and Head of Emmy Noether`s young specialists` group, the first medical department with the specialization in Gastroenterology, Rheumatology and Infectiology in the medical complex "Charite" of the University of Berlin (2002-2007)
  • PhD(2006) 
  • Therapist with specialization in Gastroenterology
  • Heisenberg-Professor of the German Research Society and Deputy Head of the Deparment (2012)
  • Authorized Head of the Department 
  • Professor W3 in Gastroenterology and Head of the Medical Department I with the specialization in Gastroenterology, Rheumatology and Infectiology in the medical complex "Charite" of the University of Berlin
  • From 2013: Head of the 1st Department of Charite, the Benjamin Franklin Campu
Publications keyboard_arrow_down

10 most important Publications

  1. B. Siegmund, H. A. Lehr, G. Fantuzzi, C. A. Dinarello. Interleukin-1-converting enzyme (caspase-1) in intestinal inflammation. PNAS 98:13249-54, 2001
  2. B. Siegmund, H. A. Lehr, G. Fantuzzi. Leptin: a pivotal role in intestinal inflammation. Gastroenterology 122:2011-2025, 2002
  3. B. Siegmund, J. A. Senello, J. Jones-Carson, F. Gamboni-Robertson, H. A. Lehr, A. Batra, I. Fedke, M. Zeitz, G. Fantuzzi. Leptin receptor on T lymphocytes modulates chronic intestinal inflammation in mice. Gut 53:965-72, 2004
  4. R. Glauben, A. Batra, I. Fedke, M. Zeitz, H. A. Lehr, F. Leoni, P. Mascagni, G. Fantuzzi, C. A. Dinarello, B. Siegmund. Histone hyperacetylation is associated with amelioration of experimental colitis in mice. J Immunol 176:5015-22, 2006
  5. Batra A, Pietsch J, Fedke I, Glauben R, Okur B, Stroh T, Zeitz M, Siegmund B. Leptindependent TLR expression and resposiveness in preadipocytes and adipocytes. Am J Pathol (2007) 170:890-5.
  6. Glauben R, Batra A, Stroh T, Erben U, Fedke I, Lehr HA, Leoni F, Mascagni P, Dinarello CA, Zeitz M, Siegmund B. Histone deacetylases: novel targets for prevention of colitis-associated cancer in mice. Gut (2008) 57:613-22.
  7. Stroh T, Batra A, Glauben R, Fedke I, Erben U, Kroesen A, Heimesaat MM, Bereswill S, Giradin S, Zeitz M, Siegmund B. Nucleotide oligomerization domains 1 and 2: regulation of expression and function in preadipocytes. J Immunol (2008) 181:3620-7.
  8. Batra A, Okur B, Glauben R, Erben U, Ihbe J, Stroh T, Fedke I, Chang HD, Zeitz M, Siegmund B. Leptin: A critical regulator of CD4+ T-cell polarization in vitro and in vivo. Endocrinology (2010) 151:56-62.
  9. Stroh T, Erben U, Kühl AA, Zeitz M, Siegmund B. Combined pulse electroporation – a novel strategy for highly efficient transfection of human and mouse cells. PLoS One (2010) 5(3):e9488.
  10. Kredel LI, Batra A, Stroh T., Kühl AA, Zeitz M, Erben U, Siegmund B. Adipokines from local cells shape the macrophage compartment of the creeping fat in Crohn’s disease. Gut (2012) in press

The Department of Gastroenterology, Infectology and Rheumatology at the University Hospital Charite offers an effective treatment in the corresponding areas. Located at the Campus Benjamin Franklin, the department is headed by Prof. Dr. Britta Siegmund.

The department is mainly focused on chronic inflammatory diseases of the gastrointestinal tract and joints, chronic diseases of the bowel and gastrointestinal tract. The treatment is offered for the patients with infectious diseases (HIV, tuberculosis, hepatitis, meningitis, endocarditis, gastroenteritis and sexually transmitted diseases), tropical diseases (malaria, schistosomiasis and leishmaniasis), as well as for immunocompromised patients (due to autoimmune diseases, oncological diseases and HIV).

The department offers both treatment and diagnosis of a wide range of rheumatic disorders. In addition, the department provides medical care to the patients suffering from typical syndromes, such as joint swelling, backache and complex rheumatic diseases.

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