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Charite University Hospital Berlin

Department of Hepatology and Gastroenterology (26116)

Frank Tacke

Prof. Dr. med.

Frank Tacke

Specialized in: hepatology, gastroenterology

About the department

The Department of Hepatology and Gastroenterology at the Charite University Hospital Berlin offers all modern options for the diagnostics and treatment of diseases of the liver, biliary tract, pancreas and other gastrointestinal organs. An important component of the department's clinical practice is the cooperation with related disciplines, such as surgery, radiology and nuclear medicine. The department positions itself as a maximum care medical facility, which priority task is to provide high-quality individualized treatment using the very latest scientific achievements and current medical standards. The Chief Physician of the department is Prof. Dr. med. Frank Tacke.

One of the department's key activities is the treatment of oncological diseases of the gastrointestinal tract and liver. The department's clinical activities are marked by many prestigious certificates of the German Cancer Society, for example, in the treatment of intestinal, liver, pancreatic and stomach cancer.

The department is part of the Section for Central Interdisciplinary Endoscopy, which provides patients with the full range of diagnostic, therapeutic, endoscopic and sonographic procedures. Most often, the department's experienced doctors perform gastroscopy and colonoscopy, as well as endoscopic examinations of the pancreas and biliary tract, including therapeutic minimally invasive procedures.

The main clinical focuses of the department include:

  • Diagnostics and treatment of pancreatic diseases (in particular, acute and chronic pancreatitis)
  • Diagnostics and treatment of chronic inflammatory bowel diseases (Crohn's disease and ulcerative colitis)
  • Diagnostics and treatment of liver and biliary tract diseases (within the specialized center)
    • Malignant liver tumors
      • Hepatocellular carcinoma
      • Intrahepatic cholangiocarcinoma
      • Rare tumors, such as sarcomas
      • Liver metastases of varying genesis
    • Malignant tumors of the extrahepatic bile ducts
      • Klatskin tumor (intraductal cholangiocarcinoma)
      • Distal bile duct carcinoma
      • Gallbladder cancer
    • Benign tumors and liver lesions
      • Focal nodular hyperplasia
      • Liver hemangioma
      • Liver adenoma
      • Congenital hepatic cyst
      • Polycystic liver
    • Benign biliary diseases
      • Acute and chronic cholecystitis
      • Bile duct cysts
    • Viral hepatitis A, B, C, D, E
    • Alcoholic liver diseases
      • Acute alcoholic hepatitis
      • Alcoholic liver disease
      • Acute and chronic liver failure
    • Fatty liver disease
      • Nonalcoholic fatty liver disease
      • Non-alcoholic fatty hepatosis
    • Autoimmune diseases
      • Primary sclerosing cholangitis
      • Primary biliary cholangitis
      • Autoimmune hepatitis
      • Autoimmune cholangitis
      • Sarcoidosis
    • Genetic liver diseases
      • Wilson's disease
      • Hemochromatosis
      • Alpha-1 antitrypsin deficiency 
    • Emergency conditions and injuries of the liver and biliary tract
      • Acute liver failure (toxic, drug, etc.)
      • Traumatic liver rupture
      • Acute haemorrhage from the hepatic vessels
      • Bile duct injury (for example, in the case of operations)
    • Liver vascular lesions
      • Acute and chronic portal vein thrombosis
      • Budd-Chiari syndrome (hepatic vein thrombosis)
      • Sinusoidal obstruction syndrome
    • Parasitic liver diseases
    • Liver diseases in pregnant women
  • Diagnostics and treatment of gastrointestinal cancers
    • Endoscopic treatment for colorectal tumors
    • Expanded diagnostics and treatment planning within the interdisciplinary boards with the participation of surgeons, oncologists, radiation therapists, radiologists
    • Follow-up care of patients
    • Planning and carrying out palliative care in advanced cancers
    • Systemic chemotherapy
    • Endoscopic therapy (for example, stent implantation, laser therapy and biliary drainage)
    • Local ablation therapy
    • Radiation therapy
    • Symptomatic treatment (for example, pain therapy, diet therapy)
  • Diagnostics and treatment of neuroendocrine tumors (within the Center of Competence)
    • Diagnostics
      • Ultrasound examination
      • Gastroscopy and colonoscopy (esophagogastroduodenoscopy and ileocolonoscopy), if necessary in combination with endosonography
      • Endoscopic examination of the small intestine using push enteroscopy and capsule endoscopy
      • Computed tomography (with or without contrast enhancement)
      • Magnetic resonance imaging (if necessary with the use of a special contrast agent)
      • Scintigraphy with radioactive-labeled somatostatin analogue (indium-111 octreotide)
      • 68Gallium DOTATOC PET-CT
      • PET-CT with radioactively labeled glucose
      • 18F-DOPA PET-CT
      • Cardiac ECG and ultrasound examination
    • Therapy
      • Somatostatin analogue therapy (octreotide LAR, lanreotide autogel)
      • Different types of chemotherapy
      • Local ablation procedures (transarterial embolization, transarterial chemoembolization, radiofrequency ablation)
      • Peptide receptor radionuclide therapy (with labeled yttrium-90 or lutetium-177 somatostatin analogue)
      • Selective internal radiation therapy
      • Nutrition counseling
  • Endoscopic diagnostic and therapeutic procedures
    • Diseases of the esophagus, stomach and duodenum
      • Diagnostic esophagogastroduodenoscopy (gastroscopy)
      • Upper gastrointestinal tract examination using chromoendoscopy and high-resolution endoscopy
      • Treatment of varicose veins using ligation, sclerotherapy and injection therapy
      • Treatment of upper gastrointestinal stenosis using balloon dilatation, bougienage or stent implantation
      • Treatment of Barrett's esophagus using resection of submucosal layer, radiofrequency ablation or hybrid argon plasma coagulation
      • Botulinum toxin injection in motility disorders
      • Treatment of achalasia cardia
      • Therapy of vascular malformations be means of argon plasma coagulation
      • Treatment of acute and chronic haemorrhages
      • Percutaneous endoscopic gastrostomy
      • Surgical treatment of precancerous lesions and malignant neoplasms by means of endoscopic resection or dissection of the submucosal layer
      • Endoscopic vacuum therapy
      • Treatment of Zenker's diverticulum
      • Endoscopic sleeve gastroplasty (in collaboration with the Department of Surgery)
    • Colon diseases
      • Diagnostic ileocolonoscopy
      • High resolution chromoendoscopy and endoscopy
      • Polyp removal
      • Endoscopic resection or dissection of the submucosal layer
      • Therapy of vascular malformations using argon plasma coagulation
      • Treatment of acute and chronic haemorrhages
      • Treatment of stenosis of the lower gastrointestinal tract (balloon dilatation, bougienage, stent implantation)
      • Endoscopic vacuum therapy
      • Hemorrhoid treatment
    • Diseases of the small intestine
      • Small intestine diseases
      • Balloon endoscopy with single and double balloon system
      • Capsule endoscopy
    • Diseases of the biliary tract and pancreas
      • Endoscopic retrograde cholangiopancreatography, percutaneous transhepatic cholangiography 
      • Cholangioscopy
      • Endoscopic removal of papillary adenomas
      • Removal of bile duct stones and pancreatic duct stones using laser lithotripsy, electrohydraulic lithotripsy
      • Treatment of stenoses using implantation of plastic or metal stents, balloon dilatation
      • Multimodal treatment of bile duct cancer
      • Monitoring of patients with primary sclerosing cholangitis
    • Endosonography
      • Diagnostic endosonography of the upper and lower gastrointestinal tract using radial and linear transducer
      • Contrast-enhanced endoscopic ultrasound
      • Ultrasound-guided puncture
      • Ultrasound-guided installation of drainage and sanitation in necrosis
    • Ultrasound examinations and ultrasound-guided interventions
  • Functional diagnostics of the gastrointestinal tract
  • Treatment within the clinical trials
  • Dietology
    • Special enteral nutrition
    • Parenteral nutrition
  • Other diagnostic and therapeutic services

Curriculum vitae

Education and Professional Career

  • 1994 - 2001 Study of Human Medicine, Hannover Medical School.
  • 1998 - 1999 Scholar of the German Academic Exchange Service, University of Texas MD Anderson Cancer Center, Houston, USA.
  • 2001 - 2004 Department of Gastroenterology, Hepatology and Endocrinology at the Hannover Medical School.
  • 2002 Doctor of Medicine, Department of Hematology and Oncology, Hannover Medical School.
  • 2001 - 2004 Training for the title of PhD, Molecular Medicine, Hannover Medical School.
  • 2004 PhD, Department of Gastroenterology and Hepatology, Hannover Medical School.
  • 2004 - 2006 Scholarship of the German Research Foundation, Mount Sinai School of Medicine, New York, USA.
  • 2006 - 2019 Senior Physician, Department of Internal Medicine III, University Hospital Aachen.
  • 2008 - 2019 Leading Senior Physician.
  • 2007 Habilitation, Rhine-Westphalian Technical Aachen University (Experimental Internal Medicine).
  • 2012 - 2014 Master of Business Administration in Healthcare, University of Erlangen-Nuremberg.
  • 2012 - 2019 W2 Professor in Hepatology and Gastroenterology, Rhine-Westphalian Technical Aachen University.
  • Since 2019 W3 Professor of Hepatology and Gastroenterology, Head of the Department of Hepatology and Gastroenterology at the Charite University Hospital Berlin.

Clinical Focuses

  • Hepatology (liver diseases).
  • Gastroenterology (gastrointestinal diseases).
  • Intensive care.
  • Hepatobiliary, gastrointestinal and neuroendocrine tumors.
  • Diagnostic and interventional endoscopy.

Research Focuses

  • Non-alcoholic fatty liver disease and hepatocellular carcinoma.
  • Biology of monocytes and macrophages.
  • Gastroenterological and internal intensive care.

Memberships in Professional Societies

  • American Association for the Study of Liver Diseases (AASLD)
  • German Society of Infectious Diseases (DGI).
  • German Society of Internal Medicine (DGIM).
  • German Society for Medical Intensive Care Medicine and Emergency Medicine (DGIIN).
  • German Society for Digestive and Metabolic Diseases (DGVS)
  • German Liver Foundation (Associate Scientist).
  • European Academy of Tumor Immunology (EATI).
  • European Association for the Study of the Liver (EASL).
  • International Liver Transplantation Society (ILTS).

Department of Hepatology and Gastroenterology.
Charite University Hospital Berlin:

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