Department of Pediatric Pulmonology, Immunology and Rheumatology - Charite University Hospital Berlin
Charite University Hospital Berlin
Berlin, Germany
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Department id #
26129
Prof. Dr. med. Marcus Mall
Department of Pediatric Pulmonology, Immunology and Rheumatology
Specialized in: pediatric pulmonology, immunology, intensive care About the Department of Pediatric Pulmonology, Immunology and Rheumatology at Charite University Hospital Berlin
The Department of Pediatric Pulmonology, Immunology and Rheumatology at the Charite University Hospital Berlin provides a full range of medical services in its areas of specialization. The department is a maximum care medical center that treats children and adolescents with all acute and chronic respiratory diseases, immunological and autoimmune disorders, cystic fibrosis, and rheumatological diseases. The department accepts patients from infancy to 18 years of age. The treatment of congenital cystic fibrosis is provided to patients of all age groups and is of particular clinical interest to the department's specialists. Depending on the complexity of the disease, treatment can be provided in inpatient or outpatient settings, as well as in a day clinic. The main focus of the department's physicians is providing comprehensive care to children with congenital lung diseases, bronchial asthma, congenital and acquired immunodeficiency conditions, tuberculosis, HIV infection, autoimmune rheumatic diseases, and fever syndromes. For more than 30 years, the clinic has maintained a leading position among the best pediatric medical facilities of this profile in Germany, providing each child with the highest level of medical care. The Head Physician of the department is Prof. Dr. med. Markus Mall.
The department's medical team has extensive experience in the treatment of cystic fibrosis – a complex hereditary disease that causes dysfunction of the respiratory system, gastrointestinal tract, endocrine glands, and other organ systems. Patients with this diagnosis are seen in a specialized center where pediatricians, therapists, psychologists, physiotherapists, dietitians, and other specialists work together. The center offers a full range of diagnostic examinations to identify this pathology: newborn screening, sweat test, genetic testing, measurement of nasal potential difference, determination of intestinal potential difference, pulmonary function testing (spirometry and body plethysmography), determination of the lung clearance index (LCI), measurement of lung diffusion capacity, CT and MRI of the lungs. Currently, doctors worldwide do not have methods to achieve a complete cure, so children with cystic fibrosis receive comprehensive therapy aimed at compensating for the functional insufficiency of affected organs and preventing the development of disease complications. Specialists develop the optimal treatment regimen individually, depending on the stage and severity of the disease. The basis of treatment consists of diet therapy, physiotherapy with autogenic drainage technique and reflex respiratory therapy, non-invasive ventilation, and antibiotic therapy. If necessary, bronchoscopic interventions are performed.
The medical facility also has an immunology division. Experts in this field treat children with primary immunodeficiency conditions, severe infections with underlying congenital or acquired immunodeficiency conditions, tuberculosis, infections caused by atypical mycobacteria, and Epstein-Barr virus. The diagnostic protocol for suspected immunodeficiency includes a clinical examination and study of the child's medical history, followed by extensive laboratory diagnostics; in cases of primary immunodeficiency conditions, genetic testing and comprehensive immunological examination are also conducted. An individual course of treatment is developed for each child – depending on the specific diagnosis, antibiotic therapy, immunoglobulin therapy, or antiviral therapy (for immunodeficiency conditions with viral infections) may be provided. Children with life-threatening primary immunodeficiency conditions may require bone marrow transplantation: the department's specialists are responsible for preparing the child for the procedure and subsequent care afterward, while the operation itself is performed by experienced physicians in the bone marrow transplantation unit of the Department of Pediatric Hematology and Oncology.
An important area of the department's clinical activity is the treatment of children with autoimmune rheumatic diseases. Consultations are provided here for patients with joint damage due to rheumatological pathology, Lyme arthritis, reactive arthritis, collagenosis, vasculitis, fever syndrome, pain syndrome, inflammatory bone diseases, and systemic inflammatory diseases. Diagnosis and treatment are mainly conducted on an outpatient basis, but if necessary, the child can be admitted to the hospital. The department's specialists carefully develop treatment tactics, taking into account the characteristics of the specific pathology and the severity of its course. First-line therapy is drug treatment with disease-modifying antirheumatic drugs, non-steroidal anti-inflammatory drugs, corticosteroids, and modern biological agents. Medication intake is supplemented by physiotherapy, occupational therapy, diet therapy, and other therapeutic measures.
The range of medical services provided by the department includes:
- Pulmonology
- Diagnostics and treatment of cystic fibrosis
- Diagnostics and treatment of bronchial asthma
- Diagnostics and treatment of pneumonia
- Diagnostics and treatment of bronchitis
- Diagnostics and treatment of tuberculosis
- Diagnostics and treatment of interstitial lung diseases
- Immunology
- Diagnostics and treatment of primary immunodeficiency conditions
- Diagnostics and treatment of severe infections with underlying congenital or acquired immunodeficiency conditions
- Diagnostics and treatment of tuberculosis
- Diagnostics and treatment of infections caused by atypical mycobacteria
- Diagnostics and treatment of Epstein-Barr virus
- Diagnostics and treatment of cytomegalovirus
- Rheumatology
- Diagnostics and treatment of chronic joint diseases and all rheumatological pathologies with joint involvement
- Diagnostics and treatment of infection-associated joint inflammation: Lyme arthritis, reactive arthritis, rheumatic fever
- Diagnostics and treatment of collagenosis: systemic lupus erythematosus, dermatomyositis, systemic scleroderma
- Diagnostics and treatment of vasculitis: hemorrhagic vasculitis, Kawasaki syndrome, Takayasu arteritis
- Diagnostics and treatment of fever syndromes: familial Mediterranean fever, TRAPS syndrome, PFAPA syndrome
- Diagnostics and treatment of pain syndromes: complex regional pain syndrome, fibromyalgia, reflex sympathetic dystrophy
- Diagnostics and treatment of inflammatory bone diseases: chronic recurrent multifocal osteomyelitis
- Diagnostics and treatment of systemic inflammatory diseases: Behçet's disease, sarcoidosis
- Other medical services
Curriculum vitae
- Since 2007 Attending Physician and Head of Cystic Fibrosis Center, Department of Pediatrics III, University Hospital Heidelberg.
- Since 2006 Faculty Member of the Molecular Medicine Partnership Unit (MMPU) of the University of Heidelberg and the EMBL.
- 2005 Junior Group Leader, Department of Pediatrics III, University Hospital Heidelberg.
- 2004 - 2006 Fellow, Department of Pediatrics III, University Hospital Heidelberg.
- 2003 - 2004 Assistant Professor, Cystic Fibrosis/Pulmonary Research and Treatment Center, School of Medicine, University of North Carolina, Chapel Hill, USA.
- 2000 - 2003 Postdoctoral Fellow, Cystic Fibrosis/Pulmonary Research and Treatment Center, School of Medicine, University of North Carolina, Chapel Hill, USA.
- 1998 - 2000 Resident, Department of Pediatrics, University Hospital Freiburg.
- 1997 Postdoctoral Fellow, Institute of Physiology, University of Freiburg.
- 1997 Doctoral thesis (Dr.med.), Institute of Physiology, University of Freiburg.
- 1990 - 1997 Medical School, University of Freiburg and University College London, Great Britain.
Senior Positions
- Since 2006 Member of the German Cystic Fibrosis Research Council.
- Since 2006 Deputy Leader, Workpackage Animal Models, European Coordination Action for Research in Cystic Fibrosis (EuroCareCF).
- 2004 - 2006 Member of the Scientific Committee for Basic Research, European Cystic Fibrosis Society (ECFS), 29th Annual Conference.
Field of Interests
- Molecular and cellular pathogenesis of cystic fibrosis and other chronic lung diseases.
- Transgenic animal models for human diseases.
- Epithelial ion transport
- Epithelial defense mechanisms.
- Airway inflammation.
- Identification of novel therapeutic targets and development of novel therapeutic strategies.
Photo of the doctor: (c) Charité – Universitätsmedizin Berlin
