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Treatment of neuroendocrine tumor (NET) of the pancreas with Lutetium-177-DOTATATE (690993) | Charite University Hospital Berlin - BookingHealth
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After that, you will undergo the necessary additional tests such as the assessment of liver and kidney function, scintigraphy of the skeleton and salivary glands, somatostatin receptor imaging with&nbsp;Ga-68 DOTATATE PET\/CT. This will allow the doctor to assess how effective the radionuclide therapy with Lutetium-177-DOTATATE will be and how well you will tolerate it. Also, the doctor will calculate your individual dosage of the radionuclide.<\/p>\n\n<p style=\"text-align:justify\"><strong>Radionuclide therapy with Lutetium-177-DOTATATE<\/strong>&nbsp;is carried out via intravenous administration of a solution with the radioactive isotope Lutetium-177-DOTATATE. The solution is injected through a catheter. 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During these 48 hours, you can read, use a mobile phone, tablet or computer &ndash; all these devices will not be a source of radiation in the future.<\/p>\n\n<p style=\"text-align:justify\"><strong>Follow-up examinations<\/strong>&nbsp;include whole-body scintigraphy or computed tomography in 24 hours and 48 hours after the procedure. Based on the results of the examination, the doctor will determine whether one procedure is enough for you, or whether you will need to visit the hospital again. As a rule, 1-2 procedures are required for achieving a stable positive result. Procedures are carried out with an interval of 8 weeks.<\/p>\n<\/div><div class=\"program_required_documents mt-4\"><h4>Required documents<\/h4><ul>\n\t<li style=\"text-align: justify;\">Medical records<\/li>\n\t<li style=\"text-align: justify;\">MRI\/CT scan (not older than 3 months)<\/li>\n\t<li style=\"text-align: justify;\">Biopsy results (if available)<\/li>\n<\/ul>\n<\/div>","program_full_story_crm":"<ul>\n\t<li>Initial presentation in the hospital<\/li>\n\t<li>Clinical history taking<\/li>\n\t<li>Physical examination<\/li>\n\t<li>Laboratory tests:\n\t<ul>\n\t\t<li>complete blood count<\/li>\n\t\t<li>biochemical analysis of blood<\/li>\n\t\t<li>TSH, free T3, free T4<\/li>\n\t\t<li>indicators of inflammation<\/li>\n\t\t<li>coagulation tests<\/li>\n\t<\/ul>\n\t<\/li>\n\t<li>Renal scintigraphy<\/li>\n\t<li>Ga-68 DOTATATE PET\/CT (if indicated)<\/li>\n\t<li>Lutetium-177-DOTATATE treatment<\/li>\n\t<li>Full body scintigraphy after 24 hours<\/li>\n\t<li>Full body scintigraphy after 48 hours<\/li>\n\t<li>Symptomatic treatment<\/li>\n\t<li>Cost of essential medicines<\/li>\n\t<li>Nursing services<\/li>\n\t<li>Stay in the hospital with full board<\/li>\n\t<li>Accommodation in 2-bedded room<\/li>\n\t<li>Elaboration of further recommendations<\/li>\n<\/ul>\n<div class=\"program_how_program_going mt-4\"><h4>How program is carried out<\/h4><p style=\"text-align:justify\"><strong>During the first visit<\/strong>, the doctor will carry out a general physical examination and go through the results of previous laboratory and instrumental tests. After that, you will undergo the necessary additional tests such as the assessment of liver and kidney function, scintigraphy of the skeleton and salivary glands, somatostatin receptor imaging with&nbsp;Ga-68 DOTATATE PET\/CT. This will allow the doctor to assess how effective the radionuclide therapy with Lutetium-177-DOTATATE will be and how well you will tolerate it. Also, the doctor will calculate your individual dosage of the radionuclide.<\/p>\n\n<p style=\"text-align:justify\"><strong>Radionuclide therapy with Lutetium-177-DOTATATE<\/strong>&nbsp;is carried out via intravenous administration of a solution with the radioactive isotope Lutetium-177-DOTATATE. The solution is injected through a catheter. This is a short procedure, as the infusion usually takes no more than 20 minutes.<\/p>\n\n<p style=\"text-align:justify\">During the procedure, you will need to apply cooling bags to the salivary glands, as Lutetium-177-DOTATATE partially accumulates in the salivary glands, affecting their function and causing dry mouth. You will also receive intravenous saline solutions and amino acid solutions to protect your kidneys.<\/p>\n\n<p style=\"text-align:justify\">After the infusion of Lutetium-177-DOTATATE, you will stay in a specially equipped (radiation-shielded) ward for 48 hours. The drug is quickly excreted by the kidneys, and after 48 hours you will no longer be dangerous to others. 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Treatment of neuroendocrine tumor (NET) of the pancreas with Lutetium-177-DOTATATE in Charite University Hospital Berlin

Charite University Hospital Berlin

Berlin, Germany
Program id # 690993
Doctor photo
Prof. Dr. med. Winfried Brenner
Department of Nuclear Medicine
Specialized in: nuclear medicine

The program includes:

  • Initial presentation in the hospital
  • Clinical history taking
  • Physical examination
  • Laboratory tests:
    • complete blood count
    • biochemical analysis of blood
    • TSH, free T3, free T4
    • indicators of inflammation
    • coagulation tests
  • Renal scintigraphy
  • Ga-68 DOTATATE PET/CT (if indicated)
  • Lutetium-177-DOTATATE treatment
  • Full body scintigraphy after 24 hours
  • Full body scintigraphy after 48 hours
  • Symptomatic treatment
  • Cost of essential medicines
  • Nursing services
  • Stay in the hospital with full board
  • Accommodation in 2-bedded room
  • Elaboration of further recommendations

How program is carried out

During the first visit, the doctor will carry out a general physical examination and go through the results of previous laboratory and instrumental tests. After that, you will undergo the necessary additional tests such as the assessment of liver and kidney function, scintigraphy of the skeleton and salivary glands, somatostatin receptor imaging with Ga-68 DOTATATE PET/CT. This will allow the doctor to assess how effective the radionuclide therapy with Lutetium-177-DOTATATE will be and how well you will tolerate it. Also, the doctor will calculate your individual dosage of the radionuclide.

Radionuclide therapy with Lutetium-177-DOTATATE is carried out via intravenous administration of a solution with the radioactive isotope Lutetium-177-DOTATATE. The solution is injected through a catheter. This is a short procedure, as the infusion usually takes no more than 20 minutes.

During the procedure, you will need to apply cooling bags to the salivary glands, as Lutetium-177-DOTATATE partially accumulates in the salivary glands, affecting their function and causing dry mouth. You will also receive intravenous saline solutions and amino acid solutions to protect your kidneys.

After the infusion of Lutetium-177-DOTATATE, you will stay in a specially equipped (radiation-shielded) ward for 48 hours. The drug is quickly excreted by the kidneys, and after 48 hours you will no longer be dangerous to others. During these 48 hours, you can read, use a mobile phone, tablet or computer – all these devices will not be a source of radiation in the future.

Follow-up examinations include whole-body scintigraphy or computed tomography in 24 hours and 48 hours after the procedure. Based on the results of the examination, the doctor will determine whether one procedure is enough for you, or whether you will need to visit the hospital again. As a rule, 1-2 procedures are required for achieving a stable positive result. Procedures are carried out with an interval of 8 weeks.

Required documents

  • Medical records
  • MRI/CT scan (not older than 3 months)
  • Biopsy results (if available)

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About the department

The Department of Nuclear Medicine at the Charite University Hospital Berlin offers the full range of radioisotope diagnostics and treatment using radionuclides. Of particular interest to the department's specialists are the diagnostics and therapy of cancers, diseases of the nervous system, heart, musculoskeletal system, ENT pathologies, surgical diseases, disorders of the urological and gynecological sphere. The department's doctors carry out outpatient diagnostics, inpatient and outpatient treatment in accordance with the guidelines of professional societies. The department is headed by Prof. Dr. med. Winfried Brenner.

The department is equipped with all the innovative equipment available in nuclear medicine. For example, the department performs all types of scintigraphy (including whole body scintigraphy), SPECT, advanced hybrid examinations (SPECT-CT, PET-CT, PET-MR). In addition, the department has several radiochemical modules, including cyclotron for the synthesis of radioactive isotopes for SPECT and PET, as well as for the creation of radioisotope drugs.

The service range of the department includes:

  • Outpatient diagnostics
    • Brain examinations
      • Perfusion
      • Dopamine D2 receptor scintigraphy
      • Dopamine transporter scintigraphy
      • Benzodiazepine receptor scintigraphy
      • Cerebrospinal fluid scintigraphy
    • Cardiovascular examinations
      • Radionuclide ventriculography
      • Myocardial perfusion scintigraphy
    • Lung examinations
      • Perfusion scintigraphy
      • Ventilation scintigraphy
      • Inhalation scintigraphy
    • Kidney examination
      • Perfusion/functional scintigraphy
      • Glomerular and tubular clearance
      • Static scintigraphy
    • Abdominal/gastrointestinal examinations
      • Hepatobiliary functional scintigraphy
      • Selective spleen scintigraphy
      • Radioactive blood pool scintigraphy
      • Search for bleeding source
    • Gastric mucosal examinations
      • Esophageal scintigraphy
      • Scintigraphy for the determination of gastric emptying degree
      • Salivary gland scintigraphy
    • Skeletal examinations
      • Skeletal scintigraphy
      • Bone marrow scintigraphy
    • Scintigraphy for the detection of inflammatory processes
    • Scintigraphy for the detection of benign and malignant neoplasms
    • Endocrine examinations
      • Thyroid scintigraphy
      • Parathyroid scintigraphy
      • Adrenal gland scintigraphy
    • Examinations of the hematopoietic system 
    • Examinations of the lymphatic system 
      • Sentinel lymph node scintigraphy
      • Scintigraphy in lymphedema
  • PET-CT and PET-MRI
    • Diagnostics of inflammations and neoplasms
    • Diagnostics of brain function
    • Skeletal diagnostics
    • Prostate cancer diagnostics
    • Diagnostics of brain tumors
    • Diagnostics of neuroendocrine tumors
  • Outpatient treatment
    • Pain therapy in bone metastases
    • Radiosynoviorthesis in joint pain
    • Cevalin therapy
  • Inpatient treatment
    • Radioiodine therapy in thyroid diseases
    • Peptide receptor radionuclide therapy in neuroendocrine tumors
    • Selective intra-arterial radiation therapy in multiple liver metastases
    • MIBG therapy in neuroblastomas
  • Other medical services

Curriculum vitae

Higher Education and Postgraduate Training

  • 1986 - 1993 Medical studies at the Universities in Budapest, Giessen, and Munich.
  • 1988 Thesis defense with honors, Institute of Pathology, University Hospital Rechts der Isar Munich. Subject: "Nucleation areas in neuroendocrine gastrointestinal and pancreatic tumors: correlation with histopathological and clinical data".
  • 2006 Habilitation in Nuclear Medicine.

Current Positions

  • Head Physician, Department of Nuclear Medicine, Charite University Hospital Berlin.

Photo of the docto: (c) Charité – Universitätsmedizin Berlin


About hospital

According to the authoritative Focus magazine, the Charite University Hospital Berlin occupies the first place in the rating of the top German medical facilities! 

The hospital in Germany provides modern diagnostics and treatment of patients, as well as the training of practicing physicians and scientists. More than half of all German Nobel Prize winners in the field of medicine and physiology, such as Emil von Behring, Robert Koch and Paul Ehrlich, trained and worked in the hospital. The structure of the medical complex includes over 100 specialized departments and institutes, which allows the doctors to guarantee their patients' services in all the existing medical fields. The hospital in Germany has outstanding experience in treating particularly complex clinical cases.

The hospital annually diagnoses and treats more than 152,693 inpatients and about 692,920 outpatients. It also has a huge medical team consisting of 4,225 scientists and doctors and and more than 4,500 nursing staff members who provide top-class medical treatment in Germany. The key task for all specialists of the medical facility is restoring the patient's health or preserving in critical cases. At the same time, the hospital offers a friendly atmosphere, and each patient feels care, respect and sympathy.

The excellent technical medical equipment, highly skilled personnel, availability of innovative diagnostic and treatment techniques, and high ethical standards form a solid foundation for successful clinical and scientific activities. Thus, the hospital is a leading provider of high-quality treatment in Germany.

Photo: (с) depositphotos

Accommodation in hospital

Patients rooms

The patients of the Charite University Hospital Berlin live in comfortable rooms made of modern design. Each room is equipped with an ensuite bathroom with a toilet and a shower. The standard room furnishing includes an automatically adjustable bed, a bedside table, a wardrobe for storing clothes, a table and chairs for receiving visitors, and a TV. If desired, Wi-Fi access can be provided. The hospital also offers enhanced-comfort rooms.

Meals and Menus

The patient and his accompanying person have a daily choice of three menus. If for any reason, you do not like the food, you will be offered an individual menu. Please inform the medical staff about your dietary preferences before the treatment.

Further details

Standard rooms include:

Toilet
Shower
Wi-Fi
TV

Religion

Religious services are available upon request.

Accompanying person

During the inpatient program, an accompanying person may stay with you in a patient room or at the hotel of your choice.

Hotel

During the outpatient program, you can live at a hotel of your choice. Managers will help you to choose the most suitable options.

The hospital offers a full range of laboratory tests (general, hormonal, tests for infections, antibodies, tumor markers, etc.), genetic tests, various modifications of ultrasound scans, CT scans, MRI and PET / CT, angiography, myelography, biopsy and other examinations. Treatment with medications, endoscopic and robotic operations, stereotaxic interventions is carried out here, modern types of radiation therapy are also used. The hospital offers patients all the necessary therapeutic techniques.

  • Proton therapy
  • CyberKnife treatment
  • Hyperthermic intraperitoneal chemotherapy (HIPEC)
  • PSMA therapy with Lutetium-177
  • Joint replacement in adults and children

These are oncological diseases, benign neoplasms of the brain and spinal cord, heart valve defects, diabetes mellitus and its complications, joint diseases and other pathologies.

  • Neurosurgery
  • Oncology
  • Plastic and reconstructive surgery
  • Interventional radiology
  • Proton therapy (Proton Therapy Center BerlinProtonen)

The medical team includes more than 4,225 highly qualified scientists and doctors.