Prostate Cancer Treatment with Actinium-225 PSMA (program ID: 447962)

University Hospital Frankfurt am Main

location_on Frankfurt am Main, Germany
10/10 from 97 Votes
Specialized hospital
Frank Grünwald

Head Physician
Prof. Dr. med.

Frank Grünwald

Specialized in: nuclear medicine

Department of Nuclear Medicine

Program includes:

  • Initial presentation in the clinic
  • clinical history taking
  • general physical examination
  • laboratory tests:
    • complete blood count
    • biochemical analysis of blood
    • urinalysis
    • TSH-basal, fT3, fT4
    • PSA blood level
    • tests for urogenital infections
    • indicators of inflammation
    • indicators of blood coagulation
  • ultrasound scan of the urogenital system
  • renal scintigraphy
  • PSMA treatment with Actinium-225
  • full body scintigraphy after 24 hours
  • full body scintigraphy after 48 hours
  • symptomatic treatment
  • cost of essential medicines
  • nursing services
  • elaboration of further recommendations
  • stay in the hospital with full board 
  • accommodation in 2-bedded room 

How program is carried out

During the first visit, the doctor will carry out a general physical examination and go through the results of previous laboratory and instrumental tests. After that, you will undergo the necessary additional tests such as the assessment of liver and kidney function, scintigraphy of the skeleton and salivary glands, PSMA PET / CT. This will allow the doctor to assess how effective PSMA therapy with Actinium-225 will be and how well you will tolerate it. Also, the doctor will calculate your individual dosage of the radionuclide.

PSMA therapy with Actinium-225 is carried out via intravenous administration of a solution with the radioactive isotope Actinium-225. The solution is injected through a catheter. This is a short procedure, as the infusion usually takes no more than 20 minutes.

During the procedure, you will need to apply cooling bags to the salivary glands, as Actinium-225 partially accumulates in the salivary glands, affecting their function and causing dry mouth. You will also receive intravenous saline solutions to protect your kidneys.

After the infusion of Actinium-225, you will stay in a specially equipped (radiation-shielded) ward for 48 hours. The drug is quickly excreted by the kidneys, and after 48 hours you will no longer be dangerous to others. During these 48 hours, you can read, use a mobile phone, tablet or computer – all these devices will not be a source of radiation in the future.

Follow-up examinations include whole-body scintigraphy or computed tomography in 24 hours and 48 hours after the procedure. Based on the results of the examination, the doctor will determine whether one procedure is enough for you, or whether you will need to visit the hospital again. As a rule, 1-2 procedures are required for achieving a stable positive result. Procedures are carried out with an interval of 8 weeks.

Required documents

  • Medical records
  • PSA blood test
  • MRI/CT scan (not older than 3 months)
  • Bone scintigraphy (if available)
  • Biopsy results (if available)
Type of program :
Expected duration of the program:

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About the department

The Department of Nuclear Medicine at the University Hospital Frankfurt am Main offers the full range of modern diagnostics and therapy using various radioisotopes. The department is headed by Prof. Dr. med. Frank Grünwald.

The department is equipped with the advanced systems for carrying out such high-precision and informative examinations as SPECT, PET, etc. The department carries out more than 8,000 outpatient examinations annually. The key focus in the field of diagnostics is on the detection of neurological, cardiac and oncological diseases. The department's therapeutic options include the treatment of benign and malignant diseases of the thyroid gland, pain therapy in bone metastases, treatment of malignant tumors in children (for example, neuroblastomas). The spectrum is also complemented by such innovative techniques as radiosynoviorthesis, selective internal radiation therapy and radioimmunotherapy.

Of particular interest to the department's specialists is the diagnostics and treatment of thyroid diseases. To make an accurate diagnosis, they conduct reliable and proven examinations, such as ultrasound and scintigraphy. The doctors mostly have to deal with such pathologies as goiter, thyroid hyperfunction and hypofunction, Graves' disease, thyroid inflammations, thyroid cancer. Once an accurate diagnosis is made, the doctor will develop an individualized treatment regimen aimed at the successful treatment outcome. One of the most common treatment methods is radioiodine therapy.

The service range of the department includes:

  • Diagnostics
    • Thyroid scintigraphy
    • (Whole-body) scintigraphy using iodine after the surgical removal of the thyroid gland
    • Brain scintigraphy
    • Kidney scintigraphy
    • Skeletal scintigraphy
    • Heart scintigraphy
    • Parathyroid scintigraphy
    • Lung scintigraphy
    • Tumor scintigraphy using mIBG
    • Sentinel lymph node scintigraphy
    • PET-CT
    • SPECT
  • Therapy
    • Radioiodine therapy
    • Radium therapy (Ra-223) in pain syndrome caused by bone metastases
    • 177Lu-PSMA-617 radioligand therapy
    • Lu-177 radio peptide therapy
    • Selective internal radiation therapy
    • Radioimmunotherapy
    • Radiosynoviorthesis
    • 131I-MIBG therapy
  • Other diagnostic examinations and treatment methods

Curriculum vitae

  • 1978 - 1984 Study of Human Medicine at the University of Bonn.
  • 1984 Medical state examination.
  • 1984 Admission to medical practice.
  • 1984 - 1986 Research Fellow at the Institute of Physiology I of the University of Bonn. 
  • 1986 Doctoral Degree.
  • 1986 Research Fellow in the Department of Nuclear Medicine at the University of Bonn 
  • 1990 Board certification in Nuclear Medicine.
  • 1992 Habilitation in Nuclear Medicine and appointment as PD.
  • 1992 Senior Physician in the Department of Nuclear Medicine.
  • 1994 Leading Senior Physician in the Department of Nuclear Medicine. 
  • 1997 Appointed as an Extraordinary Professor.
  • 1999 Taking up the duties as the Head of the Department of Nuclear Medicine at the University Hospital Frankfurt am Main.

 Photo of the doctor: (c) Universitätsklinikum Frankfurt 

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