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University Hospital Greifswald

location_on Greifswald, Germany
9.8/10 from 89 Votes

Department of Pediatric and Adolescent Medicine (568623)

Holger Lode

Prof. Dr. med.

Holger Lode

Specialized in: pediatric and adolescent medicine

About the department

The Department of Pediatric and Adolescent Medicine at the University Hospital Greifswald offers the full range of services in the field of treatment of general pediatric diseases, oncological, hematological, neurological pathologies, as well as endocrine diseases and metabolic disorders. A large team of competent specialists takes care of the health of young patients. The doctors have in their arsenal a variety of modern diagnostic and therapeutic methods. The department is awarded by the prestigious Ausgezeichnet FÜR KINDER certification, which is an undeniable confirmation of the outstanding top-class medical care.

The Chief Physician of the department is Prof. Dr. med. Holger Lode. He is a world-famous highly qualified expert in the field of his specialization. He conducts active research activities, the results of which are striking in their innovation and create the opportunities for the treatment of diseases that were previously considered incurable.

In the field of general pediatrics, the focus is on the treatment of respiratory diseases, infections, allergic reactions, gastrointestinal diseases, kidney diseases, and rheumatic diseases. If necessary, the specialists from other departments of the hospital are involved, which contributes to the comprehensive, interdisciplinary medical care.

The key focus of the department’s clinical activities is pediatric oncology and hematology. All therapeutic measures are carried out in accordance with the strictest standards of the Society for Pediatric Oncology and Hematology (GPOH) and in accordance with the quality criteria of the Federal Joint Committee for the Medical Care of Children and Adolescents with Hematological and Oncological Diseases. The competence of the department's physicians also includes the therapy of benign blood diseases in children, for example, congenital and acquired blood clotting disorders and immunodeficiency states.

In addition, the department specializes in the treatment of young patients with diseases of the endocrine glands, diabetes mellitus and metabolic disorders. The department also has a unique experience in the treatment of children of different age groups with neurological disorders, neuromuscular diseases, psychosomatic disorders, etc.

The service range of the department includes:

General pediatrics

  • Diagnostics and treatment of infectious diseases
    • Exanthem and non-exanthem infections
    • HIV/AIDS
    • Tropical infections
    • Complications from infectious diseases
    • Vaccination of at-risk patients
    • Vaccine side effects
    • Diagnostic options
      • Virological, bacteriological and parasitological diagnostics, including PCR and serology
      • Determination of viral load
      • Imaging diagnostic methods
  • Diagnostics and treatment of respiratory diseases
    • Bronchial asthma
    • Acute and chronic bronchitis of various etiologies
    • Lung malformations
    • Cystic fibrosis
    • Foreign body aspiration
    • Diagnostic options
      • Body plethysmography with the determination of diffusing capacity and spiroergometry on a treadmill
      • Tracheobronchoscopy and radiography (with video recording)
      • Sweat test
      • In vivo measurement of transmural electrical potential difference
      • PCR diagnostics
      • Alpha-1 antitrypsin test
      • Determination of the level of eosinophil cationic protein
      • Diagnostic imaging methods
      • Daily pH-metry
  • Diagnostics and treatment of allergic reactions
    • Insect venom allergy
    • Drug allergy
    • Food allergy
    • Atopic dermatitis/endogenous eczema/neurodermatitis
    • Acute and chronic urticaria
    • Diagnostic options
      • Specific and non-specific bronchial and nasal provocative test
      • Various skin tests (including epicutane, scratch, prick test, etc.)
      • Laboratory diagnostics, including the specific IgE/IgG 4/LTT, etc.
      • Provocative tests for the diagnostics of urticaria
      • Provocative tests for detecting body reaction to drugs
  • Diagnostics and treatment of diseases of the gastrointestinal tract, liver
    • Crohn's disease
    • Ulcerative colitis
    • Celiac disease
    • Diseases of the liver, bile ducts and pancreas (for example, infectious hepatitis, autoimmune hepatitis, primary sclerosing cholangitis, copper accumulation, pancreatitis)
    • Diseases caused by food intolerance (carbohydrate malabsorption, food intolerance)
    • Nutrition disorders, including the feeding problems (need for feeding tubes)
    • Diagnostic options
      • Daily pH-metry
      • H2-breath test
      • Esophagogastroduodenoscopy
      • Ileum endoscopy
      • Percutaneous endoscopic gastrostomy
      • Helicobacter pylori testing
      • Liver biopsy
      • Diagnostic imaging methods
    • Diagnostics and treatment of rheumatic diseases
    • Diagnostics and treatment of kidney diseases
    • Diagnostics and treatment of heart diseases

Pediatric hematology and oncology

  • Diagnostics and treatment of malignant diseases
    • Acute lymphocytic leukemia, including the recurrent types
    • Acute and chronic myeloid leukemia
    • Malignant liver tumor (hepatoblastoma)
    • Non-Hodgkin lymphoma
    • Hodgkin's lymphoma
    • Anaplastic large-cell lymphoma, including the recurrent types
    • Nephroblastoma
    • Neuroblastoma
    • Osteosarcoma
    • Ewing's sarcoma
    • Soft tissue sarcomas
    • Craniopharyngioma
    • Brain tumors, including the recurrent types
    • Choroid plexus tumors
    • Langerhans cell histiocytosis
    • Nasopharyngeal cancer
  • Diagnostics and treatment of benign blood diseases
    • Spherocytosis
    • Autoimmune hemolytic anemia
    • Iron deficiency anemia
    • Transient erythroblastopenia of childhood
    • Fanconi anaemia
    • Severe aplastic anemia
    • Neutropenia (for example, Kostmann syndrome, cyclic neutropenia, autoimmune neutropenia)
    • Blood clotting disorders
      • Quantitative or qualitative platelet abnormalities
      • Disorders of plasma coagulation factors
      • Thrombophilia

Neuropediatrics, diseases of the endocrine glands, metabolic disorders

  • Diagnostics and treatment of neurological diseases in children
    • Complex types of epilepsy, including the diagnostics before the surgical treatment
    • Neuromuscular diseases
    • Multidisciplinary therapy of cerebral palsy (use of orthoses, surgical interventions, botulinum toxin therapy)
    • Follow-up care for children with perinatal risk factors
    • Migraine and other types of headaches
    • Developmental disorders
  • Diagnostics and treatment of metabolic disorders
    • Neurometabolic diseases
    • Congenital disorders
    • Malformations
  • Diagnostics and treatment of diseases of the endocrine glands
    • Diseases of the thyroid gland and adrenal glands, adrenogenital syndrome
    • Diabetes mellitus
    • Obesity and its consequences
    • Disorders of puberty
    • Growth disorders
  • Other diagnostic and therapeutic services

Curriculum vitae

Professional Career and Scientific Contribution

Prof. Lode completed his undergraduate training in Medicine at the University of Tuebingen in 1992 and received his doctoral degree (summa cum laude) in 1993. He was awarded a Research Fellowship of the German research Foundation in 1996, which he used for postdoctoral training at the Scripps Research Institute, La Jolla, CA in the area of tumor immunology. In 1999 he became a Junior Faculty Member at Scripps, where he developed a tumor model to study immunotherapeutic approaches in a deadly malignancy in childhood called neuroblastoma. He demonstrated that treatment with immunocytokines, which are antibody-cytokine fusion proteins, is effective in this model and that this approach is synergistic with inhibition of angiogenesis, as well as tumor vaccines. This seminal discovery was translated to clinical application and is subject to ongoing clinical trials (PM Sondel). In 2000 he continued training in Pediatrics at the Charité University Hospital Berlin. At the same time he was awarded an Emmy Noether Fellowship by the German Research Foundation with focus on immunotherapy approaches in neuroblastoma. In this time period, he developed novel approaches by means of genetic vaccination to treat malignant disease. In particular combinations of DNA vaccines with tumor specific delivery of immunocytokine lead to important step forward to optimize efficacy of DNA vaccination. In 2002 he became a Member of the SIOPEN group and got involved in the clinical development of a monoclonal antibody directed against ganglioside GD2 (ch14.18/CHO). Professor investigated for the first time a novel delivery method of this antibody (patent) and he is currently leading two international clinical trials with this antibody.

Awards

  • 2005 Science4life, Venture Cup.

Memberships in Professional Societies

  • German Society for Pediatric and Adolescent Medicine (DGKJ).
  • German Society of Pediatric Hematology and Oncology (GPOH).
  • International Society for Pediatric Oncology Europe Neuroblastoma (SIOPEN).
  • American Association of Cancer Research.
  • American Society of Hematology.
  • American Association of Immunologists (AAI).
  • American Society of Clinical Oncology (ASCO).
  • Since 2013, Member of the SIOP Scientific Programme Advisory Committee (SPAC) of the International Society for Pediatric Oncology Europe Neuroblastoma (SIOP), Chair of the Immunotherapy Committee and Member of the Executive Board of SIOPEN.

Reviewer Activities

  • Journal of Immunology.
  • Blood.
  • Cancer Research.
  • Cancer Gene Therapy.
  • Clinical Cancer Research.
  • Oncogene.

Photo of the doctor: (с) Universitätsmedizin Greifswald 

Department of Pediatric and Adolescent Medicine.
University Hospital Greifswald:

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