In vitro fertilization (IVF) long protocol (program ID: 249619)
University Hospital Halle (Saale)
Hermann BehreSpecialized in: reproductive medicine, andrology
Department of Reproductive Medicine and Andrology
- Initial presentation in the clinic
- Case history taking
- Review of medical records
- General physical examination
- Laboratory tests:
- Complete blood count
- General urine test
- Biochemical blood test
- Inflammation markers
- Blood coagulation test
- Immune status
- Analysis for infections
- Hormone levels:
- TSH-basal, fT3, fT4
- Ultrasound examination of abdomen and small pelvic organs
- Transvaginal ultrasound examination
- Gynecological examination
- Examination of the men:
- Urethral smear analysis
- Tests for infections
- Hormonal stimulation
- In vitro fertilization (IVF)
- Nursing services
- Consultation of related specialists
- Treatment by head doctor and all leading experts
- Explanation of the individual treatment plan
All aspects of the program can be discussed with a medical advisor.
How program is carried out
You arrive in the hospital on the 19th day of the menstrual cycle. Our service starts at the airport. Our employee meets you at the airport and holds a sign with your name. In the individual folder you will find detailed information about the program.
The reproductologist will start from the general examination, you will undergo a number of laboratory and instrumental tests. After that, the doctor will elaborate an individual treatment plan, determine the drug dosages. You will receive a detailed explanation of all the procedures and will be able to contact your doctor for advice at any time.
For your convenience, we offer hotels or apartments within walking distance of the hospital. After the first appointment, you will have free time to rest. You can take the prescribed medications on your own or in the hospital. Also, several times, on the appointed days, it will be necessary to have an ultrasound examination (up to 3 times).
Stages of treatment
Blockage. On days 20-21 of the menstrual cycle, the pituitary gland is blocked with GnRH agonists. The purpose of the drug administration is to suppress ovarian function and stimulate maturation of more oocytes.
Ovarian stimulation. On the 2-4th day of the menstrual cycle, active stimulation of the ovaries with gonadotropins under constant ultrasound monitoring begins. It takes 10-14 days on average. An ultrasound examination is required to assess follicular growth. When the follicle is mature enough, a trigger injection is given.
The doctor will appoint the day of visiting the clinic. The time of oocyte collection (puncture) is determined. 36 hours before the puncture, a woman makes a stimulating (trigger) injection of hCG (human chorionic gonadotropin).
Egg collection. In the hospital, the follicles are punctured with the collection of mature eggs (on the 12-15 day of the menstrual cycle). The husband of the patient, on his turn, collects the ejaculate. The ejaculate can be collected naturally, or by a puncture of the testicle (in azoospermia, obstruction of the vas deferens in men – the ICSI procedure).
Fertilization. 2-6 hours after egg collection, eggs are fertilized with the husband’s sperm. This is a laboratory procedure and no patient involvement is required.
Embryo culture. Fertilized eggs will be cultured for 1-5 days. According to patients’ needs and embryo status, best 1-3 embryos can be transferred to the womb.
Preimplantation genetic diagnosis. PGD is usually performed on day 3. It takes 1 day to receive the results. One or two cells from the embryo can be taken without harming it, and some genetic tests can be done in one or two days.
Embryo transfer. This procedure is painless and no anesthesia is required, although some patients need sedation. One hour after the procedure, patients can leave the clinic and can return home on the same day.
Pregnancy test. This test can be done 14 days after the embryo transfer.
We fully support your trip, regardless of the chosen program. We provide an individual medical coordinator and interpreter, help with choosing and booking a hotel, booking tickets, preparing medical reports.
- Medical records
- Results of hormone blood tests (if available)
- Pelvic ultrasoud (if available)
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About the department
The Department of Reproductive Medicine and Andrology at the University Hospital Halle (Saale) offers the full range of options for the diagnostics and treatment of infertility, hormonal disorders, reduced libido, including erectile dysfunction. The patients receive medical care from an experienced medical team, consisting of highly qualified gynecologists, endocrinologists, andrologists and experts in the field of reproductive medicine. A unique offer of the department is the cryopreservation of oocytes and spermatozoa for planning future pregnancy (for example, in case of somatic pathology or chemoradiotherapy). The Chief Physician of the department is Prof. Dr. med. Hermann Behre.
The department operates four specialized laboratories. The main task of the Andrology Laboratory is to perform spermograms, while the Laboratory for Reproductive Biology deals with fertility treatment. The department also has a separate Laboratory for Germ Cell Cryopreservation. The activities of the research laboratory is focused on the study of new fertility molecular factors, the causes of hormonal disorders and the conduct of clinical trials.
The service range of the department includes:
- Identification of the causes and treatment of infertility
- Therapeutic options for women
- Hormonal stimulation to normalize the menstrual cycle in order to achieve regular ovulation and proper preparation of the uterus for pregnancy
- Minimally invasive removal of benign tumors (uterine myomas, endometrioid cysts, dermoids, etc.) or laparoscopic removal of adhesions
- Assisted reproductive techniques
- Sperm injection into the uterus (intrauterine insemination)
- In vitro fertilization
- Intracytoplasmic sperm injection (ICSI)
- Testicular sperm extraction (TESE) or microsurgical epididymal sperm aspiration (MESA)
- Cryoconservation of in vitro fertilized eggs, embryo transfer and subsequent cultivation in the following cycles
- Cryopreservation of sperm or testicular tissue to preserve fertility
- Therapeutic options for men
- Drug stimulation to normalize hormonal levels
- Antibiotic therapy for inflammation of the testicles, epididymis, prostate gland and seminal vesicles
- Surgical treatment
- Assisted hatching
- Therapeutic options for women
- Diagnostics and treatment of endocrine disorders
- Hormonal disorders in women, including girls
- Irregular periods and blood clotting disorders
- Premenstrual syndrome
- Hormonal disorders in adolescents
- Premature ovarian failure
- Chronic pelvic pain
- Hormonal disorders in men
- Hypogonadism in older men
- Hormone replacement therapy using testosterone in older men
- Hormonal disorders in women, including girls
- Diagnostics and treatment of problems in the sexual life of men and women
- Erectile dysfunction in men
- Psychosexual problems
- Planning for pregnancy after sterilization
- Germ cell cryoconservation
- Deep freezing of oocytes (pronucleus stage) after successful in vitro fertilization
- Sperm cryopreservation in case of poor baseline data prior to scheduled IVF or ICSI
- Deep freezing and storage of sperm to preserve fertility in case of indicated radiotherapy/chemotherapy for cancer treatment
- Testicular tissue cryopreservation prior to sperm extraction (TESE) and ICSI in case of azoospermia
- Ovarian tissue or oocyte cryopreservation in female cancer patients who want to have children in the future
- Other medical services
- Head of the Department of Reproductive Medicine and Andrology at the University Hospital Halle (Saale).
- President of the German Society of Andrology (DGA).
- Deputy Chairman of the Council on Reproductive Biology and Medicine (DVR).
- Treasurer of the European Academy of Andrology (EAA).
The doctor’s research priority is the aging of men with a special focus on changing the levels of sex hormones. In old age, men have the increases levels of serum gonadotropic hormones and the increased symptoms of androgen deficiency, which characterize the clinical picture of age-related hypogonadism. The causes, manifestations and methods of treatment for age-related hypogonadism are not well studied yet, but in view of the aging of society and demographic changes, they are of great importance for health care. In addition, research interests include the study of testosterone replacement therapy and fertility in old age.
Photo of the doctor: (c) Universitätsklinikum Halle (Saale)