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Allogeneic bone marrow transplantation in myelofibrosis (program ID: 250967)

University Hospital Halle (Saale)

location_on Halle, Germany
9.6/10 from 78 Votes
Specialized hospital
Mascha Binder

Head Physician
Prof. Dr. med.

Mascha Binder

Specialized in: hematology, oncology

Department of Hematology and Oncology

Program includes:

  • Initial presentation in the clinic
  • case history collection
  • general clinical examination
  • laboratory tests:
    • complete blood count
    • biochemical analysis of blood
    • TSH-basal, fT3, fT4
    • differential blood count
    • inflammation indicators (CRP, ESR)
    • indicators of blood coagulation
  • CT/MRI scans of the whole body
  • needle biopsy of the bone marrow
  • biopsy and histological examination of CSF
  • examination by experts of:
    • cardiology
    • otolaryngology
    • immunology
    • ophthalmology
  • registration in the European bone marrow donor base
  • conducting high-dose chemotherapy
  • allogeneic bone marrow transplantation from
    unrelated donor
  • the cost of blood products
  • isolation by neutropenic precautions
  • symptomatic treatment
  • control examinations
  • the cost of essential medicines and materials
  • nursing services
  • full hospital accommodation
  • explanation of future recommendations

How program is carried out

During the first visit, the doctor will conduct a clinical examination and go through the results of the available diagnostic tests. After that, you will undergo the necessary additional examination, such as the assessment of liver and kidney function, ultrasound scan, CT scan and MRI.

Also, the doctor will conduct a bone marrow biopsy followed by cytological examination of the harvested material. This will help him to determine the histological features of your bone marrow (in particular, identify HLA system antigens) and select a suitable donor. The donor can be a family member or a person from the bone marrow registry. In the second case, the donor material is stored in a bone marrow bank.

Before the procedure, you will receive chemotherapy, if necessary in combination with radiation therapy. The course of chemo- or chemoradiation therapy lasts from 2 to 8 days.

The bone marrow transplant procedure is an intravenous infusion, i.e. the healthy bone marrow will be injected through a catheter, intravenously. You will stay in your room during the procedure. A bone marrow transplant is completely painless and does not require anesthesia.

During the period of healthy bone marrow engraftment, you will stay in a sterile ward. This is a necessary precaution because during this time your immune system is very weak and cannot withstand environmental pathogens. The risk of bleeding is also quite high, so you will be advised to avoid mechanical damage.

A relative or other close person may stay in the ward with you. You will not be allowed to go outside the department and leave your ward often. The rehabilitation period can last from 1 to 2 months.

When your complete blood count returns to normal, your doctor will schedule your discharge from the department. You will receive information about the rules that you will need to follow at home, the frequency and type of control examinations, and subsequent treatment measures. You will also receive a detailed medical report, which will reflect the entire course of treatment.

Required documents

  • Medical records
  • Bone marrow biopsy results (if available)
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About the department

According to the Focus magazine, the Department of Hematology and Oncology at the University Hospital Halle (Saale) ranks among the top German medical facilities specializing in bowel cancer treatment!

The department offers the full range of specialized diagnostics, treatment and follow-up care for patients with oncological diseases and blood diseases. The department's doctors have in their arsenal many innovative effective methods to fight against cancer. In addition, a number of clinical trials are carried out here in order to develop the very latest targeted drugs, immunotherapy drugs, etc. All the department's specialists regularly undergo advanced training courses, which help them to keep abreast of innovations in medicine and to guarantee the best therapy result for patients. The Chief Physician of the department is Prof. Dr. med. Mascha Binder.

The key focus of the department is hematology. The specialists in this field have excellent qualifications in the diagnostics and treatment of benign and malignant blood diseases, as well as diseases of the hematopoietic system. The focus is on acute and chronic types of blood cancer, myeloproliferative and myelodysplastic diseases, lymphomas and multiple myeloma. The therapeutic spectrum includes various types of chemotherapy, targeted drugs, etc. The patients with end-stage pathology are offered treatment within the framework of clinical trials, which in some cases saves or significantly prolongs their life.

The department houses a specialized Bone Marrow Transplant Center. Bone marrow transplantation is one of the most effective methods for the treatment of blood diseases and cancer, especially leukemias and lymphomas. The center has been conducting successful clinical activities for over 10 years and is one of the most modern medical facilities of its kind in Germany.

The department's oncologists provide the diagnostics and treatment of malignant diseases using chemotherapy, immunotherapy, as well as targeted therapy with antibodies or tyrosine kinase inhibitors. The type of therapy or a combination of several types of treatment is selected individually for each patient. An integral part of the treatment is also professional psycho-oncological care. This implies conversations with doctors, which allow the patient to cheer up for an effective treatment while maintaining a positive attitude.

The service range of the department includes:

  • Diagnostics and treatment of benign and malignant diseases of blood, hematopoietic system
    • Acute and chronic types of blood cancer
    • Myeloproliferative diseases
    • Myelodysplastic syndromes
    • Lymphoma
    • Multiple myeloma
  • Diagnostics and treatment of malignant solid tumors
    • Gastrointestinal tumors
    • Head and neck tumors
    • Sarcomas
  • Diagnostics and treatment of blood-clotting disorders (hemostaseology)
    • Hemophilia A and B
    • Von Willebrand disease
    • Rare forms of coagulation factor deficiency and platelet dysfunction (thrombocytopathy)
  • Treatment of complications of oncological diseases and medical care in side effects of treatment
  • Diagnostics and treatment of other diseases

Curriculum vitae

​Prof. Dr. med. Mascha Binder is a therapist specializing in hematology and oncology. Of particular interest to her is immunotherapy in the treatment of cancers, as well as research on the treatment of lymphoid neoplasia. She began her professional training at the University Hospital Freiburg and also worked at the University Hospital Hamburg-Eppendorf for more than 10 years. In the last hospital, she was the Deputy Head of the department and significantly contributed to the expansion of the Comprehensive Cancer Center. Since October 2018, she heads the Department of Hematology and Oncology at the University Hospital Halle (Saale).

Positions in the Department of Hematology and Oncology

  • Head of the department.
  • Head of the Scientific Working Group on Cancer Immunology.

Clinical Focuses

  • Lymphatic neoplasias and multiple myeloma.
  • Benign hematological diseases.
  • Clinical trials.

Research Focuses

  • Translational researches in cancer immunotherapy.
  • B-cell neoplasms: biology and targeted therapy.
  • Resistance mechanisms and their overcoming in the treatment of solid tumors.

Professional Сareer and Honors

  • Since October 2018 Head of the Department of Hematology and Oncology at the University Hospital Halle (Saale).
  • 2018 Cancer Research Prize of the Hamburg Cancer Society.
  • 2016 Digital Leader Award for outstanding achievements in digital information processing at the enterprises.
  • 2015 - 2018 Deputy Head of the Department of Hematology and Oncology at the University Hospital Hamburg-Eppendorf.
  • 2014 Invitation to the position of W2 Professor in Cancer Research and Immunotherapy.
  • 2014 Secretary of the Scientific Congress at the Annual Meeting of the German Society of Hematology and Medical Oncology in Hamburg (more than 6,000 participants).
  • 2013 Senior Physician in the Department of Hematology and Oncology with the Section of Pulmonology at the University Hospital Hamburg-Eppendorf.
  • 2012 Board certification in Hematology and Oncology, habilitation.
  • 2011 Board certification in Internal Medicine, Hubertus Wald Prize for Young Scientists for Cancer Research.
  • 2010 Young Master Prize of the German Society of Hematology and Medical Oncology (DGHO).
  • 2008 - 2018 Department of Hematology and Oncology with the Section of Pulmonology at the University Hospital Hamburg-Eppendorf.
  • 2006 Paul Basset Prize of the European Cancer Center.
  • 2005 - 2007 Department of Hematology and Oncology at the University Hospital Freiburg.
  • 2004 Doctoral degree.
  • 1998 - 2000 Study of Human Medicine in Würzburg, Freiburg, Rome, as well as clinical practice in France, Switzerland, Italy, Australia and the USA.

Photo of the doctor: (c) Universitätsklinikum Halle (Saale) 


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