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Prostate Cancer Treatment with Actinium-225 PSMA (program ID: 447953)

University Hospital Jena

location_on Jena, Germany
8.9/10 from 69 Votes
Specialized hospital
Martin Freesmeyer

Head Physician
PD Dr. med.

Martin Freesmeyer

Specialized in: nuclear medicine

Department of Nuclear Medicine

Program includes:

  • Initial presentation in the clinic
  • clinical history taking
  • general physical examination
  • laboratory tests:
    • complete blood count
    • biochemical analysis of blood
    • urinalysis
    • TSH-basal, fT3, fT4
    • PSA blood level
    • tests for urogenital infections
    • indicators of inflammation
    • indicators of blood coagulation
  • ultrasound scan of the urogenital system
  • renal scintigraphy
  • PSMA PET-CT
  • PSMA treatment with Actinium-225
  • full body scintigraphy after 24 hours
  • full body scintigraphy after 48 hours
  • symptomatic treatment
  • cost of essential medicines
  • nursing services
  • elaboration of further recommendations
  • stay in the hospital with full board 
  • accommodation in 2-bedded room 

How program is carried out

During the first visit, the doctor will carry out a general physical examination and go through the results of previous laboratory and instrumental tests. After that, you will undergo the necessary additional tests such as the assessment of liver and kidney function, scintigraphy of the skeleton and salivary glands, PSMA PET / CT. This will allow the doctor to assess how effective PSMA therapy with Actinium-225 will be and how well you will tolerate it. Also, the doctor will calculate your individual dosage of the radionuclide.

PSMA therapy with Actinium-225 is carried out via intravenous administration of a solution with the radioactive isotope Actinium-225. The solution is injected through a catheter. This is a short procedure, as the infusion usually takes no more than 20 minutes.

During the procedure, you will need to apply cooling bags to the salivary glands, as Actinium-225 partially accumulates in the salivary glands, affecting their function and causing dry mouth. You will also receive intravenous saline solutions to protect your kidneys.

After the infusion of Actinium-225, you will stay in a specially equipped (radiation-shielded) ward for 48 hours. The drug is quickly excreted by the kidneys, and after 48 hours you will no longer be dangerous to others. During these 48 hours, you can read, use a mobile phone, tablet or computer – all these devices will not be a source of radiation in the future.

Follow-up examinations include whole-body scintigraphy or computed tomography in 24 hours and 48 hours after the procedure. Based on the results of the examination, the doctor will determine whether one procedure is enough for you, or whether you will need to visit the hospital again. As a rule, 1-2 procedures are required for achieving a stable positive result. Procedures are carried out with an interval of 8 weeks.

Required documents

  • Medical records
  • PSA blood test
  • MRI/CT scan (not older than 3 months)
  • Bone scintigraphy (if available)
  • Biopsy results (if available)
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About the department

The Department of Nuclear Medicine University Hospital Jena offers the full range of radioisotope diagnostics and treatment using the state-of-art gamma cameras and PET-CT systems. All medical services comply with the guidelines of national and international professional societies, which ensures an accurate diagnostics and optimal treatment outcome. The department is headed by PD Dr. med. Martin Freesmeyer.

The main therapeutic options of the department include radioiodine therapy, selective internal radiotherapy, peptide-receptor radionuclide therapy. A therapeutic method is selected depending on the specific clinical case. For example, selective internal radiation therapy (SIRT) is more effective in intensive vascularization of liver tumors. The SIRT-therapy is the most widely used in the treatment of hepatocellular carcinoma and liver metastases in breast, colon or neuroendocrine cancers. The radioiodine therapy is effectively used in the treatment of hyperthyroidism in order to reduce the size of the thyroid gland, as well as for the treatment of the thyroid cancer recurrences.

The service range of the department includes:

  • Conventional diagnostics using gamma cameras
    • Scintigraphy in inflammatory processes
    • Myocardial scintigraphy
    • Lung scintigraphy
    • Parathyroid scintigraphy
    • Renal scintigraphy
    • Thyroid scintigraphy
    • Skeletal scintigraphy
  • PET-CT diagnostics (innovative diagnostic method, which combines positron emission tomography and computed tomography)
  • Therapeutic services
    • Radioiodine therapy
    • Radiosynovectomy
    • Selective internal radiation therapy
    • Peptide receptor radionuclide therapy
    • Other diagnostic and therapeutic services

Curriculum vitae

Education

  • 01.10.1990 - 17.09.1996 Study of Human Medicine at the Friedrich Schiller University Jena.
  • 01.10.1995 - 06.09.1996 One-year practice, optional course (Radiation Therapy), Friedrich Schiller University Jena.
  • 20.09.1996 Permission to work as an Intern.
  • 01.05.1998 Admission to medical practice.

Professional Career

  • 01.09.1988 - 30.09.1990 Department of Anaesthesiology and Intensive Care, University Hospital Jena.
  • 01.10.1988 - 31.01.1990 Medical service, military service.
  • 01.11.1996 - 31.03.1997 Institute of Pathology, Friedrich Schiller University Jena, Intern.
  • 01.04.1997 - 30.04.1998 Department of Anesthesiology and Intensive Care, University Hospital Jena, Intern.
  • 01.05.1998 - 31.12.2003 Institute of Diagnostic and Interventional Radiology, Friedrich Schiller University Jena, Advanced Training.
  • Since 13.02.2003 Board certification in Diagnostic Radiology, Senior Physician.
  • 01.01.2004 - 30.04.2007 Department of Nuclear Medicine, University Hospital Halle, Advanced Training.
  • Since 26.01.2007 Board certification in Nuclear Medicine.
  • Since 01.05.2007 Head of the Department of Nuclear Medicine at the University Hospital Jena.

 Scientific Career

  • 03.05.1999 PhD thesis defense with honors, Medical Faculty, University of Jena. Subject: "Histomorphometric researches of the cancellous bone in rat after the removal of the parathyroid glands: the effect of physiological doses of parathyroid hormone and calcitriol".
  • 09.09.2014 Completion of the habilitation procedure, Faculty of Medicine, University of Jena. Subject: "Developments and examinations on the thyroid imaging: PET/CT with iodine-124, 3D ultrasound examination and nuclear sonographic image fusion".

Patent Applications

  • Hybrid imaging system for intraoperative, interventional and diagnostic purposes, German Patent and Trade Mark Office (registration, November 2012).
  • Method for the determination of the origin of the radiation signal in the measuring range and the measuring device for the simultaneous detection of decaying radionuclides in the measuring range, German Patent and Trade Mark Office (registration, June 2014).

Honors

  • 01.2009 Clinician of the Year (9 semester).
  • 2010 - 2014 Nomination for the title of the Clinician of the Year.
  • 01.2014 "Award for Outstanding Academic Activities" (9 semester).

Membership in Professional Societies and Associations

  • German Society of Nuclear Medicine (DGN).
  • German Society of Ultrasound in Medicine (DEGUM).
    • Teacher of the Section of Radiology, DEGUM.
    • Teacher of the Section of Pediatrics, DEGUM.
  • Society of Nuclear Medicine Sachsen (GNS).
  • German Society of Radiology(DRG).
  • Thuringian Society of Radiology and Nuclear Medicine (TGRN).
  • Professional Association of German Specialists in Nuclear Medicine (BDN).
  • Professional Federation of German Radiologists (BDR).
  • Association of Leading Senior Physicians (VLK).
  • German Association of Higher Education Institutions (DHV).
  • Financial Support Foundation of the University Hospital Jena.

Board Member in Professional Societies and Associations

  • Society of Nuclear Medicine Sachsen (GNS).
  • Thuringian Society of Radiology and Nuclear Medicine (TGRN).
  • Financial Support Foundation of the University Hospital Jena.

Photo of the doctor: (c) Universitätsklinikum Jena 


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