Department of Oncology, Hematology, Rheumatology and Bone Marrow Transplantation - Nuremberg Hospital
Nuremberg Hospital
Nuremberg, Germany
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Department id #
302912
Prof. Dr. med. Stefan Knop
Department of Oncology, Hematology, Rheumatology and Bone Marrow Transplantation
Specialized in: oncology, hematology, rheumatology, bone marrow transplantation About the Department of Oncology, Hematology, Rheumatology and Bone Marrow Transplantation at Nuremberg Hospital
The Department of Oncology, Hematology, Rheumatology and Bone Marrow Transplantation at the Nuremberg Hospital provides the full range of services in the fields of its competence. The team of the department's doctors specializes in the diagnostics and treatment of solid tumors of various localizations, malignant blood diseases, and rheumatic pathologies. The department also has long experience treating rare cancers. Various systemic therapies for cancer, targeted therapy, autologous and allogeneic bone marrow transplantations, CAR T-cell therapy, which belongs to the innovative treatment methods, and many other therapeutic options are available here. The department is part of the Comprehensive Cancer Center, which holds weekly tumor boards with the participation of physicians from various medical specialties. It is certified by the German Society of Hematology and Medical Oncology (DGHO). A large team consisting of 32 physicians and over 100 nursing staff members works with patients. More than 4,560 inpatients and about 4,000 outpatients are treated in the department annually. The Head Physician of the department is Prof. Dr. med. Stefan Knop.
The department's team of doctors focuses on patients with solid malignant tumors of various organs. The department's oncologists, along with specialists from the Comprehensive Cancer Center, are responsible for treating patients with cancer. The center collaborates with experts who possess excellent professional skills in the treatment of cancers affecting the gastrointestinal tract, lungs, skin, breast, female reproductive system, prostate gland, and other organs. The treatment regimen is developed for each patient during an interdisciplinary tumor board, where doctors accurately examine diagnostic data and select the optimal complex of therapeutic measures. The surgical resection of the neoplasm, including part of the affected organ (depending on the spread of the cancer process), is most often the first-line treatment. However, a single surgical intervention is often not enough to completely cure cancer or achieve stable remission, so the treatment regimen includes systemic therapies such as chemotherapy, targeted therapy, hormone therapy, immunotherapy, antibody therapy, and others.
The department's hematologists successfully treat leukemia, myelodysplastic syndrome, and lymphomas. Chemotherapy is the main treatment method for the above-mentioned pathologies. The department has been performing bone marrow transplantations for many years, which are a second-line treatment for patients with malignant blood diseases. The specialists at the medical facility perform both allogeneic and autologous transplantations. An allogeneic bone marrow transplant involves transplanting an organ from a donor (related or unrelated), while an autologous transplant involves transplanting the patient's own stem cells. Allogeneic bone marrow transplantation is usually indicated for patients with acute leukemia, myelodysplastic syndrome, and myeloproliferative diseases. Autologous bone marrow transplantation is an effective treatment for multiple myeloma and non-Hodgkin's lymphoma.
The department also offers innovative CAR T-cell immunotherapy. This personalized treatment method involves activating the patient's own immune system to destroy tumor cells. Using state-of-the-art equipment, the patient's leukocytes are separated from the rest of the blood. In a specialized laboratory, these leukocytes are genetically modified to express chimeric antigen receptors (CARs). The final step involves multiplying the modified cells in the laboratory to obtain millions of cells, which are then infused back into the patient's body. After one infusion of leukocytes with chimeric antigen receptors, they remain in the patient's body and continue to attack the tumor for months or even years. CAR T-cell immunotherapy has demonstrated high efficacy in the treatment of acute leukemia, lymphoma, multiple myeloma, and other cancers. This treatment is currently considered advanced and is practiced only at leading German medical centers.
The treatment of rheumatic diseases is another important area of the department's clinical activity. Patients receive treatment from competent rheumatologists with extensive experience. The specialists treat rheumatoid arthritis, psoriatic arthritis, collagenosis, vasculitis, sarcoidosis, osteoporosis, and immunodeficiency disorders. Depending on the severity of the clinical case, therapy may take place on an inpatient or outpatient basis. Patients with rheumatic diseases usually receive an individually developed course of drug therapy.
The department's range of medical services includes:
- Diagnostics and treatment of oncologic diseases
- Colon cancer
- Stomach cancer
- Esophageal cancer
- Liver cancer
- Pancreatic cancer
- Lung cancer
- Skin cancer
- Breast cancer
- Female reproductive cancers
- Prostate cancer
- Malignant head and neck tumors
- Diagnostics and treatment of hematologic diseases
- Leukemias
- Myelodysplastic syndromes
- Lymphomas
- Multiple myeloma
- Blood clotting disorders
- Diagnostics and treatment of rheumatic diseases
- Rheumatoid arthritis
- Psoriatic arthritis
- Collagenoses
- Vasculitis
- Sarcoidosis
- Osteoporosis
- Autoinflammatory syndromes (for example, adult-onset Still's disease)
- Immunodeficiency disorders
- Other medical services
The department's therapeutic options include the following:
- Chemotherapy
- Targeted therapy
- Hormone therapy
- Antibody therapy
- Immunotherapy, including innovative CAR T-cell therapy
- Autologous and allogeneic bone marrow transplants
- Drug therapy for rheumatic diseases
- Other treatment methods
Curriculum vitae
Since November 1, 2021, Prof. Dr. med. Stefan Knop has been heading the Department of Oncology, Hematology, Rheumatology and Bone Marrow Transplantation at the Nuremberg Hospital. Stefan Knop is a Professor at the University of Wuerzburg. He graduated from the Faculty of Medicine of the Eberhard Karl University of Tuebingen. In 2000, he defended his thesis on the subject: "The use of the cytoprotective amifostine to alleviate the toxic side effects of cisplatin- and ifosfamide- containing chemotherapy". This was followed by clinical practice at the University Hospital Tuebingen (until 2005). The next position for Prof. Stefan Knop was at the University Hospital Wuerzburg, where he underwent habilitation and became a Professor in 2015.
Prof. Knop is actively engaged in research activities, the primary focus of which is multiple myeloma treatment. For this purpose, the Department of Multiple Myeloma was established at the University Hospital Wuerzburg. This department is funded by the Wilhelm Sander Foundation and headed by Prof. Stefan Knop along with Prof. Hermann Einsele. Prof. Knop pays particular attention to teaching activities. In 2012, he was awarded the Albert Kolliker Teaching Prize in the amount of 10,000 euros by the Faculty of Medicine at the University of Wuerzburg for a series of extracurricular lectures on "Differential diagnosis of internal diseases".
Photo of the doctor: (c) Klinikum Nürnberg
