University Hospital Bonn

location_on Bonn, Germany
9.2/10 from 150 Votes

Department of Ophthalmology ( 26281)

Frank G. Holz

Prof. Dr. med.

Frank G. Holz

Specialized in: ophthalmology

Curriculum vitae keyboard_arrow_down
Education and Degrees 
  • 4/83 - 5/89 Medical School, University of Heidelberg, Germany
  • 9/1987 Johns Hopkins University Baltimore, U.S.A. Clinical Clerkship: Hematology/Bone marrow transplantation program 
  • 4/88 - 11/88 University of Chicago Pritzker School of Medicine, Chicago, U.S.A. Subinternships in surgery and internal medicine 
  • 1986-1987 Medical thesis in physiology: ‘Renovascular effects of adenosine-agonists’ (‘magna cum laude’) – doctoral degree 
  • 1994 Board Examination Ophthalmology 10/1997 Habilitation (‘Privatdozent’) for Ophthalmology: ‘Age-dependent changes in Bruch’s membrane and the retinal pigment epithelium as pathogenetic factors in age-related macular degeneration’ Academic and professional appointments 
  • Since 2003 Chairman and Professor, Department of Ophthalmology, University of Bonn 
  • 1995 – 2003 „Oberarzt“ at the Department of Ophthalmology, University of Heidelberg, Germany; 2001-2003 „Geschäftsführender Oberarzt“ 
  • 1992 – 1993 Research and Clinical Fellowship Medical Retina, Institute of Ophthalmology, Moorfields Eye Hospital, London, England Supervisor: Professor Alan C. Bird, MD, FRCS, FRCOphth 9/93 The Schepens Eye Research Institute, Boston, U.S.A., lipofuscin research project
  • 1989-1991, 1994 Residency, Department of Ophthalmology, University of Heidelberg, Germany Scholarships and awards
  • 1987-1989 Scholar of the German National Scholarship Foundation („Studienstiftung des Deutschen Volkes“)
  • 1988 Scholarship of the German Academic Exchange Service (DAAD)
  • 1992-1993 Research Scholarship Gertrud-Kusen-Foundation, Hamburg, Germany
  • 1999 Macular Degeneration Research Award for the Prevention of Blindness, Pro Retina Germany and Switzerland
  • 1999 Research Award of the German Ophthalmological Society (DOG)
  • 2000 Achievement Award of the American Academy of Ophthalmology (AAO)
  • 2001 Leonhard-Klein Award for Ophthalmic Surgery
  • 2005 DOC Award, German Ophthalmic Surgeons 
Other functions
  • Former Coordinator to the German Research Council (DFG)-Priority Program „Age-related macular degeneration“ (Deutsche Forschungsgemeinschaft SPP 1088)
  • President of the German Ophthalmological Society 
  • Editor-in-Chief of the peer-reviewed, scientific journal „Der Ophthalmologe“ (Official Organ of the German Ophthalmological Society), Publisher: Springer
  • Member of the Committee for Macular Diseases of the German Ophthalmological Society Editorial Board member: RETINA, Graefe’s Archive of Experimental and Clinical Ophthalmology; International Ophthalmology
  • Member of the Scientific Advisory Board of the AMD Alliance International
  • Member of the Scientific Advisory Board of the German Pro Retina Society Publications
  • More than 140 articles in peer-reviewed journals
  • Editor of several books on Age-related macular degeneration and Medical Retina • Author/coauthor of more than 20 book chapters 
Society Memberships
  • American Academy of Ophthalmology (AAO)
  • Association for Research in Vision and Ophthalmology (ARVO)
  • Macula Society
  • Club Jules Gonin
  • Oxford Ophthalmological Congress (OOC)
  • European Fluorescein-Angiography Club (FAN-Club)
  • Euretina
  • German Ophthalmological Society (DOG)
  • German Retinological Society 
Publications keyboard_arrow_down

Fleckenstein M, Charbel Issa P, Helb HM, Schmitz-Valckenberg S, Finger RP, Scholl HP, Loeffler KU, Holz FG.
High-resolution spectral domain-OCT imaging in geographic atrophy associated with age-related macular degeneration. 
Invest Ophthalmol Vis Sci 2008;49:4137-44

Helb HM, Charbel Issa P, van der Veen RL, Berendschot TT, Scholl HP, Holz FG.. 
Abnormal macular pigment distribution in type 2 idiopathic macular telangiectasia. 
Retina 2008;28:808-16

Holz FG, Bindewald-Wittich A, Fleckenstein M, Dreyhaupt J, Scholl HP, Schmitz-Valckenberg S; 
FAM-Study Group. Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration. 
Am J Ophthalmol 2007;143:463-72

F.G. Holz, C. Bellmann, S. Staudt, F. Schütt, H.E. Völcker: 
Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration. 
Investigative Ophthalmology and Visual Science 2001;42:1051-6

M. Bergmann, F. Schütt, F. G. Holz, J. Kopitz: 
Inhibition of the ATP-driven proton pump in RPE lysosomes by the major lipofuscin fluorophor A2-E may contribute to the pathoegnesis of age-related macular degeneration. 
FASEB J 2004;18:562-4

Bindewald-Wittich A, Han M, Schmitz-Valckenberg S, Snyder SR, Giese G, Bille JF, Holz FG. 
Two-Photon–Excited Fluorescence Imaging of Human RPE Cells with a Femtosecond Ti:Sapphire Laser. 
Invest Ophthalmol Vis Sci. 2006;47:4553-57

Scholl HP, Charbel Issa P, Walier M, Janzer S, Pollok-Kopp B, Börncke F, Fritsche LG, Chong NV, Fimmers R, Wienker T, Holz FG, Weber BH, Oppermann M. 
Systemic complement activation in age-related macular degeneration. 
PLoS ONE 2008;3(7):e2593.

F.G. Holz, F. Schütt, J. Kopitz, G.E. Eldred, F.E. Kruse, H.E. Völcker, M. Cantz: 
Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin. 
Investigative Ophthalmology and Visual Science 1999;40:734-7

F.G. Holz, T.J. Wolfensberger, B. Piguet, M. Gross-Jendroska, J.A. Wells, D.C. Minassian, I.H. Chisholm, A.C. Bird: 
Bilateral macular drusen in age-related macular degeneration: Prognosis and Risk Factors. 
Ophthalmology 1994;101:1522-28

F.G. Holz, K. Evans, C.Y. Gregory, S. Bhattacharya, A. C. Bird: 
Autosomal dominant macular dystrophy simulating north carolina macular dystrophy.
Archives of Ophthalmology 1995;113:178-184

As a medical institution of maximal care, the Department of Ophthalmology at the University Hospital Bonn covers the entire spectrum of ophthalmology. Annually the Department helps thousands of patients to achieve a better vision. The treatment is provided on both outpatient and inpatient basis and involves advanced diagnostic and treatment methods. The head of the Department is Univ.-Prof. Dr. med. Frank G. Holz. A professional team of physicians under the direction of Univ.-Prof. Dr. med. Frank G. Holz provides care to patients with any ophthalmological problems. 

There is always maintained an active cooperation with the departments of the University Hospital Bonn to provide interdisciplinary care, for example, for rare and inherited retinal diseases the Department is in cooperation with the Centre for Rare Diseases in Bonn (ZSEB). Moreover, the treatment quality is improved by a close cooperation with private practitioners and through the university quality control network “Eye Network West”.

The range of diagnostic and therapeutic services of the Department of Ophthalmology at the University Hospital Bonn includes: 

  • Surgery of the anterior eye segment: Cataract surgery with the intraocular lens implantation, glaucoma (filtration, laser, minimally invasive surgery, including trabectome-assisted surgery, all options of eyelid surgery
  • Surgery of the vitreous body, retina and macula: Diabetic retinopathy, age-related macular degeneration, epiretinal membrane, vitreomacular adhesion, vitreomacular traction, retinal detachment; eye injuries, including severe injuries; retinal vascular diseases; submacular hemorrhages.
  • Laser surgery: Diseases of the retinal vessels, including branch retinal vein occlusion, diabetic retinopathy, glaucoma, retinopathy of prematurity, photodynamic therapy.
  • Intravitreal pharmacotherapy: Intravitreal injections of VEGF inhibitors, including Lucentis, Eylea, Avastin; intravitreal injections of Jetrea for the treatment of macular holes of small diameter and symptomatic vitreomacular adhesion, intravitreal injections of Ozurdex and Iluvien.
  • Orthoptics and pediatric ophthalmology: Surgical treatment of strabismus; treatment of movement disorders of the eyes, nystagmus, neuroophthalmological diseases; botulinum toxin therapy for blepharospasm.
  • Center for Low Vision: eye prosthesis, optical and electronic devices.
  • Advanced diagnostic methods
  • Unit of the retinal degenerative changes: including retinitis pigmentosa, macular dystrophies, molecular genetic tests, phenotyping, including retinal imaging in cooperation with the Center for Rare Diseases Bonn (ZSEB)

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