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High-dose chemotherapy and peripheral blood stem cell autografts (PBSCT) in neuroblastoma (ganglioneyroblastoma) stage 4 (243079) | University Hospital Hamburg-Eppendorf - BookingHealth
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High-dose chemotherapy and peripheral blood stem cell autografts (PBSCT) in neuroblastoma (ganglioneyroblastoma) stage 4 in University Hospital Hamburg-Eppendorf

University Hospital Hamburg-Eppendorf

Hamburg, Germany
Program id # 243079
Doctor photo
Prof. Dr. med. Stefan Rutkowski
Department of Pediatric Hematology and Oncology
Specialized in: pediatric hematology, oncology

The program includes:

  • Initial presentation in the clinic
  • clinical history taking
  • physical examination
  • laboratory tests:
    • complete blood count
    • general urine analysis
    • biochemical analysis of blood
    • TSH-basal, fT3, fT4
    • tumor markers, including n-myc
    • indicators of inflammation
    • indicators of blood coagulation
  • CT scan / MRI of the abdomen and retriperitoneum
  • abdominal and retroperitoneal ultrasound scan
  • bone marrow biopsy
  • consultations of related specialists:
    • otolaryngologist
    • ophthalmologist
    • pulmonologist
    • dentist
    • cardiologist
  • harvesting stem cells
  • high-dose chemotherapy
  • peripheral blood stem cell autografts (PBSCT)
  • the cost of blood products
  • symptomatic treatment
  • cost of essential medicines
  • nursing services
  • full hospital accommodation
  • elaboration of further recommendations

How program is carried out

During the first visit, the doctor will conduct a clinical examination and go through the results of the available diagnostic tests. After that, you will undergo the necessary additional examination, such as the assessment of liver and kidney function, ultrasound scan, CT scan and MRI. If necessary, the doctor will conduct a bone marrow biopsy followed by cytological examination of the harvested material.

The next step is harvesting blood stem cells. You will be connected to the special apparatus that will filter the blood and extract stem cells from it. The duration of this procedure is 3-4 hours. The harvested stem cells will be processed with a special solution and cryopreserved. You will then receive a short, intensive course of chemotherapy, which will suppress the activity of your bone marrow and prepare space for the engraftment of healthy stem cells.

The bone marrow transplant procedure is an intravenous infusion, i.e. the thawed healthy bone marrow will be injected through a catheter, intravenously. You will stay in your room during the procedure. A bone marrow transplant is completely painless and does not require anesthesia.

During the period of healthy bone marrow engraftment, you will stay in a sterile ward. This is a necessary precaution because during this time your immune system is very weak and cannot withstand environmental pathogens. The risk of bleeding is also quite high, so you will be advised to avoid mechanical damage.

A relative or other close person may stay in the ward with you. You will not be allowed to go outside the department and leave your ward often. The rehabilitation period can last up to 3-4 weeks.

When your complete blood count returns to normal, your doctor will schedule your discharge from the department. You will receive information about the rules that you will need to follow at home, the frequency and type of control examinations, and subsequent treatment measures. You will also receive a detailed medical report, which will reflect the entire course of treatment.

Required documents

  • Medical records
  • Brain MRI/CT scan (not older than 3 months)
  • Biopsy results (if available)

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About the department

The Department of Pediatric Hematology and Oncology at the University Hospital Hamburg-Eppendorf offers all the options of modern diagnostics and therapy for children and adolescents with malignant diseases (leukemia and solid tumors), blood diseases and bleeding disorders. It is one of the largest medical facilities of this kind in Germany in this field and the only one of this kind in Hamburg. The treatment is provided in accordance with the recommendations of the Society for Pediatric Oncology and Haematology with the engagement of the necessary specialists from all related medical fields. The department is headed by Prof. Dr. med. Stefan Rutkowski.

The department's doctors have enormous and successful experience in the treatment of leukemia, brain and bone tumors, as well as other solid tumors. In addition, the doctors have excellent qualifications in the field of blood stem cell and bone marrow transplantation in leukemia, solid tumors, blood diseases, immunodeficiencies and metabolic disorders. Another focus of the department’s work is the treatment of congenital immunodeficiencies and blood clotting disorder, such as hemophilia and von Willebrand disease in children and adolescents.

The department annually treats more than 10,000 small patients on an outpatient basis. Also, the department's doctors annually perform 40 bone marrow and stem cell transplantations. An important component of the oncopathology treatment is the psychological care.

The main clinical focuses of the department include:

  • Diagnostics and treatment of solid tumors, malignant blood diseases
    • Chemotherapy
    • Radiation therapy
    • Maintenance therapy (for example, blood transfusions, antibiotic therapy)
    • Diagnostic examinations (bone marrow biopsy, lumbar puncture)
    • Functional diagnostics
  • Diagnostics and treatment of congenital and acquired hematopoietic defects
  • Diagnostics and treatment of congenital and acquired blood clotting disorders
  • Diagnostics and treatment of immunodeficiencies
  • Diagnostics and treatment of malignant systemic diseases
  • Bone marrow and stem cell transplantation
  • Palliative care
  • Psychosocial care
  • Other medical services

Curriculum vitae

  • 10.1988 - 04.1995 Study of Human Medicine, University of Bonn.
  • 12.06.1995 Medical Examination.
  • 06.1996 Doctoral thesis, University of Frankfurt. Subject: "Cytokines in umbilical cord blood of mature newborns and premature babies during normal pregnancy and under the influence of perinatal stress and infections".
  • 07.1995 - 08.2002 Intern and Research Fellow, University Hospital Würzburg.
  • 09.2002 - 03.2005 Acting Head of the Department, Department of Oncology with the focus on Neuro-Oncology, University Hospital Würzburg.
  • 12.2003 Board certification in Pediatric and Adolescent Medicine.
  • 04.2005 - 02.2009 Senior Physician, Department of Oncology and Hematology, University Hospital Würzburg.
  • 06.2005 Philip Kind Prize for the Best Scientific Work in Pediatric Oncology in German-speaking countries (in collaboration with Prof. J. Kühl).
  • 01.2007 Habilitation and Venia legendi, Faculty of Medicine, University of Würzburg.
  • 04.2007 Venia legendi in Pediatrics, University of Würzburg.
  • 02.2008 Specialization in Pediatric Oncology and Hematology.
  • 03.2009 - 09.2015 W2 Professor in Pediatric Hematology and Oncology, University Hospital Hamburg-Eppendorf, as well as Deputy Head of the Department.
  • Since 10.2015, Head of the Department of Pediatric Hematology and Oncology at the University Hospital Hamburg-Eppendorf.

Other Activities

  • Since 11.2002 Elected Head of the HIT-MED Research Group of the Society for Pediatric Oncology and Hematology.
  • Since 03.2006 Representative of the HIT Medical Network (Working Group on Pediatric Neuro-Oncology and All Researches of Brain Tumors of the Society for Pediatric Oncology and Hematology).
  • 01.2007 - 06.2012 Chairman of the European PNET Working Group of the European Society of Pediatric Oncology, the Researches of Medulloblastoma and Primitive Neuroectodermal Tumors.
  • 11.2009 - 12.2015 Board Member of the Society for Pediatric Oncology and Hematology.
  • 09.2011 Adam Balinski Academy Award, Hospital for Sick Children, Toronto, Canada.
  • 03.2012 Scientific Director at the Сonference of HIT Medical Network within the Comprehensive Cancer Centre Hamburg.
  • 09.2012 -12.2015 First Deputy Chairman of the Society for Pediatric Oncology and Hematology.
  • Since 04.2014. Member of the Ethics Committee of the Medical Association Hamburg.
  • Since 06.2014 Research Director, Multicenter Research SIOP PNET5-MB (sponsored by the University Hospital Hamburg-Eppendorf).
  • Since 06.2014 Chairman of the Pediatric Brain Tumor Committee, European Section of the International Society of Pediatric Oncology.

Memberships in Professional Societies

  • Society for Pediatric Oncology and Hematology.
  • German Cancer Society.
  • International Society of Pediatric Oncology.

Photo of the doctor: (c) Universitätsklinikum Hamburg-Eppendorf (UKE) 


About hospital

According to the Focus magazine, the University Hospital Hamburg-Eppendorf is one of the top ten hospitals in Germany! 

Since its foundation in 1889, the hospital has taken a leading position in the European medical arena, which it still holds today. A highly competent medical team of more than 15,300 employees takes care of the health of patients. Approximately 2,900 of them are physicians and researchers, and more than 3,400 work as nurses and therapists. The hospital has 1,738 beds for inpatient treatment, and many diagnostic and therapeutic services are provided on an outpatient basis. A solid foundation for successful clinical practice in the medical complex is formed by a combination of research achievements with state-of-the-art equipment and the highest professionalism of doctors. In addition, the hospital has a modern and extremely comfortable infrastructure. The most important value for every employee of the University Hospital Hamburg-Eppendorf is the health and well-being of every patient.

The medical facility was the first university hospital in Europe to implement an electronic system for storing patient medical reports. As a result, all diagnostic and treatment protocols are stored electronically. In 2011, the hospital was certified as the first fully digital hospital in Europe.

The hospital represents all areas of modern medicine. The doctors of the healthcare facility have a wealth of theoretical knowledge and vast clinical experience, which allows them to easily cope with the treatment of both common and extremely rare, complex clinical cases. About 550,000 patients are treated here each year, over 450,000 of whom receive outpatient medical care.

An important part of the work of the University Hospital Hamburg-Eppendorf is research activities aimed at developing innovative diagnostic and treatment methods. The main areas of research of the hospital include neurobiology, oncology, cardiovascular research, and research on infectious and inflammatory diseases. Special attention is also given to research in molecular imaging and skeletal biology.

The hospital is distinguished by its first-class level of medical care, which is confirmed by numerous quality certificates of European and international standards: DIN EN IS0 9001 certificate, certificates of the German Cancer Society (DKG) in the treatment of breast cancer, colon cancer, gynecological cancer, prostate cancer, and other oncological diseases, certificate of the German Cardiac Society (DGK) in the treatment of acute coronary syndrome, certificate of the German Spine Society (DWG), and others.

Photo: (с) depositphotos

Accommodation in hospital

Patients rooms

The patients of the University Hospital Hamburg-Eppendorf live in comfortable single and double rooms designed in bright colors. Each room is equipped with an ensuite bathroom with a toilet and a shower. The standard room includes an automatically adjustable bed, a bedside table, a wardrobe, a table and chairs for receiving visitors, a telephone, a radio and a TV. Also, there is Wi-Fi access.

Meals and Menus

The patient and his accompanying person have a daily choice of three menus. If for any reason you do not eat all the food, you will be offered an individual menu. Please inform the medical staff about your dietary preferences prior to the treatment.

Further details

Standard rooms include:

Toilet
Shower
Wi-Fi
TV

Religion

Religious services are available upon request.

Accompanying person

During the inpatient program, an accompanying person may stay with you in a patient room or hotel of your choice.

Hospital accommodation

During the outpatient program, you may stay in a hotel at the hospital.

Hotel

During the outpatient program, you may stay in a hotel of your choice. Managers will help you choose the most suitable options.

The hospital offers a full range of laboratory tests (general, hormonal, tests for infections, antibodies, tumor markers, etc.), genetic tests, various modifications of ultrasound scans, CT scans, MRI and PET / CT, angiography, myelography, biopsy and other examinations. Treatment with medications, endoscopic and robotic operations, stereotaxic interventions is carried out here, modern types of radiation therapy are also used. The hospital offers patients all the necessary therapeutic techniques.

  • Coiling and clipping of aneurysms of different localizations
  • Transjugular intrahepatic portosystemic shunting in patients with portal hypertension
  • Minimally invasive surgeries (da Vinci)
  • Removal and reconstruction of mammary glands
  • Hyperthermic intraperitoneal chemotherapy (HIPEC)

These are arteriovenous malformations and angiomas, vascular aneurysms, pathologies of the mammary glands, pelvic organ prolapse, urinary incontinence, malignant tumors of various localizations (area of ​​​​special attention is treatment of intestinal cancer), pathologies of liver and pancreas, cataracts and rare ophthalmic pathologies (aphakia, aniridia ), infertility and other diseases.

  • Interventional neuroradiology
  • Mammology
  • Oncology
  • Gastroenterology
  • Surgery

Over 2,900 highly qualified physicians and researchers work at the hospital.