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Treatment of neuroendocrine tumor (NET) of the pancreas with Lutetium-177-DOTATATE (690997) | University Hospital Heidelberg - BookingHealth
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After that, you will undergo the necessary additional tests such as the assessment of liver and kidney function, scintigraphy of the skeleton and salivary glands, somatostatin receptor imaging with&nbsp;Ga-68 DOTATATE PET\/CT. This will allow the doctor to assess how effective the radionuclide therapy with Lutetium-177-DOTATATE will be and how well you will tolerate it. Also, the doctor will calculate your individual dosage of the radionuclide.<\/p>\n\n<p style=\"text-align:justify\"><strong>Radionuclide therapy with Lutetium-177-DOTATATE<\/strong>&nbsp;is carried out via intravenous administration of a solution with the radioactive isotope Lutetium-177-DOTATATE. The solution is injected through a catheter. This is a short procedure, as the infusion usually takes no more than 20 minutes.<\/p>\n\n<p style=\"text-align:justify\">During the procedure, you will need to apply cooling bags to the salivary glands, as Lutetium-177-DOTATATE partially accumulates in the salivary glands, affecting their function and causing dry mouth. You will also receive intravenous saline solutions and amino acid solutions to protect your kidneys.<\/p>\n\n<p style=\"text-align:justify\">After the infusion of Lutetium-177-DOTATATE, you will stay in a specially equipped (radiation-shielded) ward for 48 hours. The drug is quickly excreted by the kidneys, and after 48 hours you will no longer be dangerous to others. During these 48 hours, you can read, use a mobile phone, tablet or computer &ndash; all these devices will not be a source of radiation in the future.<\/p>\n\n<p style=\"text-align:justify\"><strong>Follow-up examinations<\/strong>&nbsp;include whole-body scintigraphy or computed tomography in 24 hours and 48 hours after the procedure. Based on the results of the examination, the doctor will determine whether one procedure is enough for you, or whether you will need to visit the hospital again. As a rule, 1-2 procedures are required for achieving a stable positive result. Procedures are carried out with an interval of 8 weeks.<\/p>\n<\/div><div class=\"program_required_documents mt-4\"><h4>Required documents<\/h4><ul>\n\t<li style=\"text-align: justify;\">Medical records<\/li>\n\t<li style=\"text-align: justify;\">MRI\/CT scan (not older than 3 months)<\/li>\n\t<li style=\"text-align: justify;\">Biopsy results (if available)<\/li>\n<\/ul>\n<\/div>","program_full_story_crm":"<ul>\n\t<li>Initial presentation in the hospital<\/li>\n\t<li>Clinical history taking<\/li>\n\t<li>Physical examination<\/li>\n\t<li>Laboratory tests:\n\t<ul>\n\t\t<li>complete blood count<\/li>\n\t\t<li>biochemical analysis of blood<\/li>\n\t\t<li>TSH, free T3, free T4<\/li>\n\t\t<li>indicators of inflammation<\/li>\n\t\t<li>coagulation tests<\/li>\n\t<\/ul>\n\t<\/li>\n\t<li>Renal scintigraphy<\/li>\n\t<li>Ga-68 DOTATATE PET\/CT (if indicated)<\/li>\n\t<li>Lutetium-177-DOTATATE treatment<\/li>\n\t<li>Full body scintigraphy after 24 hours<\/li>\n\t<li>Full body scintigraphy after 48 hours<\/li>\n\t<li>Symptomatic treatment<\/li>\n\t<li>Cost of essential medicines<\/li>\n\t<li>Nursing services<\/li>\n\t<li>Stay in the hospital with full board<\/li>\n\t<li>Accommodation in 2-bedded room<\/li>\n\t<li>Elaboration of further recommendations<\/li>\n<\/ul>\n<div class=\"program_how_program_going mt-4\"><h4>How program is carried out<\/h4><p style=\"text-align:justify\"><strong>During the first visit<\/strong>, the doctor will carry out a general physical examination and go through the results of previous laboratory and instrumental tests. After that, you will undergo the necessary additional tests such as the assessment of liver and kidney function, scintigraphy of the skeleton and salivary glands, somatostatin receptor imaging with&nbsp;Ga-68 DOTATATE PET\/CT. This will allow the doctor to assess how effective the radionuclide therapy with Lutetium-177-DOTATATE will be and how well you will tolerate it. Also, the doctor will calculate your individual dosage of the radionuclide.<\/p>\n\n<p style=\"text-align:justify\"><strong>Radionuclide therapy with Lutetium-177-DOTATATE<\/strong>&nbsp;is carried out via intravenous administration of a solution with the radioactive isotope Lutetium-177-DOTATATE. The solution is injected through a catheter. This is a short procedure, as the infusion usually takes no more than 20 minutes.<\/p>\n\n<p style=\"text-align:justify\">During the procedure, you will need to apply cooling bags to the salivary glands, as Lutetium-177-DOTATATE partially accumulates in the salivary glands, affecting their function and causing dry mouth. You will also receive intravenous saline solutions and amino acid solutions to protect your kidneys.<\/p>\n\n<p style=\"text-align:justify\">After the infusion of Lutetium-177-DOTATATE, you will stay in a specially equipped (radiation-shielded) ward for 48 hours. The drug is quickly excreted by the kidneys, and after 48 hours you will no longer be dangerous to others. 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Treatment of neuroendocrine tumor (NET) of the pancreas with Lutetium-177-DOTATATE

University Hospital Heidelberg

Heidelberg, Germany
Program id # 690997
Doctor photo
Prof. Dr. med. Uwe Haberkorn
Department of Nuclear Medicine
Specialized in: nuclear medicine

The program includes:

  • Initial presentation in the hospital
  • Clinical history taking
  • Physical examination
  • Laboratory tests:
    • complete blood count
    • biochemical analysis of blood
    • TSH, free T3, free T4
    • indicators of inflammation
    • coagulation tests
  • Renal scintigraphy
  • Ga-68 DOTATATE PET/CT (if indicated)
  • Lutetium-177-DOTATATE treatment
  • Full body scintigraphy after 24 hours
  • Full body scintigraphy after 48 hours
  • Symptomatic treatment
  • Cost of essential medicines
  • Nursing services
  • Stay in the hospital with full board
  • Accommodation in 2-bedded room
  • Elaboration of further recommendations

How program is carried out

During the first visit, the doctor will carry out a general physical examination and go through the results of previous laboratory and instrumental tests. After that, you will undergo the necessary additional tests such as the assessment of liver and kidney function, scintigraphy of the skeleton and salivary glands, somatostatin receptor imaging with Ga-68 DOTATATE PET/CT. This will allow the doctor to assess how effective the radionuclide therapy with Lutetium-177-DOTATATE will be and how well you will tolerate it. Also, the doctor will calculate your individual dosage of the radionuclide.

Radionuclide therapy with Lutetium-177-DOTATATE is carried out via intravenous administration of a solution with the radioactive isotope Lutetium-177-DOTATATE. The solution is injected through a catheter. This is a short procedure, as the infusion usually takes no more than 20 minutes.

During the procedure, you will need to apply cooling bags to the salivary glands, as Lutetium-177-DOTATATE partially accumulates in the salivary glands, affecting their function and causing dry mouth. You will also receive intravenous saline solutions and amino acid solutions to protect your kidneys.

After the infusion of Lutetium-177-DOTATATE, you will stay in a specially equipped (radiation-shielded) ward for 48 hours. The drug is quickly excreted by the kidneys, and after 48 hours you will no longer be dangerous to others. During these 48 hours, you can read, use a mobile phone, tablet or computer – all these devices will not be a source of radiation in the future.

Follow-up examinations include whole-body scintigraphy or computed tomography in 24 hours and 48 hours after the procedure. Based on the results of the examination, the doctor will determine whether one procedure is enough for you, or whether you will need to visit the hospital again. As a rule, 1-2 procedures are required for achieving a stable positive result. Procedures are carried out with an interval of 8 weeks.

Required documents

  • Medical records
  • MRI/CT scan (not older than 3 months)
  • Biopsy results (if available)

Service

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About the department

The Department of Nuclear Medicine at the University Hospital Heidelberg offers the full range of radioisotope diagnostics and treatment of various diseases. The Chief Physician of the department is Prof. Dr. med. Uwe Haberkorn.

The department is equipped with the advanced medical equipment, which provides the most accurate scanning of all anatomical structures and organs of the human body. In the field of treatment, the focus is on oncological, cardiological and neurological diseases. The department's doctors work in accordance with the international standards, therefore, each patient receives high-quality, individualized medical care.

The service range of the department includes:

  • Diagnostics
    • Skeletal scintigraphy
    • Thyroid scintigraphy
    • Renal scintigraphy
    • Positron emission tomography (PET)
    • Lymphatic vessel scintigraphy
    • Lung scintigraphy
    • Somatostatin receptor scintigraphy
  • Therapy
    • Radiation therapy for the treatment of benign and malignant thyroid diseases
    • Metaiodobenzylguanidine (MIBG) therapy, for example, for the treatment of pheochromocytomas, paragangliomas, malignant carcinoids, neuroblastomas and unresectable medullary thyroid carcinomas.
    • Radioimmunotherapy (for example, in pancreatic tumors, lymphomas, colorectal tumors)
    • 90Y-labeled peptide therapy (for example, in neuroendocrine tumors)
    • Radionuclide therapy for the treatment of bone metastases
    • Ankylosing spondylitis therapy with the help of 224Ra-radium chloride
    • Radiosynoviorthese
  • Other diagnostic and treatment methods

Curriculum vitae

Education and Professional Career

  • 1979 - 1982 Study of Philosophy and German Philology at the Heidelberg University, Study of Human Medicine at the Universities of Marburg, Wuerzburg and Heidelberg.
  • 1988 3rd State Examination, Heidelberg University.
  • 1988 Intern and admission to medical practice, Heidelberg University.
  • 1995 Medical Specialist in Nuclear Medicine.
  • 1988 Doctoral thesis defense, Heidelberg University.
  • 1996 Habilitation, Heidelberg University.
  • Head of the Department of Nuclear Medicine at the University Hospital Heidelberg, as well as the Head of the Nuclear Medicine Clinical Cooperation Unit at the German Cancer Research Center (DKFZ).

Clinical Focuses

  • Diagnostics and treatment of thyroid diseases.
  • Diagnostics and treatment of cancers.

Research Focuses

  • Gene transfer as a method for the treatment of malignant tumors.
  • The use of tumor-affinity peptides for the diagnostics and treatment of cancers.
  • Non-invasive apoptosis diagnostics.

Awards

  • 1996 Mallinckrodt Prize of the German Society for Nuclear Medicine.
  • 1998 1st Prize for Contrast Media Research from the German Radiological Society.
  • 2018 Erwin Schrödinger Prize.

Photo: (с) depositphotos 


About hospital

According to Focus magazine, the University Hospital Heidelberg ranks among the top five hospitals in Germany! 

The hospital is one of the most advanced and reputable medical institutions not only in Germany but throughout Europe. There are more than 43 specialized departments and 13 medical institutes which cover all fields of modern medicine. A distinctive feature of the hospital is the presence of unique therapeutic methods for the treatment of complex and rare clinical cases.

Due to successful clinical practice, the hospital has been holding leading positions in the international medical arena for many years. The basis for this popularity is the combination of the very latest technologies, competent specialists, and active research activities, which allows introducing of revolutionary diagnostic and treatment methods, which save lives.

In addition to the outstanding medical achievements, it is worth noting a particularly friendly and pleasant atmosphere, and respectful attitude towards the patient. Both doctors and nursing staff make every effort to meet all the needs and wishes of the patient, pay due attention to each clinical case, and have personal communication with the patient, which contributes to a positive treatment result.

Photo: (с) depositphotos

Accommodation in hospital

Patients rooms

The patients of the University Hospital Heidelberg live in comfortable single and double rooms designed in bright colors. Each room is equipped with an ensuite bathroom with a shower and toilet. The patient rooms are quite spacious, they have a table with chairs for receiving visitors. Roomy wardrobes are provided for storing personal belongings. It is possible to connect to the Internet. In addition, the hospital offers enhanced-comfort rooms with a safe, refrigerator, and upholstered furniture. Patients have 24-hour access to the services of medical personnel.

Meals and Menus

The patient and his accompanying person have a daily choice of three menus. If you for some reason do not eat all the products, you will be offered an individual menu. Please inform the medical staff about your dietary preferences prior to the treatment.

Further details

Standard rooms include:

Toilet
Shower
Wi-Fi
TV

Religion

The religious services are available upon request.

Accompanying person

During the inpatient program, an accompanying person may stay with you in a room or hotel of your choice.

Hotel

During the outpatient program, you may live in a hotel of your choice. The managers will help you choose the most suitable options.

The hospital offers a full range of laboratory tests (general, hormonal, tests for infections, antibodies, tumor markers, etc.), genetic tests, various modifications of ultrasound scans, CT scans, MRI and PET / CT, angiography, myelography, biopsy and other examinations. Treatment with medications, endoscopic and robotic operations, stereotaxic interventions is carried out here, modern types of radiation therapy are also used. The hospital offers patients all the necessary therapeutic techniques.

  • Endovascular treatment of liver pathologies with LigaSureTM, Ultracision® and Habib®-Sealer devices
  • Correction of chest deformities in children (Nass operation)
  • Minimally invasive direct coronary artery bypass grafting
  • Replacement of ascending aorta (David procedure)
  • Operations using the da Vinci robotic system

These are primary lung tumors and metastases in the lungs, benign and malignant liver pathologies, thyroid pathologies, gastroesophageal reflux disease, heart rhythm disturbances and heart failure, infertility, fibromyalgia, damages and pathologies of large joints, polyneuropathy and other diseases.

  • Thoracic surgery
  • Cardiac surgery
  • Urology
  • Orthopedics and traumatology
  • Obstetrics and gynecology

The hospital's team consists of more than 13,000 highly qualified employees