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Treatment of Amyotrophic Lateral Sclerosis (ALS) in Germany

Due to the difficulties associated with the organization of treatment in Turkey, Switzerland, South Korea and India, we are not currently processing requests to these regions.

If you are interested in treatment in Germany, please leave a request and our specialists will contact you as soon as possible.

 

Cost for treatment

Amyotrophic Lateral Sclerosis (ALS) Diagnostics
2820.25
Diagnosis and conservative treatment of amyotrophic lateral sclerosis (als)
5430.25
Neurological rehabilitation Phase C
783

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Department of Neurology

According to the authoritative Focus magazine, the Charite University Hospital Berlin occupies the first place in the rating of the top German medical facilities! The hospital is one of the largest and leading university medical complexes in Europe. The hospital in Germany provides modern diagnostics and treatment of patients, a
Amyotrophic Lateral Sclerosis (ALS) Diagnostics
12197.25
Diagnosis and conservative treatment of amyotrophic lateral sclerosis (als)
22026.45

Bundeswehr Hospital Berlin

10/10
location_onGermany, Berlin

Department of Neurology and Epileptology

The Bundeswehr Hospital Berlin enjoys a reputation as one of the leading medical facilities in Germany, where patients receive top-class medical care corresponding to the high standards of European university medicine. The medical center is an academic hospital of the Charite University Hospital Berlin – the largest and th
Amyotrophic Lateral Sclerosis (ALS) Diagnostics
7948 help6448
Diagnosis and conservative treatment of amyotrophic lateral sclerosis (als)
12532.8 help11532.8

Beta Klinik Bonn

9.7/10
location_onGermany, Bonn

Department of Neurology and Epileptology

Beta Klinik is a modern hospital which consists of 30 specialized departments. The hospital is equipped with the state-of-the-art equipment of the university level. The operating rooms, an intensive care unit and the rehabilitation center correspond to the highest standards. It also concerns highly qualified physicians of the ho
Amyotrophic Lateral Sclerosis (ALS) Diagnostics
8466.4
Diagnosis and conservative treatment of amyotrophic lateral sclerosis (als)
15147.65

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Neurology

The University Hospital Ulm started its activities 35 years ago and during this time it has become one of the most prestigious medical institutions in Europe. The hospital is famous for its numerous discoveries and the world-class achievements in medicine and pharmaceuticals. The medical facility has 29 specialized departments a
Amyotrophic Lateral Sclerosis (ALS) Diagnostics
9124.7
Diagnosis and conservative treatment of amyotrophic lateral sclerosis (als)
15672.55

University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of Neurology

According to the Focus magazine, the University Hospital of Ludwig Maximilian University of Munich is regularly ranked among the best medical institutions in Germany! The hospital is the largest multidisciplinary medical facility, as well as a leading research and training center in Germany and Europe. The hospital is proud of i
Amyotrophic Lateral Sclerosis (ALS) Diagnostics
9340.75
Diagnosis and conservative treatment of amyotrophic lateral sclerosis (als)
16796.3

University Hospital Carl Gustav Carus Dresden

9.1/10
location_onGermany, Dresden

Department of Neurology and Epileptology

According to the reputable Focus magazine, the University Hospital Carl Gustav Carus Dresden ranks among the top five German hospitals! The hospital is the benchmark for modern high-quality medicine. Positioning itself as a maximum care medical facility, the hospital represents all medical fields. There are 26 specialized depart
Amyotrophic Lateral Sclerosis (ALS) Diagnostics
10790.75
Diagnosis and conservative treatment of amyotrophic lateral sclerosis (als)
19507.8

University Hospital Muenster

9.8/10
location_onGermany, Muenster

Department of General Neurology

According to the Focus magazine, the University Hospital Muenster ranks among the top German hospitals! The hospital belongs to the most prestigious medical institutions in Germany. The hospital is distinguished by a high professionalism of its doctors, state-of-the-art technological equipment and the availability of the most ad
Amyotrophic Lateral Sclerosis (ALS) Diagnostics
8556.3
Diagnosis and conservative treatment of amyotrophic lateral sclerosis (als)
15198.4

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Department of Neurology

According to the reputable Focus magazine, the University Hospital Frankfurt am Main ranks among the top German medical facilities! The hospital was founded in 1914 and today is a well-known German medical facility, which combines rich traditions and scientific innovations. A medical team of more than 6,500 employees cares about
Amyotrophic Lateral Sclerosis (ALS) Diagnostics
8594
Diagnosis and conservative treatment of amyotrophic lateral sclerosis (als)
14860.55

University Hospital RWTH Aachen

9.1/10
location_onGermany, Aachen

Department of Neurology

According to the prestigious Focus magazine, the University Hospital RWTH Aachen ranks among the top German hospitals! As a maximum care university medical facility, the hospital guarantees patients first-class medical services combined with a respectful and human attitude. The hospital integrates all the modern options for the
Amyotrophic Lateral Sclerosis (ALS) Diagnostics
9517.65
Diagnosis and conservative treatment of amyotrophic lateral sclerosis (als)
16762.95

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Neurology

According to Focus magazine, the University Hospital Heidelberg ranks among the top five hospitals in Germany! The hospital is one of the most advanced and reputable medical institutions not only in Germany, but throughout Europe. There are more than 43 specialized departments and 13 medical institutes, which cover all fields of
Amyotrophic Lateral Sclerosis (ALS) Diagnostics
0
Diagnosis and conservative treatment of amyotrophic lateral sclerosis (als)
0

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Neurology

According to the Focus magazine in 2019, the University Hospital Würzburg ranks among the top national German hospitals! The hospital is one of the oldest medical facilities in Germany. The centuries-old traditions of first-class treatment are combined with the very latest achievements of modern evidence-based medicine and
Amyotrophic Lateral Sclerosis (ALS) Diagnostics
8569.35
Diagnosis and conservative treatment of amyotrophic lateral sclerosis (als)
14909.85

University Hospital Erlangen

9.1/10
location_onGermany, Erlangen

Department of Neurology and Epileptology

According to the Focus magazine, University Hospital Erlangen ranks among the best medical facilities in Germany! The hospital is one of the leading healthcare facilities in Bavaria and offers top-class medical care distinguished by the close intertwining of clinical activities with research and training of medical students. The
Amyotrophic Lateral Sclerosis (ALS) Diagnostics
9029
Diagnosis and conservative treatment of amyotrophic lateral sclerosis (als)
16084.35

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of Neurology

According to the Focus magazine, the University Hospital Hamburg-Eppendorf ranks among the top ten hospitals in Germany! Since its foundation in 1889, the hospital has taken a leading position in the European medical arena and still occupies it until today. A highly competent medical team of more than 11,000 employees takes care
Amyotrophic Lateral Sclerosis (ALS) Diagnostics
11072.05
Diagnosis and conservative treatment of amyotrophic lateral sclerosis (als)
19712.25

University Hospital Marburg UKGM

8.6/10
location_onGermany, Marburg

Department of Neurology

The University Hospital Marburg UKGM offers patients modern diagnostics and comprehensive therapy at the international level. As a maximum care hospital, the medical facility specializes in all fields of modern medicine ranging from ophthalmology to traumatology and dentistry. The main areas of specialization of the hospital are
Amyotrophic Lateral Sclerosis (ALS) Diagnostics
8192.35
Diagnosis and conservative treatment of amyotrophic lateral sclerosis (als)
14089.15

University Hospital Tuebingen

9.2/10
location_onGermany, Tuebingen

Department of Neurology

According to the prestigious medical publication Focus, the University Hospital Tuebingen ranks among the top five German hospitals! The hospital was founded in 1805, therefore it is proud of its long history, unique experience, and outstanding achievements in the field of medical care, as well as research and teaching activitie
Amyotrophic Lateral Sclerosis (ALS) Diagnostics
8936.2
Diagnosis and conservative treatment of amyotrophic lateral sclerosis (als)
16223.55

University Hospital Bonn

9.2/10
location_onGermany, Bonn

Department of Neurology

According to the authoritative Focus magazine, the University Hospital Bonn ranks among the top ten medical facilities in Germany! The hospital was opened on January 1, 2001, although in fact it inherits the medical facility, which operated at the Faculty of Medicine of the University of Bonn. The hospital in Germany combin
Amyotrophic Lateral Sclerosis (ALS) Diagnostics
9542.3
Diagnosis and conservative treatment of amyotrophic lateral sclerosis (als)
16752.8
| from Booking Health GmbH

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease that affects motor neurons. Modern medicine makes it possible to slow down the development of the disease, provide the patient with the opportunity to breathe and eat independently, and eliminate most of the symptoms. German doctors use drug and non-drug methods to fight against amyotrophic lateral sclerosis and stem cells to restore and protect neurons from destruction.

Content

  1. Drug therapy
  2. Symptomatic treatment
  3. Stem cell therapy

For the treatment of ALS in Germany, medications and physiotherapy are used. Stem cells are used in specialized clinics as an innovative method for restoring damaged spinal cord neurons.

You can undergo treatment in the following clinics: Charite University Hospital Berlin, Beta Klinik Bonn, University Hospital Ulm.

Please leave your request with an indication of the diagnosis on the Booking Health website and our patient case manager will contact you on the same day. The specialist will help you select a clinic for examination and treatment, prepare a preliminary medical care program with an estimated cost of medical services, and take care of your trip to Germany. An interpreter at the clinic will accompany you, and you can contact your coordinator via messenger at any time.

Drug therapy

 

Riluzole is considered the main drug for the treatment of ALS. It has a positive effect on life expectancy and motor functions. Over the past 20 years, the results of most clinical trials of other drugs have been unpromising.

Since 2017, Edaravone has been used. It is an antioxidant developed in Japan and was originally used to treat stroke. The mechanism of beneficial effects in ALS remains unknown, but clinical trials have confirmed efficiency. The drug is effective at an early stage.

Antisense ribonucleotides are considered promising in the treatment of ALS. They are injected into the liquor (cerebrospinal fluid). As of today, these drugs are used in clinical trials.

Symptomatic treatment

 

With ALS, it is difficult for doctors to slow the progression of the disease. It is impossible to achieve a complete cure of the pathology, and therefore the main efforts of neurologists are aimed at improving the quality of life. The following methods are considered the main treatment options:

  • high-calorie foods, and in case of dysphagia (difficulty swallowing) – nutrition through a tube or gastrostomy (an opening in the anterior abdominal wall through which liquid food is injected directly into the stomach);
  • physical rehabilitation;
  • non-invasive ventilation with the use of a compact breathing device with a nasal or full-face mask;
  • invasive mechanical ventilation through a tracheostomy (hole in the neck);
  • physiotherapy, hydrotherapy and cryotherapy;
  • dopaminergic drugs to eliminate spasticity;
  • anticonvulsants;
  • botulinum toxin injections into the parotid and submandibular salivary glands to reduce salivation;
  • painkillers and antidepressants to eliminate pain.

Stem cell therapy

 

Neural stem cells originate from the neuroectoderm of embryos and are found in the embryonic, fetal, and mature nervous systems. They have the potential to differentiate into any cell type of the central nervous system. The ability of neural stem cells to integrate into the nervous system has already been proven. In addition to restoring lost nerve cells, they can also improve the functional treatment outcomes through auxiliary mechanisms: improving the trophic function of the nervous tissue and suppressing inflammatory reactions. Later it was discovered that neural stem cells protect motor neurons from destruction, thereby slowing the progression of ALS. After the injection of stem cells, a rapid, albeit temporary, functional improvement is achieved due to the activation of internal repair mechanisms in the spinal cord.

Mesenchymal stromal cells are easier to obtain, so they are used more often. They are usually taken from the patient's adipose tissue. Trials have shown that stem cells significantly slow down the progression of motor disorders and maintain the number of motor neurons. In addition, mesenchymal stem cells increase the levels of glial cell-derived neurotrophic factor (GDNF) and basic fibroblast growth factor (bFGF) in the spinal cord, providing nervous tissue trophic function, repair and protection. Stem cells can deliver neurotrophic, anti-inflammatory, and immunomodulatory molecules to the nervous system and are therefore considered a promising treatment for ALS.

Embryonic and induced pluripotent stem cells can also be used in neurology.

To date, cell therapy is not part of the standard treatment for ALS. It is used in clinical trials. The first trial started in 2009, and it continues today. Given the encouraging results, some German clinics are already offering cell therapy to their patients. 

If you want to undergo diagnostics and treatment of amyotrophic lateral sclerosis in Germany, you are welcome to visit the Booking Health website. Here you will find information about specialized clinics and real prices for diagnostics and treatment. The total cost of treatment will be decreased due to the lack of additional coefficients for foreign patients. On the Booking Health website, you can find the price of drug therapy, stem cell therapy and rehabilitation in different clinics in Germany. Please leave your request on our website, and the Booking Health specialists will select the best clinic to treat your neurological disease.

 

Authors:

The article was edited by medical experts, board certified doctors Dr. Nadezhda Ivanisova and Dr. Sergey Pashchenko. For the treatment of the conditions referred to in the article, you must consult a doctor; the information in the article is not intended for self-medication!

 

Sources:

European Academy of Neurology

Journal of Neurology, Neurosurgery and Psychiatry

Centers for Disease Control and Prevention




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