google_counter
background_img

Treatment of Thalassemia in Germany

Due to the difficulties associated with the organization of treatment in Turkey, Switzerland, South Korea and India, we are not currently processing requests to these regions.

If you are interested in treatment in Germany, please leave a request and our specialists will contact you as soon as possible.

 

Cost for treatment

Diagnosis of Thalassemia
2462.1
Allogeneic bone marrow transplantation (stem cell transplant) in thalassemia
276000
General therapeutic rehabilitation
717.22

University Hospital Mannheim

9.8/10
location_onGermany, Mannheim

Department of Hematology and Oncology

According to the reputable Focus magazine, the University Hospital Mannheim ranks among the top medical institutions of Germany, which is an undeniable confirmation of the impeccable medical care and excellent reputation of the hospital! The hospital is a high-tech modern medical institution, which provides accurate diagnosis an
Diagnosis of Thalassemia
4099.9
Allogeneic bone marrow transplantation (stem cell transplant) in thalassemia
301405.45

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Hematology, Oncology, Palliative Care, Rheumatology and Infectology

The University Hospital Ulm started its activities 35 years ago and during this time it has become one of the most prestigious medical institutions in Europe. The hospital is famous for its numerous discoveries and the world-class achievements in medicine and pharmaceuticals. The medical facility has 29 specialized departments a
Diagnosis of Thalassemia
4597.25
Allogeneic bone marrow transplantation (stem cell transplant) in thalassemia
386682.85

University Hospital Freiburg

9.7/10
location_onGermany, Freibung

Department of Hematology and Oncology

The University Hospital Freiburg is famous for its rich history and is one of the oldest and most prestigious medical facilities in Germany (one of the three best medical institutions in the country). The hospital was based on the Faculty of Medicine of the Albert Ludwig University of Freiburg, which celebrated its 550th anniver
Diagnosis of Thalassemia
4753.85
Allogeneic bone marrow transplantation (stem cell transplant) in thalassemia
415263.8

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Hematology, Oncology, Adult and Pediatric Rheumatology

According to Focus magazine, the University Hospital Heidelberg ranks among the top five hospitals in Germany! The hospital is one of the most advanced and reputable medical institutions not only in Germany, but throughout Europe. There are more than 43 specialized departments and 13 medical institutes, which cover all fields of
Diagnosis of Thalassemia
0
Allogeneic bone marrow transplantation (stem cell transplant) in thalassemia
0

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Department of Hematology, Oncology, Hemostaseology, Rheumatology and Infectology

According to the reputable Focus magazine, the University Hospital Frankfurt am Main ranks among the top German medical facilities! The hospital was founded in 1914 and today is a well-known German medical facility, which combines rich traditions and scientific innovations. A medical team of more than 6,500 employees cares about
Diagnosis of Thalassemia
4157.9
Allogeneic bone marrow transplantation (stem cell transplant) in thalassemia
358354.2

University Hospital RWTH Aachen

8.7/10
location_onGermany, Aachen

Department of Oncology and Hematology

According to the prestigious Focus magazine, the University Hospital RWTH Aachen ranks among the top German hospitals! As a maximum care university medical facility, the hospital guarantees patients first-class medical services combined with a respectful and human attitude. The hospital integrates all the modern options for the
Diagnosis of Thalassemia
4568.25
Allogeneic bone marrow transplantation (stem cell transplant) in thalassemia
415864.1

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Gastroenterology, Hematology, Oncology, Hepatology, Infectology, Rheumatology and Clinical Immunology

According to the Focus magazine in 2019, the University Hospital Würzburg ranks among the top national German hospitals! The hospital is one of the oldest medical facilities in Germany. The centuries-old traditions of first-class treatment are combined with the very latest achievements of modern evidence-based medicine and
Diagnosis of Thalassemia
3898.35
Allogeneic bone marrow transplantation (stem cell transplant) in thalassemia
329357.1

University Hospital Erlangen

9.1/10
location_onGermany, Erlangen

Department of Hematology and Oncology

According to the Focus magazine, University Hospital Erlangen ranks among the best medical facilities in Germany! The hospital is one of the leading healthcare facilities in Bavaria and offers top-class medical care distinguished by the close intertwining of clinical activities with research and training of medical students. The
Diagnosis of Thalassemia
4547.95
Allogeneic bone marrow transplantation (stem cell transplant) in thalassemia
387020.7

University Hospital Halle (Saale)

9.6/10
location_onGermany, Halle

Department of Hematology and Oncology

According to the prestigious Focus magazine, the University Hospital Halle (Saale) ranks among the top German medical facilities! The history of the hospital has more than 300 years, and during this time it managed to earn an excellent reputation not only in Germany, but throughout the world. The hospital positions itself as a s
Diagnosis of Thalassemia
3854.85
Allogeneic bone marrow transplantation (stem cell transplant) in thalassemia
330103.85

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of Hematology, Oncology and Pulmonology

According to the Focus magazine, the University Hospital Hamburg-Eppendorf ranks among the top ten hospitals in Germany! Since its foundation in 1889, the hospital has taken a leading position in the European medical arena and still occupies it until today. A highly competent medical team of more than 11,000 employees takes care
Diagnosis of Thalassemia
3859.2
Allogeneic bone marrow transplantation (stem cell transplant) in thalassemia
329428.15

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Charité Comprehensive Cancer Center

According to the authoritative Focus magazine, the Charite University Hospital Berlin occupies the first place in the rating of the top German medical facilities! The hospital is one of the largest and leading university medical complexes in Europe. The hospital in Germany provides modern diagnostics and treatment of patients, a
Diagnosis of Thalassemia
3976.65
Allogeneic bone marrow transplantation (stem cell transplant) in thalassemia
329378.85

University Hospital Bonn

9.2/10
location_onGermany, Bonn

Department of Oncology, Hematology, Rheumatology and Immunoncology

According to the authoritative Focus magazine, the University Hospital Bonn ranks among the top ten medical facilities in Germany! The hospital was opened on January 1, 2001, although in fact it inherits the medical facility, which operated at the Faculty of Medicine of the University of Bonn. The hospital in Germany combin
Diagnosis of Thalassemia
4721.95
Allogeneic bone marrow transplantation (stem cell transplant) in thalassemia
415875.7

University Hospital Giessen UKGM

9.5/10
location_onGermany, Giessen

Department of Oncology, Hematology and Palliative Care

The University Hospital Giessen UKGM positions itself as an ultramodern medical facility with outstanding quality of medical care. The hospital presents almost all areas of medicine, ranging from ophthalmology to traumatology and dentistry. The priorities of the hospital’s activities include surgery, neurosurgery, oncology
Diagnosis of Thalassemia
3905.6
Allogeneic bone marrow transplantation (stem cell transplant) in thalassemia
329797.9

University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of Oncology and Hematology

According to the Focus magazine, the University Hospital of Ludwig Maximilian University of Munich is regularly ranked among the best medical institutions in Germany! The hospital is the largest multidisciplinary medical facility, as well as a leading research and training center in Germany and Europe. The hospital is proud of i
Diagnosis of Thalassemia
4643.65
Allogeneic bone marrow transplantation (stem cell transplant) in thalassemia
415301.5

University Hospital Marburg UKGM

8.6/10
location_onGermany, Marburg

Department of Hematology, Oncology and Immunology

The University Hospital Marburg UKGM offers patients modern diagnostics and comprehensive therapy at the international level. As a maximum care hospital, the medical facility specializes in all fields of modern medicine ranging from ophthalmology to traumatology and dentistry. The main areas of specialization of the hospital are
Diagnosis of Thalassemia
3908.5
Allogeneic bone marrow transplantation (stem cell transplant) in thalassemia
329947.25

University Hospital Muenster

9.8/10
location_onGermany, Muenster

Department of Hematology, Hemostaseology, Oncology and Pulmonology

According to the Focus magazine, the University Hospital Muenster ranks among the top German hospitals! The hospital belongs to the most prestigious medical institutions in Germany. The hospital is distinguished by a high professionalism of its doctors, state-of-the-art technological equipment and the availability of the most ad
Diagnosis of Thalassemia
3969.4
Allogeneic bone marrow transplantation (stem cell transplant) in thalassemia
329867.5
| from Booking Health GmbH

Thalassemia is the most common hereditary anemia which develops due to impaired hemoglobin structure. According to the WHO, about 1,5% of the population are carriers of this disease. Hemoglobin defects lead to ineffective erythropoiesis (the maturation of red blood cells) and hemolysis (destruction of red blood cells). With a long course of the disease, an increase in the erythrocyte blood germ occurs, and extramedullary (outside the bone marrow) foci of hematopoiesis may appear.

Content

  1. Standard treatment
  2. Gene therapy
  3. Stem cell transplantation

Standard treatment involves regular blood transfusions. To completely cure the disease, donor stem cell transplantation is performed. Gene therapy can be performed as part of a clinical trial.

You can undergo treatment at the University Hospital Mannheim, the University Hospital Ulm, and the University Hospital Freiburg.

Please leave your request on the Booking Health website, and we will select the most suitable clinic and doctor for you, make an appointment, help prepare the necessary documents, and arrange flights and accommodation. During the treatment in Germany, you will be accompanied by a medical interpreter, and a personal coordinator will be constantly in touch with you.

Standard treatment

 

The standard treatment for thalassemia involves conservative therapy:

  • blood transfusions that are carried out regularly;
  • chelation therapy, which is the introduction of chelating agents to remove heavy metals (eliminates iron overload).

These treatment methods do not cure the disease but increase the life expectancy of patients. People with beta-thalassemia major can live up to 40 years. The same life expectancy is observed in the intermediate form of the disease.

However, maintenance therapy does not improve quality of life and does not cure the disease. It only helps doctors save lives and protect the patient from complications.

Splenectomy is another method of supportive treatment, but the attitude of doctors towards it is ambiguous since it is not always possible to get good results. Research data on the effectiveness of this operation are contradictory. Spleen removal is performed to reduce the need for blood transfusions and reduce iron overload, which can damage the liver, kidneys, heart, and endocrine organs. Surgeons in Germany use the laparoscopic technique for spleen removal. This operation is less traumatic as compared to conventional open surgery.

Gene therapy

 

The essence of the method is gene replacement in autologous (the patient's own) hematopoietic stem cells using viral vectors. Doctors change abnormal genes to normal ones.

Gene therapy is not yet part of standard treatment, but this innovative approach is already being used in some clinics as part of clinical trials and shows good results.

Application on small groups of patients shows that it is quite possible to achieve the production of normal hemoglobin in the body. After treatment, people no longer needed hemo transfusions (blood transfusions). Studies are currently ongoing, upon the completion of which gene therapy can be introduced into clinical practice.

Stem cell transplantation

 

So far, stem cell transplantation (bone marrow transplantation) remains the most effective treatment for thalassemia. Allogeneic (donor) transplantation provides complete recovery for the patient. The best patient survival rates are achieved in stem cell transplantation from an HLA-identical sibling (brother or sister).

Nonetheless, only 30% of patients with thalassemia have suitable donors in the family. If the patient does not have a related donor, cells are transplanted from an unrelated donor. He is selected using high-resolution HLA typing. The more matches, the better the results. The main disadvantage of this type of transplantation is the high frequency of acute and chronic graft-versus-host reactions, as well as the risk of graft rejection due to insufficient compatibility.

Modern conditioning regimes used in Germany allow for minimizing risks. The results of allogeneic transplantations are not much inferior to autologous transplantations.

The risk of complications in transplantation from the HLA-identical sibling:

  • graft rejection – 6,9%;
  • graft-versus-host reaction – 3,6%.

The risk of complications in transplantation from an unrelated donor:

  • graft rejection – 1,9%;
  • graft-versus-host reaction – 9,6%.

Overall and event-free survival of patients is comparable in these two options for stem cell transplantation.

The sources of stem cells are as follows:

  • bone marrow;
  • peripheral blood;
  • cord blood.

Studies show that the best treatment results can be achieved with the use of bone marrow. The transplantation of cells from peripheral blood is slightly inferior in efficiency. Cord blood is rarely used: studies have shown unacceptably high rates of transplant rejection. Therefore, this biomaterial can be used as stem cells only in cases where it is not possible to use the donor's blood or bone marrow.

If a suitable unrelated donor cannot be found and there is no HLA-identical sibling, haploidentical transplantation can be performed. The donor is only half matched. However, he can be found easily: in 90% of cases, a suitable person will be found among brothers, sisters, parents or second-degree relatives.

The results of such a transplantation are worse than in stem cell transplantation from the HLA-identical sibling or the compatible unrelated donor. After the procedure, acute 1-2 grade graft-versus-host reactions develop in 30% of cases; chronic reactions are common in 16% of cases, and graft rejection occurs in 16% of cases.

In Germany, significant progress has been made in stem cell transplantation from a haploidentical donor. In 2018, an international multicenter study involving 24 children was completed, in which, after haploidentical transplantation, patients were infused with donor genetically modified T lymphocytes – inducible caspase 9. The drug was used to prevent bone marrow rejection, and the risk was almost halved. In addition, no cases of grade 3-4 graft-versus-host disease were reported, and only 13% of patients developed grade 1 reactions. Thus, in terms of efficacy and safety, haploidentical transplantation approaches bone marrow transplantation from compatible unrelated donors or HLA-identical siblings.

To undergo thalassemia diagnostics and thalassemia treatment in Germany, you are welcome to use the services of the Booking Health company. On our website, you can find out the cost of medical services. You can compare how much is the price for treatment in different clinics in Germany to book a medical care program at favorable prices. The specialists of the Booking Health company will help you choose the most suitable clinic and organize your trip.

 

Authors: 

The article was edited by medical experts, board certified doctors Dr. Nadezhda Ivanisova and Dr. Sergey Pashchenko. For the treatment of the conditions referred to in the article, you must consult a doctor; the information in the article is not intended for self-medication!

 

Sources:

National Center for Biotechnology

NORD - National Organization for Rare Disorders

Healthline




Feedback of our customers from other resources

Need Help?

Thank you!

We received your treatment application in the best Europe clinics. Our manager will contact you within the next 24 hours.