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Treatment of neuroendocrine tumor (NET) of the stomach with Lutetium-177-DOTATATE (691056) | University Hospital Essen - BookingHealth
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After that, you will undergo the necessary additional tests such as the assessment of liver and kidney function, scintigraphy of the skeleton and salivary glands, somatostatin receptor imaging with&nbsp;Ga-68 DOTATATE PET\/CT. This will allow the doctor to assess how effective the radionuclide therapy with Lutetium-177-DOTATATE will be and how well you will tolerate it. Also, the doctor will calculate your individual dosage of the radionuclide.<\/p>\n\n<p style=\"text-align:justify\"><strong>Radionuclide therapy with Lutetium-177-DOTATATE<\/strong>&nbsp;is carried out via intravenous administration of a solution with the radioactive isotope Lutetium-177-DOTATATE. The solution is injected through a catheter. 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This is a short procedure, as the infusion usually takes no more than 20 minutes.<\/p>\n\n<p style=\"text-align:justify\">During the procedure, you will need to apply cooling bags to the salivary glands, as Lutetium-177-DOTATATE partially accumulates in the salivary glands, affecting their function and causing dry mouth. You will also receive intravenous saline solutions and amino acid solutions to protect your kidneys.<\/p>\n\n<p style=\"text-align:justify\">After the infusion of Lutetium-177-DOTATATE, you will stay in a specially equipped (radiation-shielded) ward for 48 hours. The drug is quickly excreted by the kidneys, and after 48 hours you will no longer be dangerous to others. 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Treatment of neuroendocrine tumor (NET) of the stomach with Lutetium-177-DOTATATE

University Hospital Essen

Essen, Germany
Program id # 691056
Doctor photo
Prof. Dr. med. Ken Herrmann
Department of Nuclear Medicine
Specialized in: nuclear medicine

The program includes:

  • Initial presentation in the hospital
  • Clinical history taking
  • Physical examination
  • Laboratory tests:
    • complete blood count
    • biochemical analysis of blood
    • TSH, free T3, free T4
    • indicators of inflammation
    • coagulation tests
  • Renal scintigraphy
  • Ga-68 DOTATATE PET/CT (if indicated)
  • Lutetium-177-DOTATATE treatment
  • Full body scintigraphy after 24 hours
  • Full body scintigraphy after 48 hours
  • Symptomatic treatment
  • Cost of essential medicines
  • Nursing services
  • Stay in the hospital with full board
  • Accommodation in 2-bedded room
  • Elaboration of further recommendations

How program is carried out

During the first visit, the doctor will carry out a general physical examination and go through the results of previous laboratory and instrumental tests. After that, you will undergo the necessary additional tests such as the assessment of liver and kidney function, scintigraphy of the skeleton and salivary glands, somatostatin receptor imaging with Ga-68 DOTATATE PET/CT. This will allow the doctor to assess how effective the radionuclide therapy with Lutetium-177-DOTATATE will be and how well you will tolerate it. Also, the doctor will calculate your individual dosage of the radionuclide.

Radionuclide therapy with Lutetium-177-DOTATATE is carried out via intravenous administration of a solution with the radioactive isotope Lutetium-177-DOTATATE. The solution is injected through a catheter. This is a short procedure, as the infusion usually takes no more than 20 minutes.

During the procedure, you will need to apply cooling bags to the salivary glands, as Lutetium-177-DOTATATE partially accumulates in the salivary glands, affecting their function and causing dry mouth. You will also receive intravenous saline solutions and amino acid solutions to protect your kidneys.

After the infusion of Lutetium-177-DOTATATE, you will stay in a specially equipped (radiation-shielded) ward for 48 hours. The drug is quickly excreted by the kidneys, and after 48 hours you will no longer be dangerous to others. During these 48 hours, you can read, use a mobile phone, tablet or computer – all these devices will not be a source of radiation in the future.

Follow-up examinations include whole-body scintigraphy or computed tomography in 24 hours and 48 hours after the procedure. Based on the results of the examination, the doctor will determine whether one procedure is enough for you, or whether you will need to visit the hospital again. As a rule, 1-2 procedures are required for achieving a stable positive result. Procedures are carried out with an interval of 8 weeks.

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About the department

The Department of Nuclear Medicine at the University Hospital Essen offers the full range of radioisotope diagnostics and treatment. Of particular interest is the detection and treatment of thyroid diseases, endocrine tumors. The department also specializes in radioiodine therapy for the treatment of thyroid diseases, radionuclide therapy for bone metastases, MIBG therapy for the treatment of neuroblastomas, malignant pheochromocytes and many other therapies. In addition, the department operates its own Radiopharmaceutical Section, which produces radiopharmaceuticals for two positron emission tomography (PET) scanners. The department is headed by Prof. Dr. med. Ken Herrmann.

The diagnostic and therapeutic service range of the department includes:

  • Diagnostic examinations
    • Thyroid gland diagnostics
      • Ultrasound examinations of the thyroid gland (high resolution)
      • Thyroid scintigraphy
      • Fine needle aspiration biopsy
      • Laboratory tests
    • PET and PET-CT cancer diagnostics
    • Kidney scintigraphy
    • Lung scintigraphy
    • Heart diagnostics
      • Myocardial scintigraphy
      • Heart scintigraphy
      • 18F-FDG-PET  
    • Skeletal scintigraphy
    • Gastrointestinal diagnostics
      • Salivary gland scintigraphy
      • Esophageal scintigraphy
  • Treatment methods
    • Radioiodine therapy for the treatment of thyroid hyperfunction, diffuse goiter, thyroid malignant tumors
    • DOTATOC therapy for the treatment of neuroendocrine tumors
    • Lu-177 PSMA therapy for the treatment of metastatic prostate cancer
    • MIBG therapy for the treatment of neuroendocrine tumors, for example, malignant pheochromocytoma and neuroblastoma, neuroendocrine tumors of the digestive tract and other rare tumors, such as medullary thyroid carcinoma
    • Selective internal radiation therapy (SIRT) with 90Y microspheres for the treatment of hepatocellular carcinoma, liver metastases in breast cancer, neuroendocrine tumors and colorectal cancer
    • Intracavitary therapy with citrate colloid (90Y) in recurrent malignant ascites
    • Zevalin therapy (90Y), for example, for the treatment of CD20 positive non-Hodgkin's lymphoma
    • Radionuclide pain therapy in bone metastases
  • Other diagnostic and therapeutic options

Curriculum vitae

Professional Activities

  • 1997 - 2004 Study of Medicine at the Charite Medical School in Berlin.
  • Internships in France, Switzerland, Chile and USA.
  • 2009 - 2011 Magistracy in Business Administration at the University of Zurich (without leaving the main activities).
  • Training for a Medical Specialist at the University Hospital Rechts der Isar Munich at the Technical University of Munich.
  • 2011 - 2015 Visiting Assistant Professor at the University of California, Los Angeles.
  • 2012 - 2016 Managing Senior Physician and Deputy Head of the Department of Nuclear Medicine at the University Hospital Würzburg.
  • 2015 - 2016 Assistant Professor and Head of the Ahmanson Translational Imaging Division at the University of California, Los Angeles.
  • Since 2016 to the present time, Associate Professor at the University of California in Los Angeles.
  • Since 2016 Head of the Department of Nuclear Medicine at the University Hospital Essen.

Clinical Focuses

  • Diagnostics and treatment of thyroid diseases (especially cancer).
  • Diagnostics and treatment of other endocrine tumors (Ga-68 Dotatoc therapy, I-124 MIBG therapy).
  • Diagnostics (Ga-68 PSMA-PET/CT) and prostate cancer therapy (Lu-177 PSMA therapy).
  • Selective intraarterial radionuclide therapy (SIRT) in liver tumors.
  • PET Center with two PET/CT and one PET/MRI.

Research Focuses

  • Development and application of new radiopharmaceuticals.
  • Diagnostics and treatment of thyroid cancer.
  • Diagnostics and treatment of endocrine tumors.
  • Diagnostics and treatment of prostate cancer.
  • Clinical use, optimization of PET, PET/CT.

Membership in Professional Societies

  • Member of the European Association of Nuclear Medicine (EANM).
  • Member of the Imaging Group, European Organisation for the Research and Treatment of Cancer (EORTC).
  • DRG Committee Member, German Society of Nuclear Medicine.

Photo of the doctor: (c) Universitätsklinikum Essen 


About hospital

According to the authoritative Focus magazine the University Hospital Essen ranks among the top German hospitals!

With 27 specialized departments and 24 institutes, the hospital in Germany is a maximum care medical facility. The hospital has 1,300 beds for inpatient treatment. A highly qualified medical team of more than 6,000 employees takes care of the health of patients. All the specialists give preference to an interdisciplinary medical care, which guarantees a comprehensive treatment taking into account the smallest aspects of a particular pathology. The hospital annually diagnoses and treats more than 50,000 inpatients and about 195,000 outpatients, which testifies to the prestige of the medical institution and the highest quality of treatment in Germany.

The hospital presents all the modern medical fields. Nevertheless, special attention should be given to the following major fields of specialization as oncology, transplantology and cardiology, as well as research activities in the field of immunology, infectology and translational examinations of pathologies of the nervous system and behavioral disorders.

Established on the basis of the standard American model of Comprehensive Cancer Centers, the West German Cancer Center (WTZ) in Essen was recognized as the best medical facility of this kind in Germany in 2009. Nowadays, the center holds leading positions both on the national and international medical markets. The basis of its successful clinical practice is the use of very latest treatment methods and an interdisciplinary approach to each clinical case. The West German Organ Transplant Centre (WZO) is also recognized as one of the best in the country and one of the few in Germany, which specializes in the transplantation of all vital organs, such as kidney, liver, pancreas, heart and lungs. Special attention is paid to kidney and liver transplantation.

The hospital in Germany is proud of its high-tech medical equipment, experienced and competent staff, productive research activities, which allow to guarantee the accurate diagnostics and effective treatment, including rare and very complex clinical cases for every patient. Consequently, the hospital is considered a perfect embodiment of high-quality treatment in Germany.

Photo: (c) depositphotos

Accommodation in hospital

Patients rooms

The patients of the University Hospital Essen live in comfortable rooms designed in bright colors. The standard room furnishing includes an automatically adjustable bed, a bedside table, a personal wardrobe, a personal call button with a built-in light panel, a telephone, a TV and a radio. The Internet access is available at an additional cost.

Meals and Menus

The patients of the hospital are offered a daily choice of three menus. The patients are also offered alternative types of menus, if their religion requires the exclusion of certain foods. If you follow a certain diet or suffer from food intolerance, you will be provided with a menu of your choice by discussing it with your attending physician in advance. The hospital also houses a bistro and a cafe, where one can have a tasty snack, enjoy hot and cold drinks.

Further details

Standard rooms include:

Toilet
Shower
TV

Accompanying person

There are a few types of hotels for the accompanying persons, who want to stay near the hospital. The hotel of the Essen University Hospital offers apartments on the first floor of the nursing high-rise building. The DRK nursing also offers single and double rooms.

The hotel in Grugapark is available for the parents, whose children stay in the hospital. The parents of children with cancer can also stay here. Moreover, The Department of Pediatrics offers its rooms for parents.