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Diagnosis and Stereotactic Biopsy for Glioblastoma (brain Cancer) in the Best Hospitals in the World

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Department of Adult and Pediatric Neurosurgery

The Department of Adult and Pediatric Neurosurgery offers the full range of accurate diagnostics and surgical treatment of diseases of the central and peripheral nervous system. The department's surgeons annually perform over 5,000 surgical interventions, which indicates their high professionalism and tremendous experience. The key attention is paid to the treatment of cerebrovascular diseases, diseases of the spine and spinal cord, brain and skull base tumors, peripheral nerve lesions, cerebrospinal fluid circulation disorders, as well as pain therapy (functional neurosurgery). The treatment of neurosurgical diseases in children and adolescents is carried out by a specially trained team of experts.

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Memorial Bahcelievler Hospital Istanbul

9.2/10
location_onTurkey, Istanbul

Department of Adult and Pediatric Neurosurgery

The Department of Adult and Pediatric Neurosurgery offers the full range of surgical treatment of diseases of the nervous system according to the highest international standards. The department's doctors specialize in the surgical treatment of pathologies of the brain and spinal cord, as well as diseases of the peripheral nerves. The department's medical team provides its services to patients of all age categories – from young children to the elderly. The department has high-tech operating rooms, where endoscopic and microsurgical interventions are successfully performed, ensuring the fastest recovery and excellent treatment results. For maximum safety of surgical treatment, the doctors widely use in their clinical practice cutting-edge neuromonitoring and neuronavigation systems, intraoperative CT O-Arm, intraoperative ultrasonography and other technologies.

University Hospital HM Monteprincipe Madrid

9/10
location_onSpain, Madrid

Department of Neurosurgery

The Department of Neurosurgery offers the full range of modern surgical treatment of diseases of the nervous system. The department's neurosurgeons have rich experience and technical options for both simple routine and especially complex interventions on the brain and spinal cord. To achieve the best treatment results, there is maintained productive cooperation with the specialists in oncology, neurology and interventional neuroradiology. The state-of-art navigation systems and computer equipment available in the department allow the surgeons to perform the most accurate manipulations, while preserving healthy tissues and vital functions of the nervous system.

University Hospital for Neurosurgery Salzburg

9.6/10
location_onAustria, Salzburg

Department of Neurosurgery

University Clinic of Neurology specializes in the surgical treatment of acute and chronic diseases of the central and peripheral nervous system, its blood supply, and nerve sheaths, as well as in preoperative and postoperative care for patients.

University Hospital Freiburg

9.7/10
location_onGermany, Freibung

Department of Adult and Pediatric Neurosurgery

The Department of Adult and Pediatric Neurosurgery offers the full range of surgical treatment of diseases of the brain, spine, spinal cord and nerves in adults and children. The department keeps pace with new trends in medicine, as well as contributes significantly to their development. Therefore, the most modern diagnostic and therapeutic methods are available here. An individual approach to each clinical case is crucial to ensure optimal treatment results with the preservation of all neurological functions.

Tel Aviv Sourasky Medical Center

9.9/10
location_onIsrael, Tel Aviv

Department of Neurosurgery

The Department of Neurosurgery offers the widest range of diagnostic examinations and therapeutic methods for patients with diseases of the brain, spinal cord and peripheral nervous system. The department is considered the leading Neurosurgical Center in Israel and around the world.When treating patients, the doctors apply all available medical innovations and adhere to the highest international standards.

Primus Super Speciality Hospital New Delhi

9/10
location_onIndia, New Delhi

Department of Adult and Pediatric Neurosurgery, Neurology

The Department of Adult and Pediatric Neurosurgery, Neurology offers the comprehensive diagnostics, conservative and surgical treatment of diseases of the nervous system. The tasks of the department's doctors also include rehabilitation of patients with neurological pathologies. Thanks to the modern infrastructure and the progressive equipment of the department, most operations can be performed using sparing minimally invasive techniques. In addition, the surgical treatment involves the use of neuromonitoring systems, which increases the safety of interventions in functionally important areas of the brain.

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Department of Adult and Pediatric Neurosurgery

According to the Focus magazine, the Department of Adult and Pediatric Neurosurgery ranks among the top German medical facilities specializing in the surgical treatment of brain tumors! The department offers the full range of diagnostics and surgical treatment of diseases of the central and peripheral nervous system. A specially trained team of pediatric neurosurgeons provides treatment for various neurosurgical pathologies in children. During the treatment, the doctors use state-of-the-art equipment, in particular, imaging-guided neuronavigation, functional imaging (fMRI), intraoperative mapping, intraoperative videoangiography, etc.

University Hospital Erlangen

9.1/10
location_onGermany, Erlangen

Department of Adult and Pediatric Neurosurgery

The Department of Adult and Pediatric Neurosurgery offers the accurate diagnostics and effective treatment of the entire spectrum of neurosurgical diseases, injuries, inflammations, tumors and malformations of the brain, spinal cord and their meninges, as well as the spine. As one of the largest medical facilities of its kind in Germany, the department performs more than 2,500 surgical interventions every year. The department has 78 beds, including 14 beds in the intensive care unit. The priority goal of the specialists is to provide patient-oriented, high-quality medical care, as well as the study of neurosurgical diseases, the development of new therapeutic methods and the training of medical students.

University Hospital Carl Gustav Carus Dresden

9.1/10
location_onGermany, Dresden

Department of Adult and Pediatric Neurosurgery

The Department of Adult and Pediatric Neurosurgery offers the full range of diagnostics and surgical treatment of diseases of the brain, spinal cord and peripheral nerves at the highest international level of modern medicine. The department has at its disposal three high-tech operating rooms, in which more than 2,000 surgical interventions are performed annually. Of particular interest of the department’s specialists is surgery of tumors of the nervous system in childhood and adulthood. The department has at its command the advanced surgical techniques, for example, navigation surgery, intraoperative neuromonitoring, hybrid surgical techniques that are the basis of the department’s successful clinical practice.

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of Adult and Pediatric Neurosurgery

The Department of Adult and Pediatric Neurosurgery offers the diagnostics and comprehensive treatment of neurosurgical pathologies, including tumors of the central and peripheral nervous system. The department is the leading Center of Neurosurgery in Northern Germany and is responsible for the implementation of new algorithms for the treatment of patients with brain tumors. To this end, there is an active participation in the international researches and the development of new surgical methods, for example, operations in the waking state. Close interdisciplinary cooperation also contributes to the achievement of optimal treatment results.

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Neurosurgery

The Department of Neurosurgery offers the full range of surgical interventions for the treatment of diseases of the central and peripheral nervous system. The department is one of the largest medical institutions of this kind in Germany. The doctors of the department provide patients with the high-quality medical care of university level, and also take an active part in the experimental fundamental studies and clinical trials to develop new treatment methods.

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Adult and Pediatric Neurosurgery

The Department of Adult and Pediatric Neurosurgery offers the diagnostics and treatment of the entire spectrum of neurosurgical diseases. The department specializes in the treatment of brain tumors, vascular diseases and intracerebral hemorrhages, spinal diseases, deep brain stimulation, etc. Special competence lies in the field of pediatric neurosurgery. The department offers the very latest highly accurate and minimally invasive treatment methods.

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Adult and Pediatric Neurosurgery

The Department of Adult and Pediatric Neurosurgery offers the full range of diagnostics and treatment of diseases of the central and peripheral nervous system. The medical institution occupies a leading position in this sector in Europe. The neurosurgeons of the department have at their disposal four high-tech operating rooms, in which more than 3,500 interventions are performed annually. Active clinical and experimental research activities, as well as close cooperation with national and international reputable research centers, promote the introduction of innovative treatment techniques that are available only in a few clinics in the world.

University Hospital Bonn

9.2/10
location_onGermany, Bonn

Department of Neurosurgery

The Department of Neurosurgery offers the full range of surgical treatment of diseases of the nervous system and belongs to the largest medical facilities of this kind at the national level. The department has 4 state-of-art operating rooms where more than 2,700 interventions are performed annually. It has the progressive surgical equipment, for example, intraoperative monitoring, neuronavigation, tools for performing minimally invasive operations, which provide the most effective and reliable therapy. The department has earned the reputation of the Center of Competence in the field of tumor surgery of the nervous system and spine.

University Hospital Essen

9.6/10
location_onGermany, Essen

Department of Adult and Pediatric Neurosurgery

The Department of Adult and Pediatric Neurosurgery offers the widest range of surgical interventions for the treatment of diseases of the central and peripheral nervous system, including stereotactic surgery and endoscopy. With more than 2,400 operations every year, the department has a unique experience, which allows it to provide the high-quality medical care even in extremely complex clinical cases. The key focus of the department is pediatric neurosurgery. In addition to the high professionalism of doctors, the treatment success is facilitated by exclusively advanced medical equipment, for example, neuronavigation systems and intraoperative fluorescence navigation.

The statistics demonstrates the constant growth of oncological pathology in recent years. The same is observed with brain tumors, which require specific measures for the precise diagnosis making.

First symptoms

The first symptoms of the tumor in the central nervous system do not give a clear picture, as they are very similar to the symptoms of many other types of brain cancer.

If general symptoms of brain tumors are manifested due to damage of the entire central nervous system and affect the general well-being, then glioblastoma symptoms depend on the lesion area.

Each part of the brain is responsible for certain functions. Depending on the location of the tumor, various brain regions are affected. Therefore, the diagnosis can cause various symptoms.

Symptoms can indicate where the tumor is located within the brain. Paralysis and convulsions are characteristic of tumor in the frontal lobes; loss of vision and hallucinations indicate the tumor in the occipital one. An affected cerebellum will result in coordination disorders, while a tumor in the temporal lobe will lead to hearing loss and memory loss.

Typical symptoms of tumor presence in the central nervous system are:

  • Headache. Headache is the most frequent and early symptom of a brain tumor.
  • Vomiting. Vomiting is also a typical symptom of the diagnosis and often occurs in the morning.
  • Dizziness. Usually, this symptom appears at the advanced stages of brain cancer.
  • Mental disorders. Clear consciousness, memory, thinking, perception, and ability to concentrate are usually impaired.
  • Vision impairment

The speed and intensity of the development of the symptoms depend on the location of the tumor and the characteristics of its growth. Tumors can press on some parts of the brain, which leads to a clear manifestation of symptoms.

In the presence of at least a few of the listed symptoms, it is necessary to start a treatment.

Diagnostics

Glioblastoma is the most aggressive form of primary brain tumors, among other tumors of the central nervous system. For a long time, doctors have tried to develop new treatments for glioblastoma diagnosis, but only recently progress has been made.

Conventional imaging techniques, such as magnetic resonance imaging (MRI) and computed tomography (CT), cannot illustrate what is happening in the brain and inside a tumor effectively enough.

An imaging technique that is used to evaluate how patients with glioblastoma respond to therapy is magnetic resonance spectroscopy. Unlike standard MRI, which only sees structural features of the tumor, magnetic resonance spectroscopy can identify the changes in the tumor that indicate how quickly the tumor grows.

MRI is the most widely used technique for detecting brain tumors. However, conventional MRI is not able to detect changes in cell density, cell type transformation, or biochemical composition of the tumor. All of this can be detected with magnetic resonance spectroscopy.

Besides, the tumors of different physiology often look the same on MRI. Therefore, MRI and magnetic resonance spectroscopy are complementary methods in diagnosis, monitoring of diagnosis progression, and response to therapy.

The ability to provide early non-invasive detection of diagnosis is highly valued by both patients and doctors. Hence, the number of hospitals that include magnetic resonance spectroscopy into their clinical practice is growing constantly.

Unlike the conventional MRI imaging, which scans the entire brain, magnetic resonance spectroscopy works like a virtual biopsy and allows clinicians to assess the peculiarities of the targeted tumor.

There’s also a positron emission tomography, which is a modern, highly sensitive method of diagnostics. This examination helps to determine the presence of cancerous tissues after surgery, identify cancer recurrence, cancer metastasis to bone tissues and other organs. Positron emission tomography and computed tomography include dual imaging with the use of positron emission tomography and computed tomography equipment.

Stereotactic biopsy

Despite all the information on innovative scanning methods, the basis for making an accurate diagnosis can only be information from the study of tumor cells under a microscope. Material for such analysis is obtained with the help of biopsy.

If the tumor is located in the brain, performing the manipulation is fraught with certain difficulties. A stereotactic biopsy allows solving this problem. The essence of the method is to elaborate a safe access scheme to a target area based on coordinates calculated from the results of prior scanning.

Stereotactic biopsy has been used for a long time and is the main method for obtaining clear and reliable results that contribute to surgery success.

The use of this technique allows doctors to obtain biopsy material with guaranteed accuracy and maximum comfort for the patient, minimizing the risk of complications development.

A stereotactic biopsy can be performed in the form of a biopsy with a stereotaxic frame or biopsy with the use of a navigation system.

  • Biopsy with stereotaxic frame.

Biopsy with the use of stereotaxic frame (frame-based) is a traditional procedure with high accuracy rate.

Before conducting a biopsy in the clinic, a patient undergoes magnetic resonance imaging with contrast enhancement. Planning of the access point, the trajectory of the instruments introduction, and the target of the biopsy is performed.

The first stage of the biopsy is the installation and fastening of the main ring with special screws, while the patient is under local anesthesia. A localizer with markers is put on the ring and the patient is sent for a scan.

At the workstation, the neurosurgeon compares the obtained information with the results of MRI. The computer analysis of the images is performed immediately, and as a result, the coordinates of the target point are obtained. The patient is transported to the operating room for a stereotaxic procedure.

According to the obtained results, the neurosurgeon makes a small incision. Through it, along a pre-calculated path, a biopsy needle is inserted and the material is harvested.

  • Biopsy with the use of a navigation system.

Biopsy with the use of a navigation system without a stereotaxic frame (frameless) takes less time and is more convenient for the patient and the neurosurgeon.

After MRI, the information is transferred to the navigation system. The technique makes it possible to establish the position of the entry point, the site for the biopsy, and the trajectory of the biopsy instrument moving.

In the operating room, under general or local anesthesia, the neurosurgeon touches the patient with a special pointer, and the computer shows the desired point. The tissue is harvested through the hole, using a biopsy needle.

Thanks to modern techniques in the field of brain surgery, stereotactic biopsy has become an outpatient procedure, which is mainly performed under local anesthesia with maximum comfort for the patient. In the absence of complications, a patient is discharged from the hospital on the next day, after performing the control computed tomography scan.

Previously, any intervention on the brain, that included biopsy and surgery, was accompanied by a huge risk of damage to important structures of the brain that are responsible for movement, coordination, sensory perception, etc. Nowadays, practically all surgery types are performed using the stereotactic method. 

Goals of stereotactic biopsy:

  • To clarify the histological structure of a hard-to-reach tumor before surgery
  • To assess the affected brain structures before surgery
  • To drain abscesses of the brain
  • To drain the ventricles of the brain (in cases of occlusive hydrocephalus and hemorrhagic stroke)

What are the risks?

The biggest risk is bleeding in the tumor and the brain due to the damage of the biopsy needle. The risk of bleeding from a biopsy is around 5%, and the risk of mortality is up to 1%. Additional risks can include headaches on the biopsy site, infections, and seizures.

To minimize risks, the patient's medical condition is assessed and improved after stereotactic biopsy or before beginning stereotactic surgery. Intraoperative antibiotics can prevent bleeding before surgery. It is also beneficial to keep the patient overnight in the hospital, for observation before stereotactic surgery.

Cost of treatment of glioblastoma in the best hospitals in the world

The cost of treatment of glioblastoma in the best-rated hospitals on the Booking Health website is relatively low. You can save up to 40% of the standard hospital prices for foreigners by booking the medical program here.

With Booking Health, you can undergo the treatment of glioblastoma at an affordable price. The cost of treatment varies in different countries, as the prices depend on the hospitals, the diagnosis, and the complexity of treatment. The cost of treatment with stereotactic biopsy abroad goes as follows:

  1. Germany – from 15,140 EUR to 25,601 EUR
  2. Austria – approximately 17,500 EUR
  3. Turkey – approximately 8,300 EUR
  4. Spain – approximately 8,200 EUR
  5. India – approximately 6,100 EUR

You can visit the Booking Health website to find out the exact price for the desired treatment.

Where can I undergo the treatment of glioblastoma?

The best hospitals for the treatment of glioblastoma are as follows:

  1. University Hospital Bergmannsheil Bochum, Germany
  2. Charite University Hospital Berlin, Germany
  3. University Hospital HM Monteprincipe Madrid, Spain
  4. University Hospital for Neurosurgery Salzburg, Austria
  5. University Hospital Freiburg, Germany

You can check out the full list of hospitals on the Booking Health website.

How can I undergo glioblastoma treatment abroad?

Organizing the treatment of glioblastoma abroad by oneself can be challenging. It is safer, easier, and less stressful to shift some responsibility onto a medical tourism agency that will support you throughout your journey.

We represent the best hospitals in the world, and you can choose which one is right for you. Clinicians of the best hospitals will do everything to make the treatment as comfortable and effective as possible.

If you want to get more information on hospitals, the cost of treatment with surgery, or the cost of diagnostics with biopsy, please leave a request on the Booking Health website. We will contact you as soon as possible, and answer all your questions.

The cost of Glioblastoma (brain cancer) | Diagnosis and Stereotactic biopsy diagnostics starts from 17269.
To apply for Glioblastoma (brain cancer) | Diagnosis and Stereotactic biopsy diagnostics of you can submit your request at BookingHealth.



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