Allogeneic bone marrow transplantation in myelofibrosis (program ID: 76381)

University Hospital Frankfurt am Main

location_on Frankfurt am Main, Germany
10/10 from 97 Votes
Specialized hospital
Hubert Serve

Head Physician
Prof. Dr. med.

Hubert Serve

Specialized in: hematology, oncology, hemostaseology, rheumatology, infectology

Department of Hematology, Oncology, Hemostaseology, Rheumatology and Infectology

Program includes:

  • Initial presentation in the clinic
  • case history collection
  • general clinical examination
  • laboratory tests:
    • complete blood count
    • biochemical analysis of blood
    • TSH-basal, fT3, fT4
    • differential blood count
    • inflammation indicators (CRP, ESR)
    • indicators of blood coagulation
  • CT/MRI scans of the whole body
  • needle biopsy of the bone marrow
  • biopsy and histological examination of CSF
  • examination by experts of:
    • cardiology
    • otolaryngology
    • immunology
    • ophthalmology
  • registration in the European bone marrow donor base
  • conducting high-dose chemotherapy
  • allogeneic bone marrow transplantation from
    unrelated donor
  • the cost of blood products
  • isolation by neutropenic precautions
  • symptomatic treatment
  • control examinations
  • the cost of essential medicines and materials
  • nursing services
  • full hospital accommodation
  • explanation of future recommendations

How program is carried out

During the first visit, the doctor will conduct a clinical examination and go through the results of the available diagnostic tests. After that, you will undergo the necessary additional examination, such as the assessment of liver and kidney function, ultrasound scan, CT scan and MRI.

Also, the doctor will conduct a bone marrow biopsy followed by cytological examination of the harvested material. This will help him to determine the histological features of your bone marrow (in particular, identify HLA system antigens) and select a suitable donor. The donor can be a family member or a person from the bone marrow registry. In the second case, the donor material is stored in a bone marrow bank.

Before the procedure, you will receive chemotherapy, if necessary in combination with radiation therapy. The course of chemo- or chemoradiation therapy lasts from 2 to 8 days.

The bone marrow transplant procedure is an intravenous infusion, i.e. the healthy bone marrow will be injected through a catheter, intravenously. You will stay in your room during the procedure. A bone marrow transplant is completely painless and does not require anesthesia.

During the period of healthy bone marrow engraftment, you will stay in a sterile ward. This is a necessary precaution because during this time your immune system is very weak and cannot withstand environmental pathogens. The risk of bleeding is also quite high, so you will be advised to avoid mechanical damage.

A relative or other close person may stay in the ward with you. You will not be allowed to go outside the department and leave your ward often. The rehabilitation period can last from 1 to 2 months.

When your complete blood count returns to normal, your doctor will schedule your discharge from the department. You will receive information about the rules that you will need to follow at home, the frequency and type of control examinations, and subsequent treatment measures. You will also receive a detailed medical report, which will reflect the entire course of treatment.

Required documents

  • Medical records
  • Bone marrow biopsy results (if available)
Type of program :
Expected duration of the program:

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About the department

The Department of Hematology, Oncology, Hemostaseology, Rheumatology and Infectology at the University Hospital Frankfurt am Main offers the full range of medical services in the fields of its specialization. The department specializes in the diagnostics and treatment of all diseases of the hematopoietic system, systemic treatment of solid tumors, infectious diseases, including outpatient admission of patients with HIV, blood clotting disorders, as well as the entire clinical and morphological group of rheumatic diseases. The department is actively engaged in research activities and regularly implements the latest medical developments into clinical practice, thereby providing treatment in accordance with the most advanced scientific achievements. The department is headed by Prof. Dr. med. Hubert Serve.

In the field of hematology and oncology, special attention is paid to the diagnostics and treatment of acute and chronic leukemia, malignant lymphoma, as well as the treatment of such solid tumors as lung cancer, gastrointestinal tumors, renal cell carcinoma, as well as soft tissue and bone sarcoma. The department includes the Transplant Center, which offers stem cell and bone marrow transplantations. With an annual number of 80-100 transplantations, the department is one of the leading centers of this kind in Germany. It transplants both autologous (patient’s own) and allogeneic (donor) stem cells. In order to provide medical services in accordance with the latest medical achievements, the department actively cooperates with the University Cancer Center Frankfurt.

Among a wide range of rheumatic diseases, the focus is on inflammatory systemic diseases. These include rheumatoid arthritis, reactive arthritis, spondyloarthropathies (for example, Bechterew's disease, psoriatic arthritis), gouty arthritis, hemochromatosis, systemic collagenoses (for example, systemic lupus erythematosus, polymyositis, dermatomyositis, systemic scleroderma), vasculitis, and Behcet's disease, etc. The patients are offered the very latest diagnostic and therapeutic options, including low-field MRI, joint puncture, monoclonal antibody therapy and innovative therapies within the clinical trials.

All pathologies of the hematopoietic system are treated within the specialized Hemostaseology/Hemophilia Center. This center has long experience in comprehensive diagnostics, therapy and counseling of patients with such diseases of the hematopoietic system as hemophilia, von Willebrand-Jürgens syndrome, rare blood clotting disorders, etc.

The department’s medical service range is complemented by infectology. It successfully treats all severe, complex and unspecified infectious diseases caused by bacteria, fungi or viruses. The department's specialists have particular competence in the treatment of tropical diseases, infectious complications of immunosuppression, bacteremia and endocarditis, infections with resistant pathogens, fever of unknown origin, all stages of HIV infection, etc.

The diagnostic and therapeutic options of the department include:

  • Hematological and oncological pathologies
    • Acute lymphocytic leukemia
    • Acute myeloid leukemia
    • Chronic lymphocytic leukemia
    • Chronic myeloid leukemia
    • Chronic myeloproliferative diseases
    • Myelodysplastic syndrome
    • Multiple myeloma
    • Hodgkin's disease
    • Non-Hodgkin's lymphoma
    • Bronchogenic carcinoma
    • Renal cell carcinoma
    • Pancreatic cancer
    • Sarcomas
    • Other solid tumors
    • Special therapeutic options
      • Inpatient / outpatient chemotherapy
      • Allogeneic stem cell transplantation from a related or unrelated donor
      • Autologous stem cell transplantation
      • Immunotherapy
      • Molecular types of therapy with targeted effect on the tumor cells
      • Phase I-II clinical trials for the development of innovative medicines
  • Rheumatic diseases
    • Rheumatoid arthritis
    • Psoriatic arthritis
    • Systemic scleroderma
    • Spondyloarthropathies (for example, ankylosing spondylitis)
    • Collagenoses (for example, systemic lupus erythematosus)
    • Vasculitis
    • Special therapeutic options
      • Autoimmune diagnostics
      • Arthrosonography (ultrasound examination of the joints)
      • Low-field MRI
      • Joint puncture 
      • Monoclonal antibody therapy
  • Infectology
    • Tropical diseases
    • Infectious complications in immunosuppression
    • Bacteremias and endocarditis
    • Infections with resistant pathogens
    • Fever of unclear genesis
    • Tuberculosis and atypical mycobacterioses
    • All stages of HIV infection
    • Diseases, which require the isolation of patient, such as Lassa fever
    • Pandemic infections
    • Complex surgical infections
    • Special therapeutic options
      • Treatment of chronic and acute, local and systemic infectious diseases
      • Chemotherapy and preparation for bone marrow transplantation in patients with HIV infection and malignant lymphomas
      • Counseling of HIV-infected pregnant women
      • Comprehensive treatment of patients with comorbid pathology (hepatitis, HIV and other infectious and concomitant diseases)
      • Diagnostics and treatment of fever of unknown origin
      • Phase I-II clinical trials for the development of innovative medicines
  • Hemostaseology
    • Hemophilia, including diagnostics and genetic counseling of hemophilia carriers
    • Von Willebrand-Jürgens syndrome
    • Rare coagulation disorders, for example, deficiency of factors II, V, X, XI or XIII
    • Peri- and postoperative coagulation disorders, for example, DIC syndrome or hyperfibrinolysis
    • Afibrinogenemia, dysfibrinogenemia and hypofibrinogenemia
    • Thrombocytopenic purpura
    • Changes in the functional state of platelets
    • Antiphospholipid syndrome, protein C and S deficiency
    • Diagnostics and treatment of arterial and venous thrombosis
    • Family diagnostics and counseling on the risk of thrombosis
    • Complications during pregnancy (miscarriages and premature labor, HELLP syndrome, preeclampsia, etc.)
    • Blood clotting disorders during pregnancy and in the postpartum period
    • Antiplatelet therapy (including the introduction of direct oral anticoagulants)
  • Diagnostics and treatment of other disorders and diseases

Curriculum vitae

  • 1988 Completion of medical studies at the University of Heidelberg.
  • 1988 Doctorate and admission to medical practice.
  • 1988 Assistant Physician, University Hospital Rechts der Isar, Technical University of Munich. 
  • 1990 Assistant Physician, University Hospital Ulm.
  • 1991 Postdoctoral Fellow, Department of Molecular Biology, Sloan Kettering Institute, NY.
  • 1994 Assistant Physician, University Hospital Benjamin Franklin at the Free University Berlin.
  • 1997 Board certification for Internal Medicine.
  • 1997 Senior Physician, Department of Internal Medicine A at the University Hospital Muenster.
  • 2000 Venia Legendi for Internal Medicine at the Faculty of Medicine, University of Freiburg.
  • 2002 Board certification for Hematology and Oncology.
  • 2002 Appointment as Professor for Internal Medicine at the University of Muenster.
  • Since 2007 Chief Physician of the Department of Hematology, Oncology, Hemostaseology, Rheumatology and Infectology at the University Hospital Frankfurt am Main.
  • Since 2008 Scientific Director of the University Cancer Center Frankfurt (UCT).
  • Since 2011 Regional Coordinator, Frankfurt/Mainz of the German Consortium for Translational Cancer Research (DKTK).

Honors and Awards

  • Research Fellowship from the German Research Foundation (DFG), Memorial Sloan Kettering Cancer Center, NY.
  • 1995 Research Prize from the University Hospital Benjamin Franklin.
  • 1996 Curt Meyer Memorial Prize from the Berlin Cancer Society.
  • 2000 "Best Abstract" at the Annual Meeting of the German/Austrian Society for Hematology and Medical Oncology (DGHO, OeGHO).

 Photo of the doctor: (c) Universitätsklinikum Frankfurt 

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