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Allogeneic bone marrow transplantation in acute lymphoblastic leukemia (413060) | University Hospital Mannheim - BookingHealth
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The rehabilitation period can last from 1 to 2 months.<\/p>\n\n<p style=\"text-align: justify;\">When your complete blood count returns to normal, your doctor will schedule your <strong>discharge from the department<\/strong>. You will receive information about the rules that you will need to follow at home, the frequency and type of control examinations, and subsequent treatment measures. 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Allogeneic bone marrow transplantation in acute lymphoblastic leukemia in University Hospital Mannheim

University Hospital Mannheim

Mannheim, Germany
Program id # 413060
Doctor photo
PD Dr. med. Stefan Klein
Department of Leukemia Treatment and Stem Cell Transplantation
Specialized in: leukemia treatment, stem cell transplantation

The program includes:

  • Initial presentation in the clinic
  • case history collection
  • general clinical examination
  • laboratory tests:
    • complete blood count
    • biochemical analysis of blood
    • TSH-basal, fT3, fT4
    • differential blood count
    • inflammation indicators (CRP, ESR)
    • indicators of blood coagulation
  • CT/MRI scans of the whole body
  • needle biopsy of the bone marrow with histological:
    • cytochemistry
    • immunocytology
    • cytogenetics (Philadelphia
      chromosome detection)
    • molecular biology
  • biopsy and histological examination of CSF
  • examination by experts of:
    • cardiology
    • otolaryngology
    • immunology
    • ophthalmology
  • registration in the European bone marrow donor base
  • conducting high-dose chemotherapy
  • allogeneic bone marrow transplantation from
    unrelated donor
  • the cost of blood products
  • isolation by neutropenic precautions
  • symptomatic treatment
  • control examinations
  • the cost of essential medicines and materials
  • nursing services
  • full hospital accommodation
  • explanation of future recommendations

How program is carried out

During the first visit, the doctor will conduct a clinical examination and go through the results of the available diagnostic tests. After that, you will undergo the necessary additional examination, such as the assessment of liver and kidney function, ultrasound scan, CT scan and MRI.

Also, the doctor will conduct a bone marrow biopsy followed by cytological examination of the harvested material. This will help him to determine the histological features of your bone marrow (in particular, identify HLA system antigens) and select a suitable donor. The donor can be a family member or a person from the bone marrow registry. In the second case, the donor material is stored in a bone marrow bank.

Before the procedure, you will receive chemotherapy, if necessary in combination with radiation therapy. The course of chemo- or chemoradiation therapy lasts from 2 to 8 days.

The bone marrow transplant procedure is an intravenous infusion, i.e. the healthy bone marrow will be injected through a catheter, intravenously. You will stay in your room during the procedure. A bone marrow transplant is completely painless and does not require anesthesia.

During the period of healthy bone marrow engraftment, you will stay in a sterile ward. This is a necessary precaution because during this time your immune system is very weak and cannot withstand environmental pathogens. The risk of bleeding is also quite high, so you will be advised to avoid mechanical damage.

A relative or other close person may stay in the ward with you. You will not be allowed to go outside the department and leave your ward often. The rehabilitation period can last from 1 to 2 months.

When your complete blood count returns to normal, your doctor will schedule your discharge from the department. You will receive information about the rules that you will need to follow at home, the frequency and type of control examinations, and subsequent treatment measures. You will also receive a detailed medical report, which will reflect the entire course of treatment.

Required documents

  • Medical records
  • MRI/CT scan (not older than 3 months)
  • Bone marrow biopsy results (if available)

Service

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About the department

The Department of Leukemia Treatment and Stem Cell Transplantation at the University Hospital Mannheim offers the full range of services in these medical fields. The medical team of the department specializes in the treatment of patients with acute lymphoblastic leukemia and acute myeloid leukemia, as well as patients requiring autologous stem cell transplantation. To this end, the department has state-of-the-art equipment and all the necessary conditions. The department is headed by PD Dr. med. Stefan Klein.

In order to protect patients from infections, the department is fitted out with seven patient rooms, in which the best possible sterility is observed (HEPA filters). In addition, each patient room is equipped with a special highly effective monitoring system that allows doctors and nurses to constantly monitor patient’s vital functions. It is possible to provide non-invasive artificial ventilation (CPAP) in the ward.

The patients of the department often have to spend a long time in the hospital, since a full recovery takes much time. To ensure that the patient can maintain the body in a tone, not lose muscle strength and maintain mobility, the department offers various physiotherapeutic options.

The basic procedures and techniques include:

  • General therapeutic exercise
  • Respiratory therapy
  • Manual lymphatic drainage
  • Classic and special massage
  • Trigger point stimulation
  • Relaxation techniques
  • Endurance training
  • Training to improve coordination of movements and balance
  • Aromatherapy
  • Neurophysiological methods
  • Yoga therapy
  • Other techniques

In the treatment of physical pathologies, the patient’s emotional state is also of great importance, which is rarely good with a diagnosis such as leukemia. Therefore, the department employs psycho-oncologists, who are always ready to listen to the patient and carry out the necessary work with him/her, in most cases contributing to positive treatment results.

Curriculum vitae

  • Since October 2009 Head of the Department of Leukemia Treatment and Stem Cell Transplantation, University Hospital Mannheim.
  • 2009 - 2010 Chairman of the Cancer Center of Upper Franconia.
  • 2006 - 2009 Medical Director of the Cancer Patient Register in Upper Franconia.
  • 2004 - 2009 Chief Physician of the Department of Internal Medicine IV (Oncology and Hematology), Bayreuth Hospital.
  • 2003 Habilitation. Subject: "Development and characterization of retroviral expressive anti-HIV-ribozymes".
  • 2002 - 2004 Member of the Board of Directors of the Center for Internal Medicine at the University Hospital Frankfurt, as well as Senior Physician of the Department of Stem Cell and Marrow Transplantation, Department of Internal Medicine III, University Hospital Frankfurt.
  • 2002 Examination of the European Society of Medical Oncology (ESMO) on Hematology and Internal Oncology.
  • 2001 - 2006 Project Manager at the Joint Research Center DFG 579 "RNA interaction with a ligand", Johann Wolfgang Goethe University Frankfurt.
  • 2000 Exam in Internal Medicine.
  • 1995 - 1998 Project Manager at the HIV Research Center, Frankfurt.
  • 1995 Admission to Medical Practice.
  • 1993- 2002 Research Assistant and Assistant Physician in the Department of Internal Medicine III, Johann Wolfgang Goethe University Frankfurt (Head: Prof. Dr. med. D. Hoelzer).
  • 1993 Medical exam.
  • 1991 - 1993 Scholarship (Studienstiftung des Deutschen Volkes).
  • 1987 - 1993 Study of Medicine, Johannes Gutenberg University Mainz.

Photo of the doctor: (c) Universitätsklinikum Mannheim 


About hospital

According to the reputable Focus magazine, the University Hospital Mannheim ranks among the top medical institutions of Germany, which is an undeniable confirmation of the impeccable medical care and excellent reputation of the hospital!

The hospital is a high-tech modern medical institution, which provides accurate diagnosis and optimal treatment, combined with quality, responsive care, attention to the patient’s individual needs and wishes. 

The history of the hospital dates back to 1701. At that time it was a small medical facility, but today it has about 30 specialized departments, centers and institutes with 4,800 first-class medical personnel.

Since the hospital functions on the basis of the Medical Faculty of the Heidelberg University, medical research is constantly conducted here at the national and international levels.

The main clinical focuses of the hospital include surgery, cardiology, oncology and hematology, gastroenterology, neurology, neurosurgery, urology, orthopedics, radiology, pediatric and adolescent medicine.

It should be noted that the hospital was repeatedly awarded prestigious quality certificates, for example, KTQ, IQM certificates, the certificate of the German Cancer Association.

Photo: (c) depositphotos

Accommodation in hospital

Patients rooms

The patients of the University Hospital Mannheim live comfortable single and double patient rooms. All rooms have an attractive design. They are fitted out with modern furniture, TV and a telephone. In addition, each room has an ensuite bathroom with a shower and a toilet. There is a beautiful park near the hospital, where one can walk, enjoying the greenery and clean air. 

Meals and Menus

The patients of the hospital are offered  delicious, balanced meals: breakfast, lunch with three menus to choose from and buffet dinner. In addition, the menu features dietary dishes. The lobby of the hospital houses a cafe where one can taste cold and hot drinks, have a snack with fresh pastries.

Further details

Standard rooms include:

Shower
Toilet
TV
Wi-Fi