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Treatment of Adrenal Cancer in Germany

Due to the difficulties associated with the organization of treatment in Turkey, Switzerland, South Korea and India, we are not currently processing requests to these regions.

If you are interested in treatment in Germany, please leave a request and our specialists will contact you as soon as possible.

 

Cost for treatment

Diagnostic tests for Adrenal cancer
781
Surgery treatment of adrenal cancers
9065
Radiotherapy for adrenal cortex carcinoma
13800

University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of Adult and Pediatric Urology

According to the Focus magazine, the University Hospital of Ludwig Maximilian University of Munich is regularly ranked among the best medical institutions in Germany! The hospital is the largest multidisciplinary medical facility, as well as a leading research and training center in Germany and Europe. The hospital is proud of i
Diagnostic tests for Adrenal cancer
1922
Surgery treatment of adrenal cancers
17963
Radiotherapy for adrenal cortex carcinoma
29648

Urology Clinic Munich-Planegg Munich

10/10
location_onGermany, Munich

Department of Adult and Pediatric Urology, Andrology

According to the Focus magazine, the Urology Clinic Munich-Planegg Munich ranks among the best specialized hospitals in Germany! The hospital was founded in 1970 by Dr. med. Rudolf Castringius. During that time, it became a leader in men's healthcare in Germany. In addition, the hospital has the status of one of the best med
Diagnostic tests for Adrenal cancer
2318 help1818
Surgery treatment of adrenal cancers
16197

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Adult and Pediatric Urology

The University Hospital Ulm started its activities 35 years ago and during this time it has become one of the most prestigious medical institutions in Europe. The hospital is famous for its numerous discoveries and the world-class achievements in medicine and pharmaceuticals. The medical facility has 29 specialized departments a
Diagnostic tests for Adrenal cancer
1850
Surgery treatment of adrenal cancers
17237
Radiotherapy for adrenal cortex carcinoma
27860

Helios Hospital Berlin-Buch

9.7/10
location_onGermany, Berlin

Department of Urology

According to the reputable Focus magazine, the Helios Hospital Berlin-Buch ranks among the top medical facilities in Germany! The clinic is proud of its rich history, which dates back over 100 years, as well as the status of a maximum care medical center with exceptionally high success treatment rates. The medical institution is
Diagnostic tests for Adrenal cancer
1799
Surgery treatment of adrenal cancers
15841
Radiotherapy for adrenal cortex carcinoma
26320

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Department of Urology

According to the reputable Focus magazine, the University Hospital Frankfurt am Main ranks among the top German medical facilities! The hospital was founded in 1914 and today is a well-known German medical facility, which combines rich traditions and scientific innovations. A medical team of more than 6,500 employees cares about
Diagnostic tests for Adrenal cancer
1791
Surgery treatment of adrenal cancers
15882
Radiotherapy for adrenal cortex carcinoma
23669

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Department of Adult and Pediatric Urology

According to the authoritative Focus magazine, the Charite University Hospital Berlin occupies the first place in the rating of the top German medical facilities! The hospital is one of the largest and leading university medical complexes in Europe. The hospital in Germany provides modern diagnostics and treatment of patients, a
Diagnostic tests for Adrenal cancer
2463
Surgery treatment of adrenal cancers
23516
Radiotherapy for adrenal cortex carcinoma
29517

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Adult and Pediatric Urology

According to Focus magazine, the University Hospital Heidelberg ranks among the top five hospitals in Germany! The hospital is one of the most advanced and reputable medical institutions not only in Germany, but throughout Europe. There are more than 43 specialized departments and 13 medical institutes, which cover all fields of
Diagnostic tests for Adrenal cancer
0
Surgery treatment of adrenal cancers
0
Radiotherapy for adrenal cortex carcinoma
0

University Hospital Jena

8.9/10
location_onGermany, Jena

Department of Adult and Pediatric Urology

According to the prestigious Focus magazine, the University Hospital Jena regularly ranks among the top German medical facilities! The hospital has positioned itself as a multidisciplinary medical facility with a long history of more than 200 years. Since its foundation, the hospital has been constantly developing and modernizin
Diagnostic tests for Adrenal cancer
1927
Surgery treatment of adrenal cancers
17696
Radiotherapy for adrenal cortex carcinoma
23511

University Hospital Erlangen

9.1/10
location_onGermany, Erlangen

Department of Adult and Pediatric Urology, Andrology

According to the Focus magazine, University Hospital Erlangen ranks among the best medical facilities in Germany! The hospital is one of the leading healthcare facilities in Bavaria and offers top-class medical care distinguished by the close intertwining of clinical activities with research and training of medical students. The
Diagnostic tests for Adrenal cancer
1914
Surgery treatment of adrenal cancers
16712
Radiotherapy for adrenal cortex carcinoma
28427

University Hospital Halle (Saale)

9.6/10
location_onGermany, Halle

Department of Urology

According to the prestigious Focus magazine, the University Hospital Halle (Saale) ranks among the top German medical facilities! The history of the hospital has more than 300 years, and during this time it managed to earn an excellent reputation not only in Germany, but throughout the world. The hospital positions itself as a s
Diagnostic tests for Adrenal cancer
1807
Surgery treatment of adrenal cancers
16109
Radiotherapy for adrenal cortex carcinoma
23682

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of Adult and Pediatric Urology

According to the Focus magazine, the University Hospital Hamburg-Eppendorf ranks among the top ten hospitals in Germany! Since its foundation in 1889, the hospital has taken a leading position in the European medical arena and still occupies it until today. A highly competent medical team of more than 11,000 employees takes care
Diagnostic tests for Adrenal cancer
2243
Surgery treatment of adrenal cancers
20948
Radiotherapy for adrenal cortex carcinoma
23291

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Adult and Pediatric Urology

According to the Focus magazine in 2019, the University Hospital Würzburg ranks among the top national German hospitals! The hospital is one of the oldest medical facilities in Germany. The centuries-old traditions of first-class treatment are combined with the very latest achievements of modern evidence-based medicine and
Diagnostic tests for Adrenal cancer
1825
Surgery treatment of adrenal cancers
15800
Radiotherapy for adrenal cortex carcinoma
23498

University Hospital Rechts der Isar Munich

9.8/10
location_onGermany, Munich

Department of Adult and Pediatric Urology

The University Hospital Rechts der Isar Munich was founded in 1834. It combines long traditions with the very latest advances in modern medicine. The medical facility includes 33 specialized departments and 20 interdisciplinary centers, where patients can receive top-class medical care in all medical fields. The hospital annuall
Diagnostic tests for Adrenal cancer
1929
Surgery treatment of adrenal cancers
17931
Radiotherapy for adrenal cortex carcinoma
29445

University Hospital RWTH Aachen

8.7/10
location_onGermany, Aachen

Department of Adult and Pediatric Urology

According to the prestigious Focus magazine, the University Hospital RWTH Aachen ranks among the top German hospitals! As a maximum care university medical facility, the hospital guarantees patients first-class medical services combined with a respectful and human attitude. The hospital integrates all the modern options for the
Diagnostic tests for Adrenal cancer
2004
Surgery treatment of adrenal cancers
17627
Radiotherapy for adrenal cortex carcinoma
29847

University Hospital Duesseldorf

9.5/10
location_onGermany, Duesseldorf

Department of Adult and Pediatric Urology

According to the authoritative Focus magazine, the University Hospital Duesseldorf ranks among the top Germany hospitals! The hospital is an excellent example of a combination of high-quality health care, research and teaching activities. With more than 50,000 inpatients and about 300,000 outpatients every year, the hospital is
Diagnostic tests for Adrenal cancer
2017
Surgery treatment of adrenal cancers
17886
Radiotherapy for adrenal cortex carcinoma
23611

University Hospital Tuebingen

9.2/10
location_onGermany, Tuebingen

Department of Urology

According to the prestigious medical publication Focus, the University Hospital Tuebingen ranks among the top five German hospitals! The hospital was founded in 1805, therefore it is proud of its long history, unique experience, and outstanding achievements in the field of medical care, as well as research and teaching activitie
Diagnostic tests for Adrenal cancer
1889
Surgery treatment of adrenal cancers
16888
Radiotherapy for adrenal cortex carcinoma
27899
| from Booking Health GmbH

Adrenal cancer, or adrenocortical carcinoma, is a fairly rare malignancy with an aggressive course. The tumor usually develops in the superficial layer – the cortical layer, where all hormones are synthesized (except for adrenaline and noradrenaline). Therefore, quite often the tumor itself starts producing hormones in abnormal amounts, causing specific syndromes that sometimes are pronounced, or sometimes latent.

Content

  1. Symptoms and types of adrenal tumors
  2. Treatment tactics
  3. How is cancer treatment in Germany carried out?
  4. Chemotherapy and drug therapy for adrenal cancer
  5. After adrenal cancer treatment in Germany
  6. The cost of treatment in German hospitals
  7. Adrenal cancer treatment in Germany with Booking Health

Symptoms and types of adrenal tumors

 

One of the most common adrenal formations is adrenal cortex tumors. Such tumors provoke excessive production of cortisol. As a consequence, patients have Cushing syndrome, which symptoms include:

  • Arterial hypertension and headaches
  • Weakness and rapid muscle fatigue
  • Obesity with fat deposits on the back, abdomen, and chest with relatively thin limbs
  • Early puberty in children
  • Early decline in sexual function in adults
  • Hormonal dysfunction, including enlarged mammary glands, testicular hypoplasia, and reduced potency in men and male-pattern hairiness, clitoral hypertrophy, and voice timbre changes in women
  • Stretch marks on the skin of the abdomen, and thighs

According to recent information, this type of cancer facilitates the appearance of osteoporosis, leading to pathological fractures. Nervous system dysfunctions are also noted in the form of overexcitation and depression. About a quarter of such patients have a kidney infection and kidney stone disease.

There are also benign aldosteronomas that are common. The cases of malignancy are also known. The hormone aldosterone produced by the tumor affects mineral-salt metabolism in the body, which, in turn, causes:

  • Cardiovascular manifestations such as hypertension, shortness of breath, arrhythmias, hypertrophy, and subsequent myocardial dystrophy
  • Renal symptoms such as increased frequency and volume of urination, frequent nocturnal urination, thirst, the appearance of alkaline reaction of urine
  • Neuromuscular symptoms: muscle weakness, seizures, or sensitivity disorders

Nonspecific symptoms of adrenal cancer are signs typical for all malignant tumors, especially pronounced in the advanced stages of the disease, including symptoms of intoxication like weakness, lethargy, and fatigue, anemia, and other changes in blood tests, exhaustion, and pain syndrome.

You should consult a doctor on any symptoms of hormonal imbalance, as well as signs that do not clearly indicate a disease. These include weakness, frequent headaches, persistent high blood pressure, thirst, and urinary disorders.

Treatment tactics

 

Adrenal tumors can be benign or malignant, with benign masses being more common. So, the treatment tactics are based on the area of focus of the treatment: it can be just a primary tumor, or it can be both tumor and its metastases that need management. Moreover, advanced adrenal cancer can occur from a secondary neoplasm that originated outside the adrenal gland, for example, in the stomach, ovaries, prostate, intestine, kidney, and other organs. So, when diffuse hyperplasia of adrenal tissue is detected, it is necessary to clarify the nature of the formation and the tactics of its further treatment (or monitoring).

Metastases to the adrenal gland are relatively common and symptomatically quite expressive, while symptoms will depend on the location and size of the primary tumor. In addition, the symptoms of metastatic cancer depend on the hormonal activity of the tumor.

After the necessary diagnostic tests and examinations, the patient with adrenocortical carcinoma is prescribed treatment, often surgical, but sometimes conservative, or the detected mass is monitored, but not yet treated (if the tumor is benign and hormonally inactive).

How is cancer treatment in Germany carried out?

 

Surgical treatment was, is, and probably will be the most effective method of adrenocortical carcinoma for a long time to come. The entire affected adrenal gland is removed during surgery. The main thing is not to damage the tumor capsule, because tumor cells can spread, and their aggressiveness is potentially very high. Some information suggests that the removal of lymph nodes that are enlarged and closest to the tumor improves long-term survival results. With a large cancerous tumor that has invaded the kidney, it may be necessary to remove the kidney.

General guidelines in medicine pose surgical treatment as preferable for stages 1 – 3 of adrenal cancer. The success of the surgical intervention is indicated by microscopically clear resection margins.

Approximately half of the operated patients experience local recurrence or metastasis of the tumor several years later. This is usually explained by the fact that there were already micrometastases in the body by the time of the primary surgery. That’s why it is so important to conduct the most extensive diagnostics to ensure the sufficiency of treatment to be carried out. The efficacy of the surgical intervention that consists of removing most of the tumor when it is first detected is questionable.

The removal of the adrenal gland using endoscopic equipment like the one used in laparoscopic adrenalectomy might be helpful for some patients with adrenocortical carcinoma. However, not enough information on the technique has been obtained due to the rarity of the tumor, and the opinions on the priority rating of this procedure differ in medicine. So far, recent studies in medicine showed that it is not recommended to perform laparoscopic adrenalectomy if the adrenal tumor is larger than 5 cm and invades the surrounding tissues with metastases to lymph nodes. Sufficient experience of the cancer surgeon is very important if the decision is made to proceed with such a procedure.

In the postoperative period, prevention or therapy of insufficient function of the remaining adrenal gland and, of course, prevention of thrombosis are included in the treatment regimen. Patients may have to take hormonal drugs for life to compensate for the function of one lost and the second atrophied adrenal gland. Replacement therapy is an inevitability that cannot be refused. At relapse after surgical treatment, doctors try to perform a resection. The degree of its radicalism is reflected in the life expectancy of the patients in such situations.

Chemotherapy and drug therapy for adrenal cancer

 

Because adrenal tumors are relatively rare, there are very few studies in medicine evaluating the efficacy of chemotherapy in treating them.

Drug therapy for adrenal cancer treatment in Germany eventually has two goals: reduction of hormone secretion by cancer cells and partial or complete reduction of the activity of the pathological process.

Drug therapy is prescribed for patients with advanced adrenal cancer and after partial resection of neoplasms. Drug therapy is carried out in combination with chemotherapy or without it. Generally, adrenocortical carcinomas are associated with high expression of a gene responsible for a protein that functions as a pump to remove chemotherapy from the cell, which neutralizes the effects of chemotherapy. Mitotane slows down this pump, making chemotherapy more effective. Therefore, chemotherapy is usually prescribed in combination with the administration of mitotane.

Mitotane is prescribed in capsules (daily intake of more than 3 g). This medication destroys normal and cancerous adrenal cells, preventing them from producing hormones (mainly cortisol). In 35% of cases, the use of this drug contributes to partial remission, much less often there is complete remission. There is no information on the effectiveness of taking the drug as an additional treatment after surgical resection of the tumor.

It is very important to monitor the level of the drug in the blood. As a rule, the maximum daily dosage of the drug should not exceed 6 g, otherwise, patients develop adverse reactions: nausea, vomiting, diarrhea, exhaustion, dizziness, loss of balance, or confusion.

The information from several clinical cases suggests that mitotane has had severe toxic effects on the liver. Among other things, mitotane increases "bad" cholesterol (LDL) levels in the blood. Not all of the above adverse reactions are related to the direct effects of mitotane on the body; they can often be seen as a consequence of insufficient production of hormones by the adrenal glands. Therefore, this drug should be prescribed in combination with medications that replenish the lack of cortisol in the body, such as hydrocortisone, prednisone, or dexamethasone.

A systematic study evaluated the efficacy of four drugs in the treatment of advanced adrenal cancer. Seventy-two patients with inoperable or advanced tumors who had not previously been treated with chemotherapy were followed up. All patients were treated with an intravenous regimen of chemotherapy every 4 weeks, combined with the administration of mitotane and cortisone replacement therapy. The information from the study showed the effectiveness of this regimen: a positive response to the treatment was observed in approximately half of the patients: in five patients the tumor disappeared, and in eleven patients it became operable. In most cases, this therapy helped to prevent hormone secretion by the tumor.

After adrenal cancer treatment in Germany

 

To maintain the overall health condition and prevent disease, all cancer survivors should maintain a healthy lifestyle and diet, and continue to have regular checkups and examinations by their physician. Former patients who have received systemic chemotherapy should be screened for acute and long-term side effects.

According to the survival study information, approximately 25% of former patients have serious chronic disease 25 years after diagnosis. These may include secondary cancer (risk increased by radiation exposure), chronic heart failure (due to certain chemotherapy drug exposure), infertility or complications during pregnancy, and terminal kidney failure or kidney dysfunction.

The cost of treatment in German hospitals

 

The cost of treatment in Germany may vary somewhat depending on the status of the German hospitals and their location. For example, the cost of treatment in Germany in a public hospital is lower than in the university hospital or private hospital. In addition, the cost of treatment in hospitals in Southern Germany will be higher than in clinics in Northern or Eastern Germany.

In addition to the general price level of each individual region, the treatment conditions affect the cost of treatment.

General prices for treatment with different procedures are as follows:

  • The cost of treatment with surgery starts at 9,065 EUR.
  • The cost of treatment with chemotherapy starts at 1,985 EUR.
  • The cost of treatment with radiation therapy starts at 13,800 EUR.
  • The prices for cancer rehabilitation start at 951 EUR.

For more information about the preliminary prices for treatment in German hospitals in your clinical case, contact Booking Health.

Adrenal cancer treatment in Germany with Booking Health

 

For everybody who contacts Booking Health for the organization of treatment in Germany, we prepare individual offers from several German hospitals which are ready to accept the patient without delay.

Booking Health contacts doctors at German hospitals directly, so the foreign patients get multivariable preliminary information quickly.

If you need any information related to the treatment of adrenal cancer in Germany, contact Booking Health by filling in the request form on the website.

Authors: Dr. Nadezhda IvanisovaDr. Farrukh Ahmed




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