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    4. Cancer of Unknown Primary (CUP)

Treatment of Cancer of Unknown Primary (CUP)

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Cost for treatment

Cancer of unknown primary (CUP) diagnosis
 from  3315
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Cancer rehabilitation
 from  951
Hospital search
Vivantes Neukölln Hospital Berlin
Maike de Wit

Head physician:

Prof. Dr. med. Maike de Wit

Vivantes Neukölln Hospital Berlin

10/10
location_onGermany, Berlin

Department of Hematology, Oncology and Palliative Medicine

The Vivantes Neukölln Hospital is the maximum care hospital and one of the largest healthcare facilities in Berlin.  There are more than 20 specialized departments and centers, including pediatric departments. In total, the hospital has 1,200 beds. The hospital uses innovative technologies and the latest treatments, as
Cancer of unknown primary (CUP) diagnosis
9878
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MediClin Robert Janker Clinic
Katri Elina Clemens

Head physician:

Dr. med. Katri Elina Clemens

MediClin Robert Janker Clinic

9.5/10
location_onGermany, Bonn

Department of Oncology and Palliative Care

The MediClin Robert Janker Clinic is a progressive medical facility, which has all the very latest diagnostic and treatment methods for the recovery of health of patients who suffer from cancers. The clinic was founded by renowned radiologist and surgeon Robert Janker. Today, its history has more than 80 years of successful clin
Cancer of unknown primary (CUP) diagnosis
10918
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Medias Cancer Clinic Burghausen
Karl Reinhard Aigner

Head physician:

Prof. Dr. med. Karl Reinhard Aigner

Medias Cancer Clinic Burghausen

10/10
location_onGermany, Burghausen

Department of Oncology and Surgical Oncology

The Medias Cancer Clinic Burghausen positions itself as a private highly specialised medical facility with international leadership in cancer treatment. The key areas of specialization of the clinic include regional chemotherapy, surgical oncology, hyperthermia, immunotherapy and pain therapy. The ultimate value of each emp
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11624
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Memorial Sisli Hospital Istanbul
Mustafa Teoman Yanmaz

Head physician:

Assoc. Prof. Dr. med. Mustafa Teoman Yanmaz

Memorial Sisli Hospital Istanbul

9.2/10
location_onTurkey, Istanbul

Department of Oncology

The Memorial Sisli Hospital Istanbul is the largest and leading medical complex in Turkey, which meets the highest standards of medical care when providing the advanced diagnostics and treatment using the very latest methods. The hospital is part of the Memorial Health Group – it was the first project of this provider of m
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5544
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Memorial Bahcelievler Hospital Istanbul
Fazilet Oner Dincbas

Head physician:

Prof. Dr. med. Fazilet Oner Dincbas

Memorial Bahcelievler Hospital Istanbul

9.2/10
location_onTurkey, Istanbul

Department of Oncology and Radiation Oncology

The Memorial Bahçelievler Hospital Istanbul is an advanced multidisciplinary medical center that began its clinical practice in 2018. It is part of the world famous Memorial Healthcare Group. The hospital was designed in accordance with the very latest standards of modern architecture with the aim of providing top-class m
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5307
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University Hospital Ulm
Hartmut Döhner

Head physician:

Prof. Dr. med. Hartmut Döhner

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Hematology, Oncology, Palliative Care, Rheumatology and Infectology

The University Hospital Ulm started its activities 35 years ago and during this time it has become one of the most prestigious medical institutions in Europe. The hospital is famous for its numerous discoveries and the world-class achievements in medicine and pharmaceuticals. The medical facility has 29 specialized departments a
Cancer of unknown primary (CUP) diagnosis
11085
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Rambam Health Care Campus Haifa
Irit Ben Aharon

Head physician:

Prof. Dr. med. Irit Ben Aharon

Rambam Health Care Campus Haifa

9.8/10
location_onIsrael, Haifa

Department of Oncology

The Rambam Health Care Campus Haifa is the largest and the most progressive hospital in Northern Israel. The medical center was founded in 1938 and nowadays is proud of its long history, rich and successful experience in providing comprehensive medical services in all medical fields. The hospital serves more than 2 million local
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7710
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Medicana International Istanbul Hospital
Mutlu Demiray

Head physician:

Prof. Dr. med. Mutlu Demiray

Medicana International Istanbul Hospital

9/10
location_onTurkey, Istanbul

Department of Oncology

The Medicana International Istanbul Hospital is a modern medical institution, which provides patients with an individual approach, excellent health service and attentive care. The hospital is part of the largest Turkish network of the Medicana hospitals. Due to its long successful clinical activities, the network has won th
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5542
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Samsung Medical Center Seoul
Park Keun Chil

Head physician:

Prof. Dr. med. Park Keun Chil

Samsung Medical Center Seoul

9.8/10
location_onSouth Korea, Seoul

Department of Oncology and Hematology

The Samsung Medical Center was founded in 1994 and soon won the reputation of a medical facility of presidential standards, which it still preserves today. The hospital has 40 departments, 10 specialized centers and a huge Cancer Center with 655 beds. The medical facility is equipped with advanced equipment (for example, a 32-ch
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5457
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University Hospital Freiburg
Justus Duyster

Head physician:

Prof. Dr. med. Justus Duyster

University Hospital Freiburg

9.7/10
location_onGermany, Freibung

Department of Hematology and Oncology

The University Hospital Freiburg is famous for its rich history and is one of the oldest and most prestigious medical facilities in Germany (one of the three best medical institutions in the country). The hospital was based on the Faculty of Medicine of the Albert Ludwig University of Freiburg, which celebrated its 550th anniver
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11656
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University Hospital Frankfurt am Main
Chris­ti­an Brandts

Head physician:

Prof. Dr. med. Chris­ti­an Brandts

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Cancer Center

According to the reputable Focus magazine, the University Hospital Frankfurt am Main ranks among the top German medical facilities! The hospital was founded in 1914 and today is a well-known German medical facility, which combines rich traditions and scientific innovations. A medical team of more than 6,500 employees cares about
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10549
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University Hospital Heidelberg
Carsten Müller-Tidow

Head physician:

Prof. Dr. med. Carsten Müller-Tidow

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Hematology, Oncology, Adult and Pediatric Rheumatology

According to the Focus magazine, the University Hospital Heidelberg ranks among the top five hospitals in Germany! The hospital is one of the most advanced and reputable medical institutions not only in Germany, but throughout Europe. There are more than 43 specialized departments and 13 medical institutes, which cover all field
Cancer of unknown primary (CUP) diagnosis
0
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University Hospital Würzburg
Hermann Einsele

Head physician:

Prof. Dr. med. Hermann Einsele

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Gastroenterology, Hematology, Oncology, Hepatology, Infectology, Rheumatology and Clinical Immunology

According to the Focus magazine in 2019, the University Hospital Würzburg ranks among the top national German hospitals! The hospital is one of the oldest medical facilities in Germany. The centuries-old traditions of first-class treatment are combined with the very latest achievements of modern evidence-based medicine and
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10125
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University Hospital RWTH Aachen
Edgar Jost

Head physician:

PD Dr. med. Edgar Jost

University Hospital RWTH Aachen

8.7/10
location_onGermany, Aachen

Department of Oncology and Hematology

According to the prestigious Focus magazine, the University Hospital RWTH Aachen ranks among the top German hospitals! As a maximum care university medical facility, the hospital guarantees patients first-class medical services combined with a respectful and human attitude. The hospital integrates all the modern options for the
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11455
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University Hospital Carl Gustav Carus Dresden
Gunnar Folprecht

Head physician:

Prof. Dr. med. Gunnar Folprecht

University Hospital Carl Gustav Carus Dresden

9.1/10
location_onGermany, Dresden

Department of Oncology

According to the prestigious Focus magazine, the University Hospital Carl Gustav Carus Dresden is among the top three hospitals in Germany! The hospital is the embodiment of the standards of modern high-quality medicine. Since the hospital positions itself as a maximum care medical facility, it represents all medical fields. The
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13415
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University Hospital Erlangen
Andreas Mackensen

Head physician:

Prof. Dr. med. Andreas Mackensen

University Hospital Erlangen

9.1/10
location_onGermany, Erlangen

Department of Hematology and Oncology

According to the Focus magazine, the University Hospital Erlangen ranks among the top German medical facilities! The hospital is one of the leading medical facilities in Bavaria and offers the highest level of medical care, which is characterized by the close intertwining of clinical activities with research and training of medi
Cancer of unknown primary (CUP) diagnosis
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About the disease

Cancer of unknown primary (CUP) is a cancer, whose primary site, where it started is unknown. In this case it can be present in several metastatic sites. Detailed tests need to be done in order to understand the origin of the cancer. It is important for further successful treatment. After the origin is identified, cancer is renamed after the organ it started to develop in. In some cases it is impossible to identify the origin of cancer. Nevertheless, even in this cases treatment can be successful. According to American Cancer Society, around 2% of all cancers are represented by CUP. Overall, over the past ten years, incidence of CUP decreased by 35%, which is good news. Mortality rate over this time also decreased almost by 42%.

Because of the fact that CUP can originate in any part of the body, it is difficult to tell its exact causes. It is believed that smoking, DNA mutations, poor nutrition, excessive ultraviolet radiation, obesity are responsible the most for development of CUP. Various researches show that it most often originates in stomach, colon, and ovaries. It can also start to develop on skin, which in this case is called melanoma.     

Symptoms

Symptoms of unidentified cancer can be various as they depend on the organs, which they spread to. Nevertheless, there are several symptoms, which proved to be common for most patients with CUP, and if you have any of those, you need to contact your doctor. 

  • Swollen lymph nodes in different parts of the body
  • Skin tumors, which are manifested as skin bumps
  • Shortness of breath
  • Pain in the abdomen
  • Fatigue
  • Anemia
  • Bone pain, if cancer spread to the bones
  • Weight loss
  • Loss of appetite

Diagnosis

Diagnosis of CUP is in most cases complex, as doctors have to check each organ of the patient to identify the origin of cancerous growth.

  • X-Ray is used to get images of all inner organs.
  • CT scan and MRI produce more precise images, which can also identify cancer origin.
  • Biopsy examines sample tissue of affected organs where doctors suspect the cancer to be the most.
  • Bone marrow aspiration is used, if patient has severe bone pain.
  • Blood test is used to examine blood cells.

Treatment

  • Surgery is used if cancer was found in one organ or in lymph nodes and it can be removed completely. Nevertheless, there is always a possibility that cancerous cells are also present in another organ.
  • Radiation is used to slow the growth of cancer and stop it from spreading further. A patient may need to undergo either external or internal radiation to kill as many malignant cells as possible.
  • Chemotherapy can be used in combination with surgery and radiation. It can also be used if those treatment methods can no longer be applied and in this case chemo is used to relieve the symptoms and prolong patient's life.

In general, in most cases doctors are able to identify the origin of unknown primary cancer and thus chances for recovery become higher. Even if the origin was not identified, but unknown primary still has not progressed very much, you have high survival chances. 

Authors: Dr. Nadezhda Ivanisova, Dr. Sergey Pashchenko

To check for the Cancer of Unknown Primary (CUP) you can submit a request on BookingHealth and our managers will find the best hospital that is specialized in Cancer of Unknown Primary (CUP) to fulfill your needs
The best hospitals for Cancer of Unknown Primary (CUP) treatment are: Vivantes Neukölln Hospital Berlin, MediClin Robert Janker Clinic, Medias Cancer Clinic Burghausen
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Marina T., Kazakhstan

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Valeriy L., Russia

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Tariq K., United Kingdom

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Nemattilo T., Kyrgyzstan

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Farid K., Jordan

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Magdy Hamed Mohamed M., Egypt

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Boris T., USA

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William E., USA

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Oksana K., Russia

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Zein B., Egypt

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Tatiana K., Russia

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Lyazzat D., Kazakhstan

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Zogaj G., Iceland

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Jaroslav V., Sweden

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Aizaryk D., Kazakhstan

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Alla R., Russia

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Olga B., Kazakhstan

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