Treatment of Cancer of Unknown Primary (CUP)

➤Cancer of Unknown Primary (CUP) ✔ Information about hospitals and doctors ★ Rankings ✔ Reviews $ Prices ✉ Send request to the hospital

Best hospitals and doctors for cancer of unknown primary (cup) treatment abroad

The selection of doctors and clinics is carried out on the basis of annual qualification reports. The main selection criterion is the number of operations or procedures performed. It takes into account experience, reputation in the medical society, the availability of quality certificates and high specialization in a certain field.

Cost for treatment

Cancer of unknown primary (CUP) diagnosis
 from  6715
Cancer rehabilitation
 from  908.14

Vivantes Neukölln Hospital Berlin

location_onGermany, Berlin

Department of Hematology, Oncology and Palliative Medicine

The Vivantes Neukölln Hospital is the maximum care hospital and one of the largest healthcare facilities in Berlin.  There are more than 20 specialized departments and centers, including pediatric departments. In total, the hospital has 1,200 beds. The hospital uses innovative technologies and the latest treatments, as
Cancer of unknown primary (CUP) diagnosis

University Hospital Ulm

location_onGermany, Ulm

Department of Hematology, Oncology, Palliative Care, Rheumatology and Infectology

The University Hospital Ulm started its activities 35 years ago and during this time it has become one of the most prestigious medical institutions in Europe. The hospital is famous for its numerous discoveries and the world-class achievements in medicine and pharmaceuticals. The medical facility has 29 specialized departments a
Cancer of unknown primary (CUP) diagnosis

Samsung Medical Center Seoul

location_onSouth Korea, Seoul

Department of Oncology and Hematology

The Samsung Medical Center was founded in 1994 and soon won the reputation of a medical facility of presidential standards, which it still preserves today. The hospital has 40 departments, 10 specialized centers and a huge Cancer Center with 655 beds. The medical facility is equipped with advanced equipment (for example, a 32-ch
Cancer of unknown primary (CUP) diagnosis
9718.4 help8857

Rambam Health Care Campus Haifa

location_onIsrael, Haifa

Department of Oncology

Rambam Health Care Campus is the largest and the most advanced hospital in Northern Israel. Founded in 1938, the medical center has a long history and a rich experience in providing comprehensive medical services in all medical specialties. Ramdam serves over 2 million residents of the country, as well as the Israel Defense Forc
Cancer of unknown primary (CUP) diagnosis
12610 help11110

Medicana International Istanbul Hospital

location_onTurkey, Istanbul

Department of Oncology

The Medicana International Istanbul Hospital is a modern medical institution, in which patients are provided with an individual approach, excellent health service and attentive care. The hospital is part of the largest Turkish network of the Medicana hospitals, which due to its long successful clinical activities has won the lea
Cancer of unknown primary (CUP) diagnosis

University Hospital Freiburg

location_onGermany, Freibung

Department of Hematology, Oncology and Stem Cell Transplantation

The University Hospital Freiburg is famous for its rich history and is one of the oldest and most prestigious medical facilities in Germany (one of the three best medical institutions in the country). The hospital was based on the Faculty of Medicine of the Albert Ludwig University of Freiburg, which celebrated its 550th anniver
Cancer of unknown primary (CUP) diagnosis

University Hospital Heidelberg

location_onGermany, Heidelberg

Department of Hematology, Oncology, Adult and Pediatric Rheumatology

According to the Focus magazine, the University Hospital Heidelberg ranks among the top five hospitals in Germany! The hospital is one of the most advanced and reputable medical institutions not only in Germany, but throughout Europe. There are more than 43 specialized departments and 13 medical institutes, which cover all field
Cancer of unknown primary (CUP) diagnosis

University Hospital Würzburg

location_onGermany, Würzburg

Department of Gastroenterology, Hematology, Oncology, Stem Cell Therapy, Hepatology, Infectology, Rheumatology and Clinical Immunology

According to the Focus magazine in 2019, the University Hospital Würzburg ranks among the top national German hospitals! The hospital is one of the oldest medical facilities in Germany. The centuries-old traditions of first-class treatment are combined with the very latest achievements of modern evidence-based medicine and
Cancer of unknown primary (CUP) diagnosis

University Hospital Erlangen

location_onGermany, Erlangen

Department of Hematology and Internal Oncology

University Hospital Erlangen is one of the leading university hospitals in Bavaria and offers advanced medicine, characterized by a tight integration of patient care with university research and teaching. It pursues a very innovative concept. The research results in Erlangen set new standards in the prevention, diagnosis and tre
Cancer of unknown primary (CUP) diagnosis

University Hospital RWTH Aachen

location_onGermany, Aachen

Department of Oncology, Hematology and Stem Cell Transplant

With its 34 clinics, 25 institutes and five multidisciplinary units covers the University Hospital Aachen not only the entire spectrum of medicine, but also it offers a patient- oriented medical care and nursing, medical education and research of international level. The University Hospital RWTH Aachen is included in t
Cancer of unknown primary (CUP) diagnosis

University Hospital Carl Gustav Carus Dresden

location_onGermany, Dresden

Department of Oncology

According to the prestigious Focus magazine, the University Hospital Carl Gustav Carus Dresden is among the top three hospitals in Germany! The hospital is the embodiment of the standards of modern high-quality medicine. Since the hospital positions itself as a maximum care medical facility, it represents all medical fields. The
Cancer of unknown primary (CUP) diagnosis

University Hospital Halle (Saale)

location_onGermany, Halle

Department of Hematology and Oncology

The University Hospital of Halle (Saale), abbreviated as UHH, combines modern medical institutions in a university rich in traditions. As the largest provider of health care services in the southern part of Saxony-Anhalt, the University Hospital has a wide range of specialized departments and institutions and ensures top-class m
Cancer of unknown primary (CUP) diagnosis

University Hospital Hamburg-Eppendorf

location_onGermany, Hamburg

Department of Hematology, Oncology, Pneumology (Medical Department II)

The University Medical Center Hamburg-Eppendorf (UKE) consists of more than 80 interdisciplinary cooperating departments, polyclinics and institutes within 14 medical centers. The Medical Center has over 1,346 beds. The University Medical Center Hamburg-Eppendorf annually treats about 92,000 inpatients and 291,000 outpatien
Cancer of unknown primary (CUP) diagnosis

Charite University Hospital Berlin

location_onGermany, Berlin

Charité Comprehensive Cancer Center

Being the medical school for both Humboldt University and Free University of Berlin and having a long experience, the Charite Hospital in Germany has gained wide recognition. It is regarded as one of the most research-intensive medical facilities in Germany and the largest university medical center in Europe. With more than
Cancer of unknown primary (CUP) diagnosis

University Hospital Cologne

location_onGermany, Cologne

Department of Oncology, Hematology, Clinical Infectiology, Clinical Immunology, Hemostasis, Intensive Care

The University Hospital Cologne is included in the Focus magazine rating of top German hospitals 2017 and offers patients first-class medical care meeting the latest medical advancements. Both doctors and researchers of the hospital are constantly searching for new techniques in the field of diagnosis and treatmen
Cancer of unknown primary (CUP) diagnosis

University Hospital Bonn

location_onGermany, Bonn

Department of Oncology, Hematology, Rheumatology and Immunoncology

According to the authoritative Focus magazine, the University Hospital Bonn ranks among the top ten medical facilities in Germany! The hospital was opened on January 1, 2001, although in fact it inherits the medical facility, which operated at the Faculty of Medicine of the University of Bonn. The hospital in Germany combin
Cancer of unknown primary (CUP) diagnosis

About the disease

Cancer of unknown primary (CUP) is a cancer, whose primary site, where it started is unknown. In this case it can be present in several metastatic sites. Detailed tests need to be done in order to understand the origin of the cancer. It is important for further successful treatment. After the origin is identified, cancer is renamed after the organ it started to develop in. In some cases it is impossible to identify the origin of cancer. Nevertheless, even in this cases treatment can be successful. According to American Cancer Society, around 2% of all cancers are represented by CUP. Overall, over the past ten years, incidence of CUP decreased by 35%, which is good news. Mortality rate over this time also decreased almost by 42%.

Because of the fact that CUP can originate in any part of the body, it is difficult to tell its exact causes. It is believed that smoking, DNA mutations, poor nutrition, excessive ultraviolet radiation, obesity are responsible the most for development of CUP. Various researches show that it most often originates in stomach, colon, and ovaries. It can also start to develop on skin, which in this case is called melanoma.     


Symptoms of unidentified cancer can be various as they depend on the organs, which they spread to. Nevertheless, there are several symptoms, which proved to be common for most patients with CUP, and if you have any of those, you need to contact your doctor. 

  • Swollen lymph nodes in different parts of the body
  • Skin tumors, which are manifested as skin bumps
  • Shortness of breath
  • Pain in the abdomen
  • Fatigue
  • Anemia
  • Bone pain, if cancer spread to the bones
  • Weight loss
  • Loss of appetite


Diagnosis of CUP is in most cases complex, as doctors have to check each organ of the patient to identify the origin of cancerous growth.

  • X-Ray is used to get images of all inner organs.
  • CT scan and MRI produce more precise images, which can also identify cancer origin.
  • Biopsy examines sample tissue of affected organs where doctors suspect the cancer to be the most.
  • Bone marrow aspiration is used, if patient has severe bone pain.
  • Blood test is used to examine blood cells.


  • Surgery is used if cancer was found in one organ or in lymph nodes and it can be removed completely. Nevertheless, there is always a possibility that cancerous cells are also present in another organ.
  • Radiation is used to slow the growth of cancer and stop it from spreading further. A patient may need to undergo either external or internal radiation to kill as many malignant cells as possible.
  • Chemotherapy can be used in combination with surgery and radiation. It can also be used if those treatment methods can no longer be applied and in this case chemo is used to relieve the symptoms and prolong patient's life.

In general, in most cases doctors are able to identify the origin of unknown primary cancer and thus chances for recovery become higher. Even if the origin was not identified, but unknown primary still has not progressed very much, you have high survival chances. 

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