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St. Vincentius Clinic Karlsruhe

9.8/10 from 23 Votes

The St. Vincentius Clinic is the largest multidisciplinary medical institution and academiс hospital of the Albert Ludwig University of Freiburg. Treatment and diagnosis of patients is conducted by doctors with a scientific degree. They are introducing the latest progressive techniques.

Cancer of unknown primary (CUP) diagnosis
11654
location_onCountry: Germany
location_searchingCity: Karlsruhe

Charite University Hospital Berlin

9/10 from 95 Votes

Being the medical school for both Humboldt University and Free University of Berlin and having a long experience, the Charite Hospital has gained wide recognition. It is regarded as one of the most research-intensive medical facilities in Germany and the largest university medical center in Europe.

Cancer of unknown primary (CUP) diagnosis
11669
location_onCountry: Germany
location_searchingCity: Berlin
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University Hospital of the Ludwig-Maximilians-University Munich (LMU)

9.2/10 from 40 Votes

The Hospital of the Ludwig-Maximilians-University (LMU) Munich is a center of high-end medicine, medical innovation and medical and technical progress, which enables an individual and safe patient care.

Cancer of unknown primary (CUP) diagnosis
13443
location_onCountry: Germany
location_searchingCity: Munich

University Hospital Rechts der Isar of the Munich Technical University

10/10 from 70 Votes

The Rechts der Isar Hospital is the University Hospital of the Technical University of Munich. There is intensive cooperation between the research facilities of the TU and the hospital in numbers of areas.

Cancer of unknown primary (CUP) diagnosis
12154
location_onCountry: Germany
location_searchingCity: Munich
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Vivantes Neukölln Hospital Berlin

10/10 from 23 Votes

The Vivantes Neukölln Hospital is the maximum care hospital and one of the largest healthcare facilities in Berlin.   There are more than 20 specialized departments and centers, including pediatric departments. In total, the hospital has 1,200 beds.

Cancer of unknown primary (CUP) diagnosis
13786
location_onCountry: Germany
location_searchingCity: Berlin

Academic Hospital Neuperlach Munich

9.8/10 from 11 Votes

The Neuperlach Clinic is a modern medical facility with a high level of service. The clinic has high-tech modern equipment, making it one of the best hospitals not only in Germany but also in Europe. There are comfortable single and double rooms with shower and toilet, TV, telephone and radio.

Cancer of unknown primary (CUP) diagnosis
11646
location_onCountry: Germany
location_searchingCity: Munich

University Hospital Muenster

9.8/10 from 78 Votes

The University Hospital Muenster is one of the most respected multi-field medical centers in Germany. It consists of more than 30 departments and numerous research institutes and centers. Every year over 58,000 inpatients are treated here and nearly 475,000 patients receive medical care on the outpatient basis.

Cancer of unknown primary (CUP) diagnosis
11568
location_onCountry: Germany
location_searchingCity: Muenster
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HELIOS Clinic Krefeld

9.7/10 from 38 Votes

Founded in 2014, the HELIOS Clinic Krefeld is one of the most modern medical facilities in Germany today. A team of highly qualified specialists, innovative medical equipment and comfortable accommodation conditions – the clinic has everything to make the treatment run smoothly and efficiently.

Cancer of unknown primary (CUP) diagnosis
11584
location_onCountry: Germany
location_searchingCity: Krefeld

Academic Hospital Harlaching Munich

9.2/10 from 32 Votes

The Academic Hospital Harlaching is an emergency medical care facility offering top-class service. With about 700 beds, the hospital treats about 32,000 patients every year.

Cancer of unknown primary (CUP) diagnosis
11843
location_onCountry: Germany
location_searchingCity: Munich
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Academic Hospital Asklepios Barmbek Hamburg

9.5/10 from 23 Votes

As an Academic Hospital of the University of Hamburg, the Asklepios Barmbek Hospital offers a wide range of medical services in the field of conservative and surgical treatment. The hospital was opened in 2005 and today it is one of the best and modern medical centers in Europe.

Cancer of unknown primary (CUP) diagnosis
11575
location_onCountry: Germany
location_searchingCity: Hamburg

University Hospital Frankfurt am Main

10/10 from 97 Votes

The University Hospital Frankfurt is part of the Johann Wolfgang Goethe University Frankfurt am Main. The hospital was founded in 1914 and today it is a famous German medical institution with rich traditions. The hospital treats about 49,000 inpatients and 220,000 outpatients every year.

Cancer of unknown primary (CUP) diagnosis
12216
location_onCountry: Germany
location_searchingCity: Frankfurt am Main
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Vivantes Humboldt Hospital Berlin

9.7/10 from 23 Votes

An academic clinic of the university medical complex Charité, the Vivantes Humboldt Hospital is one of the largest specialized medical institutions in Berlin.

Cancer of unknown primary (CUP) diagnosis
13607
location_onCountry: Germany
location_searchingCity: Berlin

Academic Hospital Schwabing Munich

8.5/10 from 7 Votes

The Schwabing Clinic is a modern medical facility with a high level of service. The clinic has high-tech modern equipment, making it one of the best hospitals not only in Germany but also in Europe. There are comfortable single and double rooms with shower and toilet, TV, telephone and radio.

Cancer of unknown primary (CUP) diagnosis
11784
location_onCountry: Germany
location_searchingCity: Munich
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University Hospital Duesseldorf

9.9/10 from 71 Votes

The University Hospital Dusseldorf  is a maximum-care hospital, and as such, we at Dusseldorf University, or UKD, are a byword for international top-quality service in all areas of medical care.

Cancer of unknown primary (CUP) diagnosis
11713
location_onCountry: Germany
location_searchingCity: Duesseldorf
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Tel Aviv Sourasky Medical Center

9.9/10 from 23 Votes

The Tel Aviv Sourasky Medical Center (Ichilov) is the second largest and one of the most advanced healthcare and research institutions in Israel. Founded in 1961, it still enjoys popularity among the local population and draws thousands of international patients.

Cancer of unknown primary (CUP) diagnosis
0.00
location_onCountry: Israel
location_searchingCity: Tel Aviv

University Hospital Cologne

9.8/10 from 82 Votes

The University Hospital Cologne is included in the Focus magazine rating of top German hospitals 2017 and offers patients first-class medical care meeting the latest medical advancements.

Cancer of unknown primary (CUP) diagnosis
11606
location_onCountry: Germany
location_searchingCity: Cologne
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About the disease

Cancer of unknown primary (CUP) is a cancer, whose primary site, where it started is unknown. In this case it can be present in several metastatic sites. Detailed tests need to be done in order to understand the origin of the cancer. It is important for further successful treatment. After the origin is identified, cancer is renamed after the organ it started to develop in. In some cases it is impossible to identify the origin of cancer. Nevertheless, even in this cases treatment can be successful. According to American Cancer Society, around 2% of all cancers are represented by CUP. Overall, over the past ten years, incidence of CUP decreased by 35%, which is good news. Mortality rate over this time also decreased almost by 42%.

Because of the fact that CUP can originate in any part of the body, it is difficult to tell its exact causes. It is believed that smoking, DNA mutations, poor nutrition, excessive ultraviolet radiation, obesity are responsible the most for development of CUP. Various researches show that it most often originates in stomach, colon, and ovaries. It can also start to develop on skin, which in this case is called melanoma.     

Symptoms

Symptoms of unidentified cancer can be various as they depend on the organs, which they spread to. Nevertheless, there are several symptoms, which proved to be common for most patients with CUP, and if you have any of those, you need to contact your doctor. 

  • Swollen lymph nodes in different parts of the body
  • Skin tumors, which are manifested as skin bumps
  • Shortness of breath
  • Pain in the abdomen
  • Fatigue
  • Anemia
  • Bone pain, if cancer spread to the bones
  • Weight loss
  • Loss of appetite

Diagnosis

Diagnosis of CUP is in most cases complex, as doctors have to check each organ of the patient to identify the origin of cancerous growth.

  • X-Ray is used to get images of all inner organs.
  • CT scan and MRI produce more precise images, which can also identify cancer origin.
  • Biopsy examines sample tissue of affected organs where doctors suspect the cancer to be the most.
  • Bone marrow aspiration is used, if patient has severe bone pain.
  • Blood test is used to examine blood cells.

Treatment

  • Surgery is used if cancer was found in one organ or in lymph nodes and it can be removed completely. Nevertheless, there is always a possibility that cancerous cells are also present in another organ.
  • Radiation is used to slow the growth of cancer and stop it from spreading further. A patient may need to undergo either external or internal radiation to kill as many malignant cells as possible.
  • Chemotherapy can be used in combination with surgery and radiation. It can also be used if those treatment methods can no longer be applied and in this case chemo is used to relieve the symptoms and prolong patient's life.

In general, in most cases doctors are able to identify the origin of unknown primary cancer and thus chances for recovery become higher. Even if the origin was not identified, but unknown primary still has not progressed very much, you have high survival chances. 




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