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Treatment of Cushing Disease in Germany

Due to the difficulties associated with the organization of treatment in Turkey, Switzerland, South Korea and India, we are not currently processing requests to these regions.

If you are interested in treatment in Germany, please leave a request and our specialists will contact you as soon as possible.

 

Cost for treatment

Diagnosis of Cushing's disease
1409.4
Surgical treatment of Cushing's disease
9335.1
Neurological rehabilitation Phase C
783

Hospital Neuperlach Munich

9.8/10
location_onGermany, Munich

Department of Endocrinology, Diabetology, Angiology and Internal Medicine

The Hospital Neuperlach Munich provides modern medical services of the highest quality. The medical center is an Academic Hospital of the Ludwig Maximilian University of Munich, and therefore it can offer its patients innovative diagnostic and therapeutic methods available only in the best German hospitals. The medical complex o
Diagnosis of Cushing's disease
3808.45

University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of Endocrinology, Rheumatology and Nephrology

According to the Focus magazine, the University Hospital of Ludwig Maximilian University of Munich is regularly ranked among the best medical institutions in Germany! The hospital is the largest multidisciplinary medical facility, as well as a leading research and training center in Germany and Europe. The hospital is proud of i
Diagnosis of Cushing's disease
4640.75
Surgical treatment of Cushing's disease
27587.7

University Hospital Carl Gustav Carus Dresden

9.1/10
location_onGermany, Dresden

Department of Endocrinology

According to the reputable Focus magazine, the University Hospital Carl Gustav Carus Dresden ranks among the top five German hospitals! The hospital is the benchmark for modern high-quality medicine. Positioning itself as a maximum care medical facility, the hospital represents all medical fields. There are 26 specialized depart
Diagnosis of Cushing's disease
5462.9
Surgical treatment of Cushing's disease
32933.85

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Department of Gastroenterology, Hepatology, Pulmonology, Allergology, Endocrinology and Diabetology

According to the reputable Focus magazine, the University Hospital Frankfurt am Main ranks among the top German medical facilities! The hospital was founded in 1914 and today is a well-known German medical facility, which combines rich traditions and scientific innovations. A medical team of more than 6,500 employees cares about
Diagnosis of Cushing's disease
4078.15
Surgical treatment of Cushing's disease
24887.8

University Hospital Jena

8.9/10
location_onGermany, Jena

Department of Nephrology, Rheumatology, Osteology and Endocrinology

According to the prestigious Focus magazine, the University Hospital Jena regularly ranks among the top German medical facilities! The hospital has positioned itself as a multidisciplinary medical facility with a long history of more than 200 years. Since its foundation, the hospital has been constantly developing and modernizin
Diagnosis of Cushing's disease
4735
Surgical treatment of Cushing's disease
27507.95

University Hospital Bonn

9.2/10
location_onGermany, Bonn

Department of Gastroenterology, Hepatology, Nephrology, Infectology, Endocrinology and Diabetology

According to the authoritative Focus magazine, the University Hospital Bonn ranks among the top ten medical facilities in Germany! The hospital was opened on January 1, 2001, although in fact it inherits the medical facility, which operated at the Faculty of Medicine of the University of Bonn. The hospital in Germany combin
Diagnosis of Cushing's disease
4726.3
Surgical treatment of Cushing's disease
28293.85

University Hospital RWTH Aachen

8.7/10
location_onGermany, Aachen

Department of Gastroenterology, Metabolic Disorders and Internal Intensive Care

According to the prestigious Focus magazine, the University Hospital RWTH Aachen ranks among the top German hospitals! As a maximum care university medical facility, the hospital guarantees patients first-class medical services combined with a respectful and human attitude. The hospital integrates all the modern options for the
Diagnosis of Cushing's disease
4671.2
Surgical treatment of Cushing's disease
27940.05

University Hospital Marburg UKGM

8.6/10
location_onGermany, Marburg

Department of Gastroenterology, Endocrinology, Metabolism and Clinical Infectology

The University Hospital Marburg UKGM offers patients modern diagnostics and comprehensive therapy at the international level. As a maximum care hospital, the medical facility specializes in all fields of modern medicine ranging from ophthalmology to traumatology and dentistry. The main areas of specialization of the hospital are
Diagnosis of Cushing's disease
4036.1
Surgical treatment of Cushing's disease
23592.95

University Hospital Halle (Saale)

9.6/10
location_onGermany, Halle

Department of Nephrology, Rheumatology, Endocrinology and Diabetology

According to the prestigious Focus magazine, the University Hospital Halle (Saale) ranks among the top German medical facilities! The history of the hospital has more than 300 years, and during this time it managed to earn an excellent reputation not only in Germany, but throughout the world. The hospital positions itself as a s
Diagnosis of Cushing's disease
4165.15
Surgical treatment of Cushing's disease
24902.3

University Hospital Rechts der Isar Munich

9.8/10
location_onGermany, Munich

Department of Gastroenterology, Hepatology, Endocrinology and Infectology

The University Hospital Rechts der Isar Munich was founded in 1834. It combines long traditions with the very latest advances in modern medicine. The medical facility includes 33 specialized departments and 20 interdisciplinary centers, where patients can receive top-class medical care in all medical fields. The hospital annuall
Diagnosis of Cushing's disease
4527.65
Surgical treatment of Cushing's disease
28180.75

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Department of Endocrinology and Metabolic Disorders

According to the authoritative Focus magazine, the Charite University Hospital Berlin occupies the first place in the rating of the top German medical facilities! The hospital is one of the largest and leading university medical complexes in Europe. The hospital in Germany provides modern diagnostics and treatment of patients, a
Diagnosis of Cushing's disease
6077.7
Surgical treatment of Cushing's disease
36975

University Hospital Duesseldorf

9.5/10
location_onGermany, Duesseldorf

Department of Endocrinology and Diabetology

According to the authoritative Focus magazine, the University Hospital Duesseldorf ranks among the top Germany hospitals! The hospital is an excellent example of a combination of high-quality health care, research and teaching activities. With more than 50,000 inpatients and about 300,000 outpatients every year, the hospital is
Diagnosis of Cushing's disease
4729.2
Surgical treatment of Cushing's disease
27641.35

University Hospital Muenster

9.8/10
location_onGermany, Muenster

Department of Gastroenterology, Hepatology, Endocrinology, Diabetology and Infectology

According to the Focus magazine, the University Hospital Muenster ranks among the top German hospitals! The hospital belongs to the most prestigious medical institutions in Germany. The hospital is distinguished by a high professionalism of its doctors, state-of-the-art technological equipment and the availability of the most ad
Diagnosis of Cushing's disease
4091.2
Surgical treatment of Cushing's disease
24674.65

University Hospital Giessen UKGM

9.5/10
location_onGermany, Giessen

Department of Endocrinology, Diabetology, Metabolic Disorders and Nutritional Medicine

The University Hospital Giessen UKGM positions itself as an ultramodern medical facility with outstanding quality of medical care. The hospital presents almost all areas of medicine, ranging from ophthalmology to traumatology and dentistry. The priorities of the hospital’s activities include surgery, neurosurgery, oncology
Diagnosis of Cushing's disease
3836
Surgical treatment of Cushing's disease
23037.6

University Hospital Essen

9.6/10
location_onGermany, Essen

Department of Endocrinology and Metabolic Disorders

According to the authoritative Focus magazine the University Hospital Essen ranks among the top German hospitals! With 27 specialized departments and 24 institutes, the hospital in Germany is a maximum care medical facility. The hospital has 1,300 beds for inpatient treatment. A highly qualified medical team of more than 6,000 e
Diagnosis of Cushing's disease
4134.7
Surgical treatment of Cushing's disease
24915.35

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Endocrinology and Metabolic Disorders

According to Focus magazine, the University Hospital Heidelberg ranks among the top five hospitals in Germany! The hospital is one of the most advanced and reputable medical institutions not only in Germany, but throughout Europe. There are more than 43 specialized departments and 13 medical institutes, which cover all fields of
Diagnosis of Cushing's disease
0
Surgical treatment of Cushing's disease
0
| from Booking Health GmbH

Itsenko-Cushing's syndrome is a neuroendocrine disorder caused by the increased production of adrenocorticotropic hormone (ACTH) by the pituitary gland. ACTH stimulates the adrenal glands. As a result, they produce too much cortisol, disrupting metabolic processes. Although the term Itsenko-Cushing's disease is used in the medical literature of Russian-speaking countries. In Europe, this pathology is called Cushing's disease.

Itsenko-Cushing's syndrome is a term that differs significantly in Russian and other literature. In the countries of the post-Soviet space, this term means a benign adrenal tumor that produces cortisol. At the same time, in Europe, Cushing's syndrome refers to any manifestation of hypercortisolism, that is, increased production of cortisol of any origin, if it leads to metabolic disorders and clinical symptoms.

Both diseases can be successfully treated. A timely surgical intervention or radiation therapy allows the patient to get rid of hormonal disorders. Doctors in Germany perform operations using minimally invasive techniques: surgical interventions on the pituitary gland are performed through the nose instead of a traumatic transcranial (with craniotomy) surgical approach. Operations on the adrenal glands are performed laparoscopically.

Content

  1. Surgical treatment
  2. Drug therapy
  3. Recurrence treatment

The basis of treatment is a minimally invasive surgical removal of the tumor. If surgery is contraindicated, then radiation therapy is performed to suppress the hormonal activity of the pituitary tumor. In severe cases of hypercortisolism, doctors resort to adrenalectomy – adrenal gland removal.

You can undergo treatment in the following hospitals: University Hospital of Ludwig Maximilian University of Munich, Hospital Neuperlach Munich, University Hospital Carl Gustav Carus Dresden.

Please leave your request with medical records on the Booking Health website, and the company will fully arrange your trip. Our medical advisor will recommend the clinic and the optimal treatment, while travel managers will take care of all organizational issues. They will help you apply for a visa and get to the clinic, provide insurance against complications during treatment, and provide interpreting services. You can contact your personal coordinator for any questions.

Surgical treatment

 

A surgical technique is used as first-line therapy for Itsenko-Cushing's disease. The operation is aimed at removing the organ responsible for the increased production of glucocorticoids.

Endoscopic transnasal adenomectomy is a minimally invasive removal of a pituitary tumor through the nose. The operation is effective in at least 65% of cases, and if performed in a specialized center in Germany, then the efficiency reaches 90%. The disease is completely cured and never recurs. At the same time, the hormone-producing function of the pituitary gland is preserved. The effect after the operation does not develop immediately. Under the influence of ACTH, the adrenal glands work harder and their hyperplasia (enlargement) occurs. The final outcomes of the operation to reduce cortisol production are achieved only after 3-6 months. Other patients instead have insufficient cortisol production and receive glucocorticoid replacement therapy for some time.

Bilateral adrenalectomy is the removal of both adrenal glands. It is used in severe cases when, due to the severity of the patient's condition, doctors do not have time to expect a decrease in cortisol production after pituitary tumor removal. This operation is indicated if the cortisol levels in the daily urine exceeds the norm by 10 times or more and in the development of life-threatening complications. In Germany, the operation is performed using a minimally invasive laparoscopic technique.

Radiation therapy is an alternative to neurosurgery. Instead of removing part of the pituitary gland, it is targeted with radiation. Various techniques can be used: stereotactic radiation therapy, radiosurgery, and brachytherapy. In Germany, irradiation methods are very precise: they ensure the destruction of the pituitary adenoma with minimal risk of developing complications caused by irradiation of the surrounding tissues. However, radiation therapy is not considered first-line therapy. It is carried out if the operation is contraindicated or is not effective enough.

Outdated methods of radiation therapy lead to the development of panhypopituitarism, which is pituitary hormone deficiency. The incidence of this complication reaches 90%. Clinics in Germany use new methods of MRI-guided irradiation. At the same time, the radiation dose decreases, and the symptoms of hypercortisolism disappear more slowly, but the risk of developing pituitary insufficiency is reduced to a minimum.

Drug therapy

 

If surgery cannot be performed, conservative treatment becomes an option. Pasireotide, a multiligand analog of somatostatin, is considered the main drug.

While waiting for a neurosurgical operation, conservative treatment with steroidogenesis blockers can be carried out.

Drugs are also required to alleviate the symptoms of the disease and prevent its complications. Patients with hypercortisolism have an increased risk of developing cardiovascular pathologies. They need antihypertensive (lowering blood pressure) therapy and the intake of drugs to adjust cholesterol levels and blood clotting. Many patients develop metabolic syndrome requiring hypoglycemic therapy.

Recurrence treatment

 

Some patients may have a relapse of the disease after treatment. The risk of recurrence is highest in the first 10 years after neurosurgery. The following treatment options can be used in case of recurrence:

  • Revision surgery for pituitary tumor removal
  • Adrenal gland removal 
  • Radiation therapy for pituitary tumor suppression
  • Drug therapy

To successfully undergo the diagnostics, treatment of Cushing's disease in Germany and rehabilitation, you are welcome to use the Booking Health services. The company's website provides real prices at which one can immediately book the desired medical care program. You can find out the cost of treatment in different clinics in Germany. Due to the absence of additional coefficients for foreign patients, the price will be lower for you than for most medical tourists. The Booking Health specialists will select the best clinic for you and arrange your trip to Germany.

 

Authors:

The article was edited by medical experts, board certified doctors Dr. Vadim Zhiliuk and Dr. Sergey Pashchenko. For the treatment of the conditions referred to in the article, you must consult a doctor; the information in the article is not intended for self-medication!

 

Sources:

Centers for Disease Control and Prevention

Medical News Today

The Lancet




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