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Treatment of Hairy Cell Leukemia in Germany

Due to the difficulties associated with the organization of treatment in Turkey, Switzerland, South Korea and India, we are not currently processing requests to these regions.

If you are interested in treatment in Germany, please leave a request and our specialists will contact you as soon as possible.

 

Cost for treatment

Hairy Cell Leukemia Diagnosis
2437.45
Splenectomy in hairy cell leukemia
6155.25
Treatment of hairy cell leukemia with cytostatics
5668.05

University Hospital Mannheim

9.8/10
location_onGermany, Mannheim

Department of Hematology and Oncology

According to the reputable Focus magazine, the University Hospital Mannheim ranks among the top medical institutions of Germany, which is an undeniable confirmation of the impeccable medical care and excellent reputation of the hospital! The hospital is a high-tech modern medical institution, which provides accurate diagnosis an
Hairy Cell Leukemia Diagnosis
3918.65
Treatment of hairy cell leukemia with cytostatics
9210.25
Treatment of hairy cell leukemia with interferon alpha
14980.9

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Hematology, Oncology, Palliative Care, Rheumatology and Infectology

The University Hospital Ulm started its activities 35 years ago and during this time it has become one of the most prestigious medical institutions in Europe. The hospital is famous for its numerous discoveries and the world-class achievements in medicine and pharmaceuticals. The medical facility has 29 specialized departments a
Hairy Cell Leukemia Diagnosis
4369.6
Splenectomy in hairy cell leukemia
17342.95
Treatment of hairy cell leukemia with cytostatics
10444.2

University Hospital Freiburg

9.7/10
location_onGermany, Freibung

Department of Hematology and Oncology

The University Hospital Freiburg is famous for its rich history and is one of the oldest and most prestigious medical facilities in Germany (one of the three best medical institutions in the country). The hospital was based on the Faculty of Medicine of the Albert Ludwig University of Freiburg, which celebrated its 550th anniver
Hairy Cell Leukemia Diagnosis
4706
Splenectomy in hairy cell leukemia
18333.3
Treatment of hairy cell leukemia with cytostatics
10803.8

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Hematology, Oncology, Adult and Pediatric Rheumatology

According to Focus magazine, the University Hospital Heidelberg ranks among the top five hospitals in Germany! The hospital is one of the most advanced and reputable medical institutions not only in Germany, but throughout Europe. There are more than 43 specialized departments and 13 medical institutes, which cover all fields of
Hairy Cell Leukemia Diagnosis
0
Splenectomy in hairy cell leukemia
0
Treatment of hairy cell leukemia with cytostatics
0

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Department of Hematology, Oncology, Hemostaseology, Rheumatology and Infectology

According to the reputable Focus magazine, the University Hospital Frankfurt am Main ranks among the top German medical facilities! The hospital was founded in 1914 and today is a well-known German medical facility, which combines rich traditions and scientific innovations. A medical team of more than 6,500 employees cares about
Hairy Cell Leukemia Diagnosis
4153.55
Splenectomy in hairy cell leukemia
16533.85
Treatment of hairy cell leukemia with cytostatics
9756.9

University Hospital RWTH Aachen

8.7/10
location_onGermany, Aachen

Department of Oncology and Hematology

According to the prestigious Focus magazine, the University Hospital RWTH Aachen ranks among the top German hospitals! As a maximum care university medical facility, the hospital guarantees patients first-class medical services combined with a respectful and human attitude. The hospital integrates all the modern options for the
Hairy Cell Leukemia Diagnosis
4704.55
Splenectomy in hairy cell leukemia
18140.45
Treatment of hairy cell leukemia with cytostatics
10724.05

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Gastroenterology, Hematology, Oncology, Hepatology, Infectology, Rheumatology and Clinical Immunology

According to the Focus magazine in 2019, the University Hospital Würzburg ranks among the top national German hospitals! The hospital is one of the oldest medical facilities in Germany. The centuries-old traditions of first-class treatment are combined with the very latest achievements of modern evidence-based medicine and
Hairy Cell Leukemia Diagnosis
4121.65
Splenectomy in hairy cell leukemia
16046.65
Treatment of hairy cell leukemia with cytostatics
9275.5

University Hospital Erlangen

9.1/10
location_onGermany, Erlangen

Department of Hematology and Oncology

According to the Focus magazine, University Hospital Erlangen ranks among the best medical facilities in Germany! The hospital is one of the leading healthcare facilities in Bavaria and offers top-class medical care distinguished by the close intertwining of clinical activities with research and training of medical students. The
Hairy Cell Leukemia Diagnosis
4516.05
Splenectomy in hairy cell leukemia
17358.9
Treatment of hairy cell leukemia with cytostatics
10255.7

University Hospital Halle (Saale)

9.6/10
location_onGermany, Halle

Department of Hematology and Oncology

According to the prestigious Focus magazine, the University Hospital Halle (Saale) ranks among the top German medical facilities! The history of the hospital has more than 300 years, and during this time it managed to earn an excellent reputation not only in Germany, but throughout the world. The hospital positions itself as a s
Hairy Cell Leukemia Diagnosis
3938.95
Splenectomy in hairy cell leukemia
16314.9
Treatment of hairy cell leukemia with cytostatics
9290

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of Hematology, Oncology and Pulmonology

According to the Focus magazine, the University Hospital Hamburg-Eppendorf ranks among the top ten hospitals in Germany! Since its foundation in 1889, the hospital has taken a leading position in the European medical arena and still occupies it until today. A highly competent medical team of more than 11,000 employees takes care
Hairy Cell Leukemia Diagnosis
3873.7
Splenectomy in hairy cell leukemia
21202.85
Treatment of hairy cell leukemia with cytostatics
9301.6

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Charité Comprehensive Cancer Center

According to the authoritative Focus magazine, the Charite University Hospital Berlin occupies the first place in the rating of the top German medical facilities! The hospital is one of the largest and leading university medical complexes in Europe. The hospital in Germany provides modern diagnostics and treatment of patients, a
Hairy Cell Leukemia Diagnosis
3899.8
Splenectomy in hairy cell leukemia
24903.25
Treatment of hairy cell leukemia with cytostatics
9166.75

University Hospital Bonn

9.2/10
location_onGermany, Bonn

Department of Oncology, Hematology, Rheumatology and Immunoncology

According to the authoritative Focus magazine, the University Hospital Bonn ranks among the top ten medical facilities in Germany! The hospital was opened on January 1, 2001, although in fact it inherits the medical facility, which operated at the Faculty of Medicine of the University of Bonn. The hospital in Germany combin
Hairy Cell Leukemia Diagnosis
4727.75
Splenectomy in hairy cell leukemia
18558.05
Treatment of hairy cell leukemia with cytostatics
10845.85

University Hospital Giessen UKGM

9.5/10
location_onGermany, Giessen

Department of Oncology, Hematology and Palliative Care

The University Hospital Giessen UKGM positions itself as an ultramodern medical facility with outstanding quality of medical care. The hospital presents almost all areas of medicine, ranging from ophthalmology to traumatology and dentistry. The priorities of the hospital’s activities include surgery, neurosurgery, oncology
Hairy Cell Leukemia Diagnosis
3889.65
Splenectomy in hairy cell leukemia
15186.8
Treatment of hairy cell leukemia with cytostatics
9198.65

University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of Oncology and Hematology

According to the Focus magazine, the University Hospital of Ludwig Maximilian University of Munich is regularly ranked among the best medical institutions in Germany! The hospital is the largest multidisciplinary medical facility, as well as a leading research and training center in Germany and Europe. The hospital is proud of i
Hairy Cell Leukemia Diagnosis
4605.95
Splenectomy in hairy cell leukemia
18334.75
Treatment of hairy cell leukemia with cytostatics
11051.75

University Hospital Marburg UKGM

8.6/10
location_onGermany, Marburg

Department of Hematology, Oncology and Immunology

The University Hospital Marburg UKGM offers patients modern diagnostics and comprehensive therapy at the international level. As a maximum care hospital, the medical facility specializes in all fields of modern medicine ranging from ophthalmology to traumatology and dentistry. The main areas of specialization of the hospital are
Hairy Cell Leukemia Diagnosis
3947.65
Splenectomy in hairy cell leukemia
15022.95
Treatment of hairy cell leukemia with cytostatics
9245.05

University Hospital Muenster

9.8/10
location_onGermany, Muenster

Department of Hematology, Hemostaseology, Oncology and Pulmonology

According to the Focus magazine, the University Hospital Muenster ranks among the top German hospitals! The hospital belongs to the most prestigious medical institutions in Germany. The hospital is distinguished by a high professionalism of its doctors, state-of-the-art technological equipment and the availability of the most ad
Hairy Cell Leukemia Diagnosis
3866.45
Splenectomy in hairy cell leukemia
16351.15
Treatment of hairy cell leukemia with cytostatics
9268.25
| from Booking Health GmbH

Hairy cell leukemia is a rare neoplasm of mature B cells. Often, the pathology develops at the age of 55-60 years. Its feature is a slow progression, a long asymptomatic period of sharp spleen enlargement against the background of slightly swollen lymph nodes. Therapy results in long-term remission. However, the disease may recur after a while. In Germany, the treatment uses the latest drugs that provide good results even for recurrent hairy cell leukemia.

Content

  1. Treatment methods
  2. Standard drug treatment
  3. Relapse treatment
  4. Organization of treatment abroad

The disease is successfully treated with innovative pharmaceuticals. Sometimes doctors perform spleen removal surgery, but most patients do not need it.

The best clinics for the treatment of hairy cell leukemia are; University Hospital Mannheim, University Hospital Freiburg, and University Hospital Ulm.

You are welcome to leave your request on the Booking Health website and we will help you start treatment as soon as possible. The doctors will recommend the most suitable hospital for you and draw up a preliminary medical care program. The Booking Health managers will help you get a visa, book airline tickets and a hotel for you and your companion and provide interpreting services, and medical insurance. You will also have a personal medical coordinator for the entire treatment period.

Treatment methods

 

Hairy cell leukemia is a non-aggressive tumor. Patients do not require treatment immediately after diagnosis. Long-term monitoring for several years is possible before the disease begins to progress.

  • Indications for the start of therapy are as follows:
  •  hemoglobin levels are less than 11 g/dl;
  •  the number of platelets is less than 100 thousand/ml;
  •  the number of neutrophils is less than 1000/ml;
  •  malignant lymphocytosis is more than 5-2 /ml;
  • increased susceptibility to infections;
  • symptomatic splenomegaly and severe lymphadenopathy (enlarged spleen and swollen lymph nodes).

The main treatment methods are chemotherapy with cytostatic and immunotherapy. Some patients require a splenectomy (spleen removal surgery). In Germany, such surgical intervention was performed using a minimally invasive laparoscopic technique.

Standard drug treatment

 

The first breakthrough in treating hairy cell leukemia was the use of alpha-interferon drugs. It has responded effectively up to 80% (decrease or disappearance of tumors), that is stable in many patients.

The nucleoside analogs (Cladribine and Pentostatin) appeared in clinical practice. This was the second breakthrough in the treatment of the disease. These drugs cause long-term remission in almost all patients.

Later, drugs for targeted therapy appeared in the arsenal of doctors, which further improved the treatment outcomes.

Cladribine is used as a single five- or seven-day course during standard therapy. Pentostatin, given every two weeks until hematological parameters normalize and splenomegaly disappears. These two purine analogs have similar clinical activity and toxicity. The treatment is effective in 90% of patients. Due to the more convenient mode of administration, cladribine is frequently used.

Rituximab is often included in the treatment regimen as well. It is used when the standard scheme is not effective enough, as well as with minimal residual disease.

When the tumors have disappeared, cancer cells can still be detected by molecular and biological methods.

Relapse treatment

 

Although standard treatment is effective in most patients, the recurrence rate is 40-50%. After relapse, the response rate to repeated standard treatment decreases. In addition, immunity is often compromised due to high myelotoxicity, increasing the risk of infections and limiting the possibility of repeated treatment with purine analogs.

In recent years, new options for the treatment of such patients have emerged. Doctors use the following drugs:

  •  Anti-CD20 monoclonal antibodies;
  • Anti-CD22 immunotoxins;
  • BRAF inhibitors;
  • MEK inhibitors;
  • Tyrosine Kinase inhibitors.

Some of these drugs have already become part of standard therapy included in the protocols. Others are in the research phase, but they have shown good results and  are expected to be approved for clinical use soon.

The repeated treatment regimen depends on how long the remission lasted. If the remission lasted more than 5 years, then it is possible to repeat the same regimen of therapy, which allowed to achieve a good response in the initial treatment. In the case of recurrence after 2-5 years, the standard procedure is the use of purine analogs in combination with an anti-CD20 monoclonal antibody.

The prognosis is less favorable if the relapse occurs less than 2 years later. In such a case, drugs of other pharmacological groups are used including those not yet part of the standard treatment and are undergoing clinical trials. In addition, doctors can use old techniques that still work in many patients: splenectomy combined with Interferon-alpha and Rituximab.

Organization of treatment abroad

 

Foreign patients who plan to visit Germany for diagnostics and treatment can contact the international medical tourism operator Booking Health. The employees of the have been working with patients from 75 countries for more than 12 years and have up-to-date information about the peculiarities of entering Germany and applying for treatment for each of them.

With the Booking Health company, you can immediately start hairy cell leukemia diagnostics and hairy cell leukemia treatment in Germany. You can find out the cost of different types of treatment in advance and compare the prices for medical services in clinics in Germany in their website. The company's doctors will select the most suitable clinic for you and organize all stages of the trip for treatment. With the Booking Health company, you entrust your health to world-famous specialists and receive treatment at the best price.

 

Authors: 

The article was edited by medical experts, board certified doctors Dr. Nadezhda Ivanisova and Dr. Farrukh Ahmed. For the treatment of the conditions referred to in the article, you must consult a doctor; the information in the article is not intended for self-medication!

 

Sources:

European Society for Medical Oncology

Cancer Support Community

Johns Hopkins Medicine




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