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Nasopharyngeal Cancer. Treatment in Germany

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If you are interested in treatment in Germany, please leave a request and our specialists will contact you as soon as possible.

 

Cost for treatment

Diagnostic tests for nasopharyngeal cancer
797
Combined chemotherapy and radiotherapy for nasopharyngeal cancer
7683
R0 resection of nasopharyngeal cancer
5763

University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of Adult and Pediatric Otolaryngology

According to the Focus magazine, the University Hospital of Ludwig Maximilian University of Munich is regularly ranked among the best medical institutions in Germany! The hospital is the largest multidisciplinary medical facility, as well as a leading research and training center in Germany and Europe. The hospital is proud of i
Diagnostic tests for nasopharyngeal cancer
1933
Combined chemotherapy and radiotherapy for nasopharyngeal cancer
23527
R0 resection of nasopharyngeal cancer
18071

Helios Hospital Berlin-Buch

9.7/10
location_onGermany, Berlin

Department of Adult and Pediatric Otolaryngology

According to the reputable Focus magazine, the Helios Hospital Berlin-Buch ranks among the top medical facilities in Germany! The clinic is proud of its rich history, which dates back over 100 years, as well as the status of a maximum care medical center with exceptionally high success treatment rates. The medical institution is
Diagnostic tests for nasopharyngeal cancer
1830
Combined chemotherapy and radiotherapy for nasopharyngeal cancer
21370
R0 resection of nasopharyngeal cancer
15833

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Adult and Pediatric Otolaryngology, Head and Neck Surgery

The University Hospital Ulm started its activities 35 years ago and during this time it has become one of the most prestigious medical institutions in Europe. The hospital is famous for its numerous discoveries and the world-class achievements in medicine and pharmaceuticals. The medical facility has 29 specialized departments a
Diagnostic tests for nasopharyngeal cancer
1945
Combined chemotherapy and radiotherapy for nasopharyngeal cancer
22660
R0 resection of nasopharyngeal cancer
17107

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Department of Adult and Pediatric Otolaryngology

According to the reputable Focus magazine, the University Hospital Frankfurt am Main ranks among the top German medical facilities! The hospital was founded in 1914 and today is a well-known German medical facility, which combines rich traditions and scientific innovations. A medical team of more than 6,500 employees cares about
Diagnostic tests for nasopharyngeal cancer
2755
Combined chemotherapy and radiotherapy for nasopharyngeal cancer
21222
R0 resection of nasopharyngeal cancer
15855

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of Otolaryngology, Head and Neck Surgery

According to the Focus magazine, the University Hospital Hamburg-Eppendorf ranks among the top ten hospitals in Germany! Since its foundation in 1889, the hospital has taken a leading position in the European medical arena and still occupies it until today. A highly competent medical team of more than 11,000 employees takes care
Diagnostic tests for nasopharyngeal cancer
3488
Combined chemotherapy and radiotherapy for nasopharyngeal cancer
19921
R0 resection of nasopharyngeal cancer
20623

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Adult and Pediatric Otolaryngology, Plastic and Aesthetic Surgery

According to the Focus magazine in 2019, the University Hospital Würzburg ranks among the top national German hospitals! The hospital is one of the oldest medical facilities in Germany. The centuries-old traditions of first-class treatment are combined with the very latest achievements of modern evidence-based medicine and
Diagnostic tests for nasopharyngeal cancer
2699
Combined chemotherapy and radiotherapy for nasopharyngeal cancer
19838
R0 resection of nasopharyngeal cancer
15765

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Department of Adult and Pediatric Otolaryngology

According to the authoritative Focus magazine, the Charite University Hospital Berlin occupies the first place in the rating of the top German medical facilities! The hospital is one of the largest and leading university medical complexes in Europe. The hospital in Germany provides modern diagnostics and treatment of patients, a
Diagnostic tests for nasopharyngeal cancer
4082
Combined chemotherapy and radiotherapy for nasopharyngeal cancer
19900
R0 resection of nasopharyngeal cancer
23728

University Hospital Erlangen

9.1/10
location_onGermany, Erlangen

Department of Adult and Pediatric Otolaryngology, Head and Neck Surgery

According to the Focus magazine, University Hospital Erlangen ranks among the best medical facilities in Germany! The hospital is one of the leading healthcare facilities in Bavaria and offers top-class medical care distinguished by the close intertwining of clinical activities with research and training of medical students. The
Diagnostic tests for nasopharyngeal cancer
1861
Combined chemotherapy and radiotherapy for nasopharyngeal cancer
22095
R0 resection of nasopharyngeal cancer
16691

University Hospital Jena

8.9/10
location_onGermany, Jena

Department of Adult and Pediatric Otolaryngology

According to the prestigious Focus magazine, the University Hospital Jena regularly ranks among the top German medical facilities! The hospital has positioned itself as a multidisciplinary medical facility with a long history of more than 200 years. Since its foundation, the hospital has been constantly developing and modernizin
Diagnostic tests for nasopharyngeal cancer
3126
Combined chemotherapy and radiotherapy for nasopharyngeal cancer
19772
R0 resection of nasopharyngeal cancer
18115

University Hospital Muenster

9.8/10
location_onGermany, Muenster

Department of Adult and Pediatric Otolaryngology

According to the Focus magazine, the University Hospital Muenster ranks among the top German hospitals! The hospital belongs to the most prestigious medical institutions in Germany. The hospital is distinguished by a high professionalism of its doctors, state-of-the-art technological equipment and the availability of the most ad
Diagnostic tests for nasopharyngeal cancer
2727
Combined chemotherapy and radiotherapy for nasopharyngeal cancer
19880
R0 resection of nasopharyngeal cancer
15795

University Hospital Bonn

9.2/10
location_onGermany, Bonn

Department of Adult and Pediatric Otolaryngology

According to the authoritative Focus magazine, the University Hospital Bonn ranks among the top ten medical facilities in Germany! The hospital was opened on January 1, 2001, although in fact it inherits the medical facility, which operated at the Faculty of Medicine of the University of Bonn. The hospital in Germany combin
Diagnostic tests for nasopharyngeal cancer
3165
Combined chemotherapy and radiotherapy for nasopharyngeal cancer
23611
R0 resection of nasopharyngeal cancer
17592

University Hospital Tuebingen

9.2/10
location_onGermany, Tuebingen

Department of Adult and Pediatric Otolaryngology

According to the prestigious medical publication Focus, the University Hospital Tuebingen ranks among the top five German hospitals! The hospital was founded in 1805, therefore it is proud of its long history, unique experience, and outstanding achievements in the field of medical care, as well as research and teaching activitie
Diagnostic tests for nasopharyngeal cancer
1938
Combined chemotherapy and radiotherapy for nasopharyngeal cancer
22092
R0 resection of nasopharyngeal cancer
16948

University Hospital Halle (Saale)

9.6/10
location_onGermany, Halle

Department of Adult and Pediatric Otolaryngology, Head and Neck Surgery

According to the prestigious Focus magazine, the University Hospital Halle (Saale) ranks among the top German medical facilities! The history of the hospital has more than 300 years, and during this time it managed to earn an excellent reputation not only in Germany, but throughout the world. The hospital positions itself as a s
Diagnostic tests for nasopharyngeal cancer
2810
Combined chemotherapy and radiotherapy for nasopharyngeal cancer
19908
R0 resection of nasopharyngeal cancer
16273

University Hospital Duesseldorf

9.5/10
location_onGermany, Duesseldorf

Department of Adult and Pediatric Otolaryngology

According to the authoritative Focus magazine, the University Hospital Duesseldorf ranks among the top Germany hospitals! The hospital is an excellent example of a combination of high-quality health care, research and teaching activities. With more than 50,000 inpatients and about 300,000 outpatients every year, the hospital is
Diagnostic tests for nasopharyngeal cancer
3184
Combined chemotherapy and radiotherapy for nasopharyngeal cancer
20089
R0 resection of nasopharyngeal cancer
17662

University Hospital Marburg UKGM

8.6/10
location_onGermany, Marburg

Department of Adult and Pediatric Otolaryngology

The University Hospital Marburg UKGM offers patients modern diagnostics and comprehensive therapy at the international level. As a maximum care hospital, the medical facility specializes in all fields of modern medicine ranging from ophthalmology to traumatology and dentistry. The main areas of specialization of the hospital are
Diagnostic tests for nasopharyngeal cancer
2682
Combined chemotherapy and radiotherapy for nasopharyngeal cancer
20051
R0 resection of nasopharyngeal cancer
14877

University Hospital Rechts der Isar Munich

9.8/10
location_onGermany, Munich

Department of Adult and Pediatric Otolaryngology, Head and Neck Surgery, Facial Plastic Surgery

The University Hospital Rechts der Isar Munich was founded in 1834. It combines long traditions with the very latest advances in modern medicine. The medical facility includes 33 specialized departments and 20 interdisciplinary centers, where patients can receive top-class medical care in all medical fields. The hospital annuall
Diagnostic tests for nasopharyngeal cancer
3082
Combined chemotherapy and radiotherapy for nasopharyngeal cancer
23886
R0 resection of nasopharyngeal cancer
17970
| from Booking Health GmbH

Nasopharyngeal cancer is a rare head and neck tumor. Its treatment mostly involves the use of radiation therapy, often in combination with chemotherapy. Less commonly, doctors perform surgery to remove the primary tumor and cervical lymph nodes. In the advanced stages, German doctors resort to chemotherapy, targeted therapy and immunotherapy. You can go to Germany to receive treatment for nasopharyngeal cancer. Most cases of the disease are successfully cured in this country.

Content

  1. What is nasopharyngeal cancer?
  2. Principles of treatment
  3. Radiation therapy
  4. Chemotherapy
  5. Targeted therapy and immunotherapy
  6. Surgical treatment
  7. Why is it worth undergoing treatment in Germany?

What is nasopharyngeal cancer?

 

The pharynx is an organ located in the head and neck. It is part of the digestive system: it is located between the oral cavity and the esophagus. The pharynx consists of three parts: nasal, oral, and laryngeal. They are called the nasopharynx, oropharynx, and laryngopharynx.

The nasopharynx is the upper part of the pharynx. Malignant tumors in this area are called nasopharyngeal cancer. The Epstein-Barr virus and chronic inflammation are considered to be the main causes of this disease. The disease is most common in Southeast Asia, Africa, and Indochina, but it is rare in Western countries. Most clinical cases are squamous cell carcinoma.

The early stages of nasopharyngeal cancer usually proceed under the guise of inflammatory diseases: acute respiratory infections, rhinopharyngitis, and adenoid vegetations. Therefore, most cases of the disease are diagnosed only after the onset of metastases in the regional lymph nodes.

Diagnostic methods for nasopharyngeal cancer include:

  • rhinoscopy – anterior and posterior (examination of the nasal cavity);
  • nasopharyngoscopy – examination of the nasopharynx, with imprint smears and biopsy specimens to confirm the diagnosis;
  • blood PCR to detect Epstein-Barr virus DNA (used to control nasopharyngeal cancer treatment in order to monitor any residual disease after chemoradiotherapy);
  • puncture biopsy of the neck lymph nodes with a cytological examination of the material – to detect nasopharyngeal cancer metastases;
  • chest CT, as well as CT or MRI of the facial part of the skull (in case of the detection of lymph node metastases);
  • MRI to clarify the characteristics of the tumor – an obligatory stage during the planning of radiation therapy.

Principles of treatment

 

Chemoradiation therapy is the main treatment for nasopharyngeal cancer.

In the early stages, only radiation therapy can be used to reduce the toxicity of the treatment.

Treatment options for locally advanced nasopharyngeal cancer include:

  • induction chemotherapy, and then – chemoradiotherapy (simultaneous use of chemotherapy and radiotherapy);
  • chemoradiotherapy and then chemotherapy.

The second option is preferable, since it produces higher survival rates for patients with nasopharyngeal cancer.

If nasopharyngeal cancer treatment is successful, the primary tumor and all the lymph nodes will disappear, then, in the future, the patient will only need monitoring. If there are metastases in the lymph nodes, a surgical intervention is required to remove them.

With the development of distant metastases, nasopharyngeal cancer is treated with chemotherapy. But, for cancer treatment in Germany, even at its advanced stage, surgical interventions are sometimes performed. A surgical intervention is possible only in the presence of single metastases, if all of them can be completely removed. In addition, chemoradiotherapy may be used if the doctor believes that all the tumor lesions can be destroyed by radiation.

With local tumor recurrence, chemotherapy is used. Surgical removal of the recurrent tumor or chemoradiotherapy is rarely performed.

Radiation therapy

 

As a rule, cancer treatment in Germany begins with surgery. However, in the fight against nasopharyngeal cancer, radiotherapy is considered the main method. It is quite effective and often cures the disease completely, and at the same time, is safer for a patient’s health compared to surgery.

The following things are important for the success of radiation therapy:

  • accurate determination of the stage of the disease by performing a CT, MRI of the head and neck, chest, as well as lymph node puncture;
  • oropharyngeal sanitation (elimination of foci of infection);
  • assessment of the condition of the oral cavity, teeth, provision of adequate nutrition.

The scope of the radiotherapy is planned immediately after a diagnosis is established and is not decreased, even with a good response to induction chemotherapy. The exception is situations where it is necessary to irradiate vital anatomical structures. If the tumor foci in these places have disappeared under the influence of chemotherapy, then the dose of radiation can be reduced to make nasopharyngeal cancer treatment safer for a patient’s health.

Preferred radiotherapy options are:

  • IMRT;
  • VMAT;
  • 3D conformal radiotherapy if possible.

In Germany, you will be treated with IMRT (intensity-modulated radiation therapy) or VMAT (volumetric modulated arc therapy). These methods of irradiation are safer for your health. They rarely cause severe post-radiation complications. With the use of new techniques, the tolerability of not only radiotherapy, but also chemoradiotherapy, improves.

Some hospitals use proton therapy. It has a higher safety rate and head and neck tumors are one of the main indications for the use of this technique. Photons are usually used to irradiate neoplasms. They emit radiation not only in the tumor, but during the entire movement towards the target. Protons release most of their energy upon reaching the target, so they do less damage to healthy tissue.

Chemotherapy

 

Most patients receive chemotherapy for nasopharyngeal cancer. It is used in the following cases:

  • induction chemotherapy is conducted to reduce the tumor size before chemoradiotherapy;
  • chemotherapy is combined with radiotherapy for nasopharyngeal cancer, within the framework of chemoradiotherapy – this is the main treatment method for the disease;
  • adjuvant chemotherapy is conducted after chemoradiotherapy to reduce the risk of recurrence (in patients who did not receive induction chemotherapy before irradiation);
  • an independent treatment method, chemotherapy is used in the advanced stage of the disease, in patients with distant metastases.

Targeted therapy and immunotherapy

 

Targeted therapy uses antibodies to target the epidermal growth factor receptor (EGFR). This protein is located on the surface of cancer cells. It receives signals that cause the cell to constantly divide. By blocking this protein with drugs, doctors thereby slow down the progression of nasopharyngeal cancer.

Targeted therapy drugs are not used as first-line treatment options. They are used in the following cases:

  • in cases with insufficient effectiveness of chemotherapy;
  • in case of cancer recurrence after a primary treatment;
  • in advanced stages of nasopharyngeal cancer.

Targeted therapy drugs are safer and better tolerated compared to cytostatic polychemotherapy. However, they sometimes cause side effects: skin rash, headache, weakness, fever, diarrhea, and nausea. Allergic reactions develop occasionally, but they can be eliminated with anti-inflammatory drugs.

Immunotherapy uses PD-1 inhibitors. They are called immune checkpoint inhibitors. They do not have a direct cytotoxic effect on the tumor, but enhance the response of antitumor immunity. PD-1 inhibitors are relatively safe for health, although they cause autoimmune reactions in some people. It is possible to carry out nasopharyngeal cancer treatment with immunotherapy, even as a first-line therapy, but more often, such treatment is used for recurrences or in the advanced stage of oncology with distant metastases.

Surgical treatment

 

In oncology, surgical treatment is considered the main treatment. However, in cases of oropharyngeal oncology, surgery is rarely performed, for two reasons:

  • radiation therapy also provides good results;
  • surgical removal of the primary tumor is technically complex.

Therefore, surgery is mainly used to remove lymph nodes. In progressive hospitals in Germany, these operations can be performed using a minimally invasive, endoscopic technique. Such operations provide a better aesthetic result: since the incisions on the neck are shorter and there are no large scars on the skin.

In specialized, progressive oncology hospitals in Germany, the removal of tumors at an early stage is carried out using an endoscopic technique. The surgical interventions are performed through the nose. The main advantage of surgery over radiotherapy is that doctors receive material for histological examination. They can check the cleanliness of the resection margin to make sure the nasopharyngeal cancer has been totally removed. In a case of incomplete removal, such measures as radiation therapy can be taken to reduce the risk of recurrence.

The surgery is most often performed to remove neck lymph nodes. Neck lymph node dissection can be:

  • selective – removal of only the lymph nodes closest to the tumor;
  • modified lymph node dissection – removal of nodes on one side of the neck between the lower jaw and collarbone, as well as the resection of muscle and nervous tissue (the brachial plexus is preserved);
  • radical lymph node dissection – removal of almost all lymph nodes, and more muscles, nerves and veins.

The more lymph nodes removed, the higher the chances of curing nasopharyngeal cancer. At the same time, more radical interventions increase the risk of complications and side effects. These surgical interventions sometimes cause problems with speech, swallowing, numbness of the ear, impaired mobility of the lower lip, and weakness in the shoulder muscles. Neurological complications resolve after a few months, but if the nerves are intersected or removed, they are permanent.

Why is it worth undergoing treatment in Germany?

 

Germany offers progressive medicine. The country uses innovative treatment methods for nasopharyngeal cancer. This disease is successfully cured in most patients. German hospitals have state-of-the-art equipment to make treatment more sparing, safer, and less traumatic.

There are a few reasons for you to go to Germany for nasopharyngeal cancer treatment:

  • accurate diagnostics allows doctors to establish the spread of the tumor process in order to ideally plan a treatment regimen;
  • German hospitals use innovative irradiation methods that deliver radiation precisely to the tumor, with minimal impact on healthy tissues;
  • there are several Proton Therapy Centers in the country, where patients can undergo the safest proton irradiation of the tumor;
  • specialized hospitals perform minimally invasive, surgical treatment – endoscopic removal of the primary nasopharyngeal tumor;
  • cervical lymph node dissection is performed using endoscopic surgery, through short incisions to reduce the trauma of the intervention;
  • the use of new regimens of drug therapy for advanced cancer, which include not only chemotherapy, but also targeted therapy and immunotherapy.

To undergo cancer treatment in Germany, please use the Booking Health service. On our website you have the opportunity to get up-to-date and accurate information about the cost of treatment in Germany, compare prices in different German hospitals and book a medical care program at a favorable price. The treatment will be easier and quicker for you, and the cost of treatment in Germany will be lower.

You are welcome to leave your request on the Booking Health website. Our employee will contact you within a few hours, consult with you, and answer all of your questions. We will take care of the organization of your trip abroad. We will provide the following benefits for you:

  • We will select the best German hospital, whose doctors specialize in nasopharyngeal cancer treatment and achieve the best results.
  • We will help you to overcome the language barrier and establish your communication with the doctor of the German hospital.
  • We will reduce the waiting period for diagnostics and treatment, and you will receive medical care on the most suitable dates for you.
  • We will reduce the price. The cost of treatment in Germany will be lower than usual due to the lack of overpricing and coefficients for foreign patients.
  • Our specialists will solve any organizational issues: paperwork, transfers from the airport to the German hospital and back, hotel booking, and interpreting services.
  • We will prepare your documents and translate them into English or German. You do not have to undergo any previously performed diagnostic procedures.
  • We will stay in contact with the German hospital after the completion of your treatment.
  • We will organize additional diagnostics and treatment, if necessary.
  • We will buy medicines in the other country and forward them to your native country.

While the best specialists in the world take care of your health, the Booking Health staff will help you to reduce the cost of treatment in Germany and take care of all your travel arrangements.

 

Authors: 

The article was edited by medical experts, board certified doctors Dr. Nadezhda Ivanisova and Dr. Farrukh Ahmed. For the treatment of the conditions referred to in the article, you must consult a doctor; the information in the article is not intended for self-medication!

 

Sources:

European Society for Medical Oncology

Cancer Research Institute

The Lancet




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