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Treatment of Neuroblastoma (ganglioneuroblastoma) in Children

Due to the difficulties associated with the organization of treatment in Turkey, Switzerland, South Korea and India, we are not currently processing requests to these regions.

If you are interested in treatment in Germany, please leave a request and our specialists will contact you as soon as possible.

 

Cost for treatment

Diagnostics of neuroblastoma (ganglioneyroblastoma)
 from  1455.3
Chemotherapy of neuroblastoma (ganglioneyroblastoma) stage 1-3 (1 course)
 from  2784.1
High-dose chemotherapy and peripheral blood stem cell autografts (PBSCT) in neuroblastoma (ganglioneyroblastoma) stage 4
 from  42429.2

Hospital Neuwerk Moenchengladbach

9.2/10
location_onGermany, Moenchengladbach

Department of Pediatric and Adolescent Medicine

The Hospital Neuwerk, which is in Moenchengladbach, has over 10 specialized operating departments. Located in the northern part of the city, the hospital has been a coordination center for the region for many years. The hospital has 310 comfortable beds for ist patients. Due to a wide range of medical services, the hospital offe
Diagnostics of neuroblastoma (ganglioneyroblastoma)
3062.1
Chemotherapy of neuroblastoma (ganglioneyroblastoma) stage 1-3 (1 course)
6566
Resection of Neuroblastoma (ganglioneyroblastoma)
31553.4

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Department of Pediatric and Adolescent Medicine

According to the reputable Focus magazine, the University Hospital Frankfurt am Main ranks among the top German medical facilities! The hospital was founded in 1914 and today is a well-known German medical facility, which combines rich traditions and scientific innovations. A medical team of more than 6,500 employees cares about
Diagnostics of neuroblastoma (ganglioneyroblastoma)
3413
Chemotherapy of neuroblastoma (ganglioneyroblastoma) stage 1-3 (1 course)
7224.9
High-dose chemotherapy and peripheral blood stem cell autografts (PBSCT) in neuroblastoma (ganglioneyroblastoma) stage 4
99503.1

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Pediatric Oncology, Hematology, Immunology and Pulmonology

According to the Focus magazine, the University Hospital Heidelberg ranks among the top five hospitals in Germany! The hospital is one of the most advanced and reputable medical institutions not only in Germany, but throughout Europe. There are more than 43 specialized departments and 13 medical institutes, which cover all field
Diagnostics of neuroblastoma (ganglioneyroblastoma)
0
Diagnostics of neuroblastoma (ganglioneyroblastoma)
0
Chemotherapy of neuroblastoma (ganglioneyroblastoma) stage 1-3 (1 course)
0

University Hospital RWTH Aachen

8.9/10
location_onGermany, Aachen

Department of Pediatric and Adolescent Medicine

According to the prestigious Focus magazine, the University Hospital RWTH Aachen ranks among the top German hospitals! As a maximum care university medical facility, the hospital guarantees patients first-class medical services combined with a respectful and human attitude. The hospital integrates all the modern options for the
Diagnostics of neuroblastoma (ganglioneyroblastoma)
3798
Chemotherapy of neuroblastoma (ganglioneyroblastoma) stage 1-3 (1 course)
7911.3
High-dose chemotherapy and peripheral blood stem cell autografts (PBSCT) in neuroblastoma (ganglioneyroblastoma) stage 4
113776.7

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of Pediatric Hematology and Oncology

According to the Focus magazine, the University Hospital Hamburg-Eppendorf ranks among the top ten hospitals in Germany! Since its foundation in 1889, the hospital has taken a leading position in the European medical arena and still occupies it until today. A highly competent medical team of more than 11,000 employees takes care
Diagnostics of neuroblastoma (ganglioneyroblastoma)
3419.6
Chemotherapy of neuroblastoma (ganglioneyroblastoma) stage 1-3 (1 course)
6835.5
High-dose chemotherapy and peripheral blood stem cell autografts (PBSCT) in neuroblastoma (ganglioneyroblastoma) stage 4
92367.4

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Pediatric and Adolescent Medicine

According to the Focus magazine in 2019, the University Hospital Würzburg ranks among the top national German hospitals! The hospital is one of the oldest medical facilities in Germany. The centuries-old traditions of first-class treatment are combined with the very latest achievements of modern evidence-based medicine and
Diagnostics of neuroblastoma (ganglioneyroblastoma)
3425.1
Chemotherapy of neuroblastoma (ganglioneyroblastoma) stage 1-3 (1 course)
6827.8
High-dose chemotherapy and peripheral blood stem cell autografts (PBSCT) in neuroblastoma (ganglioneyroblastoma) stage 4
92683.1

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Department of Pediatric Oncology and Hematology

According to the authoritative Focus magazine, the Charite University Hospital Berlin occupies the first place in the rating of the top German medical facilities! The hospital is one of the largest and leading university medical complexes in Europe. The hospital in Germany provides modern diagnostics and treatment of patients, a
Diagnostics of neuroblastoma (ganglioneyroblastoma)
3356.9
Chemotherapy of neuroblastoma (ganglioneyroblastoma) stage 1-3 (1 course)
6869.6
High-dose chemotherapy and peripheral blood stem cell autografts (PBSCT) in neuroblastoma (ganglioneyroblastoma) stage 4
92148.5

University Hospital Tuebingen

9.2/10
location_onGermany, Tuebingen

Department of General Pediatrics, Pediatric Hematology and Oncology

According to the prestigious medical publication Focus, the University Hospital Tuebingen ranks among the top five German hospitals! The hospital was founded in 1805, therefore it is proud of its long history, unique experience, and outstanding achievements in the field of medical care, as well as research and teaching activitie
Diagnostics of neuroblastoma (ganglioneyroblastoma)
3789.2
Chemotherapy of neuroblastoma (ganglioneyroblastoma) stage 1-3 (1 course)
7529.6
High-dose chemotherapy and peripheral blood stem cell autografts (PBSCT) in neuroblastoma (ganglioneyroblastoma) stage 4
106600.3

University Hospital Bonn

9.2/10
location_onGermany, Bonn

Department of Pediatric Hematology and Oncology

According to the authoritative Focus magazine, the University Hospital Bonn ranks among the top ten medical facilities in Germany! The hospital was opened on January 1, 2001, although in fact it inherits the medical facility, which operated at the Faculty of Medicine of the University of Bonn. The hospital in Germany combin
Diagnostics of neuroblastoma (ganglioneyroblastoma)
3919
Chemotherapy of neuroblastoma (ganglioneyroblastoma) stage 1-3 (1 course)
7802.4
High-dose chemotherapy and peripheral blood stem cell autografts (PBSCT) in neuroblastoma (ganglioneyroblastoma) stage 4
113353.2

University Hospital Duesseldorf

9.5/10
location_onGermany, Duesseldorf

Department of Pediatric Oncology, Hematology and Clinical Immunology

According to the authoritative Focus magazine, the University Hospital Duesseldorf ranks among the top Germany hospitals! The hospital is an excellent example of a combination of high-quality health care, research and teaching activities. With more than 50,000 inpatients and about 300,000 outpatients every year, the hospital is
Diagnostics of neuroblastoma (ganglioneyroblastoma)
3425.1
Chemotherapy of neuroblastoma (ganglioneyroblastoma) stage 1-3 (1 course)
6870.7
High-dose chemotherapy and peripheral blood stem cell autografts (PBSCT) in neuroblastoma (ganglioneyroblastoma) stage 4
92638

University Hospital Muenster

9.8/10
location_onGermany, Muenster

Department of Pediatric Hematology and Oncology

According to the Focus magazine, the University Hospital Muenster ranks among the top German hospitals! The hospital belongs to the most prestigious medical institutions in Germany. The hospital is distinguished by a high professionalism of its doctors, state-of-the-art technological equipment and the availability of the most ad
Diagnostics of neuroblastoma (ganglioneyroblastoma)
3287.6
Chemotherapy of neuroblastoma (ganglioneyroblastoma) stage 1-3 (1 course)
6970.8
High-dose chemotherapy and peripheral blood stem cell autografts (PBSCT) in neuroblastoma (ganglioneyroblastoma) stage 4
92501.6

University Hospital Halle (Saale)

9.6/10
location_onGermany, Halle

Department of General Pediatrics, Pediatric Hematology, Oncology and Neuropediatrics

According to the prestigious Focus magazine, the University Hospital Halle (Saale) ranks among the top German medical facilities! The history of the hospital has more than 300 years, and during this time it managed to earn an excellent reputation not only in Germany, but throughout the world. The hospital positions itself as a s
Diagnostics of neuroblastoma (ganglioneyroblastoma)
3267.8
Chemotherapy of neuroblastoma (ganglioneyroblastoma) stage 1-3 (1 course)
6958.7
High-dose chemotherapy and peripheral blood stem cell autografts (PBSCT) in neuroblastoma (ganglioneyroblastoma) stage 4
92647.9

University Hospital Jena

8.9/10
location_onGermany, Jena

Department of Pediatric and Adolescent Medicine

According to the prestigious Focus magazine, the University Hospital Jena regularly ranks among the top German medical facilities! The hospital has positioned itself as a multidisciplinary medical facility with a long history of more than 200 years. Since its foundation, the hospital has been constantly developing and modernizin
Diagnostics of neuroblastoma (ganglioneyroblastoma)
3308.5
Chemotherapy of neuroblastoma (ganglioneyroblastoma) stage 1-3 (1 course)
6977.4
High-dose chemotherapy and peripheral blood stem cell autografts (PBSCT) in neuroblastoma (ganglioneyroblastoma) stage 4
92119.9

University Hospital Marburg UKGM

8.6/10
location_onGermany, Marburg

Department of Pediatric and Adolescent Medicine

The University Hospital Marburg UKGM offers patients modern diagnostics and comprehensive therapy at the international level. As a maximum care hospital, the medical facility specializes in all fields of modern medicine ranging from ophthalmology to traumatology and dentistry. The main areas of specialization of the hospital are
Diagnostics of neuroblastoma (ganglioneyroblastoma)
3362.4
Chemotherapy of neuroblastoma (ganglioneyroblastoma) stage 1-3 (1 course)
6852
High-dose chemotherapy and peripheral blood stem cell autografts (PBSCT) in neuroblastoma (ganglioneyroblastoma) stage 4
92332.2

University Hospital Rechts der Isar Munich

9.8/10
location_onGermany, Munich

Department of Pediatrics and Adolescent Medicine

According to the prestigious FOCUS magazine, the University Hospital Rechts der Isar Munich ranks among the Germany's top medical institutions! Founded in 1834, the hospital combines long traditions and the very latest achievements of modern medicine. The medical facility includes 33 specialized departments, 20 interdiscipli
Diagnostics of neuroblastoma (ganglioneyroblastoma)
3968.5
Chemotherapy of neuroblastoma (ganglioneyroblastoma) stage 1-3 (1 course)
7839.8
Radiotherapy of neuroblastoma (ganglioneyroblastoma)
31971.4

University Hospital Essen

9.6/10
location_onGermany, Essen

Department of Pediatric Oncology, Hematology, Pulmonology, Cardiology and Rheumatology

According to the authoritative Focus magazine the University Hospital Essen ranks among the top German hospitals! With 27 specialized departments and 24 institutes, the hospital in Germany is a maximum care medical facility. The hospital has 1,300 beds for inpatient treatment. A highly qualified medical team of more than 6,000 e
Diagnostics of neuroblastoma (ganglioneyroblastoma)
3378.9
Chemotherapy of neuroblastoma (ganglioneyroblastoma) stage 1-3 (1 course)
6976.3
High-dose chemotherapy and peripheral blood stem cell autografts (PBSCT) in neuroblastoma (ganglioneyroblastoma) stage 4
99642.8
| from Booking Health GmbH

Content

  1. Overview
  2. Incidence of ganglioneuroblastoma
  3. Symptoms
  4. Treatment
  5. Staging
  6. Treatment of intermediate-risk neuroblastoma
  7. Statistics on recovery from neuroblastoma
  8. Prices for treatment
  9. Undergoing treatment of neuroblastoma with Booking Health

 

Neuroblastoma is a tumor of the nervous system. Here you’ll find everything about neuroblastoma: how common it is, its symptoms, peculiarities of the diagnosis making, what methods of medical care are there for children with cancer, and the chances for recovery from this form of cancer.

Overview

 

Neuroblastoma is a form of cancer that grows from mutated immature nervous cells.

Neuroblastoma can appear wherever nervous system tissue is present. Cancer most often grows in the adrenal glands (about 50% of all children with neuroblastoma). With cancer of such origin, the tumor can also grow in the abdomen, pelvis. Often, the neuroblastoma tumor appears in the abdomen (about 75% of all children with neuroblastoma). In about one-fifth of patients with neuroblastoma cancer grows in the chest and neck.

Some neuroblastomas remain where they started, while others grow further. In about 50% of people with neuroblastoma, doctors detect metastases in the bones at the time of diagnosis making. Less commonly, cancer cells can spread to the brain, lungs, or skin.

Incidence of ganglioneuroblastoma

 

Ganglioneuroblastoma is a rare type of tumor which accounts for only 0.5% of all cancer cases.

Ganglioneuroblastoma represents the type of tumor with foci of hemorrhage and necrotic areas. Ganglioneuroblastoma ranks second in frequency of occurrence among nervous system cancers. It accounts for about 40% of the tumors in this group. In half of the cases, ganglioneuroblastoma is located in the retroperitoneal space.

Ganglioneuroblastoma is the result of malignant transformation of the ganglioneuroma and is a type of neuroblastoma. To date, there’s no accurate information about the causes of ganglioneuroblastoma. Most of the time ganglioneuroblastoma occurs in children, mainly in the age range from 4 to 10 years.

Symptoms

 

Many children with neuroblastoma experience no symptoms at all. Cancer is usually detected accidentally. As a rule, children begin to complain when cancer spreads metastases.

Manifestations of the disease can be very diverse. They depend mainly on the localization of cancer metastases. The first symptom in children with neuroblastoma may be the tumor itself or metastases, which can be felt during palpation. In some children with neuroblastoma, a swollen belly attracts attention. If the tumor has grown in the abdominal cavity, then nonspecific symptoms such as abdominal pain, constipation, a feeling of heaviness in the abdomen, or diarrhea may appear. If the tumor compresses the ureter, the child with neuroblastoma may have urinary retention. Tumors that grow close to the spine can invade into the spinal canal. Therefore, the child with neuroblastoma of such localization may have specific neurological symptoms.

Common symptoms children with neuroblastoma experience are:

  • Fatigue, loss of strength, weakness, pallor
  • Persistent fever for no apparent reason, sweating
  • Swelling in the abdomen or neck; enlarged lymph nodes
  • Bloating
  • Loss of appetite, nausea, vomiting, and, as a result, weight loss
  • Bone pain

Treatment

 

Children with neuroblastoma should only be treated by doctors from pediatric hospitals specializing in pediatric oncology. Also, in such hospitals, doctors of different medical specialties participate in treatment planning. All doctors cooperate closely, they discuss cases of their patients with neuroblastoma and draw up treatment plans together.

Any treatment protocol for children with neuroblastoma is aimed to provide therapy with minimum health consequences after the treatment completion.

The individual peculiarities of the diagnosis influence a treatment choice for a child with neuroblastoma. In some children with neuroblastoma, surgery is sufficient; in others, it’s necessary to combine several methods of cancer care.

The methods that specialists use in the treatment of neuroblastoma include surgery, chemotherapy, and radiation therapy. For children with a very high risk of relapse additional high-dose chemotherapy, and autologous bone marrow transplantation, or immunotherapy are prescribed.

Surgery is performed for a tumor excision or tissue sampling for further histological examination. When chemotherapy is carried out, patients receive drugs that block cell growth, and thus chemotherapy destroys the malignant cells. Usually, doctors administer combinations of different drugs, in which each drug affects cancer cells in its own way. As a result, maximum effectiveness against cancer cells is achieved.

Staging

 

Until 1988, stages of the disease were determined according to the TNM system. However, a modified system with the elements of the previous one was approved later the same year, i.e. the International Neuroblastoma Staging System.

For stage identification, clinicians use the International Neuroblastoma Staging System. With the International Neuroblastoma Staging System, specific factors are assessed in order to determine cancer spreading, i.e. cancer invasiveness in patients with neuroblastoma.

In the International Neuroblastoma Staging System, tumors are divided into first to third stages, fourth stage (with metastases), and separate stage four for infantile metastatic pathology.

  1. The first stage is characterized by the tumor localization at its primary site
  2. At the second stage, neoplasm invades the surrounding tissues
  3. At the third stage, a tumor spreads along the spine on both sides, affecting the lymph nodes
  4. By the fourth stage of development, a pathological formation spreads to the distant tissues and organs

However, the International Neuroblastoma Staging System allows specialists to assess the degree of malignancy in a child with cancer, which is essential for the treatment planning.

Even though experts still operate the International Neuroblastoma Staging System, establishing neuroblastoma risk groups (International Neuroblastoma Staging System of risk group) is currently of choice worldwide. Operating this type of International Neuroblastoma Staging System, the cancer stage is identified before starting the treatment of children with neuroblastoma. Along with using the International Neuroblastoma Staging System of risk groups during choosing a treatment tactic, the health condition of a child with neuroblastoma and the molecular features of cancer are considered as well.

In the risk group International Neuroblastoma Staging System, the advanced stages (metastatic cancer) of neuroblastomas are subdivided as well.

With cancer, the forecast is influenced by the level of the neoplasm’s activity. Defining the cancer stage creates a basis for the choice of the optimal therapeutic strategy for children with neuroblastoma.

Treatment of intermediate-risk neuroblastoma

 

Each child with neuroblastoma belongs to a characteristic risk group or therapeutic group even before the treatment start. Recent guidelines distinguish three clinical groups of cancer: the low-risk, the high-risk, and the intermediate-risk neuroblastoma. Each of these groups has its own treatment protocol. Therefore, each child with neuroblastoma undergoes treatment according to the therapeutic regimen that considers the risk group.

The intermediate-risk neuroblastoma group includes children with cancer at the advanced stages. Therefore, the intermediate-risk neuroblastoma group consists of people with neuroblastoma at:

  • Stage 2, under 50% of the tumor was removed surgically
  • Stage 3, children under 18 months with no MYCN amplification
  • Stage 4, children under 12 months with no MYCN amplification and children with the unfavorable histopathology

Treatment regimen for intermediate-risk neuroblastoma consists of surgery, first of all. Then people with intermediate-risk neuroblastoma receive chemotherapy. Chemotherapy for intermediate-risk neuroblastoma consists of six intensive chemotherapy courses. If the child with intermediate-risk neuroblastoma wasn’t operated before chemotherapy, then doctors perform surgery for intermediate-risk neuroblastoma after chemotherapy. As intermediate-risk neuroblastoma diminishes in volume, it becomes easier to conduct the operation.

Induction chemotherapy consists of composite cytostatics. The drugs for intermediate-risk neuroblastoma are administered in specific doses per session. Drugs are generally prescribed to children with neuroblastoma in pill form.

If after the intensive chemotherapy doctors still find intermediate-risk neuroblastoma active, then children with cancer older than 18 months receive radiation therapy for intermediate-risk neuroblastoma. The radiation dose ranges from 36 to 40 gray. Radiation therapy is carried simultaneously with the maintenance chemotherapy. If the intermediate-risk neuroblastoma wasn’t operated on at all (for example, if at the beginning of intermediate-risk neuroblastoma therapy only a biopsy was conducted), it may become so reduced in size after chemotherapy that it can be excised by surgery. Surgery for intermediate-risk neuroblastoma is performed either during or after chemotherapy. The duration of the whole treatment of intermediate-risk neuroblastoma is about a year.

Statistics on recovery from neuroblastoma

 

It’s quite difficult to assess individual chances for recovering in patients with neuroblastoma. Each case is influenced significantly by the tumor activity a child was diagnosed with.

Generally, young patients with intermediate-risk neuroblastoma have a rather favorable prognosis. The average recovery rate of people with intermediate-risk neuroblastoma exceeds 90%. Kids with intermediate-risk neuroblastoma that are under 18 months old, also have good prognosis, which is connected with favorable molecular characteristics of intermediate-risk neuroblastoma. Most older children with intermediate-risk neuroblastoma have the recovery rate at about 50%.

Prices for treatment

 

The cost of treatment with tumor resection for neuroblastoma stage 1-3 in German hospitals starts at 12,612 EUR.

The cost of treatment with chemotherapy for neuroblastoma stage 1-3 in German hospitals starts at 6,547 EUR.

The cost of treatment with radiotherapy for neuroblastoma stage 1-3 in German hospitals starts at 15,300 EUR.

The cost of treatment with high-dose chemotherapy for stage 4 neuroblastoma in German hospitals starts at 85,450 EUR.

Undergoing treatment of neuroblastoma with Booking Health

 

You can undergo treatment of neuroblastoma abroad using the services of the medical tourism company Booking Health.

With Booking Health, you get:

  • Individual approach. The selection of hospitals and specialists is carried out following the medical requirements and wishes of the clients.
  • Travel support (visa issuing, accommodation booking, etc.).
  • Lower prices (Booking Health works directly with the best medical centers).

Booking Health can start working on your case right now. All you need to do is to leave a request on the website, and a medical advisor will contact you as soon as possible.

Authors: Dr. Nadezhda IvanisovaDr. Farrukh Ahmed




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