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Clinic of Advanced Biological Medicine

The Clinic of Advanced Biological Medicine in Frankfurt am Main aims to boost the immune system, to maintain and improve the quality of life in case of disease, minimize side effects of toxic treatment, to increase chances for recovery as well as to increase life span through the use of effective treatments.
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Cancer: Ovarian yolk sac tumor — Chemotherapy. Treatment

Ovarian yolk sac tumor is a rare and extremely malignant formation, characteristic mainly for girls 6 to 14 years old. The tumor develops from embryonic germ cells and produces alpha-fetoprotein, which serves as its marker. In approximately 5% cases, the disease is bilateral. The main treatment is surgery followed by chemotherapy.

Treatment Stages

The scope of manipulation depends on the tumor process prevalence and patient’s age. At stage I, the girls and young patients planning the childbirth undergo an organ-preserving intervention. The surgeon makes an abdominal incision through which s/he removes the ovary with the tumor and the adjacent fallopian tube. During surgery, the neighboring organs are scrutinized. The biopsy of the healthy ovary, peritoneum, diaphragm and any suspicious areas is performed. Tissue samples are sent for histological examination.

At a more advanced stage, the resection of the uterus with appendages and greater omentum is indicated. The surgery is performed by laparotomy, which allows a complete examination of the abdominal cavity. The swollen lymph nodes are removed, when required.

In patients with metastases, the cytoreductive intervention is performed to remove the maximum possible number of tumor nodules.

Surgical treatment is contraindicated if the patient is in serious somatic condition, for example, if she has diseases, such as:

  • diabetes,
  • kidney or liver failure,
  • severe cardiovascular disease.

A relative contraindication is the appearance of multiple metastases. In such cases, the treatment is initiated with chemotherapy, followed by surgery.

After surgery, all patients receive chemotherapy. Depending on the process stage, platinum drugs are recommended as a monotherapy or in combination with the other cytostatics. The number of courses varies from 3 to 6. The total treatment duration can be up to six months. At the 3rd stage of the disease, subject to a good treatment outcome, a repeated cytoreductive surgery is possible.

After treatment ,the patient should be followed up by the oncologist and undergo examinations, including the physical examination, determination of alpha-fetoprotein level and abdominal ultrasound. In the case of relapse, a second course of anti-tumor agents is recommend.

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See also for ovarian yolk sac tumor:

Vivantes Neukölln Hospital Berlin

10/10 from 23 Votes

Department of Hematology, Oncology and Palliative Medicine

Chemotherapy of ovarian yolk sac tumor (1 course) #358096

The Department of Hematology, Oncology and Palliative Medicine offers the full range of services in these focuses. The department specializes in the treatment of all blood diseases, oncological diseases of various organs and palliative care.


location_onCountry: Germany
location_searchingCity: Berlin

St. Vincentius Clinic Karlsruhe

9.8/10 from 23 Votes

Department of Hematology, Oncology, Immunology and Palliative Care

Chemotherapy of ovarian yolk sac tumor (1 course) #336245

he Department of Hematology, Oncology, Immunology and Palliative Care specializes in the diagnosis and treatment of patients suffering from blood diseases, oncological and immunological diseases. Palliative medicine also belongs to the main directions of the department.


location_onCountry: Germany
location_searchingCity: Karlsruhe

Academic Hospital Harlaching Munich

9.2/10 from 32 Votes

Department of Hematology, Oncology and Palliative Medicine

Chemotherapy of ovarian yolk sac tumor (1 course) #196757

The Department of Hematology, Oncology and Palliative Medicine primarily treats patients with cancer or hematologic diseases. The treatment is based on the comprehensive approach, which includes both physical and psychosocial aspects. The department is part of the interdisciplinary Cancer Center Munich Süd.


location_onCountry: Germany
location_searchingCity: Munich
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University Hospital Rechts der Isar of the Munich Technical University

10/10 from 70 Votes

Department of Hematology and Oncology

Chemotherapy of ovarian yolk sac tumor (1 course) #197403

The Department of Internal Medicine III at the university hospital Klinikum rechts der Isar focuses on the area of hematology and internistic oncology. Every year an experienced and dedicated team of doctors provides treatment to more than 7. 000 patients from both Germany and abroad.


location_onCountry: Germany
location_searchingCity: Munich
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HELIOS Clinic Krefeld

9.7/10 from 38 Votes

Department of Gastroenterology, Hepatology, Neurogastroenterology, Infectology, Hematology, Oncology and Palliative Care

Chemotherapy of ovarian yolk sac tumor (1 course) #388207

The Department of Gastroenterology, Hepatology, Neurogastroenterology, Infectology, Hematology, Oncology and Palliative Care offers the full range of services in these medical fields.


location_onCountry: Germany
location_searchingCity: Krefeld

Academic Hospital Schwabing Munich

8.5/10 from 7 Votes

Department of Hematology, Oncology, Immunology, Palliative Medicine, Infectiology and Tropical Medicine

Chemotherapy of ovarian yolk sac tumor (1 course) #212869

The Department of Hematology, Oncology, Immunology, Palliative Medicine, Infectious Diseases and Tropical Medicine in Schwabing treats all benign blood diseases, disorders of the immune and coagulation system, all forms of blood cancer, and the most of cancers.


location_onCountry: Germany
location_searchingCity: Munich
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Academic Hospital Neuperlach Munich

9.8/10 from 11 Votes

Department of Hematology and Oncology

Chemotherapy of ovarian yolk sac tumor (1 course) #196857

The department of hematology and oncology diagnosed and treated malignant tumors. The therapeutic spectrum includes all medicamentous treating methodes including chemotherapy, antibody, immune and hormone therapy. Cancer patients benefit from interdisciplinary treatment.


location_onCountry: Germany
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University Hospital Muenster

9.8/10 from 78 Votes

Department of Hematology, Hemostaseology, Oncology and Pneumology (Medical Department A)

Chemotherapy of ovarian yolk sac tumor (1 course) #196549

The Medical Department A (Med A) at the University Hospital Muenster deals with the treatment of all kinds of cancer of various organs, including the hematopoietic system.


location_onCountry: Germany
location_searchingCity: Muenster
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Academic Hospital Asklepios Barmbek Hamburg

9.5/10 from 23 Votes

Department of Oncology, Hematology and Palliative Care

Chemotherapy of ovarian yolk sac tumor (1 course) #356171

The Department of Oncology, Hematology and Palliative Care offers the full range of services in the relevant medical fields. The department is certified by the German Cancer Society, which confirms the outstanding quality of medical care.


location_onCountry: Germany
location_searchingCity: Hamburg

University Hospital Frankfurt am Main

10/10 from 97 Votes

Tumor Center

Chemotherapy of ovarian yolk sac tumor (1 course) #343577

The Tumor Center at the University Hospital Frankfurt provides cancer patients with high quality diagnosis, treatment and care.  The physicians of the center cooperate with the specialists from the Nordwest Hospital.


location_onCountry: Germany
location_searchingCity: Frankfurt am Main
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Vivantes Humboldt Hospital Berlin

9.7/10 from 23 Votes

Department of Oncology and Hematology

Chemotherapy of ovarian yolk sac tumor (1 course) #337960

The Department of Oncology provides complex treatment and care for oncological diseases and cancerous blood diseases (hematology).  It offers a full range of services in the field of these two areas. The treatment is conducted in outpatient and inpatient settings. The focus is on the needs of the patients.


location_onCountry: Germany
location_searchingCity: Berlin

University Hospital Duesseldorf

9.9/10 from 71 Votes

Department of Hematology, Oncology and Clinical Immunology

Chemotherapy of ovarian yolk sac tumor (1 course) #209089

The Department of Hematology, Oncology and Clinical Immunology at the University Hospital Dusseldorf provides treatment of patients with blood diseases, cancer and immune system diseases. The Department focuses on the treatment of malignant diseases of  blood, bone marrow and lymph nodes.


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location_searchingCity: Duesseldorf
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Tel Aviv Sourasky Medical Center

9.9/10 from 23 Votes

Department of Oncology

Chemotherapy of ovarian yolk sac tumor (1 course) #331032

The Department of Oncology at the Tel Aviv Sourasky Medical Center provides the most advanced treatment for all types of cancer and conditions related to it. The fast-track appointment service enables patients to have their initial visit within 48 hours after contacting the Department.


location_onCountry: Israel
location_searchingCity: Tel Aviv

Hannover Medical School

9.8/10 from 43 Votes

Department of Hematology, Hemostaseology, Oncology and Stem Cell Transplantation

Chemotherapy of ovarian yolk sac tumor (1 course) #246793

The Department of Hematology, Hemostasiology, Oncology and Stem Cell Transplantation at the Hannover Medical School specializes in diagnosis and treatment of the entire range of malignant tumors, benign hematological diseases and blood coagulation disorders.


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location_searchingCity: Hannover

University Hospital Cologne

9.8/10 from 82 Votes

Department of Oncology, Hematology, Clinical Infectiology, Clinical Immunology, Hemostasis, Intensive Care

Chemotherapy of ovarian yolk sac tumor (1 course) #208517

The Department of Oncology, Hematology, Clinical Infectiology, Clinical Immunology, Hemostasis, Intensive Care deals with the treatment of various internal diseases.


location_onCountry: Germany
location_searchingCity: Cologne
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Rambam Health Care Campus Haifa

9.8/10 from 23 Votes

Department of Oncology

Chemotherapy of ovarian yolk sac tumor (1 course) #328770

The Department of Oncology at Rambam specializes in the comprehensive cancer treatment, including advanced chemotherapy and radiation therapy. It is the only medical institution of its kind in Northern Israel.


location_onCountry: Israel
location_searchingCity: Haifa




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