Acute Lymphoblastic Leukemia (all) — Consolidation treatment in the Best Hospitals in the World
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Department of Hematology and Oncology
The Department of Hematology and Oncology offers the full range of services in these medical fields. It diagnoses and treats all benign and malignant blood diseases, cancers. The huge clinical experience and high competence of the doctors working in the department allow them to achieve excellent treatment results even in the most severe cases.
Department of Hematology, Oncology, Rheumatology, Infectology and Bone Marrow Transplantation
The Department of Hematology, Oncology, Rheumatology, Infectology and Bone Marrow Transplantation offers modern diagnostics and treatment in all areas of its specialization. The medical facility treats patients with solid malignant tumors of various locations, malignant and benign diseases of the hematopoietic system, rheumatic diseases, and infections. The department enjoys a reputation as one of the leading health facilities for bone marrow transplants in Germany, which is confirmed by accreditation in accordance with JACIE standards. More than 80 allogeneic and more than 100 autologous bone marrow transplants are performed in the medical facility annually. In addition, the department successfully carries out innovative CAR T-cell therapy, which is available only in the most advanced medical centers worldwide. The department is part of the Comprehensive Cancer Center Ulm (CCCU), where a multidisciplinary team of highly professional doctors takes care of the health of patients. The high quality of medical services is confirmed by the certification of the German Cancer Society (DKG). The health of patients is in the safe hands of experienced specialists who strive to provide each patient with the most effective treatment using advanced therapeutic methods. The medical facility has 112 beds and many specialized outpatient clinics.
Department of Hematology and Oncology
The Department of Hematology and Oncology offers the full range of diagnostics and treatment of blood diseases, coagulation disorders, oncological diseases and related pathological conditions. The treatment is provided both on an outpatient and inpatient basis. The patient is offered a comprehensive treatment, including intensive care to eliminate side effects associated with the tumor and therapy, development of individual recommendations on nutrition, physiotherapeutic measures and psycho-oncological care.
Department of Hematology, Oncology, Adult and Pediatric Rheumatology
The Department of Hematology, Oncology, Adult and Pediatric Rheumatology offers the full range of modern diagnostics and treatment of malignant diseases, rheumatic pathologies, including particularly complex clinical cases in these fields. In addition, the department's doctors specialize in stem cell transplantation and occupy leading positions in this field at the international level. The medical team of the department makes every effort to guarantee each patient an individual, first-class treatment, based on the very latest achievements of modern medicine and human respect, understanding of the needs of each patient.
Department of Hematology, Oncology, Hemostaseology, Rheumatology and Infectology
The Department of Hematology, Oncology, Hemostaseology, Rheumatology and Infectology offers the full range of medical services in the fields of its specialization. The department specializes in the diagnostics and treatment of all diseases of the hematopoietic system, systemic treatment of solid tumors, infectious diseases, including outpatient admission of patients with HIV, blood clotting disorders, as well as the entire clinical and morphological group of rheumatic diseases. The department is actively engaged in research activities and regularly implements the latest medical developments into clinical practice, thereby providing treatment in accordance with the most advanced scientific achievements.
Department of Hematology, Oncology and Pulmonology
According to the Focus magazine, the Department of Hematology, Oncology and Pulmonology is one of the best medical facilities in Germany for the treatment of colorectal cancer! The department provides comprehensive diagnosis and highly effective treatment of solid tumors, benign and malignant blood diseases, and pathologies of the lungs and other respiratory organs. The department's specialists have unique expertise in the treatment of leukemia, lymphomas, germ cell tumors, gastrointestinal malignancies, lung cancer, bone and soft tissue sarcomas, and head and neck tumors. The pulmonary team focuses on patients with cystic fibrosis, interstitial lung disease, and pulmonary hypertension. The specialists have well-equipped endoscopic rooms for diagnosis and treatment. The department's medical team works closely with surgeons, radiologists, radiation therapists, urologists, gynecologists, otolaryngologists, and physicians of other specialties. The healthcare facility holds weekly interdisciplinary tumor boards, where clinical cases are discussed individually and optimal treatment regimens are developed for each patient. The department is certified in accordance with the standards of the German Cancer Society (DKG) and the European Society for Medical Oncology (ESMO). More than 2,800 inpatients are treated here each year, and nearly 7,000 more patients are cared for on an outpatient basis.
Department of Oncology and Hematology
The Department of Oncology and Hematology offers accurate diagnostics and effective treatment of benign and malignant blood diseases, as well as solid tumors. The department's specialists are proud of the excellent results in the field of bone marrow transplantation, which is among the department’s priority focuses. The department has 61 beds. Medical care is carried out both on an outpatient and inpatient basis.
Department of Hematology and Oncology
The Department of Hematology and Oncology provides diagnostics and comprehensive treatment of diseases of the hematopoietic system, as well as solid tumors of various organs. Hematologists most often deal with the treatment of acute and chronic leukemias, malignant lymphomas, myelodysplastic syndromes, plasmacytomas and other pathologies. Chemotherapy is usually first-line therapy. The department's specialists also successfully perform bone marrow transplantation. In the field of oncology, the department provides effective treatment of various tumors of the gastrointestinal tract, endocrine glands, female and male reproductive system, skin cancer, soft tissue and bone sarcomas, head and neck malignancies, etc. The patients suffering from cancer are offered classical (chemotherapy, immunotherapy, hormone therapy) and innovative (immunotherapy, CAR T-cell therapy) treatment methods. Surgical resection of solid tumors is performed by specialized surgeons. The treatment regimen is developed individually for each patient at the tumor board, which plays an important role in achieving a successful treatment result.
Department of Gastroenterology, Hematology, Oncology, Hepatology, Infectology, Rheumatology and Clinical Immunology
The Department of Gastroenterology, Hematology, Oncology, Hepatology, Infectology, Rheumatology and Clinical Immunology offers the full range of diagnostics and treatment in these fields. The department specializes in the treatment of benign and malignant diseases of the digestive system, liver and bile ducts, the hematopoietic system, etc. Much attention is paid to the interdisciplinary cooperation (Cancer Center Mainfranken, etc.).
Department of Hematology and Oncology
The Department of Hematology and Oncology offers comprehensive diagnosis and effective treatment of the entire spectrum of oncological diseases of the hematopoietic system, benign blood disorders, and solid malignancies of various localizations. The primary specialization in the department is blood cancer treatment. The department's doctors have in their arsenal many methods with scientifically proven effectiveness in the fight against cancer: chemotherapy, targeted therapy, antibody therapy, hormone therapy, immunotherapy, as well as stem cell transplantation and innovative CAR T-cell therapy. Treatment tactics are developed taking into account the individual needs and wishes of each patient, thanks to which specialists manage to achieve good results. The department also offers maintenance therapy to alleviate the side effects of the basic course of cancer treatment and palliative care. The department has the status of a Leukemia and Lymphoma Center certified by the German Cancer Society (DKG). In addition, it is one of the few centers in Europe certified according to JACIE standards in the field of bone marrow transplantation. Competent physicians with in-depth knowledge and extensive clinical experience in their specialty care for the health of the patients.
Charite Comprehensive Cancer Center
The Charite Comprehensive Cancer Center offers a comprehensive range of services for the prevention, diagnosis, and treatment of all types of malignant diseases. The Charite Comprehensive Cancer Center was founded in 2008. Today, it is the largest oncology clinic in Europe certified according to the standards of the German Cancer Society (DKG). The center treats more than 14,000 cancer patients annually, including patients with the most complex and rare malignancies. The center's specialists develop a personalized treatment plan for each patient, which is compiled by a tumor board and physicians of related specialties. The center guarantees high-quality treatment of oncopathology to the patient, with special attention being paid to compassionate care, professional psychological support, and communication in self-help groups. In addition to its successful clinical practice, the Charite Comprehensive Cancer Center is also very active in research, with more than 300 research projects carried out each year, resulting in the introduction of new effective treatment methods into clinical practice worldwide, saving the lives of a large number of patients. The Charite Comprehensive Cancer Center treats many patients from Germany and other countries. Patients will find here all the resources they need to be treated with both proven classical and advanced innovative therapeutic approaches.
Department of Oncology, Hematology, Rheumatology and Immunoncology
The Department of Oncology, Hematology, Rheumatology and Immunoncology offers the full range of diagnostics and treatment of solid tumors, benign and malignant diseases of blood and bone marrow, rheumatic pathologies. The priority purpose of each employee in the department is to provide patients with an optimal medical care, based on the use of the very latest treatment methods. The department's specialists are distinguished by their high professionalism and colossal experience in the treatment of extremely complex clinical cases.
Department of Oncology, Hematology and Bone Marrow Transplantation
The Department of Oncology, Hematology and Bone Marrow Transplantation provides the full range of diagnostic and therapeutic services to patients with malignant solid tumors, and benign and malignant blood pathologies. Of particular interest is the treatment of patients with acute leukemia, lymphomas, multiple myeloma, sarcomas, gastrointestinal cancer, lung cancer, breast cancer, and rare malignant tumors. The department is part of the Comprehensive Cancer Center Munich, thanks to which doctors from related specialties are involved in the therapeutic process. All modern diagnostic methods and therapeutic procedures are available here, including bone marrow transplantation, which is often the most effective treatment method for blood cancer. The health of patients is in the safe hands of a highly qualified medical team, consisting of 65 doctors and 130 nurses. The department treats about 2,800 inpatients and more than 10,000 outpatients every year. The department's specialists pay due attention to the psychological state of their patients diagnosed with cancer, so a program of psycho-oncological care is being successfully implemented here.
Department of Oncology, Hematology and Palliative Care
The Department of Oncology, Hematology and Palliative Care offers all the options of modern medicine for the treatment of patients with the pathologies in these fields. Specialization covers the treatment of cancer of the internal organs, blood cancer, symptomatic treatment of progressive incurable diseases. Other focuses of the department are intensive care medicine and special pain therapy. To achieve successful and long-term results, the clinical practice is based on the use of effective classic and innovative treatment methods.
Department of Hematology, Hemostaseology, Oncology and Pulmonology
The Department of Hematology, Hemostaseology, Oncology and Pulmonology offers the full range of diagnostics and treatment of blood diseases, including oncopathologies and blood coagulation disorders, lung diseases, and rare malignant diseases. The department incorporates two modern Bone Marrow Transplantation Centers. In addition, the department belongs to the largest medical facilities in Germany, which specialize in the treatment of malignant lymphomas, acute leukemias, sarcomas, as well as bone marrow transplantation. The physicians of the department are committed to providing patients with the comprehensive medical care of the highest quality, based on the respective attitude towards patients.
Department of Hematology, Oncology and Immunology
According to the Focus magazine, the Department of Hematology, Oncology and Immunology ranks among the top German medical facilities specializing in leukemia treatment! The department offers accurate diagnostics and effective treatment of malignant and benign blood diseases, solid tumors. The patients are treated in close collaboration with the Comprehensive Cancer Center. Of particular interest to the department's doctors is the treatment of various types of leukemia (within the specialized center with advanced infrastructure). The department takes part in many national and international clinical trials, which makes it possible for patients with advanced stages of cancer to receive treatment using innovative therapeutic methods.
Acute lymphoblastic leukemia is one of the most dangerous oncohematological diseases. To undergo treatment of this pathology, the patients often go abroad. The occurrence of this disease in children is one and a half times more often than in adults. A child usually has a more favorable course of the disease and can more often be completely cured.
What is consolidation?
The treatment of acute lymphoblastic leukemia has the following several stages:
- Induction.
- Consolidation.
- Maintenance therapy.
Initially, the child is prescribed intensive chemotherapy. This is required for the achievement of remission. According to the protocol, the complete remission is the reduction of the number of blast cells to less than 5% according to bone marrow test. The induction usually lasts 3-4 weeks. In a month, 95% of young patients achieve a remission.
After this, the child receives a less intensive, but prolonged treatment. It is called consolidation. The goal of this therapy is to prevent a relapse.
Treatment methods
The doctors apply at least one, and sometimes two, chemotherapy options. The second one is only required if the cancer spreads to the central nervous system.
- Systemic chemotherapy involves the intravenous injection of drugs and their oral intake. They affect the whole body. This is the basis of treatment.
- Intrathecal chemotherapy involves the administration of drugs into the spinal canal. This is required in order to overcome the blood-brain barrier. With such an administration method, medicines penetrate directly into the cerebrospinal fluid, reaching the spinal cord and brain.
Here are some features of chemotherapy in some categories of patients:
- in high-risk lymphoblastic leukemia, doses of drugs increase;
- in an insufficient response to chemotherapy, delayed intensification is used (a short course with high doses of drugs, as at the induction stage);
- in case of ineffective chemotherapy, the protocol provides for stem cell transplantation or the use of immunotherapy.
Additional treatments:
- Brain irradiation. The doctors try to avoid this option, but if the tumor develops in the brain, they have to perform this procedure. Adults do not usually have significant side effects, although they may develop neurological symptoms. The child has a risk of mental retardation.
- Targeted therapy. It can be effective only in Philadelphia chromosome leukemia.
- Stem cell transplantation. The best results can be achieved when using a bone marrow transplant from a donor. It may be a brother or sister who have sufficient tissue compatibility. If the patient does not have native compatible donors, they are searched in the database.
- Immunotherapy. It can be used in the absence of a good response to chemotherapy or in a relapse after stem cell transplantation. The doctors use CAR or monoclonal antibodies.
Side effects
The use of chemotherapy drugs for tumor destruction always causes side effects, but severe consequences at this stage can rarely develop. They are more common for induction. At the consolidation stage, most patients receive lower doses of drugs.
Here are some standard side effects, which may occur in the treatment of any malignant tumors:
- hair loss;
- nausea;
- vomit;
- headache;
- diarrhea or constipation.
At the consolidation stage, the treatment lasts several months. During this time, the doctors use the drugs, which reduce the number of cells in the blood. This occurs due to the inhibition of red bone marrow function. Therefore, the patient should regularly undergo diagnostics. A complete blood count serves to assess the concentration of the formed elements.
The following symptoms may occur:
- frequent infectious diseases due to the decreased production of mature leukocytes;
- nosebleeds, bruises on the skin, bleeding gums due to the reduction of platelets;
- due to the lack of erythrocytes, such symptoms of anemia as pale skin, increased heart rate, fatigue appear.
According to the protocol for the management of such patients, the transfusion of blood and its components is required. This helps to reduce the symptoms.
Results
Consolidation and subsequent maintenance therapy provide good treatment results in most patients. Many people manage to recover from acute lymphoblastic leukemia by means of chemotherapy. Sometimes, success can be achieved with the help of stem cell transplantation.
The children have a better prognosis than adults. It is even better, if the child suffers from B-cell leukemia and he is under the age of 9 years.
The adults do not always achieve remission. It is more complex task and it takes more time. The relapses occur more often. It is possible to cure the patient completely only in 40% of cases. The worst prognosis is the age of the patient after the age of 65 years. They are often not able to undergo intensive chemotherapy course, and therefore the doctors carry out only maintenance therapy. It does not allow to achieve complete remission of the disease, but can only increase the life expectancy of the patient.
Most relapses occur during treatment or during the first year upon its completion. The tests can very rarely show a relapse of the disease after 12-24 months. If the relapse does not occur 2 years later, the treatment of acute leukemia is very likely to be successful. Only in isolated cases, can the pathology recur in such a long period of time.
Treatment abroad with the Booking Health company
You can undergo effective treatment of acute lymphoblastic leukemia abroad according to modern medical care protocols. To do this, you can contact the Booking Health company. We will arrange your trip, reduce the costs for diagnostics and therapy. You will receive the following benefits:
- Selection of the best hospital specializing in the treatment of cancer for the diagnostics and treatment of acute lymphoblastic leukemia abroad.
- Reduced cost of a therapy course or bone marrow transplant surgery due to the lack of additional coefficients and overpricing for foreign patients.
- Booking an appointment for the diagnostics, conservative treatment or surgery on the most suitable dates for you.
- Preparation of the program, taking into account previously performed examinations.
- Establishment of communication directly with the doctor of the Department of Oncology.
- Monitoring of the program at all its stages.
- Control of the costs of all procedures and operations, return of unspent funds.
- Buying and forwarding of medicines.
- Organization of additional cancer diagnostics, surgery or rehabilitation after the main program.
- Communication with the hospital upon the completion of treatment of acute lymphoblastic leukemia.
The patients of foreign clinics who booked the program with the help of the Booking Health service leave positive feedback about our work. After all, we help not only to get rid of the worries about trip organization, but also to reduce the cost of medical services. In the reviews, people respond positively about the quality of treatment in Cancer Clinics abroad. Many people manage to completely recover from a serious disease.
We will provide you with top-class services. We will translate medical documentation, medical history, help you to get a visa, book airline tickets and a hotel room. We will meet you at the airport and take you to the Cancer Center. Once your treatment course is completed, you will be taken back to the airport.
