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Acute Lymphoblastic Leukemia (all) — Consolidation treatment in the Best Hospitals of Germany

University Hospital Mannheim

9.8/10
location_onGermany, Mannheim

Department of Hematology and Oncology

The Department of Hematology and Oncology offers the full range of services in these medical fields. It diagnoses and treats all benign and malignant blood diseases, cancers. The huge clinical experience and high competence of the doctors working in the department allow them to achieve excellent treatment results even in the most severe cases.

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University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Hematology, Oncology, Palliative Care, Rheumatology and Infectology

The Department of Hematology, Oncology, Palliative Care, Rheumatology and Infectology offers the full range of services in these fields. It provides the accurate diagnostics and effective treatment of oncological diseases, benign and malignant blood pathologies, rheumatic and infectious diseases. A separate focus of the department is palliative care aimed at relieving pain and improving the quality of life of the terminally ill patients. The doctors of the department have unique clinical skills and rich experience, which contributes to high treatment success rates.

University Hospital Freiburg

9.7/10
location_onGermany, Freibung

Department of Hematology and Oncology

The Department of Hematology and Oncology offers the full range of diagnostics and treatment of blood diseases, coagulation disorders, oncological diseases and related pathological conditions. The treatment is provided both on an outpatient and inpatient basis. The patient is offered a comprehensive treatment, including intensive care to eliminate side effects associated with the tumor and therapy, development of individual recommendations on nutrition, physiotherapeutic measures and psycho-oncological care.

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Hematology, Oncology, Adult and Pediatric Rheumatology

The Department of Hematology, Oncology, Adult and Pediatric Rheumatology offers the full range of modern diagnostics and treatment of malignant diseases, rheumatic pathologies, including particularly complex clinical cases in these fields. In addition, the department's doctors specialize in stem cell transplantation and occupy leading positions in this field at the international level. The medical team of the department makes every effort to guarantee each patient an individual, first-class treatment, based on the very latest achievements of modern medicine and human respect, understanding of the needs of each patient.

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Department of Hematology, Oncology, Hemostaseology, Rheumatology and Infectology

The Department of Hematology, Oncology, Hemostaseology, Rheumatology and Infectology offers the full range of medical services in the fields of its specialization. The department specializes in the diagnostics and treatment of all diseases of the hematopoietic system, systemic treatment of solid tumors, infectious diseases, including outpatient admission of patients with HIV, blood clotting disorders, as well as the entire clinical and morphological group of rheumatic diseases. The department is actively engaged in research activities and regularly implements the latest medical developments into clinical practice, thereby providing treatment in accordance with the most advanced scientific achievements.

University Hospital RWTH Aachen

8.7/10
location_onGermany, Aachen

Department of Oncology and Hematology

The Department of Oncology and Hematology offers accurate diagnostics and effective treatment of benign and malignant blood diseases, as well as solid tumors. The department's specialists are proud of the excellent results in the field of bone marrow transplantation, which is among the department’s priority focuses. The department has 61 beds. Medical care is carried out both on an outpatient and inpatient basis.

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Gastroenterology, Hematology, Oncology, Hepatology, Infectology, Rheumatology and Clinical Immunology

The Department of Gastroenterology, Hematology, Oncology, Hepatology, Infectology, Rheumatology and Clinical Immunology offers the full range of diagnostics and treatment in these fields. The department specializes in the treatment of benign and malignant diseases of the digestive system, liver and bile ducts, the hematopoietic system, etc. Much attention is paid to the interdisciplinary cooperation (Cancer Center Mainfranken, etc.).

University Hospital Erlangen

9.1/10
location_onGermany, Erlangen

Department of Hematology and Oncology

The Department of Hematology and Oncology provides diagnostics and comprehensive treatment of diseases of the hematopoietic system, as well as solid tumors of various organs. Hematologists most often deal with the treatment of acute and chronic leukemias, malignant lymphomas, myelodysplastic syndromes, plasmacytomas and other pathologies. Chemotherapy is usually first-line therapy. The department's specialists also successfully perform bone marrow transplantation. In the field of oncology, the department provides effective treatment of various tumors of the gastrointestinal tract, endocrine glands, female and male reproductive system, skin cancer, soft tissue and bone sarcomas, head and neck malignancies, etc. The patients suffering from cancer are offered classical (chemotherapy, immunotherapy, hormone therapy) and innovative (immunotherapy, CAR T-cell therapy) treatment methods. Surgical resection of solid tumors is performed by specialized surgeons. The treatment regimen is developed individually for each patient at the tumor board, which plays an important role in achieving a successful treatment result.

University Hospital Halle (Saale)

9.6/10
location_onGermany, Halle

Department of Hematology and Oncology

According to the Focus magazine, the Department of Hematology and Oncology ranks among the top German medical facilities specializing in bowel cancer treatment! The department offers the full range of specialized diagnostics, treatment and follow-up care for patients with oncological diseases and blood diseases. The department's doctors have in their arsenal many innovative effective methods to fight against cancer. In addition, a number of clinical trials are carried out here in order to develop the very latest targeted drugs, immunotherapy drugs, etc. All the department's specialists regularly undergo advanced training courses, which help them to keep abreast of innovations in medicine and to guarantee the best therapy result for patients.

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of Hematology, Oncology and Pulmonology

According to the Focus magazine, the Department of Hematology, Oncology and Pulmonology ranks among the top medical facilities in Germany specializing in bowel cancer treatment! The department offers the full range of modern diagnostics and treatment of solid tumors, benign and malignant blood and hematopoietic system diseases, including bleeding disorders, as well as pathologies of the lungs and other organs of the respiratory system. The offer is complemented by effective palliative care. All physicians of the department are highly qualified experts in their area of specialization and apply theoretical knowledge and clinical experience to ensure an optimal therapy result.

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Charité Comprehensive Cancer Center

Charité Comprehensive Cancer Center offers patients the full range of classical and innovative examinations, treatment of malignant diseases of all organs and anatomical structures of the human body. The spectrum is complemented by follow-up medical care, rehabilitation, modern schemes for the prevention and early detection of malignant diseases. An important component of the therapeutic process in the center is psycho-oncological care. The centerdals with the treatment of patients of all age groups, ranging from small children to elderly patients.

University Hospital Bonn

9.2/10
location_onGermany, Bonn

Department of Oncology, Hematology, Rheumatology and Immunoncology

The Department of Oncology, Hematology, Rheumatology and Immunoncology offers the full range of diagnostics and treatment of solid tumors, benign and malignant diseases of blood and bone marrow, rheumatic pathologies. The priority purpose of each employee in the department is to provide patients with an optimal medical care, based on the use of the very latest treatment methods. The department's specialists are distinguished by their high professionalism and colossal experience in the treatment of extremely complex clinical cases.

University Hospital Giessen UKGM

9.5/10
location_onGermany, Giessen

Department of Oncology, Hematology and Palliative Care

The Department of Oncology, Hematology and Palliative Care offers all the options of modern medicine for the treatment of patients with the pathologies in these fields. Specialization covers the treatment of cancer of the internal organs, blood cancer, symptomatic treatment of progressive incurable diseases. Other focuses of the department are intensive care medicine and special pain therapy. To achieve successful and long-term results, the clinical practice is based on the use of effective classic and innovative treatment methods.

University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of Oncology and Hematology

The Department of Oncology and Hematology offers the full range of services in the field of diagnostics and treatment of oncological and blood diseases. Of particular interest is the treatment of patients with acute leukemia, lymphomas, carcinomas and sarcomas. The highly qualified medical team of 65 doctors and 130 nurses takes care of the health of the patients. About 2,800 inpatients and 10,000 outpatients are treated in the department annually.

University Hospital Muenster

9.8/10
location_onGermany, Muenster

Department of Hematology, Hemostaseology, Oncology and Pulmonology

The Department of Hematology, Hemostaseology, Oncology and Pulmonology offers the full range of diagnostics and treatment of blood diseases, including oncopathologies and blood coagulation disorders, lung diseases, and rare malignant diseases. The department incorporates two modern Bone Marrow Transplantation Centers. In addition, the department belongs to the largest medical facilities in Germany, which specialize in the treatment of malignant lymphomas, acute leukemias, sarcomas, as well as bone marrow transplantation. The physicians of the department are committed to providing patients with the comprehensive medical care of the highest quality, based on the respective attitude towards patients.

University Hospital Marburg UKGM

8.6/10
location_onGermany, Marburg

Department of Hematology, Oncology and Immunology

According to the Focus magazine, the Department of Hematology, Oncology and Immunology ranks among the top German medical facilities specializing in leukemia treatment! The department offers accurate diagnostics and effective treatment of malignant and benign blood diseases, solid tumors. The patients are treated in close collaboration with the Comprehensive Cancer Center. Of particular interest to the department's doctors is the treatment of various types of leukemia (within the specialized center with advanced infrastructure). The department takes part in many national and international clinical trials, which makes it possible for patients with advanced stages of cancer to receive treatment using innovative therapeutic methods.

Acute lymphoblastic leukemia can develop in patients of any age. It mostly occurs in children under 5 years old and in adults after 50 years. The disease has a more favorable prognosis in children and they more often recover completely. In adults, especially after 65 years, the doctors are not always able to cure the disease completely. Germany has achieved the tremendous success in the treatment of acute leukemia. With the help of chemotherapy or stem cell transplant, many patients can be completely cured.

What is consolidation?

The treatment of acute lymphoblastic leukemia involves several stages. Initially, the child receives intensive chemotherapy. This treatment option allows for quick remission of the disease. The next stage is consolidation. Its main task is to prevent cancer relapse.

Remission is a reduction in the number of blast cells in the red bone marrow up to 5% or less. With their number decrease to 5-20%, this is an incomplete remission. To understand whether treatment is successful, the doctors regularly take bone marrow samples for analysis. A blood test is not indicative, since blood can preserve a large number of blast cells for a long time, which were formed long ago, but have not died yet.

A child reaches complete remission in acute lymphoblastic leukemia in 95% of cases within 1 month. This is followed by the consolidation phase. It may include the following procedures:

  • conventional chemotherapy;
  • intrathecal chemotherapy;
  • radiation therapy;
  • stem cell transplant;
  • targeted therapy.

Chemotherapy is the only method, which is prescribed for each child. Other treatment options can be applied only in certain cases.

Chemotherapy

The prescription of drugs, which destroy the tumor, is the main treatment option during consolidation phase. Although the number of blast cells in the bone marrow is low, this does not mean that the cancer is cured. At the consolidation stage, the doctors strive to completely cure the disease by means of chemotherapy, as it is the main treatment method.

In children, it is often possible to be achieved. B-cell lymphoblastic leukemia, which develops during the first 9 years of life, is less resistant to treatment. Most patients fall into this category, since most of the cases occur during the first 5 years of life.

In adults, the treatment outcomes are worse. It is more difficult for them to achieve a remission. They often require prolonged, intensive chemotherapy. As a result, remission can be achieved in 85% of patients, but this may take longer. The relapses in adults occur more often. Only 40% of patients are cured of acute lymphoblastic leukemia in developed countries.

Other treatment methods

The tumor can sometimes spread to the central nervous system. Most drugs cannot penetrate through blood-brain barrier. Therefore, they have to be injected directly into the cerebrospinal fluid. The doctors perform this procedure by means of lumbar puncture. A needle is inserted between the lumbar vertebrae.

Intrathecal chemotherapy is not an option of choice for all patients. Nonetheless, if the tumor has spread to the brain, the therapy begins at the induction stage, and then it continues during the consolidation phase. The children may sometimes have seizures during the therapy. Therefore, they can be prescribed anticonvulsants.

Here are other methods of therapy, which can be used at the consolidation stage:

  • irradiation can be used in the case of tumor formation in the brain in T-cell leukemia;
  • stem cell transplantation can be applied in unfavorable prognosis, if the probability of curing the disease using chemotherapy is low;
  • targeted therapy can be effective only in leukemia with the Philadelphia chromosome (determined during genetic diagnostics);
  • immunotherapy is a less effective technique than chemotherapy, but sometimes it can be used, when the standard drugs fail to be effective.

Results and side effects

The patient reviews show that chemotherapy at the consolidation stage always has side effects. Nevertheless, the consequences are less severe than at the induction stage. This is due to the fact that:

  • less intensive chemotherapy regimens are used, although treatment lasts longer;
  • there is no tumor lysis syndrome, which is observed at the initial stage of intensive treatment of advanced cancer.

When studying medical histories of the patients and their reviews, one can find out that the course of chemotherapy is always accompanied by side effects. The side effects of cancer treatment are at least hair loss, nausea, weakness and irritable bowel syndrome. Some drugs can give additional side effects. They worsen the functioning of the heart, liver and kidneys. Therefore, the therapy in Germany is constantly monitored by tests. In the case of severe symptoms, the doctors take measures for their reduction.

A complete blood count always reveals the low levels of all cells, such as erythrocytes, platelets, leukocytes. The blast forms of leukocytes circulating in the blood are not functionally complete and cannot protect the body from infectious diseases.

Here are the main symptoms, which may occur in case of prolonged cancer treatment:

  • pale skin, shortness of breath, fatigue, increased heart rate – a consequence of the decreased levels of erythrocytes;
  • bleeding gums, bruises on the body, nosebleeds – a consequence of platelet deficiency;
  • infectious diseases – the result of reduced immunity.

Nevertheless, the treatment results are usually good. The induction takes 3-4 weeks. This is followed by consolidation, which lasts for several months. After this, maintenance therapy is required. As a result, many patients recover.

Should relapses occur, the return of the cancer will be detected during the treatment process, or not later than 12 months upon its completion. The relapses are rare in 1-2 years after therapy completion. If more than 2 years have passed, the patient is most likely to completely cure from acute lymphoblastic leukemia.

Treatment in Germany with the Booking Health company

You can undergo cancer treatment in Germany, as this country offers modern Cancer Centers, where the doctors succeed in the treatment of lymphoblastic leukemia in patients of all age groups. To receive the best medical care at an affordable cost, you can use the services of the Booking Health company. We will arrange your trip to one of the leading Cancer Clinics. You or your child will be able to undergo chemotherapy or bone marrow transplant there. The patients leave good feedback about our work. When cooperating with the Booking Health company you will get the following benefits:

  • Selection of the best Cancer Center, which apply modern chemotherapy regimens and perform effective bone marrow transplants.
  • Reduced cost of a therapy course or surgery due to the absence of overpricing and additional coefficients for foreign patients.
  • Booking an appointment on the most suitable dates for you.
  • Preparation of the program taking into account previously performed diagnostics.
  • Establishment of communication directly with the attending physician.
  • Monitoring of the program at all its stages.
  • Control of invoices, return of unspent funds.
  • Buying and forwarding of medicines.
  • Organization of additional diagnostics or treatment procedures.
  • Communication with the clinic upon treatment completion in Germany.

The Booking Health company will provide you with top-class services. We will translate a medical history and other medical documents into German, book a hotel and airline tickets for you, meet you at the German airport and take you to the clinic by car. According to feedback, most patients are satisfied with our services. Thanks to our work, you can get the medical care from the best German doctors.




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