Diagnostic of Acute Lymphoblastic Leukemia (all) in Germany
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Department of Hematology and Oncology
The Department of Hematology and Oncology offers the full range of services in these medical fields. It diagnoses and treats all benign and malignant blood diseases, cancers. The huge clinical experience and high competence of the doctors working in the department allow them to achieve excellent treatment results even in the most severe cases.
Department of Hematology, Oncology, Rheumatology, Infectology and Bone Marrow Transplantation
The Department of Hematology, Oncology, Rheumatology, Infectology and Bone Marrow Transplantation offers modern diagnostics and treatment in all areas of its specialization. The medical facility treats patients with solid malignant tumors of various locations, malignant and benign diseases of the hematopoietic system, rheumatic diseases, and infections. The department enjoys a reputation as one of the leading health facilities for bone marrow transplants in Germany, which is confirmed by accreditation in accordance with JACIE standards. More than 80 allogeneic and more than 100 autologous bone marrow transplants are performed in the medical facility annually. In addition, the department successfully carries out innovative CAR T-cell therapy, which is available only in the most advanced medical centers worldwide. The department is part of the Comprehensive Cancer Center Ulm (CCCU), where a multidisciplinary team of highly professional doctors takes care of the health of patients. The high quality of medical services is confirmed by the certification of the German Cancer Society (DKG). The health of patients is in the safe hands of experienced specialists who strive to provide each patient with the most effective treatment using advanced therapeutic methods. The medical facility has 112 beds and many specialized outpatient clinics.
Department of Hematology and Oncology
The Department of Hematology and Oncology offers the full range of diagnostics and treatment of blood diseases, coagulation disorders, oncological diseases and related pathological conditions. The treatment is provided both on an outpatient and inpatient basis. The patient is offered a comprehensive treatment, including intensive care to eliminate side effects associated with the tumor and therapy, development of individual recommendations on nutrition, physiotherapeutic measures and psycho-oncological care.
Department of Hematology, Oncology, Adult and Pediatric Rheumatology
The Department of Hematology, Oncology, Adult and Pediatric Rheumatology offers the full range of modern diagnostics and treatment of malignant diseases, rheumatic pathologies, including particularly complex clinical cases in these fields. In addition, the department's doctors specialize in stem cell transplantation and occupy leading positions in this field at the international level. The medical team of the department makes every effort to guarantee each patient an individual, first-class treatment, based on the very latest achievements of modern medicine and human respect, understanding of the needs of each patient.
Department of Hematology, Oncology, Hemostaseology, Rheumatology and Infectology
The Department of Hematology, Oncology, Hemostaseology, Rheumatology and Infectology offers the full range of medical services in the fields of its specialization. The department specializes in the diagnostics and treatment of all diseases of the hematopoietic system, systemic treatment of solid tumors, infectious diseases, including outpatient admission of patients with HIV, blood clotting disorders, as well as the entire clinical and morphological group of rheumatic diseases. The department is actively engaged in research activities and regularly implements the latest medical developments into clinical practice, thereby providing treatment in accordance with the most advanced scientific achievements.
Department of Hematology, Oncology and Pulmonology
According to the Focus magazine, the Department of Hematology, Oncology and Pulmonology is one of the best medical facilities in Germany for the treatment of colorectal cancer! The department provides comprehensive diagnosis and highly effective treatment of solid tumors, benign and malignant blood diseases, and pathologies of the lungs and other respiratory organs. The department's specialists have unique expertise in the treatment of leukemia, lymphomas, germ cell tumors, gastrointestinal malignancies, lung cancer, bone and soft tissue sarcomas, and head and neck tumors. The pulmonary team focuses on patients with cystic fibrosis, interstitial lung disease, and pulmonary hypertension. The specialists have well-equipped endoscopic rooms for diagnosis and treatment. The department's medical team works closely with surgeons, radiologists, radiation therapists, urologists, gynecologists, otolaryngologists, and physicians of other specialties. The healthcare facility holds weekly interdisciplinary tumor boards, where clinical cases are discussed individually and optimal treatment regimens are developed for each patient. The department is certified in accordance with the standards of the German Cancer Society (DKG) and the European Society for Medical Oncology (ESMO). More than 2,800 inpatients are treated here each year, and nearly 7,000 more patients are cared for on an outpatient basis.
Department of Gastroenterology, Hematology, Oncology, Hepatology, Infectology, Rheumatology and Clinical Immunology
The Department of Gastroenterology, Hematology, Oncology, Hepatology, Infectology, Rheumatology and Clinical Immunology offers the full range of diagnostics and treatment in these fields. The department specializes in the treatment of benign and malignant diseases of the digestive system, liver and bile ducts, the hematopoietic system, etc. Much attention is paid to the interdisciplinary cooperation (Cancer Center Mainfranken, etc.).
Department of Oncology and Hematology
The Department of Oncology and Hematology offers accurate diagnostics and effective treatment of benign and malignant blood diseases, as well as solid tumors. The department's specialists are proud of the excellent results in the field of bone marrow transplantation, which is among the department’s priority focuses. The department has 61 beds. Medical care is carried out both on an outpatient and inpatient basis.
Department of Hematology and Oncology
The Department of Hematology and Oncology provides diagnostics and comprehensive treatment of diseases of the hematopoietic system, as well as solid tumors of various organs. Hematologists most often deal with the treatment of acute and chronic leukemias, malignant lymphomas, myelodysplastic syndromes, plasmacytomas and other pathologies. Chemotherapy is usually first-line therapy. The department's specialists also successfully perform bone marrow transplantation. In the field of oncology, the department provides effective treatment of various tumors of the gastrointestinal tract, endocrine glands, female and male reproductive system, skin cancer, soft tissue and bone sarcomas, head and neck malignancies, etc. The patients suffering from cancer are offered classical (chemotherapy, immunotherapy, hormone therapy) and innovative (immunotherapy, CAR T-cell therapy) treatment methods. Surgical resection of solid tumors is performed by specialized surgeons. The treatment regimen is developed individually for each patient at the tumor board, which plays an important role in achieving a successful treatment result.
Department of Hematology and Oncology
The Department of Hematology and Oncology offers comprehensive diagnosis and effective treatment of the entire spectrum of oncological diseases of the hematopoietic system, benign blood disorders, and solid malignancies of various localizations. The primary specialization in the department is blood cancer treatment. The department's doctors have in their arsenal many methods with scientifically proven effectiveness in the fight against cancer: chemotherapy, targeted therapy, antibody therapy, hormone therapy, immunotherapy, as well as stem cell transplantation and innovative CAR T-cell therapy. Treatment tactics are developed taking into account the individual needs and wishes of each patient, thanks to which specialists manage to achieve good results. The department also offers maintenance therapy to alleviate the side effects of the basic course of cancer treatment and palliative care. The department has the status of a Leukemia and Lymphoma Center certified by the German Cancer Society (DKG). In addition, it is one of the few centers in Europe certified according to JACIE standards in the field of bone marrow transplantation. Competent physicians with in-depth knowledge and extensive clinical experience in their specialty care for the health of the patients.
Charité Comprehensive Cancer Center
Charité Comprehensive Cancer Center offers patients the full range of classical and innovative examinations, treatment of malignant diseases of all organs and anatomical structures of the human body. The spectrum is complemented by follow-up medical care, rehabilitation, modern schemes for the prevention and early detection of malignant diseases. An important component of the therapeutic process in the center is psycho-oncological care. The centerdals with the treatment of patients of all age groups, ranging from small children to elderly patients.
Department of Oncology, Hematology, Rheumatology and Immunoncology
The Department of Oncology, Hematology, Rheumatology and Immunoncology offers the full range of diagnostics and treatment of solid tumors, benign and malignant diseases of blood and bone marrow, rheumatic pathologies. The priority purpose of each employee in the department is to provide patients with an optimal medical care, based on the use of the very latest treatment methods. The department's specialists are distinguished by their high professionalism and colossal experience in the treatment of extremely complex clinical cases.
Department of Oncology, Hematology and Bone Marrow Transplantation
The Department of Oncology, Hematology and Bone Marrow Transplantation provides the full range of diagnostic and therapeutic services to patients with malignant solid tumors, and benign and malignant blood pathologies. Of particular interest is the treatment of patients with acute leukemia, lymphomas, multiple myeloma, sarcomas, gastrointestinal cancer, lung cancer, breast cancer, and rare malignant tumors. The department is part of the Comprehensive Cancer Center Munich, thanks to which doctors from related specialties are involved in the therapeutic process. All modern diagnostic methods and therapeutic procedures are available here, including bone marrow transplantation, which is often the most effective treatment method for blood cancer. The health of patients is in the safe hands of a highly qualified medical team, consisting of 65 doctors and 130 nurses. The department treats about 2,800 inpatients and more than 10,000 outpatients every year. The department's specialists pay due attention to the psychological state of their patients diagnosed with cancer, so a program of psycho-oncological care is being successfully implemented here.
Department of Oncology, Hematology and Palliative Care
The Department of Oncology, Hematology and Palliative Care offers all the options of modern medicine for the treatment of patients with the pathologies in these fields. Specialization covers the treatment of cancer of the internal organs, blood cancer, symptomatic treatment of progressive incurable diseases. Other focuses of the department are intensive care medicine and special pain therapy. To achieve successful and long-term results, the clinical practice is based on the use of effective classic and innovative treatment methods.
Department of Hematology, Oncology and Immunology
According to the Focus magazine, the Department of Hematology, Oncology and Immunology ranks among the top German medical facilities specializing in leukemia treatment! The department offers accurate diagnostics and effective treatment of malignant and benign blood diseases, solid tumors. The patients are treated in close collaboration with the Comprehensive Cancer Center. Of particular interest to the department's doctors is the treatment of various types of leukemia (within the specialized center with advanced infrastructure). The department takes part in many national and international clinical trials, which makes it possible for patients with advanced stages of cancer to receive treatment using innovative therapeutic methods.
Department of Hematology, Hemostaseology, Oncology and Pulmonology
The Department of Hematology, Hemostaseology, Oncology and Pulmonology offers the full range of diagnostics and treatment of blood diseases, including oncopathologies and blood coagulation disorders, lung diseases, and rare malignant diseases. The department incorporates two modern Bone Marrow Transplantation Centers. In addition, the department belongs to the largest medical facilities in Germany, which specialize in the treatment of malignant lymphomas, acute leukemias, sarcomas, as well as bone marrow transplantation. The physicians of the department are committed to providing patients with the comprehensive medical care of the highest quality, based on the respective attitude towards patients.
Acute lymphoblastic leukemia is a malignant disease of the hematopoietic system. In general, the disease is not common, but has a high mortality rate. Acute lymphoblastic leukemia accounts for about 1% in the structure of cancers. An individual risk of the development of the disease is 0.1%. The incidence in children is 1.5 times higher than in adults. The first peak of the incidence occurs at the age of 5 years, and then gradually decreases, reaching a minimal risk of leukemia at the age of 20 years. Then it gradually begins to increase and the second peak of incidence occurs in patients older than 50 years.
Symptoms
Acute lymphoblastic leukemia does not have pathognomonic (unique, characteristic manifestations only for this disease) symptoms. All of them are nonspecific. Most of the symptoms are associated with tumor intoxication and decreased number of blood cells. Volumetric formations compressing organs and vessels develop less often.
Common symptoms:
- weight loss;
- poor appetite;
- night sweats;
- fever.
The symptoms associated with the decreased number of blood cells:
- frequent infections and ulcers on the skin;
- bleeding gums, nosebleeds and bruises on the body;
- pale skin, shortness of breath, exercise intolerance, tachycardia.
The symptoms associated with the accumulation of lymphoblasts in the internal organs:
- enlarged liver and spleen;
- enlarged lymph nodes to more than 2 cm;
- joint and bone pain;
- neurological symptoms;
- enlarged thymus – it presses on the trachea causing cough and making breathing difficult, while the compression of the upper vena cava results in the swollen face, neck, arms, headache and dizziness.
Is it possible to carry out early diagnostics?
In the case of any deterioration in the health condition of the child or adult, one should consult a doctor and undergo complete blood count. This is the best type of early diagnostics. All people without exception undergo complete blood count regardless of the reason for their visit to a specialist. This examination can detect leukemia. The characteristic changes in the blood of a child include:
- decreased number of erythrocytes and platelets;
- onset of lymphoblasts – immature leukocytes.
A specific sign of leukemia is the onset of lymphoblasts in the blood. Normally, they should not be present at all. These are immature cells, which are contained only in the red bone marrow.
Confirmation and clarification of the diagnosis
To confirm the diagnosis, the patient requires two tests, namely bone marrow aspiration and biopsy. These serve to determine the number of blast cells (precursors of leukocytes). Normally, their number should not exceed 5%, but in case of leukemia their proportion increases to 20% or more.
The bone marrow aspiration is performed from the pelvic bone, less often from the sternum. The doctor uses local anesthesia. The child may have other options for pain management, such as general anesthesia or sedation. The needle is inserted into the pelvic bone. When it enters the bone marrow, the doctor pulls the aspirator piston towards himself, thereby creating a negative pressure in it. According to the mechanism for obtaining biomaterial, the procedure is similar to sampling blood from a vein.
The bone marrow biopsy is performed immediately after aspiration. To perform this procedure, the doctor uses a thicker needle. It allows him to obtain a sample of tissue in the form of a narrow column.
The examinations are indicated not only for making a diagnosis. The patient should undergo them repeatedly during the treatment process. With bone marrow biopsy, the doctor can either determine the achievement of remission or timely detect a relapse. He can see whether the treatment has any effect, and can change the regimen, if necessary.
Clarifying tests, the biological material for which is the patient's bone marrow:
- cytochemical examination – specifies the type of blast cells (myeloblasts or lymphoblasts);
- flow cytometry and immunohistochemistry;
- immunophenotyping;
- cytogenetic examination;
- fluorescence in situ hybridization (FISH);
- polymerase chain reaction (PCR).
These methods are applied to assess the risk of relapse, to predict the further development of the disease, and to plan therapeutic tactics.
Additional examinations
Some diagnostic examinations are not prescribed to all patients, but they are performed according to the indications only. These may be the following tests:
- Lumbar puncture can be carried out in suspected lesion of the structures of the central nervous system. It involves the sampling of cerebrospinal fluid by means of inserting a needle into the spinal canal through the space between the vertebrae. The procedure is not dangerous for most patients, because the analysis is taken from the area where the spinal cord ends.
- Lymph node biopsy is rarely performed. It involves the surgical removal of enlarged node (most often a cervical, axillary or inguinal one).
- X-ray helps to determine enlarged intrathoracic lymph nodes and signs of inflammatory processes of the bronchopulmonary system (a consequence of reduced immunity caused by leukemia).
- Computed tomography can be applied for the imaging of enlarged internals or lymph nodes.
- MRI allows the doctor to assess the state of the central nervous system, indicated in the case of malignant cells in the cerebrospinal fluid according to the results of lumbar puncture.
- Ultrasound can be performed to examine the abdominal organs and testicles in men.
The imaging methods are rarely applied in the diagnostics of lymphoblastic leukemia. In most cases, the doctor can get all the necessary information, which is required for the treatment by means of various diagnostic procedures with the red bone marrow.
Diagnostics in Germany with the Booking Health company
To undergo the diagnostics or treatment of acute lymphoblastic leukemia in the German clinic, you can use the services of Booking Health. When booking a treatment program with the help of our service, you will receive the following benefits:
- Selection of the best Oncohematological Center for the diagnostics and treatment of acute lymphoblastic leukemia in children.
- Reduced cost for the diagnostics and treatment of acute lymphoblastic leukemia in children.
- Booking an appointment with a doctor on the most suitable dates for you.
- Preparation of the diagnostic program taking into account previously performed examinations.
- Establishment of communication directly with the attending physician.
- Monitoring of the diagnostic program at all its stages.
- Control of invoices and return of unspent funds.
- Buying and forwarding of medicines.
- Organization of additional diagnostic or therapeutic procedures.
- Communication with the clinic after the diagnostics and treatment of acute lymphoblastic leukemia in adults.
The Booking Health company will provide the top-class services. We will book a hotel and airline tickets for you, meet you at the German airport, take you to the clinic and provide interpreting services.
