google_counter
background_img

Diagnostic and treatment of Acute Lymphoblastic Leukemia

Due to the difficulties associated with the organization of treatment in Turkey, Switzerland, South Korea and India, we are not currently processing requests to these regions.

If you are interested in treatment in Germany, please leave a request and our specialists will contact you as soon as possible.

 

Cost for treatment

Acute Lymphoblastic Leukemia (ALL) Diagnosis
12909.35
Allogeneic bone marrow transplantation in acute lymphoblastic leukemia
141192.3
Consolidation treatment for acute lymphoblastic leukemia
63776.8

University Hospital Mannheim

9.8/10
location_onGermany, Mannheim

Department of Hematology and Oncology

According to the reputable Focus magazine, the University Hospital Mannheim ranks among the top medical institutions of Germany, which is an undeniable confirmation of the impeccable medical care and excellent reputation of the hospital! The hospital is a high-tech modern medical institution, which provides accurate diagnosis an
Acute Lymphoblastic Leukemia (ALL) Diagnosis
18686.6
Allogeneic bone marrow transplantation in acute lymphoblastic leukemia
300860.25
Consolidation treatment for acute lymphoblastic leukemia
98823.05

University Hospital Ulm

8.7/10
location_onGermany, Ulm

Department of Hematology, Oncology, Palliative Care, Rheumatology and Infectology

The University Hospital Ulm started its activities 35 years ago and during this time it has become one of the most prestigious medical institutions in Europe. The hospital is famous for its numerous discoveries and the world-class achievements in medicine and pharmaceuticals. The medical facility has 29 specialized departments a
Acute Lymphoblastic Leukemia (ALL) Diagnosis
21879.5
Allogeneic bone marrow transplantation in acute lymphoblastic leukemia
386490
Consolidation treatment for acute lymphoblastic leukemia
97679

University Hospital Freiburg

9.7/10
location_onGermany, Freibung

Department of Hematology and Oncology

The University Hospital Freiburg is famous for its rich history and is one of the oldest and most prestigious medical facilities in Germany (one of the three best medical institutions in the country). The hospital was based on the Faculty of Medicine of the Albert Ludwig University of Freiburg, which celebrated its 550th anniver
Acute Lymphoblastic Leukemia (ALL) Diagnosis
23116.35
Allogeneic bone marrow transplantation in acute lymphoblastic leukemia
415700.25
Consolidation treatment for acute lymphoblastic leukemia
121878.05

University Hospital Heidelberg

9.8/10
location_onGermany, Heidelberg

Department of Hematology, Oncology, Adult and Pediatric Rheumatology

According to Focus magazine, the University Hospital Heidelberg ranks among the top five hospitals in Germany! The hospital is one of the most advanced and reputable medical institutions not only in Germany, but throughout Europe. There are more than 43 specialized departments and 13 medical institutes, which cover all fields of
Acute Lymphoblastic Leukemia (ALL) Diagnosis
0
Allogeneic bone marrow transplantation in acute lymphoblastic leukemia
0
Consolidation treatment for acute lymphoblastic leukemia
0

University Hospital Frankfurt am Main

10/10
location_onGermany, Frankfurt am Main

Department of Hematology, Oncology, Hemostaseology, Rheumatology and Infectology

According to the reputable Focus magazine, the University Hospital Frankfurt am Main ranks among the top German medical facilities! The hospital was founded in 1914 and today is a well-known German medical facility, which combines rich traditions and scientific innovations. A medical team of more than 6,500 employees cares about
Acute Lymphoblastic Leukemia (ALL) Diagnosis
20004.65
Allogeneic bone marrow transplantation in acute lymphoblastic leukemia
358433.95
Consolidation treatment for acute lymphoblastic leukemia
107088.05

University Hospital RWTH Aachen

8.7/10
location_onGermany, Aachen

Department of Oncology and Hematology

According to the prestigious Focus magazine, the University Hospital RWTH Aachen ranks among the top German hospitals! As a maximum care university medical facility, the hospital guarantees patients first-class medical services combined with a respectful and human attitude. The hospital integrates all the modern options for the
Acute Lymphoblastic Leukemia (ALL) Diagnosis
22587.1
Allogeneic bone marrow transplantation in acute lymphoblastic leukemia
415495.8
Consolidation treatment for acute lymphoblastic leukemia
121756.25

University Hospital Würzburg

9.2/10
location_onGermany, Würzburg

Department of Gastroenterology, Hematology, Oncology, Hepatology, Infectology, Rheumatology and Clinical Immunology

According to the Focus magazine in 2019, the University Hospital Würzburg ranks among the top national German hospitals! The hospital is one of the oldest medical facilities in Germany. The centuries-old traditions of first-class treatment are combined with the very latest achievements of modern evidence-based medicine and
Acute Lymphoblastic Leukemia (ALL) Diagnosis
18641.65
Allogeneic bone marrow transplantation in acute lymphoblastic leukemia
329808.05
Consolidation treatment for acute lymphoblastic leukemia
99559.65

University Hospital Erlangen

9.1/10
location_onGermany, Erlangen

Department of Hematology and Oncology

According to the Focus magazine, University Hospital Erlangen ranks among the best medical facilities in Germany! The hospital is one of the leading healthcare facilities in Bavaria and offers top-class medical care distinguished by the close intertwining of clinical activities with research and training of medical students. The
Acute Lymphoblastic Leukemia (ALL) Diagnosis
21540.2
Allogeneic bone marrow transplantation in acute lymphoblastic leukemia
386711.85
Consolidation treatment for acute lymphoblastic leukemia
97697.85

University Hospital Halle (Saale)

9.6/10
location_onGermany, Halle

Department of Hematology and Oncology

According to the prestigious Focus magazine, the University Hospital Halle (Saale) ranks among the top German medical facilities! The history of the hospital has more than 300 years, and during this time it managed to earn an excellent reputation not only in Germany, but throughout the world. The hospital positions itself as a s
Acute Lymphoblastic Leukemia (ALL) Diagnosis
19169.45
Allogeneic bone marrow transplantation in acute lymphoblastic leukemia
329857.35
Consolidation treatment for acute lymphoblastic leukemia
99468.3

University Hospital Hamburg-Eppendorf

9.2/10
location_onGermany, Hamburg

Department of Hematology, Oncology and Pulmonology

According to the Focus magazine, the University Hospital Hamburg-Eppendorf ranks among the top ten hospitals in Germany! Since its foundation in 1889, the hospital has taken a leading position in the European medical arena and still occupies it until today. A highly competent medical team of more than 11,000 employees takes care
Acute Lymphoblastic Leukemia (ALL) Diagnosis
19204.25
Allogeneic bone marrow transplantation in acute lymphoblastic leukemia
329758.75
Consolidation treatment for acute lymphoblastic leukemia
99221.8

Charite University Hospital Berlin

9/10
location_onGermany, Berlin

Charité Comprehensive Cancer Center

According to the authoritative Focus magazine, the Charite University Hospital Berlin occupies the first place in the rating of the top German medical facilities! The hospital is one of the largest and leading university medical complexes in Europe. The hospital in Germany provides modern diagnostics and treatment of patients, a
Acute Lymphoblastic Leukemia (ALL) Diagnosis
18679.35
Allogeneic bone marrow transplantation in acute lymphoblastic leukemia
329326.65
Consolidation treatment for acute lymphoblastic leukemia
99033.3

University Hospital Bonn

9.2/10
location_onGermany, Bonn

Department of Oncology, Hematology, Rheumatology and Immunoncology

According to the authoritative Focus magazine, the University Hospital Bonn ranks among the top ten medical facilities in Germany! The hospital was opened on January 1, 2001, although in fact it inherits the medical facility, which operated at the Faculty of Medicine of the University of Bonn. The hospital in Germany combin
Acute Lymphoblastic Leukemia (ALL) Diagnosis
22485.6
Allogeneic bone marrow transplantation in acute lymphoblastic leukemia
415110.1
Consolidation treatment for acute lymphoblastic leukemia
121988.25

University Hospital Giessen UKGM

9.5/10
location_onGermany, Giessen

Department of Oncology, Hematology and Palliative Care

The University Hospital Giessen UKGM positions itself as an ultramodern medical facility with outstanding quality of medical care. The hospital presents almost all areas of medicine, ranging from ophthalmology to traumatology and dentistry. The priorities of the hospital’s activities include surgery, neurosurgery, oncology
Acute Lymphoblastic Leukemia (ALL) Diagnosis
19165.1
Allogeneic bone marrow transplantation in acute lymphoblastic leukemia
329758.75
Consolidation treatment for acute lymphoblastic leukemia
98843.35

University Hospital of Ludwig Maximilian University of Munich

10/10
location_onGermany, Munich

Department of Oncology and Hematology

According to the Focus magazine, the University Hospital of Ludwig Maximilian University of Munich is regularly ranked among the best medical institutions in Germany! The hospital is the largest multidisciplinary medical facility, as well as a leading research and training center in Germany and Europe. The hospital is proud of i
Acute Lymphoblastic Leukemia (ALL) Diagnosis
23159.85
Allogeneic bone marrow transplantation in acute lymphoblastic leukemia
415433.45
Consolidation treatment for acute lymphoblastic leukemia
104320

University Hospital Marburg UKGM

8.6/10
location_onGermany, Marburg

Department of Hematology, Oncology and Immunology

The University Hospital Marburg UKGM offers patients modern diagnostics and comprehensive therapy at the international level. As a maximum care hospital, the medical facility specializes in all fields of modern medicine ranging from ophthalmology to traumatology and dentistry. The main areas of specialization of the hospital are
Acute Lymphoblastic Leukemia (ALL) Diagnosis
19085.35
Allogeneic bone marrow transplantation in acute lymphoblastic leukemia
330003.8
Consolidation treatment for acute lymphoblastic leukemia
99263.85

University Hospital Muenster

9.8/10
location_onGermany, Muenster

Department of Hematology, Hemostaseology, Oncology and Pulmonology

According to the Focus magazine, the University Hospital Muenster ranks among the top German hospitals! The hospital belongs to the most prestigious medical institutions in Germany. The hospital is distinguished by a high professionalism of its doctors, state-of-the-art technological equipment and the availability of the most ad
Acute Lymphoblastic Leukemia (ALL) Diagnosis
19094.05
Allogeneic bone marrow transplantation in acute lymphoblastic leukemia
329554.3
Consolidation treatment for acute lymphoblastic leukemia
99468.3
| from Booking Health GmbH

Acute lymphoblastic leukemia is a type of blood cancer that develops from immature white blood cells. This is a severe disease that, in its natural course, leads to death in a few months. Nonetheless, doctors in developed countries usually successfully deal with the treatment of acute lymphoblastic leukemia. Even in the case of the development of the most aggressive forms, the therapy helps to cure the disease completely.

Content

  1. Chemotherapy
  2. Targeted therapy and immunotherapy
  3. Radiation therapy
  4. Recurrence treatment
  5. Stem cell transplant
  6. CAR T-cell therapy
  7. Where to undergo treatment?

Acute lymphoblastic leukemia is a cancer that affects white blood cells (lymphocytes).

Stages of leukemia are early pre-B ALL, common ALL, pre-B(T) ALL, and mature B(T)-cell ALL.

Treatment includes chemo- and immunotherapy, irradiation, CAR T-cell therapy, and stem cell transplantation.

Cost of treatment with chemotherapy – from €43,781. Price for bone marrow transplantation – from €97,374. Cost of CAR T-cell therapy – from €81,970.

Best hospitals in Europe are:

  • University Hospital of Ludwig Maximilian University of Munich
  • University Hospital Rechts der Isar Munich
  • University Hospital Frankfurt am Main
  • Helios Hospital Berlin-Buch
  • Clinic of Advanced Biological Medicine Frankfurt am Main

Chemotherapy

 

While surgery is considered the primary treatment for most cancers, acute lymphoblastic leukemia can be cured with chemotherapy. The participation of surgeons is usually not required, except in cases of emergency, when a tumor mass is so large that it compresses the vital organs.

Blood cancer treatment is carried out in three stages:

Induction is aggressive chemotherapy that aims to achieve cancer remission. Remission means that leukemia cells are absent in bone marrow samples. Remission does not yet mean a cure, since a small number of leukemia cells still remain in a patient's body. It is for this reason that treatment continues after induction. The starting stage of chemotherapy for acute lymphoblastic leukemia lasts about 1 month, while the total duration of treatment for blood cancer reaches 2-3 years.

Conventional cancer chemotherapy regimens are effective in more than 90% of patients. The younger the age, the better the results. Remission of acute lymphoblastic leukemia in children can be achieved in more than 95% of cases.

Since a chemotherapy regimen during this period is quite intense and may cause side effects, patients at this stage of treatment for acute lymphoblastic leukemia stay at the hospital all the time. Chemotherapy blocks the division of not only cancer cells, but also other cells that are rapidly dividing. The function of the bone marrow is almost always affected. As a result, the production of blood cells decreases. To overcome side effects, patients frequently require antibiotics, as well as red blood cell and platelet transfusions.

The most common treatment regimen involves chemotherapy with three drugs. In high-risk patients, four drugs can be used at once. In Philadelphia-positive acute lymphoblastic leukemia, targeted therapy can be additionally prescribed.

At the stage of induction, patients receive not only systemic, but also intrathecal chemotherapy. This involves injecting drugs into the cerebrospinal fluid. This necessity is due to the fact that blood cancer often spreads to the central nervous system. However, most drugs cannot cross the blood-brain barrier, so leukemic cells remain in the brain. Doctors perform a lumbar puncture to destroy them. The procedure involves the injection of drugs into the spinal canal, just below the point where the spinal cord ends. In total, 2 injections are required in the first month, and then several more injections 1 time in the next 2 months. In high-risk acute lymphoblastic leukemia, drugs can be injected into the cerebrospinal fluid even more often.

Consolidation begins after achieving remission and lasts for several months. This phase of treatment for acute leukemia destroys any remaining cancer cells in the body. Doctors use combinations of several drugs to avoid the formation of resistance in cells to chemotherapy agents. Intrathecal chemotherapy is still going on, although injections are becoming rarer.

As a rule, during the consolidation phase, treatment is not as intense as during induction. However, some patients still have leukemic cells. In this case, minor residual disease is diagnosed. These patients require more aggressive drug treatment for cancer. Doctors can also repeat the course of induction chemotherapy, which is called "delayed intensification".

Maintenance therapy lasts about 2 years. The task of this stage of treatment is to prevent the recurrence of the disease and destroy the remaining cancer cells to cure acute lymphoblastic leukemia completely. Patients take several drugs. Some of them are taken constantly, and others in short courses.

Targeted therapy and immunotherapy

 

Other drugs that are effective in the treatment of some forms of acute lymphoblastic leukemia are as follows:

BCR-ABL inhibitors can be used in the presence of the Philadelphia chromosome in cancer cells. This is more common in myelogenous leukemia but can also be found in some patients with lymphoblastic leukemia. BCR-ABL inhibitors are combined with chemotherapy.

CD19/CD3 monoclonal antibodies can be used for B-cell lymphoblastic leukemia. The drug is used after chemotherapy. The course of treatment is 4 weeks, and a patient spends all this time at the hospital, so the infusions are carried out continuously. In addition, immunotherapy with monoclonal antibodies may cause complications, and, in this case, a person should be provided with timely medical care. The course of treatment with antibodies can sometimes be repeated after 2 weeks.

Radiation therapy

 

Radiation therapy is highly effective for acute lymphoblastic leukemia, but not all patients require this treatment option. As a rule, cancer can only be cured with chemotherapy. Irradiation can be required in the following cases:

  • a large number of leukemia cells were detected in the cerebrospinal fluid;
  • preparation for a bone marrow transplant.

In recent years, more and more new drugs have appeared, and drug therapy regimens for blood cancer have improved, so even in these two cases, radiation therapy is used less and less frequently. This is due to the fact that most patients with acute lymphoblastic leukemia are children, and irradiation of the brain and spinal cord may cause a developmental delay with impaired cognitive functions. For this reason, even in high-risk acute lymphoblastic leukemia, doctors are more likely to prefer more intensive chemotherapy, but try to avoid radiation therapy.

Recurrence treatment

 

If cancer has recurred after treatment, the further treatment tactics depend on how aggressive acute lymphoblastic leukemia was, what the previous treatment was, how successful it was, and how much time has passed from remission to recurrence.

As a rule, doctors prescribe chemotherapy to treat cancer recurrence. If the time before the onset of recurrence of acute lymphoblastic leukemia turns out to be significant, it is possible to use the same regimen as for the first time, or one that is similar to it. A short remission requires the use of other drugs, and the treatment regimen becomes more aggressive. Even in cancer recurrence, acute lymphoblastic leukemia can still be cured in many patients.

Recurrence can be extramedullary. This is when cancer recurs outside of the bone marrow. Most often, this is a recurrence from the central nervous system, and, in boys, a tumor may recur in the testicles. This form of the disease can be treated with chemotherapy in combination with radiation therapy.

Stem cell transplant

 

A bone marrow transplant is the most effective treatment for acute lymphoblastic leukemia. This can be resorted to in the most severe cases, when it is not possible to cure cancer with another method.

A stem cell transplant can be:

  • autologous – transplantation of a patient's own cells;
  • allogeneic – transplantation of donor cells.

An allogeneic transplant is mostly used for acute lymphoblastic leukemia. Before it is carried out, doctors destroy all cancer cells in the body with high-dose chemotherapy, sometimes combined with irradiation. A successful transplant results in the activation of the graft-versus-tumor immune response. Immune cells are formed and they completely cure acute lymphoblastic leukemia.

Indications for a stem cell transplant include:

  • a high risk of cancer recurrence;
  • unsuccessful attempts to achieve remission at the stage of induction;
  • cancer recurrence, especially up to 6 months after successful chemotherapy;
  • Philadelphia chromosome-positive acute leukemia.

In acute myeloblastic leukemia, the need for a stem cell transplant is less common than in lymphoblastic leukemia because this type of cancer is less likely to recur after its initial treatment, and the response rate to chemotherapy is higher.

CAR T-cell therapy

 

CAR T-cell therapy is used to treat leukemia that has recurred and is not responding to any other treatment.

Doctors take immune cells from a patient's body. Their genotype is then changed. Once modified, leukocytes are able to attack cells containing CD19 receptors. Therefore, they destroy the tumor, but do not damage healthy tissue. The modified cells are cultured to increase their numbers and then injected into the body after several days of chemotherapy. The whole process, from obtaining cells to their injection, takes several weeks.

Although CAR T-cell therapy is expensive and sometimes causes complications, this treatment for acute lymphoblastic leukemia is very effective. Even the most aggressive and advanced forms of cancer can be cured with its help. The most dangerous complication is cytokine release syndrome. This is a very severe inflammation that leads to fever, nausea, muscle and joint pain, as well as breathing difficulties. Doctors are usually able to manage these symptoms, but additional medical procedures and drugs are required for the treatment of complications.

Where to undergo treatment?

 

You can undergo your treatment of acute lymphoblastic leukemia abroad, in one of the best Cancer Centers in the world. In this case, you will get the best results with a minimal risk of complications. Developed countries offer the most modern drugs and techniques to cope with even severe cases of the disease.

There are a few reasons for you to undergo your treatment abroad:

  • modern chemotherapy regimens curing leukemia in most patients;
  • innovative drugs for targeted therapy and immunotherapy, including BCR-ABL inhibitors and monoclonal antibodies;
  • the use of the latest types of radiation therapy that destroy leukemic cells and almost do not damage healthy tissues;
  • even severe cases of leukemia can be successfully treated: in high-risk patients, in a high concentration of leukemic cells in the central nervous system, in recurrences, including extramedullary ones;
  • doctors abroad use innovative procedures, including a stem cell transplant and CAR T-cell therapy.

You can make your treatment appointment through the Booking Health service. Our website presents the best clinics, and shows the cost of treatment in each of the Oncohematological Centers. You can make your treatment appointment at the selected clinic through the Booking Health service. In this case, the cost of treatment for you will be lower due to the lack of additional taxes for foreign patients. The specialists of the Booking Health company will advise you on all issues and organize your trip abroad.

 

Authors: 

The article was edited by medical experts, board certified doctors Dr. Nadezhda Ivanisova and Dr. Farrukh Ahmed. For the treatment of the conditions referred to in the article, you must consult a doctor; the information in the article is not intended for self-medication!

 

Sources:

National Center for Biotechnology

American Cancer Society

Cancer Support Community




Feedback of our customers from other resources

Need Help?

Thank you!

We received your treatment application in the best Europe clinics. Our manager will contact you within the next 24 hours.