Chronic Myelogenous Leukemia (CML) — Chemotherapy and Immunotherapy: treatment in the Best Hospitals of Germany
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Department of Hematology and Oncology
The Department of Hematology and Oncology offers the full range of services in these medical fields. It diagnoses and treats all benign and malignant blood diseases, cancers. The huge clinical experience and high competence of the doctors working in the department allow them to achieve excellent treatment results even in the most severe cases.
Department of Hematology, Oncology, Rheumatology, Infectology and Bone Marrow Transplantation
The Department of Hematology, Oncology, Rheumatology, Infectology and Bone Marrow Transplantation offers modern diagnostics and treatment in all areas of its specialization. The medical facility treats patients with solid malignant tumors of various locations, malignant and benign diseases of the hematopoietic system, rheumatic diseases, and infections. The department enjoys a reputation as one of the leading health facilities for bone marrow transplants in Germany, which is confirmed by accreditation in accordance with JACIE standards. More than 80 allogeneic and more than 100 autologous bone marrow transplants are performed in the medical facility annually. In addition, the department successfully carries out innovative CAR T-cell therapy, which is available only in the most advanced medical centers worldwide. The department is part of the Comprehensive Cancer Center Ulm (CCCU), where a multidisciplinary team of highly professional doctors takes care of the health of patients. The high quality of medical services is confirmed by the certification of the German Cancer Society (DKG). The health of patients is in the safe hands of experienced specialists who strive to provide each patient with the most effective treatment using advanced therapeutic methods. The medical facility has 112 beds and many specialized outpatient clinics.
Department of Hematology and Oncology
The Department of Hematology and Oncology offers the full range of diagnostics and treatment of blood diseases, coagulation disorders, oncological diseases and related pathological conditions. The treatment is provided both on an outpatient and inpatient basis. The patient is offered a comprehensive treatment, including intensive care to eliminate side effects associated with the tumor and therapy, development of individual recommendations on nutrition, physiotherapeutic measures and psycho-oncological care.
Department of Hematology, Oncology, Adult and Pediatric Rheumatology
The Department of Hematology, Oncology, Adult and Pediatric Rheumatology offers the full range of modern diagnostics and treatment of malignant diseases, rheumatic pathologies, including particularly complex clinical cases in these fields. In addition, the department's doctors specialize in stem cell transplantation and occupy leading positions in this field at the international level. The medical team of the department makes every effort to guarantee each patient an individual, first-class treatment, based on the very latest achievements of modern medicine and human respect, understanding of the needs of each patient.
Department of Hematology, Oncology, Hemostaseology, Rheumatology and Infectology
The Department of Hematology, Oncology, Hemostaseology, Rheumatology and Infectology offers the full range of medical services in the fields of its specialization. The department specializes in the diagnostics and treatment of all diseases of the hematopoietic system, systemic treatment of solid tumors, infectious diseases, including outpatient admission of patients with HIV, blood clotting disorders, as well as the entire clinical and morphological group of rheumatic diseases. The department is actively engaged in research activities and regularly implements the latest medical developments into clinical practice, thereby providing treatment in accordance with the most advanced scientific achievements.
Department of Hematology, Oncology and Pulmonology
According to the Focus magazine, the Department of Hematology, Oncology and Pulmonology is one of the best medical facilities in Germany for the treatment of colorectal cancer! The department provides comprehensive diagnosis and highly effective treatment of solid tumors, benign and malignant blood diseases, and pathologies of the lungs and other respiratory organs. The department's specialists have unique expertise in the treatment of leukemia, lymphomas, germ cell tumors, gastrointestinal malignancies, lung cancer, bone and soft tissue sarcomas, and head and neck tumors. The pulmonary team focuses on patients with cystic fibrosis, interstitial lung disease, and pulmonary hypertension. The specialists have well-equipped endoscopic rooms for diagnosis and treatment. The department's medical team works closely with surgeons, radiologists, radiation therapists, urologists, gynecologists, otolaryngologists, and physicians of other specialties. The healthcare facility holds weekly interdisciplinary tumor boards, where clinical cases are discussed individually and optimal treatment regimens are developed for each patient. The department is certified in accordance with the standards of the German Cancer Society (DKG) and the European Society for Medical Oncology (ESMO). More than 2,800 inpatients are treated here each year, and nearly 7,000 more patients are cared for on an outpatient basis.
Department of Gastroenterology, Hematology, Oncology, Hepatology, Infectology, Rheumatology and Clinical Immunology
The Department of Gastroenterology, Hematology, Oncology, Hepatology, Infectology, Rheumatology and Clinical Immunology offers the full range of diagnostics and treatment in these fields. The department specializes in the treatment of benign and malignant diseases of the digestive system, liver and bile ducts, the hematopoietic system, etc. Much attention is paid to the interdisciplinary cooperation (Cancer Center Mainfranken, etc.).
Department of Oncology and Hematology
The Department of Oncology and Hematology offers accurate diagnostics and effective treatment of benign and malignant blood diseases, as well as solid tumors. The department's specialists are proud of the excellent results in the field of bone marrow transplantation, which is among the department’s priority focuses. The department has 61 beds. Medical care is carried out both on an outpatient and inpatient basis.
Department of Hematology and Oncology
The Department of Hematology and Oncology provides diagnostics and comprehensive treatment of diseases of the hematopoietic system, as well as solid tumors of various organs. Hematologists most often deal with the treatment of acute and chronic leukemias, malignant lymphomas, myelodysplastic syndromes, plasmacytomas and other pathologies. Chemotherapy is usually first-line therapy. The department's specialists also successfully perform bone marrow transplantation. In the field of oncology, the department provides effective treatment of various tumors of the gastrointestinal tract, endocrine glands, female and male reproductive system, skin cancer, soft tissue and bone sarcomas, head and neck malignancies, etc. The patients suffering from cancer are offered classical (chemotherapy, immunotherapy, hormone therapy) and innovative (immunotherapy, CAR T-cell therapy) treatment methods. Surgical resection of solid tumors is performed by specialized surgeons. The treatment regimen is developed individually for each patient at the tumor board, which plays an important role in achieving a successful treatment result.
Department of Hematology and Oncology
The Department of Hematology and Oncology offers comprehensive diagnosis and effective treatment of the entire spectrum of oncological diseases of the hematopoietic system, benign blood disorders, and solid malignancies of various localizations. The primary specialization in the department is blood cancer treatment. The department's doctors have in their arsenal many methods with scientifically proven effectiveness in the fight against cancer: chemotherapy, targeted therapy, antibody therapy, hormone therapy, immunotherapy, as well as stem cell transplantation and innovative CAR T-cell therapy. Treatment tactics are developed taking into account the individual needs and wishes of each patient, thanks to which specialists manage to achieve good results. The department also offers maintenance therapy to alleviate the side effects of the basic course of cancer treatment and palliative care. The department has the status of a Leukemia and Lymphoma Center certified by the German Cancer Society (DKG). In addition, it is one of the few centers in Europe certified according to JACIE standards in the field of bone marrow transplantation. Competent physicians with in-depth knowledge and extensive clinical experience in their specialty care for the health of the patients.
Charité Comprehensive Cancer Center
Charité Comprehensive Cancer Center offers patients the full range of classical and innovative examinations, treatment of malignant diseases of all organs and anatomical structures of the human body. The spectrum is complemented by follow-up medical care, rehabilitation, modern schemes for the prevention and early detection of malignant diseases. An important component of the therapeutic process in the center is psycho-oncological care. The centerdals with the treatment of patients of all age groups, ranging from small children to elderly patients.
Department of Oncology, Hematology, Rheumatology and Immunoncology
The Department of Oncology, Hematology, Rheumatology and Immunoncology offers the full range of diagnostics and treatment of solid tumors, benign and malignant diseases of blood and bone marrow, rheumatic pathologies. The priority purpose of each employee in the department is to provide patients with an optimal medical care, based on the use of the very latest treatment methods. The department's specialists are distinguished by their high professionalism and colossal experience in the treatment of extremely complex clinical cases.
Department of Oncology, Hematology and Bone Marrow Transplantation
The Department of Oncology, Hematology and Bone Marrow Transplantation provides the full range of diagnostic and therapeutic services to patients with malignant solid tumors, and benign and malignant blood pathologies. Of particular interest is the treatment of patients with acute leukemia, lymphomas, multiple myeloma, sarcomas, gastrointestinal cancer, lung cancer, breast cancer, and rare malignant tumors. The department is part of the Comprehensive Cancer Center Munich, thanks to which doctors from related specialties are involved in the therapeutic process. All modern diagnostic methods and therapeutic procedures are available here, including bone marrow transplantation, which is often the most effective treatment method for blood cancer. The health of patients is in the safe hands of a highly qualified medical team, consisting of 65 doctors and 130 nurses. The department treats about 2,800 inpatients and more than 10,000 outpatients every year. The department's specialists pay due attention to the psychological state of their patients diagnosed with cancer, so a program of psycho-oncological care is being successfully implemented here.
Department of Hematology, Hemostaseology, Oncology and Pulmonology
The Department of Hematology, Hemostaseology, Oncology and Pulmonology offers the full range of diagnostics and treatment of blood diseases, including oncopathologies and blood coagulation disorders, lung diseases, and rare malignant diseases. The department incorporates two modern Bone Marrow Transplantation Centers. In addition, the department belongs to the largest medical facilities in Germany, which specialize in the treatment of malignant lymphomas, acute leukemias, sarcomas, as well as bone marrow transplantation. The physicians of the department are committed to providing patients with the comprehensive medical care of the highest quality, based on the respective attitude towards patients.
Department of Oncology, Hematology and Palliative Care
The Department of Oncology, Hematology and Palliative Care offers all the options of modern medicine for the treatment of patients with the pathologies in these fields. Specialization covers the treatment of cancer of the internal organs, blood cancer, symptomatic treatment of progressive incurable diseases. Other focuses of the department are intensive care medicine and special pain therapy. To achieve successful and long-term results, the clinical practice is based on the use of effective classic and innovative treatment methods.
Department of Hematology, Oncology and Immunology
According to the Focus magazine, the Department of Hematology, Oncology and Immunology ranks among the top German medical facilities specializing in leukemia treatment! The department offers accurate diagnostics and effective treatment of malignant and benign blood diseases, solid tumors. The patients are treated in close collaboration with the Comprehensive Cancer Center. Of particular interest to the department's doctors is the treatment of various types of leukemia (within the specialized center with advanced infrastructure). The department takes part in many national and international clinical trials, which makes it possible for patients with advanced stages of cancer to receive treatment using innovative therapeutic methods.
Chronic myelogenous leukemia is a slow-growing cancer that can be controlled with drugs. However, if a person does not receive timely and high-quality treatment, they may develop complications such as tumor spread in the body, an enlarged spleen, a low number of cells in the blood, or the transition of chronic myelogenous leukemia to acute myeloid leukemia (AML), which is much more difficult to treat. To take the disease under control in a timely manner, contact one of the German medical centers. Doctors at German hospitals use the latest therapy regimens that effectively suppress the tumor process with a minimal risk of side effects.
Content
Chronic myelogenous leukemia is treated with targeted therapy. If this treatment does not work, cytotoxic chemotherapy and immunotherapy can be used. If these methods can no longer curb the development of the disease, children and young patients resort to high-dose chemotherapy with an allogeneic stem cell transplant.
You can undergo your treatment at one of the following university hospitals: University Hospital Freiburg, University Hospital Mannheim, or University Hospital Ulm.
You do not have to arrange your trip yourself. The Booking Health company will take care of the organization of your trip. Our employees will choose a clinic and a doctor, tell you about possible treatment programs, make an appointment on the preferred dates, help you to apply for a visa and prepare medical records, take care of transfer and interpreting services, and control the cost of treatment. The Booking Health coordinator will be in touch with you 24/7 until you return home.
Cytotoxic chemotherapy
Classical chemotherapy involves the administration of cytotoxic agents that affect all cells with a high division rate. First of all, these are cancer cells, but others are also affected, for example, the hematopoietic system. To reduce harm to the body, chemotherapy is given in cycles. Each course is followed by a rest period to allow normal cells to regenerate.
Chronic myelogenous leukemia chemotherapy in Germany with the use of cytotoxic agents is rarely used because more effective drug therapies have become available. In chronic myelogenous leukemia, cytotoxic drugs can be prescribed only in the absence of the effect of targeted therapy, and also before a stem cell transplant, which is also becoming an increasingly rare procedure for chronic myelogenous leukemia.
Targeted therapy
Targeted therapy is considered the main treatment for chronic myelogenous leukemia. It also belongs to systemic therapy, but instead of classic cytotoxic drugs, doctors use drugs that target particular molecules.
In myeloid leukemia, tyrosine kinase inhibitors are considered the first choice drugs. They are prescribed as pills. Since the disease can never be completely cured, drug intake continues for a very long time. The drugs are not canceled even in the case of the development of side effects, although, in some cases, it is possible to reduce dosages.
Drugs that target BCR-ABL help to control the disease for many years and prevent it from progressing to a more aggressive stage. Since patients are treated at home on their own, it is very important to strictly follow the doctor's prescriptions in order to get the desired result. Here is what you should pay attention to first of all:
- dosages should be exactly as prescribed by a doctor, even if side effects have appeared (lower doses will lead to insufficient effects, and higher doses will lead to excessive toxicity);
- frequency of administration – a patient should not skip a dose, as this will lead to a decrease in the treatment effectiveness (most drugs are taken only once a day);
- some drugs interact with tyrosine kinase inhibitors, so it is worth informing your doctor about any drugs, supplements or herbs you are taking;
- some drugs cannot be combined with food, as their bioavailability is reduced;
- some medicines affect blood glucose levels, heart rate, etc., so it is worth undergoing regular check-ups to avoid complications.
Regular examinations will help doctors to understand if the treatment is effective. As a rule, drugs work for a long time, but if the effect weakens, a doctor may prescribe a different tyrosine kinase inhibitor or increase the dosage. Some patients with T315I mutations may require other drugs.
When standard treatment does not work, a person will be given second-line drugs and then third-line drugs. Finally, if targeted therapy does not work at all, immunotherapy and cytotoxic chemotherapy can be used separately or in addition to it.
Immunotherapy for chronic myelogenous leukemia
Myeloid leukemia can be treated with immunotherapy with interferons. As of today, this treatment option is not used as often as it used to be. There are several reasons:
- more effective targeted therapy was developed;
- targeted therapy is more convenient: taking pills is easier than doing daily injections;
- interferons sometimes cause severe side effects;
- interferon treatment is less well tolerated: body temperature may rise, a patient may develop headaches and muscle pain, weakness, etc.
Therefore, interferon therapy is no longer considered the first-line treatment. These drugs are only given to people who are no longer getting the effects of targeted therapy.
You are welcome to use the Booking Health service to undergo your diagnostics, treatment and rehabilitation for chronic myelogenous leukemia in Germany. Here you can find the average cost of treatment and book an appointment at the clinic at the best price. Our specialists will help you to select the best clinics in Germany and arrange your trip.
Authors:
The article was edited by medical experts, board-certified doctors Dr. Nadezhda Ivanisova and Dr. Sergey Pashchenko. For the treatment of the conditions referred to in the article, you must consult a doctor; the information in the article is not intended for self-medication!
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