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Allogeneic bone marrow transplantation in acute lymphoblastic leukemia (565104) | University Hospital Tuebingen - BookingHealth
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Allogeneic bone marrow transplantation in acute lymphoblastic leukemia

University Hospital Tuebingen

Tuebingen, Germany
Program id # 565104
Doctor photo
Prof. Dr. med. Lothar Kanz
Department of Oncology, Hematology, Clinical Immunology, Rheumatology and Pulmonology
Specialized in: oncology, hematology, clinical immunology, rheumatology, pulmonology

The program includes:

  • Initial presentation in the clinic
  • case history collection
  • general clinical examination
  • laboratory tests:
    • complete blood count
    • biochemical analysis of blood
    • TSH-basal, fT3, fT4
    • differential blood count
    • inflammation indicators (CRP, ESR)
    • indicators of blood coagulation
  • CT/MRI scans of the whole body
  • needle biopsy of the bone marrow with histological:
    • cytochemistry
    • immunocytology
    • cytogenetics (Philadelphia
      chromosome detection)
    • molecular biology
  • biopsy and histological examination of CSF
  • examination by experts of:
    • cardiology
    • otolaryngology
    • immunology
    • ophthalmology
  • registration in the European bone marrow donor base
  • conducting high-dose chemotherapy
  • allogeneic bone marrow transplantation from
    unrelated donor
  • the cost of blood products
  • isolation by neutropenic precautions
  • symptomatic treatment
  • control examinations
  • the cost of essential medicines and materials
  • nursing services
  • full hospital accommodation
  • explanation of future recommendations

How program is carried out

During the first visit, the doctor will conduct a clinical examination and go through the results of the available diagnostic tests. After that, you will undergo the necessary additional examination, such as the assessment of liver and kidney function, ultrasound scan, CT scan and MRI.

Also, the doctor will conduct a bone marrow biopsy followed by cytological examination of the harvested material. This will help him to determine the histological features of your bone marrow (in particular, identify HLA system antigens) and select a suitable donor. The donor can be a family member or a person from the bone marrow registry. In the second case, the donor material is stored in a bone marrow bank.

Before the procedure, you will receive chemotherapy, if necessary in combination with radiation therapy. The course of chemo- or chemoradiation therapy lasts from 2 to 8 days.

The bone marrow transplant procedure is an intravenous infusion, i.e. the healthy bone marrow will be injected through a catheter, intravenously. You will stay in your room during the procedure. A bone marrow transplant is completely painless and does not require anesthesia.

During the period of healthy bone marrow engraftment, you will stay in a sterile ward. This is a necessary precaution because during this time your immune system is very weak and cannot withstand environmental pathogens. The risk of bleeding is also quite high, so you will be advised to avoid mechanical damage.

A relative or other close person may stay in the ward with you. You will not be allowed to go outside the department and leave your ward often. The rehabilitation period can last from 1 to 2 months.

When your complete blood count returns to normal, your doctor will schedule your discharge from the department. You will receive information about the rules that you will need to follow at home, the frequency and type of control examinations, and subsequent treatment measures. You will also receive a detailed medical report, which will reflect the entire course of treatment.

Required documents

  • Medical records
  • MRI/CT scan (not older than 3 months)
  • Bone marrow biopsy results (if available)

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About the department

The Department of Oncology, Hematology, Clinical Immunology, Rheumatology and Pulmonology at the University Hospital Tuebingen offers the full range of medical services in these fields. The department specializes in the treatment of lung, stomach and rectal cancer, sarcomas, therapy of malignant blood diseases using autologous and allogeneic stem cell transplantation, etc. In addition, in the field of autoimmune and rheumatological diseases, the department is one of the leading centers in Germany. The Chief Physician of the department is Prof. Dr. med. Lothar Kanz.

The cancer patients are offered the full range of systemic therapy, as well as other methods of treatment. In particular, the department specializes in bronchogenic lung cancer, metastatic colorectal cancer, advanced gastric cancer, sarcomas, etc. In the field of hematology, special focus is on the treatment of multiple myeloma, myelodysplastic syndrome, all types of leukemia, lymphomas, allogeneic and autologous bone marrow transplantation. Each patient receives an individual treatment program corresponding to the relevant international standards and protocols.

In the field of pulmonology, the department offers the treatment of all diseases of the lungs and respiratory tract. Particular attention is paid to the diagnostics/treatment of bronchogenic lung cancer. The Laboratory for Functional Diagnostics has all modern methods for the assessment of complaints associated with the respiratory system. For example, to assess lung function, the doctors use spirometry and the whole-body plethysmography, interventional bronchoscopy, etc. For the therapeutic purposes, bronchoscopy is used in respiratory tract occlusion due to the tumors and foreign bodies, pulmonary emphysema, etc.

In addition, the department has exceptional expertise in the field of immunological, rheumatological and autoimmune diseases. The department ranks among the leading European centers for the treatment of progressive systemic scleroderma. The department is proud to be the only center in Germany, which offers autologous stem cell transplantation for the treatment of this disease.

The diagnostic and therapeutic range of the department includes the following options:

  • Multiple myeloma
  • Lung cancer
  • Stomach and colon cancer
  • Myelodysplastic syndrome
  • All types of leukemia
  • Malignant lymphomas
  • Allogeneic stem cell transplantation, haploid stem cell transplantation
  • Sarcomas
  • Immunotherapy
  • Diagnostics and treatment of rheumatological diseases (for example, autologous stem cell transplantation in scleroderma, etc.)
  • Diagnostics and treatment of benign and malignant diseases of the lungs and respiratory tract (non-invasive ventilation, bronchoscopic lung biopsy, etc.)
  • Diagnostics and treatment of other diseases in the areas of specialization

Curriculum vitae

  • 1972 - 1978 Study of Medicine at the University of Freiburg.
  • 1978 Thesis defense on the subject: "Subcellular localization of prostaglandin synthase".
  • Internship in the Department of Internal Medicine at the University Hospital Freiburg.
  • 1985 - 1987 Specialization in Hematology/Oncology.
  • 1987 Doctoral thesis defense on the subject: "Human megakaryocyte progenitor cells".
  • 1994 Invitation to the position of (C4) Professor of Internal Medicine at the University of Hannover, then to the position of (C4) Professor of Internal Medicine at the Faculty of Medicine of the University of Tuebingen.
  • Since 1995, Medical Director of the Department of Oncology, Hematology, Clinical Immunology, Rheumatology and Pulmonology at the University Hospital Tuebingen.

Awards and Prizes

  • Goedecke Research Award of the University Hospital Tuebingen.
  • 1996 European Scientific Prize in Hematology.

Photo of the doctor: (c) Universitätsklinikum Tübingen 


About hospital

According to the prestigious medical publication Focus, the University Hospital Tuebingen ranks among the top five German hospitals! 

The hospital was founded in 1805, therefore it is proud of its long history, unique experience, and outstanding achievements in the field of medical care, as well as research and teaching activities. Nowadays, it is one of the most advanced medical institutions, which provides a wide range of general and highly specialized medical services. The hospital combines the state-of-art medical technologies in the field of diagnostics and the very latest treatment methods of a wide range of diseases.

The hospital has 17 specialized departments, which cover almost all fields of modern medicine and contribute to the top-class medical service in Germany. It treats about 367,000 outpatients and 74,000 inpatients annually. This testifies to the high authority of the hospital at the national and international medical arena. This is the first German hospital, which confirmed the high quality of healthcare and the effectiveness of service with a KTQ certification (in 2009).

Photo: (с) depositphotos

Accommodation in hospital

Patients rooms

The patients of the University Hospital Tuebingen live in comfortable single and double rooms with an ensuite bathroom equipped with a shower and toilet. The beds in the patient rooms are equipped with orthopedic mattresses that promote good and full sleep. There is a TV in the room, and it is also possible to connect a smartphone or laptop to the Internet. In addition, there is enough space in the patient room to receive 2-3 guests without inconvenience for the second patient.

The enhanced-comfort rooms include a hairdryer, heated towel rail, a large mirror, a direct dial telephone, a flat-screen satellite TV, a writing desk, free Internet access, a mini-bar and a refrigerator.

Meals and Menus

The patients of the hospital are offered tasty and healthy three meals a day: breakfast, lunch and dinner. Breakfast is served as a buffet, while for lunch and dinner there is a choice of several menus. Also, if desired, the patient will be provided with an individual menu. There are several cafes and cafeterias on the territory of the hospital, where one can have a tasty meal or enjoy a cup of coffee, tea and dessert.

Further details

Standard rooms include:

Toilet
Shower
Wi-Fi
TV

Religion

Religious services are available upon request.

Accompanying person

During the inpatient program, an accompanying person can stay with you in a patient room or in a hotel of your choice.

Hotel

During the outpatient program, you can stay in a hotel of your choice. Our managers will help you choose the most suitable option for you.